Research Topics
Genomes and Genes
| Michael E MendelsohnSummaryAffiliation: Tufts-New England Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular and cellular basis of cardiovascular gender differencesMichael E Mendelsohn
Molecular Cardiology Research Institute, Department of Medicine, and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, MA 02111, USA
Science 308:1583-7. 2005....- Rapid recruitment of temporally distinct vascular gene sets by estrogenKatrin K Schnoes
Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Box 080, Boston, Massachusetts 02111, USA
Mol Endocrinol 22:2544-56. 2008..These data define the temporal recruitment of specific vascular genes by estrogen and enable further analysis of the mechanisms by which estrogen directly regulates vascular function... - Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha geneInga Peter
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
Hypertension 49:1000-6. 2007..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure... - 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overloadRichard D Patten
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
J Card Fail 14:245-53. 2008..However, E2 decreases hypertrophy in pressure overload models. We hypothesized that the effect of estrogen on cardiac hypertrophy was dependent on the type of hypertrophic stimulus... - Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levelsInga Peter
Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
J Clin Endocrinol Metab 93:2779-85. 2008..To explore potential mechanisms by which these gene variants may contribute to cardiovascular disease, we tested the hypothesis that the polymorphisms were associated with endogenous steroid hormone levels... - Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathwaysBrenna G Newfell
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 31:1871-80. 2011..Here we define the early Aldo-regulated vascular transcriptome and investigate the mechanisms of gene regulation by Aldo in the vasculature that may contribute to vascular disease... - Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesionMassimiliano Caprio
Department of Medicine Division of Cardiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
Circ Res 102:1359-67. 2008..These studies describe a novel mechanism by which aldosterone may influence ischemic cardiovascular events and support a new explanation for the decrease in ischemic events in patients treated with aldosterone antagonists... - Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptorPaul Bridgman
Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, MA 02111, USA
Am J Physiol Heart Circ Physiol 289:H586-92. 2005..Further work is necessary to explore the potential mechanisms underlying these gender-based differences... - Placental growth factor mediates aldosterone-dependent vascular injury in miceIris Z Jaffe
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
J Clin Invest 120:3891-900. 2010.... - Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen speciesRaegan O'Lone
Department of Biology, Boston University, Boston, Massachusetts 02215, USA
Mol Endocrinol 21:1281-96. 2007..Overall, these findings provide a foundation for understanding the molecular basis for estrogen effects on vasculature gene expression... - Renal actions of RGS2 control blood pressureSusan B Gurley
Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
J Am Soc Nephrol 21:1847-51. 2010..These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension... - Mineralocorticoid receptor activation promotes vascular cell calcificationIris Z Jaffe
Tufts University School of Medicine, New England Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 80, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 27:799-805. 2007..This study examines the effects of MR activation by aldosterone on the process of in vitro vascular calcification... - Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valveEric C Wooten
MCRI Center for Translational Genomics, Molecular Cardiology Research Institute, Boston, Massachusetts, United States of America
PLoS ONE 5:e8830. 2010..Further, these studies demonstrate that leveraging existing expression and genomic data in the context of GWAS studies can identify biologically relevant genes and pathways associated with a congenital heart defect... - Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphataseAlok K Sharma
Divison of Molecular and Vascular Medicine, Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 283:32860-9. 2008..Taken together these data support a role for the LZ domain of PKG-Ialpha and the CC domain of MBS in this requisite contractile complex... - Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in miceEiki Takimoto
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 119:408-20. 2009..Thus, RGS2 is required for early myocardial compensation to pressure overload and mediates the initial antihypertrophic and cardioprotective effects of PDE5 inhibitors... - The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring CohortAlyson Kelley-Hedgepeth
aMCRI Center for Translational Genomics, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, USA
J Hypertens 27:55-60. 2009..We and others have reported that E65K carriers have reduced blood pressure... - Cyclic GMP-dependent protein kinase Ialpha inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cellsEva N Christensen
Molecular Cardiology Research Institute, Tufts-New England Medical Center and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 281:8409-16. 2006..These results support that PKGIalpha is the principal cGMP-dependent protein kinase isoform mediating inhibition of VSMC activation by the nitric oxide/cyclic GMP pathway... - Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in womenInga Peter
Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Hypertens 18:1388-95. 2005..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure... - 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signalingRichard D Patten
Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Boston MA 02111, USA
Circ Res 95:692-9. 2004.... - Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alphaSerban P Georgescu
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Mol Endocrinol 19:2491-501. 2005..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells... - Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alphaQing Lu
Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 101:17126-31. 2004..Furthermore, by demonstrating independent regulation of nongenomic vs. genomic ER-dependent signaling, these findings provide conceptual support for the potential development of "pathway-specific" selective ER modulators... - Rapid progress for non-nuclear estrogen receptor signalingMichael E Mendelsohn
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
J Clin Invest 120:2277-9. 2010.... - Genomic and nongenomic effects of estrogen in the vasculatureMichael E Mendelsohn
Tufts University School of Medicine, Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Cardiol 90:3F-6F. 2002..This results in nitric oxide-mediated increases in cyclic guanosine monophosphate in vascular smooth muscle cells, which mediate vasodilatation. This article briefly reviews recent progress in this field of vascular biology... - High blood pressure arising from a defect in vascular functionSimon K Michael
Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 105:6702-7. 2008.... - Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cellsIris Z Jaffe
Molecular Cardiology Research Institute, Department of Medicine, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Mass 02111, USA
Circ Res 96:643-50. 2005.... - Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complexSatoru Takahashi
Department of Medicine and Division of Cardiology, Molecular Cardiology Research Institute New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 278:30821-7. 2003..These results demonstrate that HSP90 and Akt synergistically activate eNOS and suggest that this synergy contributes to Ca2+-independent eNOS activation in response to insulin... - Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cellsYuepeng Wang
Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 279:24420-6. 2004..Based on the known functions of FHOD1, the data are consistent with a role for FHOD1 in cyclic GMP-dependent inhibition of VSMC stress fiber formation and/or migration... - Abnormal vascular function and hypertension in mice deficient in estrogen receptor betaYan Zhu
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
Science 295:505-8. 2002..Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure... - Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinaseAkira Endo
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachussetts, USA
J Biol Chem 279:42055-61. 2004..These data identify hZIPK as the unique SMPP-1-associated kinase expressed in human vesicular smooth muscle and support a role for Rho in promoting the hZIPK-MBS interaction... - Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusionNavin K Kapur
Molecular Cardiology Research Institute, Division of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 31:443-50. 2011..Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO... - Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cellsMaria Claudia Montefusco
Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
BMC Genet 11:22. 2010..ROCK1 and the partial gene copy, which the gene databases also currently call ROCK1, include non-unique single nucleotide polymorphisms (SNPs)... - Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart StudyInga Peter
Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
J Hypertens 23:2193-200. 2005..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women... - Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failureNavin K Kapur
Molecular Cardiology Research Institute, Tufts Medical Center, 800 Washington St, Box 80, Boston, MA 02111, USA
Circulation 125:2728-38. 2012..Membrane-associated endoglin is a coreceptor for TGF?1 signaling and has been studied in vascular remodeling and preeclampsia. We hypothesized that reduced endoglin expression may limit cardiac fibrosis in heart failure... - A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expressionJeffrey T Kuvin
Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, Boston, Mass, USA
Am Heart J 144:165-72. 2002.... - Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failureNavin K Kapur
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiol 106:1770-6. 2010..sEng levels also decreased in association with a reduced cardiac filling pressure after diuresis. These findings have identified circulating sEng as a sensitive measure of elevated left heart filling pressures... - Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouseRichard D Patten
Molecular Cardiology Research Institute, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
Clin Sci (Lond) 104:109-18. 2003..These results serve as an important basis for planned investigations to evaluate the anti-remodelling effects of these agents on mice in which genetic manipulations are used to disrupt components of the Ang II signalling system... - In hypertension, the kidney is not always the heart of the matterMichael E Mendelsohn
Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts, USA
J Clin Invest 115:840-4. 2005.... - Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90Satoru Takahashi
Molecular Cardiology Research Institute, Department of Medicine and Division of Cardiology, New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 278:9339-44. 2003..These studies contribute to our understanding of eNOS activation by HSP90 and provide a basis for in vitro studies of other eNOS-interacting proteins... - Protective effects of estrogen on the cardiovascular systemMichael E Mendelsohn
Tufts University School of Medicine, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
Am J Cardiol 89:12E-17E; discussion 17E-18E. 2002..Advanced atherosclerosis and certain progestins, however, may attenuate some of the protective effects of estrogen... - Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressureK Mary Tang
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Med 9:1506-12. 2003..Our study shows that RGS-2 is required for normal vascular function and blood pressure and is a new drug development target for hypertension... - Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient miceMie Higashimori
Tufts Medical Center, Boston, MA 02111, USA
Arterioscler Thromb Vasc Biol 31:50-7. 2011.... - Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injuryGary Pare
