ROBERTA M O'CONNOR

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. pmc Expression of Cpgp40/15 in Toxoplasma gondii: a surrogate system for the study of Cryptosporidium glycoprotein antigens
    R M O'Connor
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, 50 Washington Street, Boston, MA 02111, USA
    Infect Immun 71:6027-34. 2003
  2. pmc Stable expression of Cryptosporidium parvum glycoprotein gp40/15 in Toxoplasma gondii
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA, United States
    Mol Biochem Parasitol 152:149-58. 2007
  3. pmc Cryptosporidium parvum glycoprotein gp40 localizes to the sporozoite surface by association with gp15
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Biochem Parasitol 156:80-3. 2007
  4. pmc Polymorphic mucin antigens CpMuc4 and CpMuc5 are integral to Cryptosporidium parvum infection in vitro
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Eukaryot Cell 8:461-9. 2009
  5. pmc Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro
    Jane W Wanyiri
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Eukaryot Cell 8:470-7. 2009
  6. pmc Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall
    Anirban Chatterjee
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Eukaryot Cell 9:84-96. 2010
  7. ncbi request reprint Expression of the highly polymorphic Cryptosporidium parvum Cpgp40/15 gene in genotype I and II isolates
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Tufts University School of Medicine, Box 041, 750 Washington Street, Boston, MA 02111, USA
    Mol Biochem Parasitol 119:203-15. 2002
  8. pmc Genetic diversity of Cryptosporidium spp. from Bangladeshi children
    Kirthi G Hira
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Clin Microbiol 49:2307-10. 2011

Research Grants

  1. ZEISS AXIOPLAN 2 IMAGING SYSTEM
    ROBERTA O CONNOR; Fiscal Year: 2005
  2. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
  3. Role of Cryptosporidium Mucins in Host-parasite interactions
    ROBERTA O CONNOR; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. pmc Expression of Cpgp40/15 in Toxoplasma gondii: a surrogate system for the study of Cryptosporidium glycoprotein antigens
    R M O'Connor
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, 50 Washington Street, Boston, MA 02111, USA
    Infect Immun 71:6027-34. 2003
    ..These results suggest that a surrogate system using T. gondii for the study of Cryptosporidium biology may be useful...
  2. pmc Stable expression of Cryptosporidium parvum glycoprotein gp40/15 in Toxoplasma gondii
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA, United States
    Mol Biochem Parasitol 152:149-58. 2007
    ..The ability to express and isolate appropriately glycosylated Cryptosporidium glycoproteins will enable further investigations into host-parasite interactions of this important pathogen...
  3. pmc Cryptosporidium parvum glycoprotein gp40 localizes to the sporozoite surface by association with gp15
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Biochem Parasitol 156:80-3. 2007
    ....
  4. pmc Polymorphic mucin antigens CpMuc4 and CpMuc5 are integral to Cryptosporidium parvum infection in vitro
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Eukaryot Cell 8:461-9. 2009
    ..Sequencing of CpMuc4 and CpMuc5 from C. hominis clinical isolates identified several polymorphic alleles. The data suggest that these antigens are integral for Cryptosporidium infection in vitro and may be potential vaccine candidates...
  5. pmc Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro
    Jane W Wanyiri
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA
    Eukaryot Cell 8:470-7. 2009
    ..parvum infection of HCT-8 cells. These studies indicate that CpSUB1 plays a significant role in infection of host cells by the parasite and suggest that this enzyme may serve as a target for intervention...
  6. pmc Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall
    Anirban Chatterjee
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Eukaryot Cell 9:84-96. 2010
    ..These results suggest that mucin-like glycoproteins, which are associated with the sporozoite surface, may contribute to fibrils and/or globules that tether sporozoites to the inner surface of oocyst walls...
  7. ncbi request reprint Expression of the highly polymorphic Cryptosporidium parvum Cpgp40/15 gene in genotype I and II isolates
    ROBERTA M O'CONNOR
    Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Tufts University School of Medicine, Box 041, 750 Washington Street, Boston, MA 02111, USA
    Mol Biochem Parasitol 119:203-15. 2002
    ..7% homology with TU502 3'UTRs. Actinomycin D treatment of GCH1-infected Caco-2A cells followed by Northern blot analysis, revealed that the stability of the 1.5 kb message was considerably greater than that of the 2.3 kb transcript...
  8. pmc Genetic diversity of Cryptosporidium spp. from Bangladeshi children
    Kirthi G Hira
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Clin Microbiol 49:2307-10. 2011
    ..Seven C. hominis and C. parvum subtype families (including a new family, IIm) and 15 subtypes (including 2 new subtypes) were identified. The dominance of specific families and subtypes was different from that in other countries...

Research Grants3

  1. ZEISS AXIOPLAN 2 IMAGING SYSTEM
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..abstract_text> ..
  2. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..New England Medical Center, in association with Tufts University and the wider Boston scientific community provides researchers with diverse and excellent scientific resources, and is exceptional environment for a young scientist...
  3. Role of Cryptosporidium Mucins in Host-parasite interactions
    ROBERTA O CONNOR; Fiscal Year: 2007
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