David M Kent

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. pmc Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis
    Rodney A Hayward
    Department of Veterans Affairs, VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    BMC Med Res Methodol 6:18. 2006
  2. ncbi request reprint The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2957-62. 2006
  3. ncbi request reprint Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2963-9. 2006
  4. ncbi request reprint Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 63, Boston, MA 02111, USA
    J Am Soc Nephrol 18:1959-65. 2007
  5. ncbi request reprint Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 99:1384-8. 2007
  6. ncbi request reprint "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Stroke 36:1695-9. 2005
  7. ncbi request reprint Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
    Stroke 36:62-5. 2005
  8. ncbi request reprint Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarction
    David M Kent
    Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
    J Clin Epidemiol 57:843-52. 2004
  9. ncbi request reprint Limitations of applying summary results of clinical trials to individual patients: the need for risk stratification
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    JAMA 298:1209-12. 2007
  10. doi request reprint A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:790-5. 2008

Research Grants

Detail Information

Publications67

  1. pmc Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis
    Rodney A Hayward
    Department of Veterans Affairs, VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    BMC Med Res Methodol 6:18. 2006
    ..conventional subgroup analysis...
  2. ncbi request reprint The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2957-62. 2006
    ..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke...
  3. ncbi request reprint Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2963-9. 2006
    ..We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours...
  4. ncbi request reprint Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 63, Boston, MA 02111, USA
    J Am Soc Nephrol 18:1959-65. 2007
    ..Patients with proteinuria <500 mg/d do not seem to benefit, even when at relatively high risk for progression...
  5. ncbi request reprint Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 99:1384-8. 2007
    ..Previous meta-regressions appear to have underestimated the PPCI-related delay that would nullify the incremental benefits of PPCI...
  6. ncbi request reprint "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Stroke 36:1695-9. 2005
    ..We explored this hypothesis using a combined database including 4 major clinical trials of intravenous (IV) thrombolytic therapy...
  7. ncbi request reprint Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
    Stroke 36:62-5. 2005
    ..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke...
  8. ncbi request reprint Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarction
    David M Kent
    Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
    J Clin Epidemiol 57:843-52. 2004
    ..We sought to explore the patient-specific cost-effectiveness in a community-based sample for a therapy for which the average cost-effectiveness in a clinical trial has been well-described...
  9. ncbi request reprint Limitations of applying summary results of clinical trials to individual patients: the need for risk stratification
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    JAMA 298:1209-12. 2007
  10. doi request reprint A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:790-5. 2008
    ..Incorporated into electrocardiogram, it may assist targeting PCI to those who benefit most and identifying patients before hospitalization for whom a receiving hospital should prepare for PCI...
  11. ncbi request reprint New and dis-improved: on the evaluation and use of less effective, less expensive medical interventions
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Med Decis Making 24:281-6. 2004
    ....
  12. ncbi request reprint In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
    Stroke 35:1141-6. 2004
    ..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)...
  13. pmc Are "treatment" bare metal stents superior to "control" bare metal stents? A meta-analytic approach
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Am Heart J 155:624-9, 629.e1-2. 2008
    ....
  14. ncbi request reprint Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?
    David M Kent
    Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
    Stroke 34:464-7. 2003
    ....
  15. pmc Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 3:506-13. 2010
    ..This study evaluated the comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies to increase the use of PCI against standard emergency transport and care...
  16. pmc Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database
    Benjamin S Wessler
    Division of Cardiology, Tufts Medical Center, Boston, MA
    Circ Cardiovasc Imaging 7:125-31. 2014
    ..The association of these transesophageal echocardiography features with other markers of pathogenicity has not been examined...
