Research Topics
| DAVID RICHARD SNYDMANSummaryAffiliation: Tufts-New England Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
The safety of probioticsDavid R Snydman
Division of Geographic Medicine and Infectious Diseases and Department of Medicine, Tufts New England Medical Center, and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Clin Infect Dis 46:S104-11; discussion S144-51. 2008..The use of probiotics in clinical trials should be accompanied by the use of a data-safety monitoring board and by knowledge of the antimicrobial susceptibilities of the organism used...
National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004D R Snydman
Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
Antimicrob Agents Chemother 51:1649-55. 2007..In 2002, one isolate resistant to metronidazole (MIC = 64 microg/ml) was noted. These data indicate changes in susceptibility over time; surprisingly, some antimicrobial agents are more active now than they were 5 years ago...
The case for cytomegalovirus prophylaxis in solid organ transplantationDavid R Snydman
Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
Rev Med Virol 16:289-95. 2006..Future trials with longer periods of prophylaxis are being undertaken...- Evaluation of in vitro interaction of daptomycin with gentamicin or beta-lactam antibiotics against Staphylococcus aureus and Enterococci by FIC index and timed-kill curvesD R Snydman
Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
J Chemother 17:614-21. 2005..A bactericidal effect was exerted in 5/7 synergistic combinations. The in vitro data suggest that daptomycin combined with other antibiotics may be microbiologically beneficial and not antagonistic... - Evaluation of the in vitro activity of NVP-LMB415 against clinical anaerobic isolates with emphasis on the Bacteroides fragilis groupDavid R Snydman
Tufts New England Medical Center, Boston, MA 02111, USA
J Antimicrob Chemother 55:1024-8. 2005..To compare the in vitro activity of NVP-LMB415 (formerly referred to as NVP-PDF 713) with that of other agents with anti-anaerobe activity against clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group... - Counterpoint: prevention of cytomegalovirus (CMV) infection and CMV disease in recipients of solid organ transplants: the case for prophylaxisDavid R Snydman
Division of Geographic Medicine and Infectious Diseases and Department of Medicine, TuftsNew England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Clin Infect Dis 40:709-12. 2005 - Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremiaA Mangili
Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Clin Infect Dis 40:1058-60. 2005..Although daptomycin is an alternative agent for treatment of drug-resistant gram-positive bacterial infections, development of resistance during prolonged use may occur with MRSA bacteremia from a persistent focus... - Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortalityD D Poutsiaka
Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
Bone Marrow Transplant 40:63-70. 2007..GNR BSI and vancomycin-resistant enterococcal BSI also were significantly associated with death. We concluded that BSI is a common complication of HSCT associated with increased mortality throughout the post-HSCT period... - In vitro activities of tigecycline against the Bacteroides fragilis groupN V Jacobus
Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Antimicrob Agents Chemother 48:1034-6. 2004..fragilis group. Tigecycline geometric mean MICs were statistically higher against B. distasonis than other Bacteroides species (P value of 0.0001)... - In vitro activities of newer quinolones against bacteroides group organismsD R Snydman
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Antimicrob Agents Chemother 46:3276-9. 2002..B. fragilis was the most susceptible of the species, and Bacteroides vulgatus was the most resistant. Association of specific antibiotic resistance with Bacteroides species was noted for all quinolones... - National survey on the susceptibility of Bacteroides Fragilis Group: report and analysis of trends for 1997-2000D R Snydman
Departments of Medicine, Community Health, and Clinical Research, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Clin Infect Dis 35:S126-34. 2002..All strains were susceptible to chloramphenicol and metronidazole concentrations <8 microgram/mL. The data underscore the need for species identification and continued surveillance to monitor resistance patterns... - Comparative In vitro activities of daptomycin and vancomycin against resistant gram-positive pathogensD R Snydman
New England Medical Center, Boston, Massachusetts 02111, USA
Antimicrob Agents Chemother 44:3447-50. 2000..Daptomycin was bactericidal against 82% of 17 VREF isolates. The antibacterial activity of daptomycin was strongly dependent on the calcium concentration of the medium. Daptomycin was active against all gram-positive cocci tested... - Multicenter study of in vitro susceptibility of the Bacteroides fragilis group, 1995 to 1996, with comparison of resistance trends from 1990 to 1996D R Snydman
Departments of Medicine, Pathology, and Community Health, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 1526, USA
Antimicrob Agents Chemother 43:2417-22. 1999..The majority of the resistance decrease has been for the beta-lactams in B. fragilis, compared to other species. The reasons for these changes are not readily apparent... - Comparative in vitro activities of clinafloxacin and trovafloxacin against 1,000 isolates of bacteroides fragilis group: effect of the medium on test resultsD R Snydman
Department of Medicine, Division of Clinical Care Research, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Antimicrob Agents Chemother 44:1710-2. 2000..distasonis, B. ovatus, and B. thetaiotaomicron but lower against B. vulgatus. High cross resistance between trovafloxacin and clinafloxacin was observed... - Risk factors leading to clinical failure in the treatment of intra-abdominal or skin/soft tissue infectionsM E Falagas
Division of Infectious Diseases, New England Medical Center, Boston, Massachusetts, USA
Eur J Clin Microbiol Infect Dis 15:913-21. 1996..in its spectrum when this organism is isolated from patients with such infections...
Research Grants
- Clinical Research Training in Infectious DiseasesDavid Snydman; Fiscal Year: 2007..The goal of this training program will be to develop independent infectious diseases clinical research investigators highly skilled in clinical research methodologies and application. ..