Research Topics
Genomes and Genes
| Fotini GounariSummaryAffiliation: Tufts-New England Medical Center Country: USA Publications
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Detail Information
Publications
Loss of adenomatous polyposis coli gene function disrupts thymic developmentFotini Gounari
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Nat Immunol 6:800-9. 2005..Thus, loss of APC in immature thymocytes has consequences distinct from those of deregulation of beta-catenin signaling and is essential for T cell differentiation...
CDK6 kinase activity is required for thymocyte developmentMiaofen G Hu
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA
Blood 117:6120-31. 2011..This role of CDK6 as a downstream mediator of Notch identifies CDK6 kinase activity as a potential therapeutic target in human lymphoid malignancies...- Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformationZhuyan Guo
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
Blood 109:5463-72. 2007..Thus, beta-catenin activation may provide a mechanism for the induction of T-cell-acute lymphoblastic leukemia (T-ALL) that does not depend on Notch activation... - c-Myc mediates pre-TCR-induced proliferation but not developmental progressionMarei Dose
Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
Blood 108:2669-77. 2006.... - A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesisMiaofen G Hu
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
Cancer Res 69:810-8. 2009..These results show a critical requirement for CDK6 in Notch/Akt-dependent T-cell development and tumorigenesis and strongly support CDK6 as a specific therapeutic target in human lymphoid malignancies... - A critical role for the cytoplasmic tail of pTalpha in T lymphocyte developmentIannis Aifantis
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
Nat Immunol 3:483-8. 2002..In contrast, the pTalpha juxtamembrane cysteine appeared to be dispensable for pre-TCR function... - TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversityTaras Kreslavsky
Laboratory of Lymphocyte Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Proc Natl Acad Sci U S A 106:12453-8. 2009..Interestingly, expression of this TCR transgene led to the development of spontaneous dermatitis... - Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte developmentChristine Borowski
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
J Exp Med 199:607-15. 2004..We conclude that features intrinsic to the pre-TCR, which are absent in TCRalpha, are essential for its unique function... - Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transitionChangchuin Mao
Molecular Oncology Research Institute, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
J Immunol 178:5443-53. 2007..Akt1 and Akt2 also contribute to the differentiation process by promoting the survival of the DP thymocytes... 
Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signalingDamian Kovalovsky
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
J Immunol 183:3873-84. 2009..These observations are consistent with beta-catenin/Tcf signaling acting as a switch that determines the outcome of thymic selection downstream the alphabetaTCR cascade...- Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1Xiaoyu Li
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 205:2851-61. 2008..As judged by array-based comparative genomic hybridization (array CGH) and spectral karyotype (SKY) analysis, none of the tumors arise because of genomic instability... - Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fateAnnette I Garbe
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 203:1579-90. 2006.... - Thymic selection revisited: how essential is it?Harald von Boehmer
Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
Immunol Rev 191:62-78. 2003..Ectopically expressed organ-specific antigens contribute to thymic self-nonself discrimination, which represents an essential feature for the evolutionary fitness of mammalian species... - Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epitheliaFotini Gounari
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute Harvard Medical School, Boston, Massachusetts, MA 02115, USA
Oncogene 21:4099-107. 2002..Our observations indicate that beta-catenin stabilization is a crucial event for the initiation of PIN-like lesions, but induces squamous metaplasia rather than tumorigenesis in secretory epithelia other than the prostate... - Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter geneFotini Gounari
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
Nat Immunol 3:489-96. 2002..Thus, the pTalpha reporter can be used to trace lymphopoiesis between CLPs and alphabeta T cells. The slower extinction of the hCD25 reporter compared to pTalpha enabled us to define points at which pTalpha(-) lineages branched off... - On the brink of becoming a T cellChristine Borowski
Department of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Curr Opin Immunol 14:200-6. 2002..Receptor editing and lineage commitment of alphabeta T cells still represent controversial topics that need further study... - Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potentialColin H Martin
Department of Pathology, Harvard Medical School, Dana-Farber Cancer Institute Boston, Massachusetts, 02115, USA
Nat Immunol 4:866-73. 2003..Although the CLP-2 subset may represent the most differentiated population with T cell potential before commitment to the B cell lineage, other subsets of thymic immigrants capable of generating T cells may exist... - Mast cells are an essential hematopoietic component for polyp developmentElias Gounaris
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:19977-82. 2007..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention... - Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasiasKeiko Miyoshi
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:219-24. 2002..These data demonstrate that the activation of beta-catenin signaling induces a program that results in loss of mammary epithelial cell differentiation and induction of epidermal structures...