Mark J Sarnak

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. ncbi request reprint The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study
    Mark J Sarnak
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 142:342-51. 2005
  2. ncbi request reprint Cardiovascular complications in chronic kidney disease
    Mark J Sarnak
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 41:11-7. 2003
  3. pmc Cystatin C and aging success
    Mark J Sarnak
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Arch Intern Med 168:147-53. 2008
  4. pmc Waist-to-hip ratio and body mass index as risk factors for cardiovascular events in CKD
    Essam F Elsayed
    Department of Medicine, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 52:49-57. 2008
  5. doi request reprint Waist-to-hip ratio, body mass index, and subsequent kidney disease and death
    Essam F Elsayed
    Nephrology Research Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 52:29-38. 2008
  6. pmc Chronic kidney disease in octogenarians
    Shani Shastri
    Tufts Medical Center, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 6:1410-7. 2011
  7. ncbi request reprint The Framingham predictive instrument in chronic kidney disease
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 50:217-24. 2007
  8. ncbi request reprint Factors associated with lipoprotein(a) in chronic kidney disease
    Katrin Uhlig
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:28-38. 2005
  9. ncbi request reprint Relationship of phosphorus and calcium-phosphorus product with mortality in CKD
    Vandana Menon
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Am J Kidney Dis 46:455-63. 2005
  10. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009

Detail Information

Publications95

  1. ncbi request reprint The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study
    Mark J Sarnak
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 142:342-51. 2005
    ..Hypertension is a risk factor for progression of chronic kidney disease. The optimal blood pressure to slow progression is unknown...
  2. ncbi request reprint Cardiovascular complications in chronic kidney disease
    Mark J Sarnak
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 41:11-7. 2003
    ..Treatment of both traditional and uremia-related risk factors should be initiated in the earlier stages of CKD. Additional clinical trials with a goal to reduce CVD are urgently needed in CKD...
  3. pmc Cystatin C and aging success
    Mark J Sarnak
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Arch Intern Med 168:147-53. 2008
    ..To our knowledge, the effect of kidney function on successful aging has not been examined...
  4. pmc Waist-to-hip ratio and body mass index as risk factors for cardiovascular events in CKD
    Essam F Elsayed
    Department of Medicine, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 52:49-57. 2008
    ..Waist-to-hip ratio (WHR) is less influenced by muscle and bone mass than body mass index (BMI). We compared WHR and BMI as risk factors for cardiac events (myocardial infarction and fatal coronary disease) in persons with CKD...
  5. doi request reprint Waist-to-hip ratio, body mass index, and subsequent kidney disease and death
    Essam F Elsayed
    Nephrology Research Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 52:29-38. 2008
    ..Chronic kidney disease (CKD) and obesity are important public health concerns. We examined the association between anthropomorphic measures and incident CKD and mortality...
  6. pmc Chronic kidney disease in octogenarians
    Shani Shastri
    Tufts Medical Center, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 6:1410-7. 2011
    ..There are limited data on the prevalence of chronic kidney disease (CKD) and its clinical importance in the very old. We examined the prevalence of CKD in octogenarians and its association with cardiovascular disease (CVD)...
  7. ncbi request reprint The Framingham predictive instrument in chronic kidney disease
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 50:217-24. 2007
    ..We sought to determine the utility of the Framingham equations in individuals with chronic kidney disease (CKD)...
  8. ncbi request reprint Factors associated with lipoprotein(a) in chronic kidney disease
    Katrin Uhlig
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:28-38. 2005
    ....
  9. ncbi request reprint Relationship of phosphorus and calcium-phosphorus product with mortality in CKD
    Vandana Menon
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Am J Kidney Dis 46:455-63. 2005
    ..There are limited data investigating relationships of phosphorus and calcium-phosphorus product with outcomes in patients with chronic kidney disease (CKD) stages 3 to 4...
  10. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
    ..Obesity assessed in midlife has been associated with chronic kidney disease...
