Fotini Gounari

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. ncbi Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005
  2. pmc CDK6 kinase activity is required for thymocyte development
    Miaofen G Hu
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA
    Blood 117:6120-31. 2011
  3. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
  4. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
  5. pmc A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis
    Miaofen G Hu
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Cancer Res 69:810-8. 2009
  6. ncbi A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
    Iannis Aifantis
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:483-8. 2002
  7. pmc TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity
    Taras Kreslavsky
    Laboratory of Lymphocyte Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 106:12453-8. 2009
  8. pmc Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Exp Med 199:607-15. 2004
  9. ncbi Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition
    Changchuin Mao
    Molecular Oncology Research Institute, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    J Immunol 178:5443-53. 2007
  10. doi Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling
    Damian Kovalovsky
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Immunol 183:3873-84. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Loss of adenomatous polyposis coli gene function disrupts thymic development
    Fotini Gounari
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Nat Immunol 6:800-9. 2005
    ..Thus, loss of APC in immature thymocytes has consequences distinct from those of deregulation of beta-catenin signaling and is essential for T cell differentiation...
  2. pmc CDK6 kinase activity is required for thymocyte development
    Miaofen G Hu
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA
    Blood 117:6120-31. 2011
    ..This role of CDK6 as a downstream mediator of Notch identifies CDK6 kinase activity as a potential therapeutic target in human lymphoid malignancies...
  3. pmc Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    Zhuyan Guo
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Blood 109:5463-72. 2007
    ..Thus, beta-catenin activation may provide a mechanism for the induction of T-cell-acute lymphoblastic leukemia (T-ALL) that does not depend on Notch activation...
  4. pmc c-Myc mediates pre-TCR-induced proliferation but not developmental progression
    Marei Dose
    Tufts New England Medical Center, 750 Washington St, Tufts NEMC no 5602, Boston, MA 02111, USA
    Blood 108:2669-77. 2006
    ....
  5. pmc A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis
    Miaofen G Hu
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Cancer Res 69:810-8. 2009
    ..These results show a critical requirement for CDK6 in Notch/Akt-dependent T-cell development and tumorigenesis and strongly support CDK6 as a specific therapeutic target in human lymphoid malignancies...
  6. ncbi A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
    Iannis Aifantis
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:483-8. 2002
    ..In contrast, the pTalpha juxtamembrane cysteine appeared to be dispensable for pre-TCR function...
  7. pmc TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity
    Taras Kreslavsky
    Laboratory of Lymphocyte Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 106:12453-8. 2009
    ..Interestingly, expression of this TCR transgene led to the development of spontaneous dermatitis...
  8. pmc Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Exp Med 199:607-15. 2004
    ..We conclude that features intrinsic to the pre-TCR, which are absent in TCRalpha, are essential for its unique function...
  9. ncbi Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition
    Changchuin Mao
    Molecular Oncology Research Institute, Tufts New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    J Immunol 178:5443-53. 2007
    ..Akt1 and Akt2 also contribute to the differentiation process by promoting the survival of the DP thymocytes...
  10. doi Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling
    Damian Kovalovsky
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    J Immunol 183:3873-84. 2009
    ..These observations are consistent with beta-catenin/Tcf signaling acting as a switch that determines the outcome of thymic selection downstream the alphabetaTCR cascade...
  11. pmc Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
    Xiaoyu Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2851-61. 2008
    ..As judged by array-based comparative genomic hybridization (array CGH) and spectral karyotype (SKY) analysis, none of the tumors arise because of genomic instability...
  12. pmc Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate
    Annette I Garbe
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:1579-90. 2006
    ....
  13. ncbi Thymic selection revisited: how essential is it?
    Harald von Boehmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 191:62-78. 2003
    ..Ectopically expressed organ-specific antigens contribute to thymic self-nonself discrimination, which represents an essential feature for the evolutionary fitness of mammalian species...
  14. ncbi Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia
    Fotini Gounari
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute Harvard Medical School, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:4099-107. 2002
    ..Our observations indicate that beta-catenin stabilization is a crucial event for the initiation of PIN-like lesions, but induces squamous metaplasia rather than tumorigenesis in secretory epithelia other than the prostate...
  15. ncbi Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene
    Fotini Gounari
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:489-96. 2002
    ..Thus, the pTalpha reporter can be used to trace lymphopoiesis between CLPs and alphabeta T cells. The slower extinction of the hCD25 reporter compared to pTalpha enabled us to define points at which pTalpha(-) lineages branched off...
  16. ncbi On the brink of becoming a T cell
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Immunol 14:200-6. 2002
    ..Receptor editing and lineage commitment of alphabeta T cells still represent controversial topics that need further study...
  17. ncbi Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
    Colin H Martin
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute Boston, Massachusetts, 02115, USA
    Nat Immunol 4:866-73. 2003
    ..Although the CLP-2 subset may represent the most differentiated population with T cell potential before commitment to the B cell lineage, other subsets of thymic immigrants capable of generating T cells may exist...
  18. pmc Mast cells are an essential hematopoietic component for polyp development
    Elias Gounaris
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:19977-82. 2007
    ..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention...
  19. pmc Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
    Keiko Miyoshi
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:219-24. 2002
    ..These data demonstrate that the activation of beta-catenin signaling induces a program that results in loss of mammary epithelial cell differentiation and induction of epidermal structures...