Research Topics
Species | David M KentSummaryAffiliation: Tufts-New England Medical Center Country: USA Publications
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Publications
Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysisRodney A Hayward
Department of Veterans Affairs, VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
BMC Med Res Methodol 6:18. 2006..conventional subgroup analysis...
The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic strokeDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Stroke 37:2957-62. 2006..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke...- Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?David M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Stroke 37:2963-9. 2006..We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours... - "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic strokeDavid M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Stroke 36:1695-9. 2005..We explored this hypothesis using a combined database including 4 major clinical trials of intravenous (IV) thrombolytic therapy... - Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trialsDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
Stroke 36:62-5. 2005..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke... - Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarctionDavid M Kent
Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
J Clin Epidemiol 57:843-52. 2004..We sought to explore the patient-specific cost-effectiveness in a community-based sample for a therapy for which the average cost-effectiveness in a clinical trial has been well-described... - Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney diseaseDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 63, Boston, MA 02111, USA
J Am Soc Nephrol 18:1959-65. 2007..Patients with proteinuria <500 mg/d do not seem to benefit, even when at relatively high risk for progression... - Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarctionDavid M Kent
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Am J Cardiol 99:1384-8. 2007..Previous meta-regressions appear to have underestimated the PPCI-related delay that would nullify the incremental benefits of PPCI... 
A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarctionDavid M Kent
Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 101:790-5. 2008..Incorporated into electrocardiogram, it may assist targeting PCI to those who benefit most and identifying patients before hospitalization for whom a receiving hospital should prepare for PCI...- In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?David M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
Stroke 35:1141-6. 2004..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)... - Limitations of applying summary results of clinical trials to individual patients: the need for risk stratificationDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
JAMA 298:1209-12. 2007 
Are "treatment" bare metal stents superior to "control" bare metal stents? A meta-analytic approachDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
Am Heart J 155:624-9, 629.e1-2. 2008....- New and dis-improved: on the evaluation and use of less effective, less expensive medical interventionsDavid M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Med Decis Making 24:281-6. 2004.... - Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?David M Kent
Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
Stroke 34:464-7. 2003.... - Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategiesThomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Circ Cardiovasc Qual Outcomes 3:506-13. 2010..This study evaluated the comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies to increase the use of PCI against standard emergency transport and care... - An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinaseDavid M Kent
Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Med 113:104-11. 2002..3% 30-day mortality, compared with a mortality of 7.3% among those treated with streptokinase, despite a greater risk of intracranial hemorrhage with tPA. However, in part because of its higher cost, tPA has not been adopted universally... - Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?Thomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
Circ Cardiovasc Qual Outcomes 2:9-15. 2009..For many patients, first contact with the health system is through emergency medical services (EMS). We set out to identify patient-level and neighborhood-level factors that were associated with elapsed time in EMS... - A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarctionThomas W Concannon
Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Am J Cardiol 101:69-74. 2008..In conclusion, the selection of high-benefit patients for transport or transfer to PCI-capable hospitals can reduce mortality while minimizing major shifts in hospital patient volumes... - Testing therapies less effective than the best current standard: ethical beliefs in an international sample of researchersDavid M Kent
Tufts-New England Medical Center, Boston, USA
Am J Bioeth 3:W11. 2003..To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard... - Patent foramen ovale closure and medical treatments for secondary stroke prevention: a systematic review of observational and randomized evidenceGeorgios D Kitsios
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