  11. ncbi request reprint Relationship between C-reactive protein, albumin, and cardiovascular disease in patients with chronic kidney disease
    Vandana Menon
    Department of Medicine, Division of Clinical Care Research, Tufts New England Medical Center, Boston, MA, USA
    Am J Kidney Dis 42:44-52. 2003
    ..Data are limited regarding relationships between CRP levels and glomerular filtration rate (GFR), nutritional indices, and CVD in patients with earlier stages of kidney disease...
  12. doi request reprint Kidney function and mortality in octogenarians: Cardiovascular Health Study All Stars
    Shani Shastri
    Division of Nephrology, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Am Geriatr Soc 60:1201-7. 2012
    ..To examine the association between kidney function and all-cause mortality in octogenarians...
  13. pmc Role of adipose tissue in determining muscle mass in patients with chronic kidney disease
    Carmen Castaneda-Sceppa
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Ren Nutr 17:314-22. 2007
    ..Arm muscle area was used as an indicator of muscle mass...
  14. pmc Depression and cognitive function in maintenance hemodialysis patients
    Brian T Agganis
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 56:704-12. 2010
    ..Both depression and cognitive impairment are common in hemodialysis patients, are associated with adverse clinical outcomes, and place an increased burden on health care resources...
  15. doi request reprint The relationship between nontraditional risk factors and outcomes in individuals with stage 3 to 4 CKD
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 51:212-23. 2008
    ..Chronic kidney disease is associated with increased risk for cardiovascular disease and mortality. Both traditional and nontraditional cardiovascular disease risk factors may contribute...
  16. ncbi request reprint Glycosylated hemoglobin and mortality in patients with nondiabetic chronic kidney disease
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 16:3411-7. 2005
    ..43; P = 0.07). HbA(1c) is associated with increased mortality in nondiabetic kidney disease. Hyperglycemia may be a potential therapeutic target and HbA(1c) may be important as a risk stratification tool in this high-risk population...
  17. ncbi request reprint Cystatin C as a risk factor for outcomes in chronic kidney disease
    Vandana Menon
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 147:19-27. 2007
    ....
  18. ncbi request reprint Relationship between homocysteine and mortality in chronic kidney disease
    Vandana Menon
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, MA, USA
    Circulation 113:1572-7. 2006
    ..The relationship between total homocysteine (tHcy) and outcomes has not been investigated in patients with chronic kidney disease stages 3 to 4...
  19. pmc Uric acid and long-term outcomes in CKD
    Magdalena Madero
    Department of Medicine, Division of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Am J Kidney Dis 53:796-803. 2009
    ..Hyperuricemia is prevalent in patients with chronic kidney disease (CKD); however, data are limited about the relationship of uric acid levels with long-term outcomes in this patient population...
  20. pmc Retinal microvascular signs and disability in the Cardiovascular Health Study
    Dae Hyun Kim
    Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Ophthalmol 130:350-6. 2012
    ..To study the associations of retinal microvascular changes, which are associated with systemic conditions and cognitive decline, with disability in performing activities of daily living (ADL)...
  21. ncbi request reprint Anemia as a risk factor for cardiovascular disease and all-cause mortality in diabetes: the impact of chronic kidney disease
    Panagiotis T Vlagopoulos
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 16:3403-10. 2005
    ..66) for all-cause mortality. Anemia was not a risk factor for any outcome in those without CKD (P > 0.2 for all outcomes). In persons with diabetes, anemia is primarily a risk factor for adverse outcomes in those who also have CKD...
  22. ncbi request reprint Anemia as a risk factor for kidney function decline in individuals with heart failure
    Nisha Bansal
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 99:1137-42. 2007
    ..03 to 1.31) of rapid decrease (p for interaction <0.001). In conclusion, anemia is associated with a rapid decrease in kidney function in patients with heart failure, particularly in those with underlying CKD...
  23. doi request reprint Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 53:208-17. 2009
    ..We examined the effect of a very low-protein diet on the development of kidney failure and death during long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study...
  24. ncbi request reprint Homocysteine in chronic kidney disease: Effect of low protein diet and repletion with B vitamins
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:1539-46. 2005
    ..Data are limited on the determinants of homocysteine (tHcy) and its relationship with nutritional indices, and dietary protein intake, in the earlier stages of chronic kidney disease (CKD)...
