Michael E Mendelsohn

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. ncbi request reprint Molecular and cellular basis of cardiovascular gender differences
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA
    Science 308:1583-7. 2005
  2. pmc Rapid recruitment of temporally distinct vascular gene sets by estrogen
    Katrin K Schnoes
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 080, Boston, Massachusetts 02111, USA
    Mol Endocrinol 22:2544-56. 2008
  3. pmc Direct binding and regulation of RhoA protein by cyclic GMP-dependent protein kinase Iα
    Mikio Kato
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:41342-51. 2012
  4. pmc Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo
    Robert M Blanton
    Molecular Cardiology Research Institute and Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    J Am Heart Assoc 1:e003731. 2012
  5. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
  6. ncbi request reprint Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene
    Inga Peter
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Hypertension 49:1000-6. 2007
  7. pmc Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways
    Brenna G Newfell
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:1871-80. 2011
  8. doi request reprint 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload
    Richard D Patten
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Card Fail 14:245-53. 2008
  9. pmc Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    Massimiliano Caprio
    Department of Medicine Division of Cardiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Circ Res 102:1359-67. 2008
  10. pmc Renal actions of RGS2 control blood pressure
    Susan B Gurley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1847-51. 2010

Research Grants

  1. Cellular Fluorescence-Contractility Imaging System
    Michael Mendelsohn; Fiscal Year: 2005
  2. Molecular Biology of the Vasculature
    Michael Mendelsohn; Fiscal Year: 2005
  3. TRAINING PROGRAM IN CARDIOVASCULAR RESEARCH
    Michael Mendelsohn; Fiscal Year: 2007

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Molecular and cellular basis of cardiovascular gender differences
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA
    Science 308:1583-7. 2005
    ....
  2. pmc Rapid recruitment of temporally distinct vascular gene sets by estrogen
    Katrin K Schnoes
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 080, Boston, Massachusetts 02111, USA
    Mol Endocrinol 22:2544-56. 2008
    ..These data define the temporal recruitment of specific vascular genes by estrogen and enable further analysis of the mechanisms by which estrogen directly regulates vascular function...
  3. pmc Direct binding and regulation of RhoA protein by cyclic GMP-dependent protein kinase Iα
    Mikio Kato
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:41342-51. 2012
    ..Collectively, these results support that RhoA is a PKGIα target and that direct binding of activated PKGIα to RhoA is central to cGMP-mediated inhibition of the VSMC Rho kinase contractile pathway...
  4. pmc Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo
    Robert M Blanton
    Molecular Cardiology Research Institute and Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA
    J Am Heart Assoc 1:e003731. 2012
    ..Therefore, we tested whether the cGMP downstream effector, cGMP-dependent protein kinase G Iα (PKGIα), attenuates pressure overload-induced remodeling in vivo...
  5. pmc Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels
    Inga Peter
    Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    J Clin Endocrinol Metab 93:2779-85. 2008
    ..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels...
  6. ncbi request reprint Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene
    Inga Peter
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Hypertension 49:1000-6. 2007
    ..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure...
  7. pmc Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways
    Brenna G Newfell
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:1871-80. 2011
    ..Here we define the early Aldo-regulated vascular transcriptome and investigate the mechanisms of gene regulation by Aldo in the vasculature that may contribute to vascular disease...
  8. doi request reprint 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload
    Richard D Patten
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Card Fail 14:245-53. 2008
    ..However, E2 decreases hypertrophy in pressure overload models. We hypothesized that the effect of estrogen on cardiac hypertrophy was dependent on the type of hypertrophic stimulus...
  9. pmc Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    Massimiliano Caprio
    Department of Medicine Division of Cardiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Circ Res 102:1359-67. 2008
    ..These studies describe a novel mechanism by which aldosterone may influence ischemic cardiovascular events and support a new explanation for the decrease in ischemic events in patients treated with aldosterone antagonists...
  10. pmc Renal actions of RGS2 control blood pressure
    Susan B Gurley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1847-51. 2010
    ..These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension...
  11. ncbi request reprint Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor
    Paul Bridgman
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 289:H586-92. 2005
    ..Further work is necessary to explore the potential mechanisms underlying these gender-based differences...
  12. pmc Placental growth factor mediates aldosterone-dependent vascular injury in mice
    Iris Z Jaffe
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Clin Invest 120:3891-900. 2010
    ....
