Sarah L Booth

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Roles for vitamin K beyond coagulation
    Sarah L Booth
    Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA 02111, USA
    Annu Rev Nutr 29:89-110. 2009
  2. doi request reprint The role of osteocalcin in human glucose metabolism: marker or mediator?
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nat Rev Endocrinol 9:43-55. 2013
  3. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  4. ncbi request reprint Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:143-8. 2004
  5. doi request reprint Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?
    Sarah L Booth
    Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachussetts 02111, USA
    Nutr Rev 68:178-81. 2010
  6. pmc Effect of vitamin K supplementation on bone loss in elderly men and women
    Sarah L Booth
    U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 93:1217-23. 2008
  7. ncbi request reprint Vitamin K status in the elderly
    Sarah L Booth
    Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 10:20-3. 2007
  8. ncbi request reprint Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 rats
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:492-6. 2008
  9. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
  10. ncbi request reprint Vitamin K intake and bone mineral density in women and men
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:512-6. 2003

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Roles for vitamin K beyond coagulation
    Sarah L Booth
    Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA 02111, USA
    Annu Rev Nutr 29:89-110. 2009
    ..There is also an emerging viewpoint that the biochemical function of vitamin K may extend beyond that of a cofactor for the VKD carboxylation of glutamyl residues (Glus) to carboxylated Glus in VKD proteins...
  2. doi request reprint The role of osteocalcin in human glucose metabolism: marker or mediator?
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nat Rev Endocrinol 9:43-55. 2013
    ..Carefully designed studies are required to define the role of osteocalcin and its carboxylated or undercarboxylated forms in the regulation of glucose metabolism in humans...
  3. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  4. ncbi request reprint Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:143-8. 2004
    ..Although a vitamin E-vitamin K interaction was proposed to underlie this effect, it has not been systematically investigated in adults with normal baseline coagulation status...
  5. doi request reprint Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?
    Sarah L Booth
    Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachussetts 02111, USA
    Nutr Rev 68:178-81. 2010
    ..While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required...
  6. pmc Effect of vitamin K supplementation on bone loss in elderly men and women
    Sarah L Booth
    U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 93:1217-23. 2008
    ..Vitamin K has been implicated in bone health, primarily in observational studies. However, little is known about the role of phylloquinone supplementation on prevention of bone loss in men and women...
  7. ncbi request reprint Vitamin K status in the elderly
    Sarah L Booth
    Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 10:20-3. 2007
    ..To understand the impact of vitamin K nutrition on healthy aging it is necessary to assess both the determinants and the adequacy of vitamin K nutritional status of the elderly...
  8. ncbi request reprint Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 rats
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:492-6. 2008
    ..Dihydrophylloquinone may be used in models for the study of tissue-specific vitamin K deficiency...
  9. ncbi request reprint Associations between vitamin K biochemical measures and bone mineral density in men and women
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:4904-9. 2004
    ..Clinical trials are required to isolate any putative effects of vitamin K on rates of bone loss. The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study...
  10. ncbi request reprint Vitamin K intake and bone mineral density in women and men
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 77:512-6. 2003
    ..Low dietary vitamin K intake has been associated with an increased risk of hip fracture in men and women. Few data exist on the association between dietary vitamin K intake and bone mineral density (BMD)...
  11. ncbi request reprint Dietary phylloquinone depletion and repletion in older women
    Sarah L Booth
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:2565-9. 2003
    ..Moreover, our findings suggest that the current recommended Adequate Intake levels of vitamin K (90 micro g/d) in women do not support maximal osteocalcin gamma-carboxylation in older women...
  12. pmc Vitamin K supplementation and progression of coronary artery calcium in older men and women
    M Kyla Shea
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1799-807. 2009
    ..A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor...
  13. pmc Gamma-carboxylation of osteocalcin and insulin resistance in older men and women
    M Kyla Shea
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 90:1230-5. 2009
    ..In vitro and animal studies indicate that high uncarboxylated osteocalcin is associated with reduced insulin resistance. However, associations between osteocalcin and measures of insulin resistance in humans are less clear...
