Bela Asztalos

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
    Atherosclerosis 164:361-9. 2002
  2. pmc Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 57:77-83. 2008
  3. ncbi request reprint Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins
    Bela F Asztalos
    Cardiovascular Research Laboratory, Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 99:681-5. 2007
  4. ncbi request reprint Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
  5. ncbi request reprint LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 188:59-67. 2006
  6. ncbi request reprint Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
  7. ncbi request reprint Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 46:2246-53. 2005
  8. ncbi request reprint Protease inhibitor-based HAART, HDL, and CHD-risk in HIV-infected patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 184:72-7. 2006
  9. doi request reprint Metabolic and functional relevance of HDL subspecies
    Bela F Asztalos
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 22:176-85. 2011
  10. ncbi request reprint High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:2181-7. 2004

Research Grants

Detail Information

Publications46

  1. ncbi request reprint Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
    Atherosclerosis 164:361-9. 2002
    ..The order of efficacy of statins in increasing alpha-1 HDL subpopulation was: atorvastatin, simvastatin, pravastatin, lovastatin and fluvastatin...
  2. pmc Relation of gemfibrozil treatment and high-density lipoprotein subpopulation profile with cardiovascular events in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 57:77-83. 2008
    ..It is quite possible that much of the cardiovascular benefits of gemfibrozil are due to a much wider spectrum of effects on metabolic processes that is not reflected by changes in blood lipids and HDL subpopulations...
  3. ncbi request reprint Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins
    Bela F Asztalos
    Cardiovascular Research Laboratory, Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 99:681-5. 2007
    ..In conclusion, our data show that both statins, given at their maximal doses, favorably alter the HDL subpopulation profile, but also that rosuvastatin is significantly more effective in this regard than atorvastatin...
  4. ncbi request reprint Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
    ....
  5. ncbi request reprint LpA-I, LpA-I:A-II HDL and CHD-risk: The Framingham Offspring Study and the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 188:59-67. 2006
    ..We tested the hypothesis that concentrations of LpA-I and/or LpA-I:A-II HDL subclasses are significantly associated with CHD prevalence and recurrent cardiovascular events...
  6. ncbi request reprint Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
    ....
  7. ncbi request reprint Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 46:2246-53. 2005
    ..Cholesterol efflux via the SR-BI pathway is associated with several HDL subpopulations with different apolipoprotein composition, lipid content, and size...
  8. ncbi request reprint Protease inhibitor-based HAART, HDL, and CHD-risk in HIV-infected patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 184:72-7. 2006
    ....
  9. doi request reprint Metabolic and functional relevance of HDL subspecies
    Bela F Asztalos
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 22:176-85. 2011
    ..Our purpose is to review recent findings highlighting the metabolic and functional diversity of HDL subspecies...
  10. ncbi request reprint High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA at Tufts University, 711 Washington Street, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 24:2181-7. 2004
    ..We tested the hypothesis whether specific HDL subpopulations are significantly associated with CHD-prevalence...
  11. ncbi request reprint High-density lipoprotein metabolism and progression of atherosclerosis: new insights from the HDL Atherosclerosis Treatment Study
    Bela F Asztalos
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Cardiol 19:385-91. 2004
    ..The purpose of this review is to summarize the current understanding of the potentially antiatherogenic properties of high-density lipoprotein related to its different components...
  12. ncbi request reprint Change in alpha1 HDL concentration predicts progression in coronary artery stenosis
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 23:847-52. 2003
    ..We examined the effects of simvastatin-niacin and antioxidant vitamins on changes in high-density lipoprotein (HDL) subpopulations and alterations in coronary artery stenosis, as assessed by angiography...
  13. pmc Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women
    Bela F Asztalos
    Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA
    J Lipid Res 51:2405-12. 2010
    ..05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients...
  14. ncbi request reprint Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 45:448-55. 2004
    ....
  15. ncbi request reprint HDL in atherosclerosis: actor or bystander?
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, MA 02111, USA
    Atheroscler Suppl 4:21-9. 2003
    ..The cholesterol in HDL can either be transferred to apolipoprotein B-containing particles via CETP or delivered directly to the liver with the help of scavenger receptor B1...
  16. doi request reprint High-density lipoprotein particles, coronary heart disease, and niacin
    Bela F Asztalos
    Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Clin Lipidol 4:405-10. 2010
    ..Based on the Framingham Heart Study data, HDL-C <35 mg/dl was established an independent risk factor and HDL-C >60 mg/dl as protective.(3) Presently the cut point is <40 mg/dl for men and <50 mg/dl for women...
  17. doi request reprint Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels
    Seiko Otokozawa
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA 02111, USA
    Atherosclerosis 205:197-201. 2009
    ..Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin...
  18. ncbi request reprint Effects of estrogen and medroxyprogesterone acetate on subpopulations of triglyceride-rich lipoproteins and high-density lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory and the Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 52:1330-6. 2003
    ....
  19. doi request reprint Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels
    Masumi Ai
    Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA
    Am J Cardiol 101:315-8. 2008
    ....
  20. pmc Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism
    Margaret E Brousseau
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA, USA
    J Lipid Res 50:1456-62. 2009