  25. ncbi request reprint Level of kidney function as a risk factor for cardiovascular outcomes in the elderly
    Guruprasad Manjunath
    Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 63:1121-9. 2003
    ..We evaluated whether the level of kidney function is an independent risk factor for CVD outcomes in the Cardiovascular Health Study (CHS), a cohort of subjects whose age at baseline was 65 years old or older...
  26. pmc Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease
    Jill Melendez Young
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 4:1115-20. 2009
    ..This dimethylated amino acid accumulates in chronic kidney disease and may be involved in the pathophysiology of cardiovascular disease (CVD) in this population...
  27. pmc Association between baseline kidney function and change in CRP: an analysis of the cardiovascular health study
    Dena E Rifkin
    Division of Nephrology, University of California, San Diego and Veterans Affair Hospital, San Diego, CA 92093 9111, USA
    Nephron Clin Pract 115:c114-21. 2010
    ..In cross-sectional analyses, C-reactive protein (CRP) levels are inversely related to levels of kidney function. The relationship between kidney function and subsequent changes in CRP is unknown...
  28. ncbi request reprint C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 68:766-72. 2005
    ..There are limited data evaluating the relationships between CRP, albumin, and outcomes in chronic kidney disease (CKD) stages 3 and 4...
  29. pmc Cystatin C concentration as a predictor of systolic and diastolic heart failure
    Andrew Moran
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Card Fail 14:19-26. 2008
    ..We hypothesized that kidney dysfunction would predict diastolic HF (DHF) better than systolic HF (SHF) in the Cardiovascular Health Study...
  30. pmc Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)
    Joachim H Ix
    Department of Medicine, University of California San Diego, USA
    J Am Coll Cardiol 54:1176-84. 2009
    ..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI...
  31. ncbi request reprint Cystatin C concentration as a risk factor for heart failure in older adults
    Mark J Sarnak
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 142:497-505. 2005
    ..Previous studies that evaluated the association of kidney function with incident heart failure may be limited by the insensitivity of serum creatinine concentration for detecting abnormal kidney function...
  32. ncbi request reprint Cardiovascular disease and subsequent kidney disease
    Essam F Elsayed
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Campus Box 391, Boston, MA 02111
    Arch Intern Med 167:1130-6. 2007
    ..Chronic kidney disease is a risk factor for cardiovascular disease (CVD); however, it is uncertain if CVD is a risk factor for progression or development of kidney disease...
  33. pmc Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 25:119-24. 2010
    ..The objective of this study was to determine whether elevated markers of inflammation are independently associated with longitudinal kidney function decline...
  34. pmc Frequency of and risk factors for poor cognitive performance in hemodialysis patients
    Mark J Sarnak
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Neurology 80:471-80. 2013
    ..There are few detailed data on cognition in patients undergoing dialysis. We evaluated the frequency of and risk factors for poor cognitive performance using detailed neurocognitive testing...
  35. ncbi request reprint Apolipoprotein E and kidney function in older adults
    Rebecca Kurnik Seshasai
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Clin Nephrol 78:174-80. 2012
    ..We evaluated the associations of apolipoprotein E alleles with kidney function among older adults in the cardiovascular health study (CHS)...
  36. pmc Predictors of sudden cardiac death: a competing risk approach in the hemodialysis study
    Shani Shastri
    Division of Nephrology, Tufts Medical Center, 800 Washington Street, Box 391, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 7:123-30. 2012
    ..The study objective was to identify predictors associated with various causes of death in the Hemodialysis (HEMO) Study and to develop a prediction model for SCD using a competing risk approach...
  37. ncbi request reprint Kidney function, electrocardiographic findings, and cardiovascular events among older adults
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    Clin J Am Soc Nephrol 2:501-8. 2007
    ..Associations seemed stronger for participants with CKD; however, no significant interactions were detected. Resting electrocardiographic abnormalities are common in CKD and independently predict future clinical CV events in this setting...
  38. ncbi request reprint Effect of dietary protein restriction on the progression of kidney disease: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Kidney Dis 48:879-88. 2006
    ..We evaluated effects of protein restriction on kidney failure and all-cause mortality during extended follow-up of the Modification of Diet in Renal Disease Study...