  13. ncbi request reprint Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species
    Raegan O'Lone
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Endocrinol 21:1281-96. 2007
    ..Overall, these findings provide a foundation for understanding the molecular basis for estrogen effects on vasculature gene expression...
  14. ncbi request reprint Mineralocorticoid receptor activation promotes vascular cell calcification
    Iris Z Jaffe
    Tufts University School of Medicine, New England Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 80, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:799-805. 2007
    ..This study examines the effects of MR activation by aldosterone on the process of in vitro vascular calcification...
  15. pmc Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase
    Alok K Sharma
    Divison of Molecular and Vascular Medicine, Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 283:32860-9. 2008
    ..Taken together these data support a role for the LZ domain of PKG-Ialpha and the CC domain of MBS in this requisite contractile complex...
  16. pmc Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve
    Eric C Wooten
    MCRI Center for Translational Genomics, Molecular Cardiology Research Institute, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8830. 2010
    ..Further, these studies demonstrate that leveraging existing expression and genomic data in the context of GWAS studies can identify biologically relevant genes and pathways associated with a congenital heart defect...
  17. pmc Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
    Eiki Takimoto
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 119:408-20. 2009
    ..Thus, RGS2 is required for early myocardial compensation to pressure overload and mediates the initial antihypertrophic and cardioprotective effects of PDE5 inhibitors...
  18. pmc The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort
    Alyson Kelley-Hedgepeth
    aMCRI Center for Translational Genomics, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, USA
    J Hypertens 27:55-60. 2009
    ..We and others have reported that E65K carriers have reduced blood pressure...
  19. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  20. pmc Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha
    Qing Lu
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 101:17126-31. 2004
    ..Furthermore, by demonstrating independent regulation of nongenomic vs. genomic ER-dependent signaling, these findings provide conceptual support for the potential development of "pathway-specific" selective ER modulators...
  21. ncbi request reprint Cyclic GMP-dependent protein kinase Ialpha inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells
    Eva N Christensen
    Molecular Cardiology Research Institute, Tufts New England Medical Center and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 281:8409-16. 2006
    ..These results support that PKGIalpha is the principal cGMP-dependent protein kinase isoform mediating inhibition of VSMC activation by the nitric oxide/cyclic GMP pathway...
  22. ncbi request reprint Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha
    Serban P Georgescu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Endocrinol 19:2491-501. 2005
    ..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells...
  23. pmc Rapid progress for non-nuclear estrogen receptor signaling
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    J Clin Invest 120:2277-9. 2010
    ....
  24. ncbi request reprint 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling
    Richard D Patten
    Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Boston MA 02111, USA
    Circ Res 95:692-9. 2004
    ....
  25. doi request reprint Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure
    Navin K Kapur
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington St, Box 80, Boston, MA 02111, USA
    Circulation 125:2728-38. 2012
    ..Membrane-associated endoglin is a coreceptor for TGFβ1 signaling and has been studied in vascular remodeling and preeclampsia. We hypothesized that reduced endoglin expression may limit cardiac fibrosis in heart failure...
  26. ncbi request reprint Genomic and nongenomic effects of estrogen in the vasculature
    Michael E Mendelsohn
    Tufts University School of Medicine, Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 90:3F-6F. 2002
    ..This results in nitric oxide-mediated increases in cyclic guanosine monophosphate in vascular smooth muscle cells, which mediate vasodilatation. This article briefly reviews recent progress in this field of vascular biology...
  27. pmc High blood pressure arising from a defect in vascular function
    Simon K Michael
    Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 105:6702-7. 2008
    ....
  28. ncbi request reprint Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex
    Satoru Takahashi
    Department of Medicine and Division of Cardiology, Molecular Cardiology Research Institute New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 278:30821-7. 2003
    ..These results demonstrate that HSP90 and Akt synergistically activate eNOS and suggest that this synergy contributes to Ca2+-independent eNOS activation in response to insulin...
  29. ncbi request reprint Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells
    Iris Z Jaffe
    Molecular Cardiology Research Institute, Department of Medicine, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Mass 02111, USA
    Circ Res 96:643-50. 2005
    ....
