Powers J, Evinger M, Zhi J, Picard K, Tischler A. Pheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile. Neuroscience. 2007;147:928-37 pubmed
Powers J, Tischler A, Mohammed M, Naeem R. Microarray-based comparative genomic hybridization of pheochromocytoma cell lines from neurofibromatosis knockout mice reveals genetic alterations similar to those in human pheochromocytomas. Cancer Genet Cytogenet. 2005;159:27-31 pubmed
..Additional changes that may be specific to this model included complete or partial gains of chromosome 12 as seen in 3 of the 4 lines analyzed by array CGH. ..
Powers J, Brachold J, Ehsani S, Tischler A. Up-regulation of ret by reserpine in the adult rat adrenal medulla. Neuroscience. 2005;132:605-12 pubmed
..Our findings suggest potential utility of the rat model for studying the roles of ret in the adrenal medulla and the mechanisms of its involvement in MEN 2 and other pheochromocytoma syndromes. ..
Powers J, Picard K, Nyska A, Tischler A. Adrenergic differentiation and Ret expression in rat pheochromocytomas. Endocr Pathol. 2008;19:9-16 pubmed publisher
..Loss of p27(Kip1) does not appear to account for the high frequency of pheochromocytomas in commonly utilized rat strains. ..
Powers J, Brachold J, Tischler A. Ret protein expression in adrenal medullary hyperplasia and pheochromocytoma. Endocr Pathol. 2003;14:351-61 pubmed
..The association of high-level Ret expression with neuronal morphology suggests that the variable overexpression of Ret in pheochromocytomas might in part be an epiphenomenon, reflecting the known phenotypic plasticity of these tumors...