  39. ncbi request reprint Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies
    Daniel E Weiner
    Division of Nephrology, Department of Clinical Care Research, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1307-15. 2004
    ..It is hypothesized that this effect may be due to more frequent or more severe subclinical vascular disease secondary to hypertension or diabetes in black individuals...
  40. ncbi request reprint Kidney disease as a risk factor for recurrent cardiovascular disease and mortality
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 44:198-206. 2004
    ..Few studies have evaluated the effect of CKD on cardiovascular events in a diverse community-based population with underlying CVD...
  41. ncbi request reprint Body mass index and mortality in CKD
    Magdalena Madero
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 50:404-11. 2007
    ..Data are limited on the relationship of BMI with mortality in patients in the earlier stages of chronic kidney disease (CKD)...
  42. ncbi request reprint Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 16:1803-10. 2005
    ..15 [95% CI, 2.62 to 6.56] and 3.92 [95% CI, 2.05 to 7.48]; P = 0.02 and 0.01 for interaction term, respectively). The combination of anemia and LVH in CKD identifies a high-risk population...
  43. doi request reprint Serum bicarbonate and long-term outcomes in CKD
    Vandana Menon
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:907-14. 2010
    ..A low serum bicarbonate level is prevalent in chronic kidney disease (CKD); however, its relationship to long-term outcomes is unclear...
  44. pmc Cognitive function and dialysis adequacy: no clear relationship
    Lena M Giang
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Nephrol 33:33-8. 2011
    ..The impact of dialysis dose on cognitive function remains uncertain, particularly in the current era of increased dialysis dose and flux...
  45. pmc Hyperlipidemia and long-term outcomes in nondiabetic chronic kidney disease
    Varun Chawla
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Clin J Am Soc Nephrol 5:1582-7. 2010
    ..Dyslipidemia confers a paradoxical survival advantage in patients with kidney failure. Data are limited in the earlier stages of chronic kidney disease (CKD)...
  46. pmc Alcohol consumption and kidney function decline in the elderly: alcohol and kidney disease
    Vandana Menon
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:3301-7. 2010
    ..Alcohol consumption appears to be protective for cardiovascular disease; however, its relationship with kidney disease is unclear...
  47. pmc Association of visceral and subcutaneous adiposity with kidney function
    Jill A Young
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1786-91. 2008
    ..Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations...
  48. pmc Rapid kidney function decline and mortality risk in older adults
    Dena E Rifkin
    Division of Nephrology, Tufts Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Arch Intern Med 168:2212-8. 2008
    ..It remains unknown, however, whether longitudinal declines in kidney function are independently associated with increased cardiovascular and all-cause mortality in older adults...
  49. ncbi request reprint Cardiovascular outcomes and all-cause mortality: exploring the interaction between CKD and cardiovascular disease
    Daniel E Weiner
    Division of Nephrology, Department of Internal Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 48:392-401. 2006
    ..Concurrently, CVD may promote CKD, resulting in a vicious cycle. We evaluated this hypothesis by exploring whether CKD and CVD have an additive or synergistic effect on future cardiovascular and mortality outcomes...
  50. pmc CKD classification based on estimated GFR over three years and subsequent cardiac and mortality outcomes: a cohort study
    Daniel E Weiner
    Division of Nephrology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    BMC Nephrol 10:26. 2009
    ..It is unknown whether defining chronic kidney disease (CKD) based on one versus two estimated glomerular filtration rate (eGFR) assessments changes the prognostic importance of reduced eGFR in a community-based population...
  51. ncbi request reprint Lowest systolic blood pressure is associated with stroke in stages 3 to 4 chronic kidney disease
    Daniel E Weiner
    Division of Nephrology, Box 391, Tufts New England Medical Center, Boston, MA 02111, USA
    J Am Soc Nephrol 18:960-6. 2007
    ..CKD and elevated SBP are independent risk factors for incident stroke. In CKD, individuals with the lowest BP are at increased risk for stroke. This pattern is not seen in the general population...
