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Affiliation: Tufts University
Lewis J, Scangarello F, Murphy J, Eidell K, Sodipo M, Ophir M, et al. ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters. J Cell Sci. 2018;131: pubmed publisher
Bunnell S, Singer A, Hong D, Jacque B, Jordan M, Seminario M, et al. Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol. 2006;26:7155-66 pubmed
..These data indicate that multivalent cooperative interactions stabilize these persistent signaling clusters, which may correspond to the functional complexes predicted by kinetic proofreading models of T-cell activation. ..