JAMES BALEJA

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
    James D Baleja
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Antiviral Res 72:49-59. 2006
  2. ncbi request reprint Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 43:7421-31. 2004
  3. ncbi request reprint Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 46:10864-74. 2007
  4. ncbi request reprint Structure and function of the papillomavirus E6 protein and its interacting proteins
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Front Biosci 13:121-34. 2008
  5. pmc Determinants of stability for the E6 protein of papillomavirus type 16
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Mol Biol 386:1123-37. 2009
  6. ncbi request reprint Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors
    Donald N Cullis
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Biol Chem 277:49158-66. 2002
  7. ncbi request reprint The role of conserved histidines in the structure and stability of human papillomavirus type 16 E2 DNA-binding domain
    Kakoli Bose
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biochemistry 46:1402-11. 2007
  8. pmc Design and characterization of an enhanced repressor of human papillomavirus E2 protein
    Kakoli Bose
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    FASEB J 25:2354-61. 2011
  9. pmc Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2
    Jie Wei
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biochemistry 48:549-57. 2009
  10. ncbi request reprint Identification of a region of fast skeletal troponin T required for stabilization of the coiled-coil formation with troponin I
    Subhradip Mukhopadhyay
    Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Biol Chem 280:538-47. 2005

Research Grants

Collaborators

  • Elliot Androphy
  • Marc C Nicklaus
  • Zhiguo Liu
  • Yuqi Liu
  • Kakoli Bose
  • Gillian D Henry
  • Joseph V Dineen
  • Jie Wei
  • Subhradip Mukhopadhyay
  • Soyoun Kim
  • Donald N Cullis
  • Andrew Bohm
  • Gretchen Meinke
  • Daniel J Corrigan
  • Jonathan J Cherry
  • Nicholas C Yoder
  • Rashmi S Hegde
  • Krishna Kumar
  • Walter F Stafford
  • Satyapriya Sarkar
  • Knut Langsetmo
  • Jason Chen
  • Shalom Avraham
  • Alan Meisler
  • Radoslaw Zagozdzon
  • Betsey Philip
  • Hava Avraham
  • Yigong Fu
  • Larry A Feig

Detail Information

Publications12

  1. pmc Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
    James D Baleja
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Antiviral Res 72:49-59. 2006
    ..Such compounds provide leads for the development of new pharmacologic agents to treat papillomavirus infections and their associated cancers...
  2. ncbi request reprint Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 43:7421-31. 2004
    ..The data also indicate that conformational change is common in E6-binding proteins during the formation of the complex with the viral E6 protein...
  3. ncbi request reprint Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 46:10864-74. 2007
    ..Comparison of the NMR complex structure to previously determined X-ray structures of PDZ2 by itself and bound to different peptides allows a description of conformational changes required for PDZ2 to bind to HPV-18 E6...
  4. ncbi request reprint Structure and function of the papillomavirus E6 protein and its interacting proteins
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Front Biosci 13:121-34. 2008
    ....
  5. pmc Determinants of stability for the E6 protein of papillomavirus type 16
    Yuqi Liu
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Mol Biol 386:1123-37. 2009
    ..These studies allow a model in which the C-terminal zinc-binding domain of E6 recruits a target protein such as hDlg and the N-terminal domain is mostly responsible for recruiting a ubiquitin ligase to mediate target protein degradation...
  6. ncbi request reprint Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors
    Donald N Cullis
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Biol Chem 277:49158-66. 2002
    ..These findings suggest that Rab11-FIP2 may participate in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes...
  7. ncbi request reprint The role of conserved histidines in the structure and stability of human papillomavirus type 16 E2 DNA-binding domain
    Kakoli Bose
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biochemistry 46:1402-11. 2007
    ..Moreover, identification of residues crucial for E2 stability will help in the design of modified proteins with desired characteristics...
  8. pmc Design and characterization of an enhanced repressor of human papillomavirus E2 protein
    Kakoli Bose
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    FASEB J 25:2354-61. 2011
    ..More generally, this approach may be used to target the subunit interfaces of any multisubunit protein having a similar mechanism of action...
  9. pmc Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2
    Jie Wei
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biochemistry 48:549-57. 2009
    ..Together, these data allow us to build a model in which the binding of FIP family proteins to Rab11 can be described in terms of conformational changes and that suggests new modes of regulation...
  10. ncbi request reprint Identification of a region of fast skeletal troponin T required for stabilization of the coiled-coil formation with troponin I
    Subhradip Mukhopadhyay
    Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Biol Chem 280:538-47. 2005
    ..We discuss the implication of our finding in the fast skeletal troponin isoform in the light of the crystal structure of the cardiac isoform...
  11. pmc Charge effects in the selection of NPF motifs by the EH domain of EHD1
    Gillian D Henry
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 49:3381-92. 2010
    ....
  12. ncbi request reprint Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer
    Soyoun Kim
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:36465-70. 2002
    ..These new CHK high affinity binding constructs may serve as good candidates for inhibition of the ErbB-2/Src transduction pathway in gene therapy studies in breast cancer...

Research Grants10

  1. Molecular Interactions in Signaling and Vesicle Sorting
    JAMES BALEJA; Fiscal Year: 2007
    ..These investigations on the EH domain:NPF interaction are also expected to advance the application of NMR in understanding molecular recognition. ..
  2. DESIGN OF HUMAN PAPILLOMAVIRUS INHIBITORS
    JAMES BALEJA; Fiscal Year: 2004
    ....
  3. Molecular Interactions in B cell Development
    JAMES BALEJA; Fiscal Year: 2007
    ..Determining the structures will provide the necessary background for understanding and refining models put forward for signal transduction from the pre-B cell receptor that allow proper B cell formation and immunological competency. ..