  17. ncbi request reprint An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase
    David M Kent
    Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Med 113:104-11. 2002
    ..3% 30-day mortality, compared with a mortality of 7.3% among those treated with streptokinase, despite a greater risk of intracranial hemorrhage with tPA. However, in part because of its higher cost, tPA has not been adopted universally...
  18. pmc Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Circ Cardiovasc Qual Outcomes 2:9-15. 2009
    ..For many patients, first contact with the health system is through emergency medical services (EMS). We set out to identify patient-level and neighborhood-level factors that were associated with elapsed time in EMS...
  19. ncbi request reprint A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarction
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:69-74. 2008
    ..In conclusion, the selection of high-benefit patients for transport or transfer to PCI-capable hospitals can reduce mortality while minimizing major shifts in hospital patient volumes...
  20. pmc Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale
    David E Thaler
    Department of Neurology, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 44:675-80. 2013
    ..We examined whether specific radiological findings are associated with PFO among subjects with cryptogenic stroke and known PFO status...
  21. pmc An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Neurology 81:619-25. 2013
    ..We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO...
  22. doi request reprint Evidence of systematic duplication by new percutaneous coronary intervention programs
    Thomas W Concannon
    THE RAND CORPORATION, Boston, MA 02116, USA
    Circ Cardiovasc Qual Outcomes 6:400-8. 2013
    ..Evidence suggests that recent and projected future investments in percutaneous coronary intervention (PCI) programs at US hospitals fail to increase access to timely reperfusion for patients with ST-segment elevation myocardial infarction...
  23. pmc The risk of paradoxical embolism (RoPE) study: initial description of the completed database
    David E Thaler
    Department of Neurology, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Int J Stroke 8:612-9. 2013
    ..However, individual databases generally have too few stroke recurrences to support risk modeling. Prior studies of this population have been limited by low statistical power for examining factors related to recurrence...
  24. ncbi request reprint Testing therapies less effective than the best current standard: ethical beliefs in an international sample of researchers
    David M Kent
    Tufts New England Medical Center, Boston, USA
    Am J Bioeth 3:W11. 2003
    ..To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard...
  25. pmc Patent foramen ovale closure and medical treatments for secondary stroke prevention: a systematic review of observational and randomized evidence
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 43:422-31. 2012
    ..We synthesized the available evidence on secondary stroke prevention in patients with patent foramen ovale and cryptogenic stroke...
  26. ncbi request reprint The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Neurology 71:1080-3. 2008
    ..This nullification of the usual gender effect among rtPA-treated patients has not been confirmed...
  27. ncbi request reprint Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach
    Daniel G Kramer
    Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 56:392-406. 2010
    ..The purpose of this study was to quantitatively assess the relationship between therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in patients with left ventricular dysfunction (LVD)...
  28. doi request reprint Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction
    Benjamin S Wessler
    Division of Cardiology, Cardiovascular Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Circ Heart Fail 4:578-88. 2011
    ....
  29. doi request reprint Risk of arrhythmic and nonarrhythmic death in patients with heart failure and chronic kidney disease
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Am Heart J 161:204-209.e1. 2011
    ....
  30. pmc Random treatment assignment using mathematical equipoise for comparative effectiveness trials
    Harry P Selker
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts, USA
    Clin Transl Sci 4:10-6. 2011
    ..This approach may have utility for comparative effectiveness trials and for application of trial results to clinical practice...
  31. pmc Is primary angioplasty for some as good as primary angioplasty for all?
    David M Kent
    Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
    J Gen Intern Med 17:887-94. 2002
    ..To investigate whether proper patient selection might allow most of the benefits of population-wide primary coronary angioplasty to be captured in a subgroup of high-risk patients...
  32. ncbi request reprint Clinical trials in sub-Saharan Africa and established standards of care: a systematic review of HIV, tuberculosis, and malaria trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass
    JAMA 292:237-42. 2004
    ..The minimum standard of care required for participants in clinical trials conducted in resource-poor settings is a matter of controversy; international documents offer contradictory guidance...
  33. pmc The Stroke Practice Improvement Network: a quasiexperimental trial of a multifaceted intervention to improve quality
    Judith A Hinchey
    Institute of Clinical Care Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02135, USA
    J Stroke Cerebrovasc Dis 19:130-7. 2010
    ....
  34. pmc Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Trials 11:85. 2010
    ..A standardized and transparent approach to HTE assessment and reporting could substantially improve clinical trial utility and interpretability...
  35. pmc Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
    Circ Cardiovasc Genet 4:58-67. 2011
    ..We assessed the extent of phenotypic heterogeneity and quantified its impact in a large literature sample of association studies...
  36. ncbi request reprint Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eye
    Catherine E Milch
    Institute for Clinical Research and Health Policy Studies, Center for Cardiovascular Health Services Research, Tufts New England Medical Center, Boston, MA 02111, USA
    J Investig Med 54:76-85. 2006
    ..Many studies have shown differences in cardiac care by racial/ethnic groups without accounting for institutional factors at the location of care...
  37. pmc The Risk of Paradoxical Embolism (RoPE) Study: developing risk models for application to ongoing randomized trials of percutaneous patent foramen ovale closure for cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
    Trials 12:185. 2011
    ..These probabilities are likely to be important determinants of the benefits of PFO closure in CS...
  38. ncbi request reprint Willingness-to-pay for predictive tests with no immediate treatment implications: a survey of US residents
    Peter J Neumann
    Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Health Econ 21:238-51. 2012
    ....
  39. ncbi request reprint A nomogram to predict major complications after hip and knee arthroplasty
    Thomas H Wuerz
    Center for Predictive Medicine Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts Clinical Research Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio
    J Arthroplasty 29:1457-62. 2014
    ..Compared to the SAS, the NRI was 71.5% overall. We developed a clinical prediction tool, the Morbidity and Mortality Acute Predictor for arthroplasty (arthro-MAP) that might be useful for postoperative risk stratification. ..
  40. pmc Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Division of Cardiology, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 40:2349-55. 2009
    ..Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental...
  41. pmc Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
    Issa J Dahabreh
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Genet Med 12:606-15. 2010
    ..We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans...
  42. pmc Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis
    Thomas A Trikalinos
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Lancet 373:911-8. 2009
    ..We undertook a systematic overview of randomised trials comparing these interventions with each other and with medical therapy in patients with non-acute coronary artery disease...
  43. doi request reprint Statins, low-density lipoprotein cholesterol, and risk of cancer
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 52:1141-7. 2008
    ..We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer...
  44. pmc The Surgical Apgar Score in hip and knee arthroplasty
    Thomas H Wuerz
    Center for Predictive Medicine Research, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 35 Kneeland Street, Boston, MA 02111, USA
    Clin Orthop Relat Res 469:1119-26. 2011
    ....
  45. pmc Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy
    Genève M Allison
    Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts
    Clin Infect Dis 58:812-9. 2014
    ..More intensive interventions to prevent OPAT readmissions should be targeted and tested with those at highest risk. ..
  46. doi request reprint Out-of-hospital use of proton pump inhibitors and hypomagnesemia at hospital admission: a nested case-control study
    Ioannis Koulouridis
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA Department of Medicine, Tufts University School of Medicine, Boston, MA
    Am J Kidney Dis 62:730-7. 2013
    ..Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use of PPIs...
  47. doi request reprint 25-hydroxyvitamin D levels and juvenile idiopathic arthritis: is there an association with disease activity?
    Christina F Pelajo
    Division of Pediatric Rheumatology, Floating Hospital for Children at Tufts Medical Center, 800 Washington St Box 190, Boston, MA 02111, USA
    Rheumatol Int 32:3923-9. 2012
    ..Future larger, long-term studies with new-onset JIA patients are needed to further explore the association between serum 25(OH)D levels and disease activity...
