Lesley A Stevens

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. ncbi Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
  2. ncbi Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Kidney Dis 55:S23-33. 2010
  3. ncbi Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease
    Lesley A Stevens
    Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 16:2439-48. 2005
  4. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts-New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  5. ncbi Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 50:21-35. 2007
  6. ncbi Surrogate end points for clinical trials of kidney disease progression
    Lesley A Stevens
    Division of Nephrology, Tufts-New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 1:874-84. 2006
  7. ncbi Evaluation of the modification of diet in renal disease study equation in a large diverse population
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 18:2749-57. 2007
  8. ncbi Measurement of kidney function
    Lesley A Stevens
    Division of Nephrology, Tufts University School of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Med Clin North Am 89:457-73. 2005
  9. ncbi Standardization of serum creatinine and estimated GFR in the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:S77-82. 2008
  10. ncbi A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009

Detail Information

Publications54

  1. ncbi Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    ..We report the development and evaluation of GFR-estimating equations using serum cystatin C alone and serum cystatin C, serum creatinine, or both with demographic variables...
  2. ncbi Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Kidney Dis 55:S23-33. 2010
    ..In all 3 data sources, we also explored comorbid conditions and CKD-related complications...
  3. ncbi Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease
    Lesley A Stevens
    Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 16:2439-48. 2005
    ....
  4. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts-New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  5. ncbi Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 50:21-35. 2007
    ..Variation in performance of glomerular filtration rate (GFR) estimating equations is related to variation in calibration of the creatinine assay across clinical laboratories...
  6. ncbi Surrogate end points for clinical trials of kidney disease progression
    Lesley A Stevens
    Division of Nephrology, Tufts-New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 1:874-84. 2006
  7. ncbi Evaluation of the modification of diet in renal disease study equation in a large diverse population
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 18:2749-57. 2007
    ..73 m(2). In individual patients, interpretation of GFR estimates near 60 ml/min per 1.73 m(2) should be interpreted with caution to avoid misclassification of chronic kidney disease in the context of the clinical setting...
  8. ncbi Measurement of kidney function
    Lesley A Stevens
    Division of Nephrology, Tufts University School of Medicine, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    Med Clin North Am 89:457-73. 2005
    ..The current recommended method is to use estimating equations based on serum creatinine and which incorporate demographic and clinical variables...
  9. ncbi Standardization of serum creatinine and estimated GFR in the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:S77-82. 2008
    ..We describe the calibration of creatinine assays used in the National Kidney Foundation Kidney Early Evaluation Program (KEEP)...
  10. ncbi A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    ..Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values...
  11. ncbi A predictive model for progression of chronic kidney disease to kidney failure
    Navdeep Tangri
    Department of Medicine, Tufts Medical Center, 800 Washington St, PO Box 391, Boston, MA 02111, USA
    JAMA 305:1553-9. 2011
    ....
  12. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    ..We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods...
  13. ncbi Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
    ..Hence, we found that cystatin C is affected by factors other than GFR which should be considered when the GFR is estimated using serum levels of cystatin C...
  14. ncbi Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
    ..Here, performance of a more accurate GFR-estimating equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, is reported by level of GFR and clinical characteristics...
  15. ncbi Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP)
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 57:S9-16. 2011
    ..Before implementing this change in the Kidney Early Evaluation Program (KEEP), we compared characteristics of reclassified individuals and mortality risk predictions using the new equation...
  16. ncbi Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate
    Navdeep Tangri
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:471-7. 2011
    ..Hence, cystatin C may allow more accurate estimates of GFR than creatinine for patients with reduced protein intake. Further study of other non-GFR determinants of cystatin C is needed before the widespread adoption...
  17. ncbi Prevalence of ICD-9-CM codes for chronic kidney disease in individuals with cardiovascular disease risk factors
    Ashish Mahajan
    Tufts Medical Center Scientific and Clinical Research Center, Boston, Massachusetts, USA
    J Nephrol 22:523-33. 2009
    ..Chronic kidney disease (CKD) is a risk factor for cardiovascular disease (CVD)...
  18. ncbi Development and validation of GFR-estimating equations using diabetes, transplant and weight
    Lesley A Stevens
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:449-57. 2010
    ..Here, we describe the development and validation of this equation as well as other equations that incorporate diabetes, transplant and weight as additional predictor variables...
  19. ncbi Early change in proteinuria as a surrogate outcome in kidney disease progression: a systematic review of previous analyses and creation of a patient-level pooled dataset
    Nicholas Stoycheff
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 26:848-57. 2011
    ..There is a reasonably sound biological basis for this hypothesis, but only preliminary empirical evidence currently exists...
