DAVID L contact WOODLAND

Summary

Affiliation: Trudeau Institute
Country: USA

Publications

  1. pmc Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells
    Hirokazu Hikono
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:1625-36. 2007
  2. pmc Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections
    Sherry R Crowe
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    J Exp Med 198:399-410. 2003
  3. pmc Differential contributions of central and effector memory T cells to recall responses
    Alan D Roberts
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 202:123-33. 2005
  4. pmc Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs
    R J Hogan
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 193:981-6. 2001
  5. pmc Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus
    Eric J Yager
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Immun Ageing 7:3. 2010
  6. ncbi Cell-mediated immunity to respiratory virus infections
    David L Woodland
    Trudeau Institute, New York, NY 12983, USA
    Curr Opin Immunol 15:430-5. 2003
  7. ncbi Immunity and age: living in the past?
    David L Woodland
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Trends Immunol 27:303-7. 2006
  8. ncbi Jump-starting the immune system: prime-boosting comes of age
    David L Woodland
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 25:98-104. 2004
  9. pmc T cell memory in the lung airways
    David L Woodland
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Proc Am Thorac Soc 2:126-31. 2005
  10. pmc Memories of Santa Fe. Symposium on immunologic memory
    David L Woodland
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    EMBO Rep 8:823-8. 2007

Research Grants

  1. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 1999
  2. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
  3. Regulation of memory CD8+ T cell recruitment to the lung
    David L Woodland; Fiscal Year: 2010
  4. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2007
  5. T cell responses to chronic bacterial infection
    DAVID WOODLAND; Fiscal Year: 2009
  6. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2009
  7. Regulation of memory CD8+ T cell recruitment to the lung
    David L Woodland; Fiscal Year: 2010
  8. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
  9. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2009
  10. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004