  30. ncbi request reprint Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells
    Yuepeng Wang
    Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:24420-6. 2004
    ..Based on the known functions of FHOD1, the data are consistent with a role for FHOD1 in cyclic GMP-dependent inhibition of VSMC stress fiber formation and/or migration...
  31. ncbi request reprint Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    Yan Zhu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Science 295:505-8. 2002
    ..Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure...
  32. pmc Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
    Amy McCurley
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Nat Med 18:1429-33. 2012
    ..This study identifies a new role for vascular MR in blood pressure control and in vascular aging and supports the emerging hypothesis that vascular tone contributes directly to systemic blood pressure...
  33. ncbi request reprint Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase
    Akira Endo
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachussetts, USA
    J Biol Chem 279:42055-61. 2004
    ..These data identify hZIPK as the unique SMPP-1-associated kinase expressed in human vesicular smooth muscle and support a role for Rho in promoting the hZIPK-MBS interaction...
  34. pmc Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells
    Maria Claudia Montefusco
    Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    BMC Genet 11:22. 2010
    ..ROCK1 and the partial gene copy, which the gene databases also currently call ROCK1, include non-unique single nucleotide polymorphisms (SNPs)...
  35. doi request reprint Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion
    Navin K Kapur
    Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:443-50. 2011
    ..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO...
  36. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  37. pmc Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure
    Navin K Kapur
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 106:1770-6. 2010
    ..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures...
  38. ncbi request reprint A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression
    Jeffrey T Kuvin
    Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Mass, USA
    Am Heart J 144:165-72. 2002
    ..The purpose of this study was to examine the effect of increased HDL levels on endothelium-dependent vasodilation...
  39. ncbi request reprint Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse
    Richard D Patten
    Molecular Cardiology Research Institute, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Clin Sci (Lond) 104:109-18. 2003
    ..These results serve as an important basis for planned investigations to evaluate the anti-remodelling effects of these agents on mice in which genetic manipulations are used to disrupt components of the Ang II signalling system...
  40. pmc In hypertension, the kidney is not always the heart of the matter
    Michael E Mendelsohn
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Clin Invest 115:840-4. 2005
    ....
  41. ncbi request reprint Protective effects of estrogen on the cardiovascular system
    Michael E Mendelsohn
    Tufts University School of Medicine, Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 89:12E-17E; discussion 17E-18E. 2002
    ..Advanced atherosclerosis and certain progestins, however, may attenuate some of the protective effects of estrogen...
  42. ncbi request reprint Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90
    Satoru Takahashi
    Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 278:9339-44. 2003
    ..These studies contribute to our understanding of eNOS activation by HSP90 and provide a basis for in vitro studies of other eNOS-interacting proteins...
  43. pmc Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice
    Mie Higashimori
    Tufts Medical Center, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:50-7. 2011
    ....
  44. ncbi request reprint Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
    K Mary Tang
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Med 9:1506-12. 2003
    ..Our study shows that RGS-2 is required for normal vascular function and blood pressure and is a new drug development target for hypertension...
  45. ncbi request reprint Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury
    Gary Pare
    Molecular Cardiology Research Institute, New England Medical Center, Boston, Massachusetts, USA
    Circ Res 90:1087-92. 2002
    ..These data demonstrate that estrogen receptor-alpha mediates the protective effects of estrogen on the response to vascular injury...
  46. ncbi request reprint Dimerization of cGMP-dependent protein kinase 1alpha and the myosin-binding subunit of myosin phosphatase: role of leucine zipper domains
    Howard K Surks
    Molecular Cardiology Research Institute, Cardiology Division, Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, 750 Washington Street, Box 80, Boston, MA 02111, USA
    Cell Signal 15:937-44. 2003
    ..The contribution of these domains to both homodimerization and their specific interaction with each other suggest that additional regulatory mechanisms involving these domains may exist...
  47. ncbi request reprint Effects of estrogen on cardiac electrophysiology in female mice
    Samir Saba
    Molecular Cardiology Research Institute, New England Cardiac Arrhythmia Center, Tufts University New England Medical Center, Boston, Massachusetts 02111, USA
    J Cardiovasc Electrophysiol 13:276-80. 2002
    ..We examined the effect of hormonal status on the electrophysiologic (EP) properties of the mouse heart in an in vivo, closed chest model...