  52. ncbi request reprint Adiponectin and mortality in patients with chronic kidney disease
    Vandana Menon
    Tufts New England Medical Center, Division of Nephrology, 750 Washington Street, NEMC 391, Boston, MA 02111, USA
    J Am Soc Nephrol 17:2599-606. 2006
    ..Further studies are necessary to confirm this association and to elucidate the underlying mechanisms...
  53. pmc The risk of infection-related hospitalization with decreased kidney function
    Lorien S Dalrymple
    Department of Medicine, University of California Davis, USA
    Am J Kidney Dis 59:356-63. 2012
    ..Moderate kidney disease may predispose to infection. We sought to determine whether decreased kidney function, estimated by serum cystatin C level, was associated with the risk of infection-related hospitalization in older individuals...
  54. pmc Filtration markers may have prognostic value independent of glomerular filtration rate
    Navdeep Tangri
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    J Am Soc Nephrol 23:351-9. 2012
    ..trace protein and cystatin C seem to provide more consistent prognostic information than creatinine...
  55. doi request reprint β-Blockers for prevention of sudden cardiac death in patients on hemodialysis: a propensity score analysis of the HEMO Study
    Navdeep Tangri
    Division of Nephrology, Department of Medicine, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 58:939-45. 2011
    ..Although the efficacy of β-blockers for the prevention of sudden cardiac death has been proven in the general population, little evidence exists in patients with kidney failure...
  56. pmc Chronic kidney disease and the risk of end-stage renal disease versus death
    Lorien S Dalrymple
    Department of Medicine, University of California Davis, 4150 V Street, 3500 PSSB, Sacramento, CA 95817, USA
    J Gen Intern Med 26:379-85. 2011
    ..Among older adults with chronic kidney disease (CKD), the comparative event rates of end-stage renal disease (ESRD) and cause-specific death are unknown...
  57. ncbi request reprint Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community
    Guruprasad Manjunath
    Division of Nephrology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 41:47-55. 2003
    ....
  58. pmc Cystatin C and albuminuria as risk factors for development of CKD stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Shani Shastri
    Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
    Am J Kidney Dis 57:832-40. 2011
    ..The growing burden and morbidity of chronic kidney disease (CKD) warrant effective strategies for identifying those at increased risk. We examined the association of cystatin C level and albuminuria with the development of CKD stage 3...
  59. ncbi request reprint Serum C-reactive protein and leptin as predictors of kidney disease progression in the Modification of Diet in Renal Disease Study
    Mark J Sarnak
    New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Kidney Int 62:2208-15. 2002
    ..In vitro and in vivo data suggest that markers of inflammation and nutritional status may be risk factors for the progression of chronic kidney disease...
  60. pmc Cystatin C and carotid intima-media thickness in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Anh L Bui
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Kidney Dis 53:389-98. 2009
    ..We therefore explored whether serum cystatin C level is associated with carotid intima-media thickness (IMT) in ambulatory adults without clinical heart disease...
  61. doi request reprint Creatinine-based formulae for estimating glomerular filtration rate: is it time to change to chronic kidney disease epidemiology collaboration equation?
    Magdalena Madero
    Division of Nephrology, Department of Medicine, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Curr Opin Nephrol Hypertens 20:622-30. 2011
    ....
  62. pmc Homocysteine lowering and cardiovascular disease risk: lost in translation
    Jeremy Marcus
    Department of Medicine, Division of Nephrology, Tufts New England Medical Centre, Boston, Massachusetts 02111, USA
    Can J Cardiol 23:707-10. 2007
    ..Several more interventional trials are ongoing, but the available data thus far do not support screening for or treatment of hyperhomocysteinemia...
  63. ncbi request reprint Kidney disease, Framingham risk scores, and cardiac and mortality outcomes
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, Mass 02111, USA
    Am J Med 120:552.e1-8. 2007
    ..The Framingham equations were developed to predict incident coronary heart disease. It remains unknown how the presence of chronic kidney disease affects their performance...
  64. pmc Cardiovascular disease and cognitive function in maintenance hemodialysis patients
    Daniel E Weiner
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 58:773-81. 2011
    ....