  14. pmc Age group and sex do not influence responses of vitamin K biomarkers to changes in dietary vitamin K
    Jennifer T Truong
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:936-41. 2012
    ..012), regardless of sex. Adiposity measures and circulating TG did not predict response of any measures. In conclusion, poor vitamin K status can be similarly improved with vitamin K supplementation, regardless of age group or sex...
  15. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008
    ..Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro...
  16. pmc Effect of vitamin K supplementation on insulin resistance in older men and women
    Makiko Yoshida
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center, Tufts University, Boston, Massachusetts, USA
    Diabetes Care 31:2092-6. 2008
    ..Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women...
  17. pmc Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women
    M Kyla Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1029-34. 2010
    ..Additional studies are needed to further explore the relationships among body fat, storage of vitamin K in adipose tissue, and implications for vitamin K status and function...
  18. ncbi request reprint Determinants of plasma dihydrophylloquinone in men and women
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:701-8. 2005
    ..Despite this caveat, higher plasma dihydrophylloquinone was associated with higher dihydrophylloquinone intake and higher trans fatty acid intake...
  19. pmc Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats
    Ala Al Rajabi
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:841-5. 2012
    ..These data demonstrate that MK-4 is the predominant form of vitamin K in multiple tissues, but there appears to be a tissue-specific regulation for the conversion of PK to MK-4...
  20. pmc Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study
    Enju Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1627-33. 2010
    ..Accumulating evidence suggests that vitamin D is involved in the development of type 2 diabetes (T2D)...
  21. ncbi request reprint Dietary and nondietary determinants of vitamin K biochemical measures in men and women
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1329-34. 2002
    ..Despite these caveats, these findings support the use of a FFQ for a relative assessment of vitamin K status in population-based studies...
  22. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  23. pmc Plasma alkylresorcinols, biomarkers of whole-grain intake, are related to lower BMI in older adults
    Jiantao Ma
    Nutrition Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:1859-64. 2012
    ....
  24. pmc Matrix Gla protein polymorphisms are associated with coronary artery calcification in men
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:59-65. 2009
    ..The results of this study suggest a role for MGP genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations...
  25. pmc Calcium intake is not associated with increased coronary artery calcification: the Framingham Study
    Elizabeth J Samelson
    Department of Medicine, Harvard Medical School and Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    Am J Clin Nutr 96:1274-80. 2012
    ..Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern...
  26. pmc Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults
    Nicola M McKeown
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1950-5. 2009
    ..Higher intakes of cereal fiber, particularly from whole-grain sources, are associated with lower total percent body fat and percent trunk fat mass in older adults...
  27. ncbi request reprint Phylloquinone intake, insulin sensitivity, and glycemic status in men and women
    Makiko Yoshida
    Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 88:210-5. 2008
    ..Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity...
  28. pmc Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults
    Enju Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 139:329-34. 2009
    ..Among adults without diabetes, vitamin D status was inversely associated with surrogate fasting measures of insulin resistance. These results suggest that vitamin D status may be an important determinant for type 2 diabetes mellitus...
  29. pmc Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:112-9. 2009
    ..Polymorphisms in genes encoding enzymes involved in vitamin K metabolism may modulate plasma concentrations of phylloquionone and percent carboxylation of osteocalcin...
  30. ncbi request reprint 9-Cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcification by altering vitamin K-dependent gamma-carboxylation of matrix gamma-carboxyglutamic acid protein in A/J male mice
    Xueyan Fu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:2337-41. 2008
    ..The mechanisms by which 9-cis RA and 1,25(OH)(2)D3 alter vitamin K concentrations warrant further investigation...
  31. ncbi request reprint Threshold-dependent variability of coronary artery calcification measurements -- implications for contrast-enhanced multi-detector row-computed tomography
    Fabian Moselewski
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur J Radiol 57:390-5. 2006
    ..The present study investigated the threshold-dependent variability of coronary artery calcification (CAC) measurements and the potential to quantify CAC in contrast-enhanced multi-detector row-computed tomography (MDCT)...
