Geraldine Finlay


Affiliation: Tufts-New England Medical Center
Country: USA


  1. request reprint
    Finlay G, Hunter D, Walker C, Paulson K, Fanburg B. Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. Am J Physiol Cell Physiol. 2003;285:C409-18 pubmed
    ..Understanding the mechanisms that regulate the diverse responses to the steroid hormone estrogen could lead to novel approaches to the treatment of estrogen-related diseases that are characterized by aberrant cell proliferation. ..
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    Finlay G, York B, Karas R, Fanburg B, Zhang H, Kwiatkowski D, et al. Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem. 2004;279:23114-22 pubmed
    ..Furthermore, the opposing effects of tuberin on estrogen-induced activation of PDGFRbeta and ERK-1/-2 suggest a pivotal role for tuberin in directing the signaling events that dictate the growth response to E2. ..
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    Finlay G, Malhowski A, Liu Y, Fanburg B, Kwiatkowski D, Toksoz D. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res. 2007;67:9878-86 pubmed
    ..Atorvastatin may have potential therapeutic benefit in TSC syndromes, including LAM. ..