Molecular Cardiology Research Institute, New England Medical Center, Boston, Massachusetts, USA
Circ Res 90:1087-92. 2002..These data demonstrate that estrogen receptor-alpha mediates the protective effects of estrogen on the response to vascular injury... - Dimerization of cGMP-dependent protein kinase 1alpha and the myosin-binding subunit of myosin phosphatase: role of leucine zipper domainsHoward K Surks
Molecular Cardiology Research Institute, Cardiology Division, Department of Medicine, New England Medical Center Hospitals, Inc, Tufts University School of Medicine, 750 Washington Street, Box 80, Boston, MA 02111, USA
Cell Signal 15:937-44. 2003..The contribution of these domains to both homodimerization and their specific interaction with each other suggest that additional regulatory mechanisms involving these domains may exist... - Effects of estrogen on cardiac electrophysiology in female miceSamir Saba
Molecular Cardiology Research Institute, New England Cardiac Arrhythmia Center, Tufts University-New England Medical Center, Boston, Massachusetts 02111, USA
J Cardiovasc Electrophysiol 13:276-80. 2002..Taken together, these data suggest that hormonal status affects aspects of cardiac EP function. Future application of this mouse model will be helpful in determining the molecular pathways that mediate hormonal differences in cardiac EP... - ERbeta has nongenomic action in caveolaeKen L Chambliss
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Endocrinol 16:938-46. 2002..These findings in the ER-eNOS signaling paradigm indicate that endogenous ERbeta has nongenomic action in caveolae... - Evidence-based guidelines for cardiovascular disease prevention in women. American Heart Association scientific statementLori Mosca
Arterioscler Thromb Vasc Biol 24:e29-50. 2004 - Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endotheliumTodd S Sherman
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9063, USA
Am J Respir Cell Mol Biol 26:610-6. 2002..These mechanisms may play a role in pulmonary vasodilation in the perinatal period... - Association between estrogen receptor alpha gene variation and cardiovascular diseaseAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
JAMA 290:2263-70. 2003..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk... - Estrogen causes dynamic alterations in endothelial estrogen receptor expressionChristopher E Ihionkhan
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75390-9063, USA
Circ Res 91:814-20. 2002..We postulate that E2-induced changes in ERalpha and ERbeta expression modify the effects of the hormone on vascular endothelium... - Hormonal regulation of normal vascular tone in malesMichael E Mendelsohn
Circ Res 93:1142-5. 2003 - Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart StudySerkalem Demissie
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
Atherosclerosis 185:210-8. 2006..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women... - Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein levelAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Hum Mol Genet 14:2405-13. 2005..454-397 T and c.454-351 A alleles with increased myocardial infarction and ischaemic heart disease, independent of the standard, established cardiovascular risk factors... - Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart StudyCaroline S Fox
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
J Clin Endocrinol Metab 90:6257-62. 2005..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power... - Estrogen receptor alpha gene variation and the risk of strokeAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Stroke 36:2281-2. 2005..Given that there is a significantly higher risk of myocardial infarction among men with the CC genotype (PP of PvuII) of c.454-397T>C (rs2234693), we asked whether this genotype is associated with a higher risk of stroke... - Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohortsAmanda M Shearman
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Circ Res 98:590-2. 2006..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)... - Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studiesJudith L Turgeon
Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California Davis, Davis, California 95616, USA
Endocr Rev 27:575-605. 2006..Only then will we have a better understanding of what hormonal compounds should be used in which populations of women and at what stages of menopausal/postmenopausal life... - 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarctionMartin van Eickels
Medizinsche Poliklinik II, University of Bonn, Bonn, Germany
J Am Coll Cardiol 41:2084-92. 2003..However, estrogen increased post-MI ventricular remodeling and mortality. Further studies will be necessary to elucidate the mechanisms underlying the complex effects of estrogen observed in the present study... - Introduction: the role of hormone replacement therapy in prevention and treatment of cardiovascular disease in postmenopausal womenDaniel R Mishell
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Am J Cardiol 89:1E-4E. 2002 - Viagra: now mending heartsMichael E Mendelsohn
Nat Med 11:115-6. 2005 - HRT and the young at heartMichael E Mendelsohn
N Engl J Med 356:2639-41. 2007 - Evidence-based guidelines for cardiovascular disease prevention in womenLori Mosca
Circulation 109:672-93. 2004 - Evidence-based guidelines for cardiovascular disease prevention in womenLori Mosca
J Am Coll Cardiol 43:900-21. 2004 - Summary of the American Heart Association's evidence-based guidelines for cardiovascular disease prevention in womenLori Mosca
Arterioscler Thromb Vasc Biol 24:394-6. 2004
Research Grants
- Cellular Fluorescence-Contractility Imaging SystemMichael Mendelsohn; Fiscal Year: 2005..Acquisition of this system will facilitate the extensive and complementary studies of cardiovascular signal transduction within our institution. ..
- Molecular Biology of the VasculatureMichael Mendelsohn; Fiscal Year: 2005..abstract_text> ..
- TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHMichael Mendelsohn; Fiscal Year: 2007..This Training Program in Cardiovascular Research is exemplary of the approach that the NHLBI seeks to develop to train the next generation of cardiovascular scientists. (End of Abstract) ..