  32. ncbi request reprint Dihydrophylloquinone intake is associated with low bone mineral density in men and women
    Lisa M Troy
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 86:504-8. 2007
    ..Poor diet may affect bone status by displacing nutrients involved in bone health. Dihydrophylloquinone, a form of vitamin K present in foods made with partially hydrogenated fat, is a potential marker of a low-quality dietary pattern...
  33. pmc Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry
    Xueyan Fu
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    Anal Chem 81:5421-5. 2009
    ..13). The LC-APCI/MS method is a sensitive technique for simultaneous determination of both unlabeled and labeled phylloquinone and can be applied to bioavailability studies...
  34. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  35. pmc Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides
    Natalia A Crivello
    Nutrition and Neurocognition Laboratory, JMUSDA HNRCA at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 21:1083-8. 2010
    ..Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure and behavior functions...
  36. pmc Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis
    Devyani Misra
    Clinical Epidemiology Unit, Boston, Massachusetts 02118, USA
    J Rheumatol 38:1960-5. 2011
    ..We therefore evaluated the relationship of MGP concentrations and polymorphisms at the MGP locus to hand OA...
  37. ncbi request reprint Vitamin k contents of meat, dairy, and fast food in the u.s. Diet
    Sonya J Elder
    Jean Mayer U S Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Agric Food Chem 54:463-7. 2006
    ..The presence of MK-4 in meat, eggs, and dairy foods could be important as physiologic functions unique to MK-4 are identified...
  38. ncbi request reprint Update on the role of vitamin K in skeletal health
    M Kyla Shea
    Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Rev 66:549-57. 2008
    ..However, there are emerging data that suggest the efficacy of vitamin K supplementation on bone loss is inconclusive...
  39. ncbi request reprint Phylloquinone intake and risk of cardiovascular diseases in men
    Arja T Erkkilä
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Nutr Metab Cardiovasc Dis 17:58-62. 2007
    ....
  40. doi request reprint Determinants of vitamin K status in humans
    Sarah L Booth
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Vitam Horm 78:1-22. 2008
    ....
  41. pmc Measurement of menadione in urine by HPLC
    Ala Al Rajabi
    USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA ala al
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2457-60. 2010
    ..Using this method, urinary menadione was shown to increase in response to 3 years of phylloquinone supplementation. This HPLC method is a sensitive and reproducible way to detect menadione in urine...
  42. ncbi request reprint Plasma transport of vitamin K in men using deuterium-labeled collard greens
    Arja T Erkkilä
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:215-21. 2004
    ..8 hours (n = 3). Deuterated-phylloquinone was not detectable in plasma or TRL fraction at 72 hours. These results suggest rapid uptake and transport of physiologic doses of phylloquinone...
  43. ncbi request reprint Vitamin K content of nuts and fruits in the US diet
    MacKenzie L Dismore
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Diet Assoc 103:1650-2. 2003
    ..Menu planning for patients on warfarin can include a healthy diet including fruits and nuts without compromising the stability of their oral anticoagulation therapy...
  44. ncbi request reprint Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies
    David T Felson
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:129-36. 2007
    ..To confirm reports that 25-hydroxyvitamin D (25[OH]D) deficiency is associated with an increased risk of joint space narrowing or cartilage loss in osteoarthritis (OA)...
  45. pmc Vitamin D(3) in fat tissue
    Miriam Blum
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA, 02111, USA
    Endocrine 33:90-4. 2008
    ..Compatible with the long-standing concept that fat tissue is a storage site for vitamin D, fat tissue and serum vitamin D(3) concentrations were positively correlated...
  46. ncbi request reprint Quantification of phylloquinone and menaquinones in feces, serum, and food by high-performance liquid chromatography-mass spectrometry
    J Philip Karl
    Vitamin K Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, United States Energy Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 963:128-33. 2014
    ..This method can be applied in human and animal studies examining the role of vitamin K vitamers derived from the diet and gut bacteria synthesis in health and disease. ..
  47. ncbi request reprint Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women
    Sarah L Booth
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:2609-12. 2002
    ..001). These data emphasize that the use of different approaches for the assessment of vitamin K absorption can result in disparate conclusions...
