J F Powers


Affiliation: Tufts-New England Medical Center
Country: USA


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    Powers J, Evinger M, Zhi J, Picard K, Tischler A. Pheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile. Neuroscience. 2007;147:928-37 pubmed
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    Powers J, Tischler A, Mohammed M, Naeem R. Microarray-based comparative genomic hybridization of pheochromocytoma cell lines from neurofibromatosis knockout mice reveals genetic alterations similar to those in human pheochromocytomas. Cancer Genet Cytogenet. 2005;159:27-31 pubmed
    ..Additional changes that may be specific to this model included complete or partial gains of chromosome 12 as seen in 3 of the 4 lines analyzed by array CGH. ..
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    Powers J, Brachold J, Ehsani S, Tischler A. Up-regulation of ret by reserpine in the adult rat adrenal medulla. Neuroscience. 2005;132:605-12 pubmed
    ..Our findings suggest potential utility of the rat model for studying the roles of ret in the adrenal medulla and the mechanisms of its involvement in MEN 2 and other pheochromocytoma syndromes. ..
  4. Powers J, Picard K, Nyska A, Tischler A. Adrenergic differentiation and Ret expression in rat pheochromocytomas. Endocr Pathol. 2008;19:9-16 pubmed publisher
    ..Loss of p27(Kip1) does not appear to account for the high frequency of pheochromocytomas in commonly utilized rat strains. ..
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    Powers J, Brachold J, Tischler A. Ret protein expression in adrenal medullary hyperplasia and pheochromocytoma. Endocr Pathol. 2003;14:351-61 pubmed
    ..The association of high-level Ret expression with neuronal morphology suggests that the variable overexpression of Ret in pheochromocytomas might in part be an epiphenomenon, reflecting the known phenotypic plasticity of these tumors...