Howard K Surks

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. ncbi M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells
    Howard K Surks
    Molecular Cardiology Research Institute and Department of Medicine, Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:42543-51. 2005
  2. ncbi ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells
    Yuepeng Wang
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Circ Res 104:531-40. 2009
  3. ncbi Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase
    Nadeene Riddick
    Molecular Cardiology Research Institute and the Division of Cardiology, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, Massachusetts 02111, USA
    J Cell Biochem 103:1158-70. 2008
  4. ncbi Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells
    Yuepeng Wang
    Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:24420-6. 2004
  5. ncbi Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase
    Alok K Sharma
    Divison of Molecular and Vascular Medicine, Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 283:32860-9. 2008
  6. ncbi Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase
    Akira Endo
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachussetts, USA
    J Biol Chem 279:42055-61. 2004
  7. ncbi Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA
    Howard K Surks
    Molecular Cardiology Research Institute, Cardiology Division and Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 278:51484-93. 2003
  8. ncbi Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state
    Matthew E Kutcher
    Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Pathol 171:693-701. 2007
  9. ncbi Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
    Qing Lu
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 101:17126-31. 2004
  10. ncbi High blood pressure arising from a defect in vascular function
    Simon K Michael
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 105:6702-7. 2008

Research Grants

  1. CGMP DEPENDENT PROTEIN KINASE IN VASCULAR BIOLOGY
    HOWARD SURKS; Fiscal Year: 2003

Collaborators

Detail Information

Publications13

  1. ncbi M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells
    Howard K Surks
    Molecular Cardiology Research Institute and Department of Medicine, Division of Cardiology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:42543-51. 2005
    ....
  2. ncbi ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells
    Yuepeng Wang
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Circ Res 104:531-40. 2009
    ..These data support that although the ROCK isoforms both regulate MLCP and myosin light chain phosphorylation through different mechanisms, they have distinct roles in VSMC function...
  3. ncbi Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase
    Nadeene Riddick
    Molecular Cardiology Research Institute and the Division of Cardiology, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, Massachusetts 02111, USA
    J Cell Biochem 103:1158-70. 2008
    ..Silencing of M-RIP lead to loss of stress fiber-associated RhoA, suggesting that myosin phosphatase-rho interacting protein is a scaffold linking RhoA to regulate myosin phosphatase at the stress fiber...
  4. ncbi Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells
    Yuepeng Wang
    Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:24420-6. 2004
    ..Based on the known functions of FHOD1, the data are consistent with a role for FHOD1 in cyclic GMP-dependent inhibition of VSMC stress fiber formation and/or migration...
  5. ncbi Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase
    Alok K Sharma
    Divison of Molecular and Vascular Medicine, Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 283:32860-9. 2008
    ..Taken together these data support a role for the LZ domain of PKG-Ialpha and the CC domain of MBS in this requisite contractile complex...
  6. ncbi Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase
    Akira Endo
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachussetts, USA
    J Biol Chem 279:42055-61. 2004
    ..These data identify hZIPK as the unique SMPP-1-associated kinase expressed in human vesicular smooth muscle and support a role for Rho in promoting the hZIPK-MBS interaction...
  7. ncbi Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA
    Howard K Surks
    Molecular Cardiology Research Institute, Cardiology Division and Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 278:51484-93. 2003
    ..M-RIP can assemble a complex containing both RhoA and MBS, suggesting that M-RIP may play a role in myosin phosphatase regulation by RhoA...
  8. ncbi Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state
    Matthew E Kutcher
    Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Pathol 171:693-701. 2007
    ..These data strongly suggest that signaling through the pericyte Rho GTPase pathway may provide critical cues to the processes of microvascular stabilization, maturation, and contractility during development and disease...
  9. ncbi Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
    Qing Lu
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 101:17126-31. 2004
    ..Furthermore, by demonstrating independent regulation of nongenomic vs. genomic ER-dependent signaling, these findings provide conceptual support for the potential development of "pathway-specific" selective ER modulators...
  10. ncbi High blood pressure arising from a defect in vascular function
    Simon K Michael
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 105:6702-7. 2008
    ....
  11. ncbi Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells
    Maria Claudia Montefusco
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    BMC Genet 11:22. 2010
    ..ROCK1 and the partial gene copy, which the gene databases also currently call ROCK1, include non-unique single nucleotide polymorphisms (SNPs)...
  12. ncbi Dimerization of cGMP-dependent protein kinase 1alpha and the myosin-binding subunit of myosin phosphatase: role of leucine zipper domains
    Howard K Surks
    Molecular Cardiology Research Institute, Cardiology Division, Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, 750 Washington Street, Box 80, Boston, MA 02111, USA
    Cell Signal 15:937-44. 2003
    ..The contribution of these domains to both homodimerization and their specific interaction with each other suggest that additional regulatory mechanisms involving these domains may exist...
  13. ncbi Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A
    Qing Lu
    Department of Medicine and Molecular Cardiology Research Institute, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 278:4639-45. 2003
    ....

Research Grants1

  1. CGMP DEPENDENT PROTEIN KINASE IN VASCULAR BIOLOGY
    HOWARD SURKS; Fiscal Year: 2003
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