  65. ncbi request reprint Update on cystatin C: new insights into the importance of mild kidney dysfunction
    Michael G Shlipak
    Department of Medicine, University of California, San Francisco, California 94121, USA
    Curr Opin Nephrol Hypertens 15:270-5. 2006
    ..Studies have questioned, however, whether cystatin C is predominantly a measure of kidney function. This review summarizes the research literature on cystatin C...
  66. ncbi request reprint Subcortical cognitive impairment in dialysis patients
    Arema A Pereira
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Hemodial Int 11:309-14. 2007
    ..These results suggest that, despite relatively normal MMSE scores, mild cognitive impairment may be prevalent in hemodialysis patients. The pattern of cognitive dysfunction is primarily subcortical in nature...
  67. ncbi request reprint Impact of chronic kidney disease and anemia on hospitalization expense in patients with left ventricular dysfunction
    Douglas D Gregory
    Division of Clinical Decision Making, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 92:1300-5. 2003
    ....
  68. ncbi request reprint Hematocrit and left ventricular mass: the Framingham Heart study
    Manish G Amin
    Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 43:1276-82. 2004
    ....
  69. pmc Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients
    Cindy X Huang
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 77:624-9. 2010
    ..These studies show that body composition in end-stage renal disease bears a complex relationship to all-cause mortality...
  70. ncbi request reprint Serum cystatin C as a marker of glomerular filtration rate
    Magdalena Madero
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 15:610-6. 2006
    ..This review summarizes the currently available glomerular filtration rate estimating equations based on cystatin C and the literature comparing cystatin C and creatinine as filtration markers...
  71. pmc Albuminuria, cognitive functioning, and white matter hyperintensities in homebound elders
    Daniel E Weiner
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 53:438-47. 2009
    ..Albuminuria, a kidney marker of microvascular disease, may herald microvascular disease elsewhere, including in the brain...
  72. doi request reprint Cognitive function in chronic kidney disease
    Magdalena Madero
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Semin Dial 21:29-37. 2008
    ..Given the high prevalence of cognitive impairment in all stages of CKD, additional studies are needed to evaluate potential risk factors and treatments in this vulnerable population...
  73. ncbi request reprint Cognitive function in dialysis patients
    Arema A Pereira
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:448-62. 2005
    ..We explore potential measures to reduce cognitive impairment in this population. We conclude that additional research is needed in this area...
  74. ncbi request reprint Homocysteine, cysteine, and B vitamins as predictors of kidney disease progression
    Mark J Sarnak
    New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 40:932-9. 2002
    ..Elevated total homocysteine (tHcy) levels and low B vitamin levels are risk factors for atherosclerosis, but have not been evaluated sufficiently as risk factors for the progression of kidney disease...
  75. pmc Managing dyslipidemia in chronic kidney disease
    Daniel E Weiner
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Gen Intern Med 19:1045-52. 2004
    ..One potentially modifiable risk factor for CVD in patients with CKD is dyslipidemia. In the current manuscript we review observational and trial data assessing dyslipidemia and its treatment in this patient population...
  76. ncbi request reprint Traditional cardiac risk factors in individuals with chronic kidney disease
    Katrin Uhlig
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Semin Dial 16:118-27. 2003
    ..Treatment recommendations are provided using evidence available from populations with CKD or evidence extrapolated from the general population when there are insufficient data on individuals with CKD...
  77. ncbi request reprint The epidemiology of chronic kidney disease stages 1 to 4 and cardiovascular disease: a high-risk combination
    Vandana Menon
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 45:223-32. 2005
  78. ncbi request reprint Apolipoprotein A-I, B-100, and B-48 metabolism in subjects with chronic kidney disease, obesity, and the metabolic syndrome
    Marcelo C Batista
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:1255-61. 2004
    ....
  79. ncbi request reprint Recent trends in hospital management practices and prognosis after acute myocardial infarction in patients with kidney disease
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts University School of Medicine New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 94:1290-3. 2004
    ....
  80. ncbi request reprint Anemia as a risk factor for cardiovascular disease in The Atherosclerosis Risk in Communities (ARIC) study
    Mark J Sarnak
    Division of Nephrology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 40:27-33. 2002
    ..We investigated whether the presence of anemia is a risk factor for cardiovascular disease (CVD) outcomes in the general population...