  20. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    ..73 m2. By using the reexpressed MDRD Study equation with the standardized serum creatinine assay, clinical laboratories can report more accurate GFR estimates...
  21. ncbi Cystatin C and creatinine in an HIV cohort: the nutrition for healthy living study
    Clara Y Jones
    Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Kidney Dis 51:914-24. 2008
    ..Serum creatinine level may underestimate the prevalence of CKD in subjects with decreased lean body mass or liver disease. Level of serum cystatin C, an alternative kidney function marker, is independent of lean body mass...
  22. ncbi Risk factors for proteinuria in HIV-infected and -uninfected Hispanic drug users
    Martin S Rhee
    Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 52:683-90. 2008
    ..Minorities are at greater risk of chronic kidney disease. Data are limited about risk factors for proteinuria in Hispanic drug users with and without HIV infection...
  23. ncbi Current status and future perspectives for CKD testing
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:S17-26. 2009
    ..Repeated testing for urine protein and interpretation of GFR estimates in the context of kidney damage and the clinical context of patient presentation can help overcome these limitations...
  24. ncbi Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:555-62. 2011
    ..Thus, heterogeneity in performance among the ethnic and geographic groups precludes use of the four-level race equation. The CKD-EPI two-level race equation can be used in the United States and Europe across a wide range of ethnicity...
  25. ncbi Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 54:33-42. 2009
    ....
  26. ncbi Automatic reporting of estimated glomerular filtration rate--just what the doctor ordered
    Andrew S Levey
    Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Boston, MA 02111, USA
    Clin Chem 52:2188-93. 2006
  27. ncbi Variation in the serum creatinine assay calibration: a practical application to glomerular filtration rate estimation
    Kalyani Murthy
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 68:1884-7. 2005
    ..Variation among clinical laboratories in calibration of serum creatinine assays is a source of error in glomerular filtration rate (GFR) estimation equations. We evaluated impact of this variation on GFR estimates...
  28. ncbi Chronic kidney disease, diabetes, and hypertension: what's in a name?
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 78:19-22. 2010
    ..We provide data on the frequency of diabetes, hypertension, or both, according to albumin-to-creatinine ratio and eGFR, and review the rationale for retaining the current name...
  29. ncbi Conceptual model of CKD: applications and implications
    Andrew S Levey
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:S4-16. 2009
    ....
  30. ncbi Evaluating the performance of equations for estimating glomerular filtration rate
    Lesley A Stevens
    Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Box 391 Boston, MA 02111, USA
    J Nephrol 21:797-807. 2008
    ....
  31. ncbi Chronic kidney disease and end-stage renal disease in the elderly population: current prevalence, future projections, and clinical significance
    Lesley A Stevens
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Adv Chronic Kidney Dis 17:293-301. 2010
    ....
  32. ncbi Serum cystatin C as a marker of glomerular filtration rate
    Magdalena Madero
    Division of Nephrology, Tufts-New England Medical Center, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 15:610-6. 2006
    ..SUMMARY: Cystatin C shows promise as an alternative to serum creatinine but several important questions remain before it can be recommended for use in clinical practice...
  33. ncbi Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition
    Nicholas Stoycheff
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 54:840-9. 2009
    ..These threshold levels have not been rigorously evaluated in patients with diabetic kidney disease or by using urine albumin excretion, the preferred measure of proteinuria in patients with diabetes...
  34. ncbi Measured GFR as a confirmatory test for estimated GFR
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2305-13. 2009
    ..We suggest plasma clearance of nonradioactive markers be more widely implemented in clinical settings. Further research is necessary on the impact of the use of measured GFR as a confirmatory test...
  35. ncbi Comparison of CKD awareness in a screening population using the Modification of Diet in Renal Disease (MDRD) study and CKD Epidemiology Collaboration (CKD-EPI) equations
    Manjula Kurella Tamura
    Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA 94304, USA
    Am J Kidney Dis 57:S17-23. 2011
    ..Whether reclassification of CKD severity using the CKD Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) modifies estimates of CKD awareness is unknown...
  36. ncbi Toward optimal health: Lesley A. Stevens, M.D. discusses issues of chronic kidney disease in women. Interview by Jodi R. Godfrey
    Lesley A Stevens
    Tufts University School of Medicine, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 15:123-6. 2006
  37. ncbi Advances in glomerular filtration rate-estimating equations
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Curr Opin Nephrol Hypertens 19:298-307. 2010
    ..Here, we review the performance of current creatinine and cystatin C-based estimating equations as well as demonstration of their utility in public health and clinical practice...