  48. pmc Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal Registry
    Martin Wagner
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 57:894-902. 2011
    ..No prediction tool is used widely in current clinical practice. We aimed to predict long-term mortality in incident dialysis patients using easily obtainable variables...
  49. pmc Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Ritesh Dhar
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Heart Rhythm 5:807-13. 2008
    ..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)...
  50. ncbi request reprint Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: setting the research agenda
    David M Kent
    Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 37:S13-24. 2003
    ....
  51. pmc Against pragmatism: on efficacy, effectiveness and the real world
    David M Kent
    Institute for Clinical Research and Health Policy Studies and Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, USA
    Trials 10:48. 2009
    ..Simplistic interpretation of pragmatic trials runs the risk of driving harmful policies...
  52. pmc The empirical basis for determinations of medical futility
    Ezra Gabbay
    Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    J Gen Intern Med 25:1083-9. 2010
    ..Our objective was to systematically review the criteria for futility and the strength of empirical evidence across clinical studies that purport to support or refute claims of futility...
  53. pmc Rethinking trial strategies for stroke and patent foramen ovale
    David E Thaler
    Department of Neurology, Boston, Massachusetts, USA
    Curr Opin Neurol 23:73-8. 2010
    ..This has generally been attributed to paradoxical embolism. Regardless of mechanism, nearly 30,000 young patients each year have a cryptogenic stroke and PFO. Optimal management is uncertain...
  54. ncbi request reprint Much cheaper, almost as good: decrementally cost-effective medical innovation
    Aaron L Nelson
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 151:662-7. 2009
    ..001 to 0.021 quality-adjusted life-years (approximately 8 hours to 1 week). These findings demonstrate the rarity of decrementally cost-effective innovations in the medical literature...
  55. pmc Is patent foramen ovale a modifiable risk factor for stroke recurrence?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Box 63, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:S26-30. 2010
    ....
  56. ncbi request reprint Gender differences in tPA-related arterial recanalization
    David M Kent
    Stroke 36:2529; author reply 2529-30. 2005
  57. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
    ..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset...
  58. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
    ..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
  59. doi request reprint Benchmarks and determinants of adherence to stroke performance measures
    Judith A Hinchey
    Stroke 39:1619-20. 2008
    ..Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence...
  60. ncbi request reprint Implantable or external defibrillators for individuals at increased risk of cardiac arrest: where cost-effectiveness hits fiscal reality
    Peter Cram
    University of Iowa College of Medicine, Iowa City, IA, USA
    Value Health 9:292-302. 2006
    ..We used decision analysis to evaluate the clinical and economic trade-offs of AEDs, ICDs, and emergency medical services equipped with defibrillators (EMS-D) for reducing cardiac arrest mortality...
  61. ncbi request reprint Primary angioplasty or thrombolysis for acute myocardial infarction?
    David M Kent
    Lancet 361:78; author reply 78-9. 2003
  62. ncbi request reprint Predicting nursing home admission: estimates from a 7-year follow-up of a nationally representative sample of older Americans
    Jane Banaszak-Holl
    Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor, 48109 2029, USA
    Alzheimer Dis Assoc Disord 18:83-9. 2004
    ..Interventions for individuals with dementia should impact the behavioral aspects of the condition and slow disease progression in addition to improving physical functioning...
  63. ncbi request reprint Improved perioperative outcomes from carotid endarterectomy: yet another statin side effect?
    David M Kent
    Stroke 36:2058-9. 2005
  64. ncbi request reprint Reporting clinical trial results to inform providers, payers, and consumers
    Rodney A Hayward
    Department of Veterans Affairs VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, University of Michigan, USA
    Health Aff (Millwood) 24:1571-81. 2005
    ....
  65. doi request reprint Stroke prevention--insights from incoherence
    David M Kent
    N Engl J Med 359:1287-9. 2008
  66. ncbi request reprint Differences in response to reperfusion therapies in acute stroke between men and women: mediated by sex or by chance?
    David M Kent
    Stroke 37:2878-9. 2006

Research Grants2

  1. Extending Safe and Effective Thrombolysis for Stroke
    David Kent; Fiscal Year: 2005
    ..abstract_text> ..
  2. Assisted Patient-Selection for Thrombolytics in Stroke
    David Kent; Fiscal Year: 2007
    ..unreadable] [unreadable]..