Collaborators

Detail Information

Publications78

  1. pmc Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells
    Hirokazu Hikono
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:1625-36. 2007
    ..These findings extend our understanding of how recall responses are generated and suggest that activation and migration markers define distinct, and unrelated, characteristics of memory T cells...
  2. pmc Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections
    Sherry R Crowe
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    J Exp Med 198:399-410. 2003
    ..Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies...
  3. pmc Differential contributions of central and effector memory T cells to recall responses
    Alan D Roberts
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 202:123-33. 2005
    ..These data indicate that the contribution of effector memory and central memory T cells to the recall response changes substantially over time...
  4. pmc Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs
    R J Hogan
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 193:981-6. 2001
    ..Taken together, these data demonstrate that activated memory CD4(+) T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity...
  5. pmc Differential impact of ageing on cellular and humoral immunity to a persistent murine gamma-herpesvirus
    Eric J Yager
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Immun Ageing 7:3. 2010
    ..This observation has potential relevance for understanding gamma-herpesvirus immune control during disease-associated or therapeutic immunosuppression...
  6. ncbi Cell-mediated immunity to respiratory virus infections
    David L Woodland
    Trudeau Institute, New York, NY 12983, USA
    Curr Opin Immunol 15:430-5. 2003
    ..Recent advances include the identification of effector memory T-cell populations in the lungs and an appreciation for the role of cytokines in regulating memory T-cell pools...
  7. ncbi Immunity and age: living in the past?
    David L Woodland
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Trends Immunol 27:303-7. 2006
    ..This predicts highly stochastic responses to new infections that should vary between individuals, and has important implications for vaccination strategies in the elderly...
  8. ncbi Jump-starting the immune system: prime-boosting comes of age
    David L Woodland
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 25:98-104. 2004
    ..This Review discusses the impact of these recent developments on the future of prime-boost vaccine strategies...
  9. pmc T cell memory in the lung airways
    David L Woodland
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Proc Am Thorac Soc 2:126-31. 2005
    ..Here we address recent developments in our understanding of lung airway memory T cells and their role in infectious disease...
  10. pmc Memories of Santa Fe. Symposium on immunologic memory
    David L Woodland
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    EMBO Rep 8:823-8. 2007
  11. ncbi Migration, maintenance and recall of memory T cells in peripheral tissues
    David L Woodland
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Rev Immunol 9:153-61. 2009
    ..In this Review, we discuss recent insights into the generation, control and recall of peripheral T-cell memory responses...
  12. ncbi Cellular immunity and memory to respiratory virus infections
    D L Woodland
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Res 24:53-67. 2001
    ..A thorough understanding of the cellular immune response to infection in the lungs is essential for future vaccine development...
  13. ncbi Heterogeneity of CD4(+) and CD8(+) T cells
    David L Woodland
    Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA
    Curr Opin Immunol 15:336-42. 2003
    ..More recently it has become apparent that T-cell populations display additional diversity in terms of phenotype, anatomical distribution and effector function...
  14. ncbi Antiviral memory T-cell responses in the lung
    David L Woodland
    Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Microbes Infect 4:1091-8. 2002
    ..Here we discuss the establishment, maintenance and recall of memory T cells in the lung...
  15. ncbi Antigen expression during murine gamma-herpesvirus infection
    D L Woodland
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunobiology 204:649-58. 2001
    ..In addition, recent data suggest that in addition to B cells, both macrophages and dendritic cells harbor latent MHV-68 infection, adding further complexity to their role in controlling the T cell response to this infection...
  16. ncbi Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 170:1423-9. 2003
    ..Together, these data suggest that inflammation can accelerate memory T cell migration to nonlymphoid tissues and is a part of the normal recall response during respiratory infections...
  17. pmc Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    Eric J Yager
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 205:711-23. 2008
    ..These observations have important implications for the design of vaccine strategies for the elderly...
  18. ncbi Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype
    Linda S Cauley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:6655-8. 2002
    ..Differences in CD25 and CD11a expression indicate that the CD4(+) cells from the lung airways and parenchyma are distinct memory populations...
  19. ncbi Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza
    Frances E Lund
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:5236-43. 2002
    ..However, the presence of LTalpha and/or lymph nodes does accelerate the initiation of immune responses, which leads to protection from larger doses of virus...