  81. ncbi request reprint Management of intradialytic hypertension: the ongoing challenge
    Joline Chen
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Semin Dial 19:141-5. 2006
    ..We conclude that additional epidemiologic, basic science, and interventional studies are needed to further elucidate the prevalence, prognostic importance, pathophysiology, and potential treatment of intradialytic hypertension...
  82. ncbi request reprint How can the cardiac death rate be reduced in dialysis patients?
    Guruprasad Manjunath
    Division of Nephrology, Department of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Semin Dial 15:18-20. 2002
  83. ncbi request reprint Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease
    Michael G Shlipak
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Ann Intern Med 145:237-46. 2006
    ..73 m2)...
  84. ncbi request reprint Cystatin-C and mortality in elderly persons with heart failure
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, 4150 Clement Street, University of California San Francisco, San Francisco, CA 94121, USA
    J Am Coll Cardiol 45:268-71. 2005
    ..We sought to evaluate cystatin-C, a novel measure of renal function, as a predictor of mortality in elderly persons with heart failure (HF) and to compare it with creatinine...
  85. ncbi request reprint Cystatin-C and inflammatory markers in the ambulatory elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, Calif 94121, USA
    Am J Med 118:1416. 2005
    ..We compared cystatin-C, a novel marker of renal function, with creatinine and estimated glomerular filtration rate (eGFR) as predictors of C-reactive protein and fibrinogen levels...
  86. ncbi request reprint Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am Heart J 151:492-500. 2006
    ..Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both conditions are present...
  87. ncbi request reprint Cerebrovascular disease in maintenance hemodialysis patients: results of the HEMO Study
    James A Delmez
    Washington University, St Louis, MO, USA
    Am J Kidney Dis 47:131-8. 2006
    ....
  88. ncbi request reprint Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Hypertension 42:1050-65. 2003
  89. ncbi request reprint Kidney function and mortality among patients with left ventricular systolic dysfunction
    Nadia A Khan
    Division of Internal Medicine, University of British Columbia, Department of Medicine, 620 B, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    J Am Soc Nephrol 17:244-53. 2006
    ..Rate of decline in kidney function is a strong predictor of increased mortality in this population, independent of worsening heart failure and baseline kidney function...
  90. ncbi request reprint Microalbuminuria: a marker of cardiovascular risk
    Daniel E Weiner
    Am J Kidney Dis 42:596-8. 2003
  91. ncbi request reprint Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  92. ncbi request reprint Kidney function as a predictor of noncardiovascular mortality
    Linda F Fried
    VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    J Am Soc Nephrol 16:3728-35. 2005
    ..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease...
  93. ncbi request reprint Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  94. ncbi request reprint Evidence for increased cardiovascular disease risk in patients with chronic kidney disease
    Josef Coresh
    Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Curr Opin Nephrol Hypertens 13:73-81. 2004
    ....
  95. ncbi request reprint Relationship of uric acid with progression of kidney disease
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 50:239-47. 2007
    ..Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression...

Research Grants5

  1. CARDIOVASCULAR RISK FACTORS--CHRONIC RENAL INSUFFICIENCY
    Mark Sarnak; Fiscal Year: 2004
    ..The proposed L training program and research project will prepare him for a career as an independent investigator. ..
  2. Cardiac Risk Factors in Chronic Kidney Disease
    Mark Sarnak; Fiscal Year: 2006
    ..Evaluating the importance of traditional and non-traditional risk factors in CKD is essential in that it will focus attention on the most important cardiac risk factors in this population. ..
  3. Cognition and Vascular Disease in Dialysis Patients
    Mark Sarnak; Fiscal Year: 2006
    ..Evaluating the prevalence of, as well as potential risk factors for, cognitive impairment may lead to intervention trials to reduce the burden of cognitive impairment in this patient population. ..
  4. Chronic Kidney Disease, Vascular Disease and Aging
    Mark Sarnak; Fiscal Year: 2007
    ..Training future investigators in POR will be essential to reduce the burden of CKD in the future. ..