Research Topics
Genomes and Genes | Masumi AiSummaryAffiliation: Tufts University Country: USA Publications
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Publications
Paraoxonase (PON1) is associated with familial combined hyperlipidemiaThomas M van Himbergen
Department of Clinical Chemistry and Haematology, UMC Utrecht, Utrecht, The Netherlands
Atherosclerosis 199:87-94. 2008..0 (95% CI, 1.3-19.1, P=0.02)). In conclusion, in this population of subjects from well-defined families with FCH, PON1 is biochemically and genetically associated with FCH...
Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathwayThomas M van Himbergen
Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
Arterioscler Thromb Vasc Biol 30:113-20. 2010..In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members...
Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markersThomas M van Himbergen
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Lipid Res 50:730-9. 2009..In addition, alterations in absolute values of plasma sterols correlated with the cholesterol lowering response...
Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch womenThomas M van Himbergen
Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
Atherosclerosis 199:408-14. 2008..3-69.5, P < 0.0001, multivariate model). In conclusion, this study shows that in middle-aged women paraoxonase activity was associated with an increased risk for AMI and that the risk was modified by the effects of smoking...
Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levelsSeiko Otokozawa
Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA 02111, USA
Atherosclerosis 205:197-201. 2009..Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin...
Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammationNuntakorn Thongtang
Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Am J Cardiol 107:387-92. 2011..5% vs -4.9%, p = 0.15). In conclusion, our data have indicated that the maximum dosage of atorvastatin or rosuvastatin therapy significantly lower C-reactive protein levels but also moderately increase insulin levels...
Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring StudyMasumi Ai
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Atherosclerosis 217:543-8. 2011..Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk...
Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart StudyThomas M van Himbergen
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Arch Neurol 69:594-600. 2012....
Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjectsSeiko Otokozawa
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Metabolism 58:1536-42. 2009..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects...
Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: results from the Framingham Offspring StudySeiko Otokozawa
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Atherosclerosis 213:251-5. 2010..We evaluated direct low density lipoprotein (LDL) cholesterol (C) and high density lipoprotein (HDL) cholesterol (C) versus standard methods using fasting plasma samples from participants in cycle 6 of the Framingham Offspring Study...
Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levelsMasumi Ai
Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University, Boston, Massachusetts, USA
Am J Cardiol 101:315-8. 2008....
Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese womenBela F Asztalos
Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA
J Lipid Res 51:2405-12. 2010..05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients...
Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring StudyMasumi Ai
Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chem 56:967-76. 2010..We sought to establish reference values for a new direct assay for small dense LDL cholesterol (sdLDL-C) and to measure sdLDL-C concentrations in patients with established coronary heart disease (CHD) vs controls...
Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteinsStefania Lamon-Fava
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 28:1672-8. 2008..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitusMasumi Ai
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chim Acta 406:71-4. 2009....
Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adultsSonia Vega-Lopez
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Atherosclerosis 210:555-62. 2010..Information is scarce regarding the effect of dietary protein type, with specific focus on the lysine-to-arginine (Lys:Arg) ratio, on cardiovascular risk factors and vascular reactivity in humans...