  20. pmc Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 185:3456-62. 2010
    ....
  21. ncbi Renewal of peripheral CD8+ memory T cells during secondary viral infection of antibody-sufficient mice
    Linda S Cauley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 170:5597-606. 2003
    ..These studies provide important new insight into mechanisms that control the maintenance and renewal of peripheral memory T cell populations during natural infections...
  22. ncbi Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:3535-42. 2007
    ..These data suggest that memory T cell pools become progressively dysregulated over time and this may have a significant impact on immune responsiveness in the aged...
  23. ncbi Cutting edge: effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 171:3338-42. 2003
    ..These data demonstrate that lung airway memory CD8(+) T cells are not terminally differentiated cells and retain the capacity to mediate recall responses to infection...
  24. pmc The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen
    Shiki Takamura
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 207:1153-60. 2010
    ..Thus, two independent factors, initial CD8+ T cell priming in the MLN and prolonged presentation of residual antigen in the MLN, are required to maintain large numbers of antigen-specific memory CD8+ T cells in the lung airways...
  25. pmc CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 183:4378-84. 2009
    ..These findings demonstrate that CXCR3 controls virus-specific effector CD4+ T cell migration in vivo, and suggest that blocking CXCR3-mediated recruitment may limit T cell-induced immunopathology during respiratory virus infections...
  26. ncbi Memory T-cells in non-lymphoid tissues
    Linda S Cauley
    The Trudeau Institute, Saranac Lake, NY 12983, USA
    Curr Opin Investig Drugs 3:33-6. 2002
    ....
  27. pmc Early establishment of gamma-herpesvirus latency: implications for immune control
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:4972-8. 2005
    ..These observations emphasize that prophylactic vaccination strategies must target latent gamma-herpesvirus at the site of infection...
  28. ncbi Cutting edge: effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung
    Alan D Roberts
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:6533-7. 2004
    ..These data contrast with other studies indicating that central memory CD8(+) T cells are the prominent contributors to systemic virus infections...
  29. ncbi Memory T cell populations in the lung airways are maintained by continual recruitment
    Kenneth H Ely
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 176:537-43. 2006
    ..These data indicate that peripheral T cell memory is dynamic and depends on a systemic source of T cells...
  30. ncbi Cutting edge: Antigen is not required for the activation and maintenance of virus-specific memory CD8+ T cells in the lung airways
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 178:4721-5. 2007
    ..These findings alter the current perceptions concerning the contribution of Ag to the maintenance of peripheral T cell memory...
  31. doi Immunity to respiratory viruses
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:61-82. 2009
    ....
  32. ncbi Vaccination with an acidic polymerase epitope of influenza virus elicits a potent antiviral T cell response but delayed clearance of an influenza virus challenge
    Sherry R Crowe
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:696-701. 2005
    ..These data suggest that differential Ag presentation impacts the efficacy of T cell responses to specific epitopes and that this needs to be considered for the development of peptide-based vaccination strategies...
  33. ncbi Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation
    Robert J Hogan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:4976-81. 2002
    ..These data have significant implications for vaccines designed to promote cellular immunity at mucosal sites such as the lung...
  34. ncbi A replication-deficient murine gamma-herpesvirus blocked in late viral gene expression can establish latency and elicit protective cellular immunity
    Basak Kayhan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:8392-402. 2007
    ....
  35. pmc Aging and CD8+ T cell immunity to respiratory virus infections
    Kenneth H Ely
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Exp Gerontol 42:427-31. 2007
    ..Here we discuss age-related changes in memory CD8(+) T cell pools elicited by influenza and parainfluenza viruses and the impact of these changes on immunity in general...
  36. ncbi Viral immunology: challenges associated with the progression from bench to clinic
    Marcia A Blackman
    Trudeau Institute, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 23:565-7. 2002
    ..The third in a series of workshops, 'Immunity to Viral Infections', was held at the Trudeau Institute, NY, USA from 20-22 September 2002...
  37. pmc Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge
    Jacob E Kohlmeier
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Immunity 33:96-105. 2010
    ..These findings demonstrate that innate inflammatory signals act directly on memory T cells, enabling them to rapidly destroy infected host cells once they enter infected tissues...
  38. ncbi Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells
    In Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 171:886-92. 2003
    ..These data directly demonstrate viral exploitation of the normal B cell differentiation pathway to maintain latency...
  39. pmc The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunity 29:101-13. 2008