    ..Our findings indicate that CETP inhibition increases plasma concentrations of apoA-II by delaying HDL apoA-II catabolism and significantly alters the remodeling of apoA-II-containing HDL subpopulations...
  21. doi request reprint Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects
    Seiko Otokozawa
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 58:1536-42. 2009
    ..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects...
  22. pmc Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo
    Frank M Sacks
    Harvard School of Public Health and Harvard Medical School, Boston, MA, USA, USA
    J Lipid Res 50:894-907. 2009
    ..Treatment with delipidated plasma tended to reduce diet-induced aortic atherosclerosis in monkeys measured by intravascular ultrasound. These findings link the conversion of small to large HDL, in vivo, to improvement in atherosclerosis...
  23. pmc Changes in remnant and high-density lipoproteins associated with hormone therapy and progression of coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 205:325-30. 2009
    ....
  24. pmc Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus status
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1794-800. 2010
    ..Faster progression of coronary atherosclerosis in women with diabetes could be mediated in part by a worse lipoprotein profile in these women than in women without diabetes, both before and during HRT...
  25. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  26. doi request reprint Marked HDL deficiency and premature coronary heart disease
    Ernst J Schaefer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 21:289-97. 2010
    ..Our purpose is to review recent publications in the area of marked human HDL deficiency, HDL particles, coronary heart disease (CHD), amyloidosis, the immune response, and kidney disease...
  27. doi request reprint Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
    ..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women...
  28. ncbi request reprint Increasing high-density lipoprotein cholesterol, inhibition of cholesteryl ester transfer protein, and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 100:n25-31. 2007
    ..Another alternative for increasing HDL levels is to develop more effective and better tolerated niacin preparations...
  29. ncbi request reprint High-density lipoprotein subpopulations in pathologic conditions
    Bela F Asztalos
    Atherosclerosis Research Laboratory, New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 91:12E-17E. 2003
    ..A new statin, rosuvastatin, produces greater increases in HDL cholesterol than atorvastatin, but its effect on HDL particle distribution is yet to be determined...
  30. pmc Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
    Margaret E Brousseau
    Lipid Metabolism Laboratory, JM USDA HNRCA at Tufts University and Tufts New England Medical Center, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 25:1057-64. 2005
    ..The present study was designed to address these issues...
  31. ncbi request reprint Effects of atorvastatin on the HDL subpopulation profile of coronary heart disease patients
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 43:1701-7. 2002
    ....
  32. ncbi request reprint Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjects
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 95:1025-32. 2005
    ....
  33. ncbi request reprint The effects of statins on high-density lipoproteins
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Curr Atheroscler Rep 8:41-9. 2006
    ....
  34. ncbi request reprint Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 17:394-8. 2006
    ....
  35. ncbi request reprint Should we target HDL-cholesterol to reduce coronary heart disease risk?
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Nat Clin Pract Endocrinol Metab 2:358-9. 2006
  36. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  37. ncbi request reprint Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Cardiol 22:373-8. 2007
    ..To review recent research in the area of high-density lipoprotein raising and coronary heart disease risk reduction...
  38. pmc Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Infect Dis 202:614-23. 2010
    ..These results indicate that SIV infection is a significant contributor to primary dyslipidemia, likely through the ability of Nef to suppress ABCA1-dependent reverse cholesterol transport...
  39. ncbi request reprint Apolipoprotein A-I, B-100, and B-48 metabolism in subjects with chronic kidney disease, obesity, and the metabolic syndrome
    Marcelo C Batista
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:1255-61. 2004
    ....
  40. pmc Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring Study
    Masumi Ai
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem 56:967-76. 2010
    ..We sought to establish reference values for a new direct assay for small dense LDL cholesterol (sdLDL-C) and to measure sdLDL-C concentrations in patients with established coronary heart disease (CHD) vs controls...
  41. pmc Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Endocrinol (Oxf) 72:169-75. 2010
    ..Subjects Postmenopausal Caucasian women (n = 208) participating in a placebo-controlled randomized trial of 3.2 years of hormone therapy (HT)...
  42. doi request reprint Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus
    Masumi Ai
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chim Acta 406:71-4. 2009
    ....
  43. ncbi request reprint SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome
    Patricia G Yancey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Lipid Res 45:1724-32. 2004
    ..0 +/- 0.6%) and was positively correlated with prebeta-1 HDL. These studies demonstrated that prebeta-1 HDL is the preferred acceptor for ABCA1 efflux, whereas many particles mediate SR-BI efflux...
  44. doi request reprint Cardiovascular events with increased lipoprotein-associated phospholipase A(2) and low high-density lipoprotein-cholesterol: the Veterans Affairs HDL Intervention Trial
    Sander J Robins
    Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 28:1172-8. 2008
    ..We sought to determine whether increased Lp-PLA(2) would also predict CV events in the absence of high LDL-cholesterol (LDL-C), in a population with low high-density lipoprotein-cholesterol (HDL-C)...
  45. ncbi request reprint Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
    ..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner...
  46. ncbi request reprint Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency
    Raul D Santos
    Lipid Clinic and Lipid Metabolism Laboratory, Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    J Lipid Res 49:349-57. 2008
    ....

Research Grants4

  1. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..