  48. ncbi request reprint Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium
    Todd S Sherman
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Respir Cell Mol Biol 26:610-6. 2002
    ..These mechanisms may play a role in pulmonary vasodilation in the perinatal period...
  49. ncbi request reprint Evidence-based guidelines for cardiovascular disease prevention in women. American Heart Association scientific statement
    Lori Mosca
    Arterioscler Thromb Vasc Biol 24:e29-50. 2004
  50. ncbi request reprint ERbeta has nongenomic action in caveolae
    Ken L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Endocrinol 16:938-46. 2002
    ..These findings in the ER-eNOS signaling paradigm indicate that endogenous ERbeta has nongenomic action in caveolae...
  51. ncbi request reprint Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study
    Serkalem Demissie
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
    Atherosclerosis 185:210-8. 2006
    ..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women...
  52. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
    ..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)...
  53. ncbi request reprint Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies
    Judith L Turgeon
    Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California Davis, Davis, California 95616, USA
    Endocr Rev 27:575-605. 2006
    ..Only then will we have a better understanding of what hormonal compounds should be used in which populations of women and at what stages of menopausal/postmenopausal life...
  54. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005
    ..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...
  55. ncbi request reprint Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hum Mol Genet 14:2405-13. 2005
    ..454-397 T and c.454-351 A alleles with increased myocardial infarction and ischaemic heart disease, independent of the standard, established cardiovascular risk factors...
  56. ncbi request reprint Estrogen causes dynamic alterations in endothelial estrogen receptor expression
    Christopher E Ihionkhan
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390 9063, USA
    Circ Res 91:814-20. 2002
    ..We postulate that E2-induced changes in ERalpha and ERbeta expression modify the effects of the hormone on vascular endothelium...
  57. ncbi request reprint Estrogen receptor alpha gene variation and the risk of stroke
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Stroke 36:2281-2. 2005
    ..Given that there is a significantly higher risk of myocardial infarction among men with the CC genotype (PP of PvuII) of c.454-397T>C (rs2234693), we asked whether this genotype is associated with a higher risk of stroke...
  58. ncbi request reprint Hormonal regulation of normal vascular tone in males
    Michael E Mendelsohn
    Circ Res 93:1142-5. 2003
  59. ncbi request reprint Association between estrogen receptor alpha gene variation and cardiovascular disease
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    JAMA 290:2263-70. 2003
    ..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk...
  60. ncbi request reprint 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction
    Martin van Eickels
    Medizinsche Poliklinik II, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 41:2084-92. 2003
    ..This study was designed to examine the effects of estrogen replacement on infarct size, ventricular remodeling, and mortality after myocardial infarction (MI) in mice...
  61. ncbi request reprint Viagra: now mending hearts
    Michael E Mendelsohn
    Nat Med 11:115-6. 2005
  62. ncbi request reprint HRT and the young at heart
    Michael E Mendelsohn
    N Engl J Med 356:2639-41. 2007
  63. ncbi request reprint Summary of the American Heart Association's evidence-based guidelines for cardiovascular disease prevention in women
    Lori Mosca
    Arterioscler Thromb Vasc Biol 24:394-6. 2004
  64. ncbi request reprint Evidence-based guidelines for cardiovascular disease prevention in women
    Lori Mosca
    J Am Coll Cardiol 43:900-21. 2004
  65. ncbi request reprint Evidence-based guidelines for cardiovascular disease prevention in women
    Lori Mosca
    Circulation 109:672-93. 2004
  66. ncbi request reprint Introduction: the role of hormone replacement therapy in prevention and treatment of cardiovascular disease in postmenopausal women
    Daniel R Mishell
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Cardiol 89:1E-4E. 2002

Research Grants3

  1. Cellular Fluorescence-Contractility Imaging System
    Michael Mendelsohn; Fiscal Year: 2005
    ..Acquisition of this system will facilitate the extensive and complementary studies of cardiovascular signal transduction within our institution. ..
  2. Molecular Biology of the Vasculature
    Michael Mendelsohn; Fiscal Year: 2005
    ..abstract_text> ..
  3. TRAINING PROGRAM IN CARDIOVASCULAR RESEARCH
    Michael Mendelsohn; Fiscal Year: 2007
    ..This Training Program in Cardiovascular Research is exemplary of the approach that the NHLBI seeks to develop to train the next generation of cardiovascular scientists. (End of Abstract) ..