    ..These data highlight the critical importance of early memory T cell recruitment for the efficacy of cellular immunity in the lung...
  40. ncbi Anatomical features of anti-viral immunity in the respiratory tract
    David L Woodland
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Semin Immunol 16:163-70. 2004
    ....
  41. ncbi Differential gamma-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 170:3828-34. 2003
    ..These data have important implications for understanding the establishment and maintenance of latency by gamma(2)-herpesviruses...
  42. ncbi T-cell memory and recall responses to respiratory virus infections
    Hirokazu Hikono
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:119-32. 2006
    ..This review focuses on memory T cells that mediate recall responses to influenza and parainfluenza virus infections in the lung...
  43. pmc T-cell immunosenescence: lessons learned from mouse models of aging
    Alexander C Maue
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Trends Immunol 30:301-5. 2009
    ..This review describes key findings regarding age-related defects in T-cell function and discusses the impact these defects have on vaccine efficacy and immunity...
  44. ncbi Memory T cell recruitment to the lung airways
    Jacob E Kohlmeier
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA
    Curr Opin Immunol 18:357-62. 2006
    ..These advances have demonstrated that different memory subsets contribute to the maintenance of the airway memory T cell population and have identified molecules that influence trafficking to the lung tissue and the lung airways...
  45. ncbi Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
    Juan E Moyron-Quiroz
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    Nat Med 10:927-34. 2004
    ..Thus, iBALT functions as an inducible secondary lymphoid tissue for respiratory immune responses...
  46. pmc In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 183:8004-14. 2009
    ..These results demonstrate that homeostatic chemokines perform distinct functions that cooperate to mediate effective expression of immunity against Mtb infection...
  47. pmc Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection
    Michael L Freeman
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Virol 84:2881-92. 2010
    ....
  48. ncbi Uneven distribution of MHC class II epitopes within the influenza virus
    Sherry R Crowe
    Trudeau Institute, 154 Algoquin Ave, Saranac Lake, NY 12983, USA
    Vaccine 24:457-67. 2006
    ....
  49. pmc Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration
    Richard T Robinson
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 207:591-605. 2010
    ..tuberculosis-specific T cell activation. IL-12Rbeta1DeltaTM thus represents a novel positive-regulator of IL12Rbeta1-dependent DC function and of the immune response to M. tuberculosis...
  50. ncbi Antibody-mediated control of persistent gamma-herpesvirus infection
    In Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 168:3958-64. 2002
    ..These data directly demonstrate an important contribution of humoral immunity to control of gamma-herpesvirus latency, and have significant implications for clinical intervention...
  51. ncbi The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-gamma production
    Katrin D Mayer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:7732-9. 2005
    ..Highly eYFP fluorescent cells produced elevated levels of proinflammatory cytokines and chemokines in addition to IFN-gamma, suggesting their coregulated expression as a functional unit in highly differentiated effector T cells...
  52. ncbi T cell responses to influenza virus infection: effector and memory cells
    Susan L Swain
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 17:197-209. 2004
    ....
  53. ncbi Vaccines against pandemic influenza
    Richard W Dutton
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 20:326-7. 2007
    ..Vaccination with live attenuated influenza A virus (LAIV) has the potential to provide protection against the more severe consequences of pandemic flu regardless of subtype. This possibility should be explored...
  54. ncbi Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs
    In Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 178:1692-701. 2007
    ..Furthermore, there were defects in normal latency reservoirs within the germinal center cells and IgD(+)"naive" B cells in SAP-deficient mice, showing a profound effect of the SAP mutation on latency reservoirs...
  55. ncbi T cell reactivity during infectious mononucleosis and persistent gammaherpesvirus infection in mice
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:3078-85. 2004
    ..This murine model of infection may provide insight into the role of unusual populations of activated T cells associated with persistent viral infections...
  56. pmc ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes
    William W Reiley
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 105:10961-6. 2008
    ..These data define a key period in the adaptive immune response to Mtb infection...
  57. ncbi Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus
    Timothy J Powell
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 178:1030-8. 2007
    ..Our results suggest that intranasal vaccination with cold-adapted, attenuated live virus has the potential to provide effective emergency protection against emerging influenza strains for several months...
  58. ncbi A mouse model for infectious mononucleosis
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Res 25:201-17. 2002
    ..The focus of this article will be to highlight the similarities and differences in the infectious mononucleosis syndrome associated with human and murine gamma-herpesviruses...