  38. ncbi Impact of reporting estimated glomerular filtration rate: it's not just about us
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 76:245-7. 2009
    ..In our view, a complete assessment requires a broader perspective. Most patients with CKD do not require referral to a nephrologist. Improving outcomes requires coordinated efforts of all physicians...
  39. ncbi CKD in the elderly--old questions and new challenges: World Kidney Day 2008
    Lesley A Stevens
    Am J Kidney Dis 51:353-7. 2008
  40. ncbi Prevalence and associations of anemia of CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Samy I McFarlane
    Division of Endocrinology, SUNY Downstate and Kings County Hospital Centers, Brooklyn, NY 11203, USA
    Am J Kidney Dis 51:S46-55. 2008
    ..We compared anemia prevalence and characteristics in the National Kidney Foundation Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004 populations...
  41. ncbi Clinical implications of estimating equations for glomerular filtration rate
    Lesley A Stevens
    Ann Intern Med 141:959-61. 2004
  42. ncbi Chronic kidney disease in the elderly--how to assess risk
    Lesley A Stevens
    N Engl J Med 352:2122-4. 2005
  43. ncbi Trends in mineral metabolism: Kidney Early Evaluation Program (KEEP) and the National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Joseph A Vassalotti
    National Kidney Foundation, Mount Sinai School of Medicine, One Gustave L Levy Pl, Nephrology Box 1243, New York, NY 10029 6574, USA
    Am J Kidney Dis 51:S56-68. 2008
    ..No study specifically examined mineral metabolism trends in a generalizable sample of patients at increased CKD risk...
  44. ncbi Serum cystatin C in the United States: the Third National Health and Nutrition Examination Survey (NHANES III)
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Am J Kidney Dis 51:385-94. 2008
    ..However, information for serum cystatin C levels in the general population, specifically across a wide age range and different ethnicities, is lacking...
  45. ncbi CKD and cardiovascular disease in screened high-risk volunteer and general populations: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Peter A McCullough
    Department of Medicine, Divisions of Cardiology, Nutrition, and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Kidney Dis 51:S38-45. 2008
    ..Chronic kidney disease (CKD) is recognized as an independent cardiovascular disease risk state. The relationship between CKD and cardiovascular disease in volunteer and general populations has not been explored...
  46. ncbi Diabetes mellitus in CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition and Examination Survey (NHANES) 1999-2004
    Adam T Whaley-Connell
    University of Missouri Columbia School of Medicine and Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Am J Kidney Dis 51:S21-9. 2008
    ..Early diabetes identification through targeted screening programs is important for the development of preventive strategies...
  47. ncbi Anaemia, cardiovascular disease and kidney disease: integrating new knowledge in 2002
    Lesley A Stevens
    University of British Columbia, Vancouver, Canada
    Curr Opin Nephrol Hypertens 12:133-8. 2003
    ..Well designed prospective studies with both CVD events and mortality as outcomes, and with enrollment beginning before the start of dialysis, are essential if we are to determine the optimal therapeutic strategies...
  48. ncbi CKD in the United States: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Adam T Whaley-Connell
    University of Missouri Columbia School of Medicine and the Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Am J Kidney Dis 51:S13-20. 2008
    ..CKD is silent and undetected until advanced stages. The study of populations with earlier stages of kidney disease may improve outcomes of CKD...
  49. ncbi Testing for chronic kidney disease: a position statement from the National Kidney Foundation
    Joseph A Vassalotti
    National Kidney Foundation, New York, NY, USA
    Am J Kidney Dis 50:169-80. 2007
    ..Application of CKD testing in national and international screening and surveillance programs could improve public health related to CKD...
  50. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
    ..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
  51. ncbi Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Kidney Dis 50:918-26. 2007
    ....
  52. ncbi Chronic kidney disease is common: what do we do next?
    Josef Coresh
    Johns Hopkins Medical Institutions, Baltimore, USA
    Nephrol Dial Transplant 23:1122-5. 2008
  53. ncbi Executing change in the management of chronic kidney disease: perspectives on guidelines and practice
    Adeera Levin
    Nephrology Education and Research, St Paul s Hospital, 1081 Burrard Street, Room 6010A, Vancouver, BC V6Z 1Y6, Canada
    Med Clin North Am 89:701-9. 2005
    ..The systematic evaluation of all patients and incorporation of simplified definitions and classification systems should enhance the ability to improve the outcomes of patients with kidney disease irrespective of time of identification...
  54. ncbi The profile of cardiac patients with renal artery stenosis
    Christopher E Buller
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, Canada
    J Am Coll Cardiol 43:1606-13. 2004
    ....