  48. pmc Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats
    Xueyan Fu
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab (Lond) 9:12. 2012
    ..abstract:..
  49. ncbi request reprint Epidemiology and association of vascular and valvular calcium quantified by multidetector computed tomography in elderly asymptomatic subjects
    Ricardo C Cury
    Department of Radiology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Cardiol 94:348-51. 2004
    ..Further evidence is provided for the notion that calcifications in those regions are associated and that MDCT can be used as a tool for the global assessment of vascular and valvular calcium...
  50. ncbi request reprint Vitamin K and sphingolipid metabolism: evidence to date
    Natalia A Denisova
    Nutrition and Neurocognition Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 63:111-21. 2005
    ..However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied...
  51. ncbi request reprint Low vitamin K status is associated with osteoarthritis in the hand and knee
    Tuhina Neogi
    Boston University School of Medicine, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 54:1255-61. 2006
    ..Furthermore, osteophyte growth, seen in osteoarthritis (OA), may be a vitamin K-dependent process. We undertook this study to determine whether vitamin K deficiency is associated with radiographic features of OA...
  52. ncbi request reprint Vitamin K contents of rodent diets: a review
    Xueyan Fu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Am Assoc Lab Anim Sci 46:8-12. 2007
    ..This review summarizes current recommendations for vitamin K in rodent diets relative to our evolving knowledge about this fat-soluble vitamin...
  53. doi request reprint Vitamin K intake and atherosclerosis
    Arja T Erkkilä
    School of Public Health and Clinical Nutrition, University of Kuopio, Finland
    Curr Opin Lipidol 19:39-42. 2008
    ..The evidence to support this putative role of vitamin K intake in atherosclerosis is reviewed...
  54. ncbi request reprint Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes
    Dominic J Harrington
    The Centre for Haemostasis and Thrombosis, St Thomas Hospital, London SE1 7EH, UK
    J Nutr 137:1763-8. 2007
    ..699, P < 0.001). We conclude that the urinary excretion of vitamin K metabolites reflects dietary phylloquinone intake and offers the first candidate marker of global vitamin K status...
  55. ncbi request reprint Relationship between diet and anticoagulant response to warfarin: a factor analysis
    Silvia Maria Custódio das Dôres
    Depto de Nutrição e Dietética da Faculdade de Nutrição, Universidade Federal Fluminense UFF, Rua São Paulo, 30 4 andar Centro, Niteroi, RJ 24015 110, Brazil
    Eur J Nutr 46:147-54. 2007
    ..Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin...
  56. ncbi request reprint Subclinical vitamin K deficiency in hemodialysis patients
    Rachel M Pilkey
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Am J Kidney Dis 49:432-9. 2007
    ..Nondietary determinants of vitamin K status include apolipoprotein E (apoE) genotype, which may influence vitamin K transport to peripheral tissues...
  57. ncbi request reprint Vascular calcification in chronic kidney disease: the role of vitamin K
    Rachel M Holden
    Queen s University, Department of Medicine, Kingston, ON, Canada
    Nat Clin Pract Nephrol 3:522-3. 2007
  58. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  59. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking...
  60. ncbi request reprint Effects of orlistat on fat-soluble vitamins in obese adolescents
    Jennifer R McDuffie
    Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1862, USA
    Pharmacotherapy 22:814-22. 2002
    ..To determine whether orlistat causes fat-soluble vitamin deficiencies in African-American and Caucasian adolescents...
  61. ncbi request reprint Calcium kinetics are altered in clinically stable girls with cystic fibrosis
    Kerry J Schulze
    Center for Human Nutrition, The Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Clin Endocrinol Metab 89:3385-91. 2004
    ..Rates of bone Ca deposition were lower than typically reported in healthy children, as were indirect markers of bone formation. These alterations in bone turnover contribute to reduced bone mass in girls with CF...

Research Grants17

  1. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2007
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  2. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2006
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  3. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2005
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  4. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  5. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  6. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2004
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  7. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2003
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  8. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2003
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  9. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2002
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  10. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2002
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  11. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2001
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  12. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  13. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2001
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  14. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2000
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  15. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 1999
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..