Stroke 43:422-31. 2012..We synthesized the available evidence on secondary stroke prevention in patients with patent foramen ovale and cryptogenic stroke... - Is primary angioplasty for some as good as primary angioplasty for all?David M Kent
Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
J Gen Intern Med 17:887-94. 2002..To investigate whether proper patient selection might allow most of the benefits of population-wide primary coronary angioplasty to be captured in a subgroup of high-risk patients... - The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modificationDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
Neurology 71:1080-3. 2008..This nullification of the usual gender effect among rtPA-treated patients has not been confirmed... - Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approachDaniel G Kramer
Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 56:392-406. 2010..The purpose of this study was to quantitatively assess the relationship between therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in patients with left ventricular dysfunction (LVD)... - Risk of arrhythmic and nonarrhythmic death in patients with heart failure and chronic kidney diseaseAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Am Heart J 161:204-209.e1. 2011.... - Random treatment assignment using mathematical equipoise for comparative effectiveness trialsHarry P Selker
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA
Clin Transl Sci 4:10-6. 2011..This approach may have utility for comparative effectiveness trials and for application of trial results to clinical practice... - Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fractionBenjamin S Wessler
Division of Cardiology, Cardiovascular Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Circ Heart Fail 4:578-88. 2011.... - Clinical trials in sub-Saharan Africa and established standards of care: a systematic review of HIV, tuberculosis, and malaria trialsDavid M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Mass
JAMA 292:237-42. 2004..In determining clinical standards for trials in sub-Saharan Africa, researchers and ethics committees appear to take the local level of care into account... - The Stroke Practice Improvement Network: a quasiexperimental trial of a multifaceted intervention to improve qualityJudith A Hinchey
Institute of Clinical Care Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02135, USA
J Stroke Cerebrovasc Dis 19:130-7. 2010.... - Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposalDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Trials 11:85. 2010..A standardized and transparent approach to HTE assessment and reporting could substantially improve clinical trial utility and interpretability... - The Risk of Paradoxical Embolism (RoPE) Study: developing risk models for application to ongoing randomized trials of percutaneous patent foramen ovale closure for cryptogenic strokeDavid M Kent
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
Trials 12:185. 2011..Finally, we will apply this composite index to completed clinical trials (currently on-going) testing endovascular PFO closure against medical therapy, to stratify patients from low-expected-benefit to high-expected-benefit... - Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studiesGeorgios D Kitsios
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
Circ Cardiovasc Genet 4:58-67. 2011..We assessed the extent of phenotypic heterogeneity and quantified its impact in a large literature sample of association studies... - Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eyeCatherine E Milch
Institute for Clinical Research and Health Policy Studies, Center for Cardiovascular Health Services Research, Tufts New England Medical Center, Boston, MA 02111, USA
J Investig Med 54:76-85. 2006..Many studies have shown differences in cardiac care by racial/ethnic groups without accounting for institutional factors at the location of care... - Willingness-to-pay for predictive tests with no immediate treatment implications: a survey of US residentsPeter J Neumann
Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Health Econ 21:238-51. 2012.... - The Surgical Apgar Score in hip and knee arthroplastyThomas H Wuerz
Center for Predictive Medicine Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 35 Kneeland Street, Boston, MA 02111, USA
Clin Orthop Relat Res 469:1119-26. 2011.... - Statins, low-density lipoprotein cholesterol, and risk of cancerAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 52:1141-7. 2008..We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer... - Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysisThomas A Trikalinos
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
Lancet 373:911-8. 2009..We undertook a systematic overview of randomised trials comparing these interventions with each other and with medical therapy in patients with non-acute coronary artery disease... - Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?Alawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Division of Cardiology, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Stroke 40:2349-55. 2009..Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental... - Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysisIssa J Dahabreh
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
Genet Med 12:606-15. 2010..We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans... - Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal RegistryMartin Wagner
Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
Am J Kidney Dis 57:894-902. 2011..No prediction tool is used widely in current clinical practice. We aimed to predict long-term mortality in incident dialysis patients using easily obtainable variables... - Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)Ritesh Dhar
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Heart Rhythm 5:807-13. 2008..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)... - Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: setting the research agendaDavid M Kent
Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Clin Infect Dis 37:S13-24. 2003.... - 25-Hydroxyvitamin D levels and juvenile idiopathic arthritis: Is there an association with disease activity?Christina F Pelajo
Division of Pediatric Rheumatology, Floating Hospital for Children at Tufts Medical Center, 800 Washington St Box 190, Boston, MA, 02111, USA
Rheumatol Int 32:3923-9. 2012..Future larger, long-term studies with new-onset JIA patients are needed to further explore the association between serum 25(OH)D levels and disease activity... - Much cheaper, almost as good: decrementally cost-effective medical innovationAaron L Nelson
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA
Ann Intern Med 151:662-7. 2009..001 to 0.021 quality-adjusted life-years (approximately 8 hours to 1 week). These findings demonstrate the rarity of decrementally cost-effective innovations in the medical literature... - Against pragmatism: on efficacy, effectiveness and the real worldDavid M Kent
Institute for Clinical Research and Health Policy Studies and Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, USA
Trials 10:48. 2009..Simplistic interpretation of pragmatic trials runs the risk of driving harmful policies... - Is patent foramen ovale a modifiable risk factor for stroke recurrence?David M Kent
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Box 63, 800 Washington St, Boston, MA 02111, USA
Stroke 41:S26-30. 2010.... - Rethinking trial strategies for stroke and patent foramen ovaleDavid E Thaler
Department of Neurology, Boston, Massachusetts, USA
Curr Opin Neurol 23:73-8. 2010..This has generally been attributed to paradoxical embolism. Regardless of mechanism, nearly 30,000 young patients each year have a cryptogenic stroke and PFO. Optimal management is uncertain... - The empirical basis for determinations of medical futilityEzra Gabbay
Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
J Gen Intern Med 25:1083-9. 2010..Our objective was to systematically review the criteria for futility and the strength of empirical evidence across clinical studies that purport to support or refute claims of futility... - Implantable or external defibrillators for individuals at increased risk of cardiac arrest: where cost-effectiveness hits fiscal realityPeter Cram
University of Iowa College of Medicine, Iowa City, IA, USA
Value Health 9:292-302. 2006..We used decision analysis to evaluate the clinical and economic trade-offs of AEDs, ICDs, and emergency medical services equipped with defibrillators (EMS-D) for reducing cardiac arrest mortality... - Benchmarks and determinants of adherence to stroke performance measuresJudith A Hinchey
Stroke 39:1619-20. 2008..CONCLUSIONS: High levels of adherence are achievable for several acute stroke PM. Use of standing orders is associated with adherence to PM requiring immediate action on admission... - Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS IIImanuel Dzialowski
Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
Stroke 37:973-8. 2006..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset... - Gender differences in tPA-related arterial recanalizationDavid M Kent
Stroke 36:2529; author reply 2529-30. 2005 - Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 studyMichael D Hill
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Stroke 37:2322-5. 2006..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set... - Stroke prevention--insights from incoherenceDavid M Kent
N Engl J Med 359:1287-9. 2008 - Primary angioplasty or thrombolysis for acute myocardial infarction?David M Kent
Lancet 361:78; author reply 78-9. 2003 - Reporting clinical trial results to inform providers, payers, and consumersRodney A Hayward
Department of Veterans Affairs VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, University of Michigan, USA
Health Aff (Millwood) 24:1571-81. 2005.... - Improved perioperative outcomes from carotid endarterectomy: yet another statin side effect?David M Kent
Stroke 36:2058-9. 2005 - Differences in response to reperfusion therapies in acute stroke between men and women: mediated by sex or by chance?David M Kent
Stroke 37:2878-9. 2006 - Predicting nursing home admission: estimates from a 7-year follow-up of a nationally representative sample of older AmericansJane Banaszak-Holl
Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor, 48109 2029, USA
Alzheimer Dis Assoc Disord 18:83-9. 2004..Interventions for individuals with dementia should impact the behavioral aspects of the condition and slow disease progression in addition to improving physical functioning...
Research Grants
- Extending Safe and Effective Thrombolysis for StrokeDavid Kent; Fiscal Year: 2005..abstract_text> ..
- Assisted Patient-Selection for Thrombolytics in StrokeDavid Kent; Fiscal Year: 2007....