Geraldine Finlay

Summary

Affiliation: Tufts-New England Medical Center
Country: USA

Publications

  1. request reprint
    Finlay G, Hunter D, Walker C, Paulson K, Fanburg B. Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. Am J Physiol Cell Physiol. 2003;285:C409-18 pubmed
    ..Understanding the mechanisms that regulate the diverse responses to the steroid hormone estrogen could lead to novel approaches to the treatment of estrogen-related diseases that are characterized by aberrant cell proliferation. ..
  2. request reprint
    Finlay G, York B, Karas R, Fanburg B, Zhang H, Kwiatkowski D, et al. Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem. 2004;279:23114-22 pubmed
    ..Furthermore, the opposing effects of tuberin on estrogen-induced activation of PDGFRbeta and ERK-1/-2 suggest a pivotal role for tuberin in directing the signaling events that dictate the growth response to E2. ..
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    Finlay G, Malhowski A, Liu Y, Fanburg B, Kwiatkowski D, Toksoz D. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res. 2007;67:9878-86 pubmed
    ..Atorvastatin may have potential therapeutic benefit in TSC syndromes, including LAM. ..