  59. pmc Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells
    Emilio Flano
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 196:1363-72. 2002
    ..Together, these observations suggested that gamma-herpesviruses exploit the B cell life cycle in the spleen...
  60. ncbi Identification of protective and non-protective T cell epitopes in influenza
    Sherry R Crowe
    Trudeau Institute, Department of Immunology, 154 Algoquin Avenue, Saranac Lake, NY 12983, USA
    Vaccine 24:452-6. 2006
    ....
  61. ncbi Immunity: it's in our bones
    David L Woodland
    Trudeau Institiute, Inc, Saranac Lake, NY 12983, USA
    Immunity 22:143-4. 2005
    ..In this issue of Immunity, show that bone marrow CD8+ T cells are predominantly CCR7+/CD62L+ "central memory" cells and describe specific signals that mediate their constitutive recruitment from the blood...
  62. ncbi Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection
    Katrin D Mayer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 180:693-7. 2008
    ..Whereas IFN-gammaR signals are dispensable for the T-bet-dependent IFN-gamma production, direct IL-27Ralpha signals are critical...
  63. pmc Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection
    William W Reiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 107:19408-13. 2010
    ..Our findings suggest that antigen-specific T-cell responses are maintained during chronic mycobacterial infection through the continual production of terminal effector cells from a proliferating precursor population...
  64. ncbi Vaccine development: baring the 'dirty little secret'
    David L Woodland
    Nat Med 11:715-6. 2005
  65. ncbi Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin
    David Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 172:4875-82. 2004
    ..These observations will help refine our understanding of effector and memory CD8 T cell migration patterns...
  66. ncbi Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    Creg J Workman
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 172:5450-5. 2004
    ..In summary, these data suggest that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool...
  67. ncbi Tissue-resident memory CD8+ T cells can be deleted by soluble, but not cross-presented antigen
    Cheng Hong Wei
    Department of Immunology, The Scripps Institute, La Jolla, CA 92037, USA
    J Immunol 175:6615-23. 2005
    ....
  68. ncbi Persistence and turnover of antigen-specific CD4 T cells during chronic tuberculosis infection in the mouse
    Gary M Winslow
    Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12201, USA
    J Immunol 170:2046-52. 2003
    ....
  69. ncbi Aryl hydrocarbon receptor activation impairs the priming but not the recall of influenza virus-specific CD8+ T cells in the lung
    B Paige Lawrence
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164, USA
    J Immunol 177:5819-28. 2006
    ....
  70. doi Vaccination strategies
    David L Woodland
    Viral Immunol 21:1-2. 2008
  71. doi Gaining momentum
    David L Woodland
    Viral Immunol 21:97-8. 2008
  72. ncbi Immunologic memory
    David L Woodland
    Viral Immunol 20:229-30. 2007
  73. pmc Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis
    Alastair I Macrae
    Department of Medical Microbiology and Genitourinary Medicine, Centre for Comparative Infectious Diseases, University of Liverpool, Liverpool, United Kingdom
    J Virol 77:9700-9. 2003
    ..We also demonstrate that expression of M2 is restricted to B cells in the spleen and that M2 encodes a 30-kDa protein localizing predominantly in the cytoplasm and plasma membrane of B cells...
  74. pmc Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation
    Emilio Flano
    Center for Vaccines and Immunity, Columbus Children s Research Institute, Columbus, OH 43205, USA
    J Immunol 175:3225-34. 2005
    ..Taken together, these observations indicate that gamma2-herpesvirus infection of DCs is a mechanism of viral immune evasion, partially mediated by IL-10...
  75. doi Mechanisms of antiviral immunity: new concepts
    David L Woodland
    Viral Immunol 21:279-80. 2008
  76. ncbi Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells
    Paula Y Arnold
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    J Immunol Methods 271:137-51. 2002
    ..Furthermore, we have successfully used these reagents to stain T cells generated following viral infection. Thus, MHC class II:gamma2aFc multimers are robust and reliable reagents for the analysis of MHC class II-restricted T cells...
  77. pmc Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2
    Wayne W Hancock
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:3005-10. 2004
    ..gondii infection and allograft rejection. Together, our findings suggest that Fgl2, although highly conserved and IFN gamma-inducible, is not a critical mediator of either type 1 immunity or immune-associated coagulant activity...
  78. ncbi The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues
    Paula Y Arnold
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 169:739-49. 2002
    ..This key feature, which is not shared by MHC class I-restricted responses, may underlie the broad functional diversity displayed by MHC class II-restricted T cells...

Research Grants33

  1. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 1999
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  2. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  3. Regulation of memory CD8+ T cell recruitment to the lung
    David L Woodland; Fiscal Year: 2010
    ..These cells play a ..
  4. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2007
    ....
  5. T cell responses to chronic bacterial infection
    DAVID WOODLAND; Fiscal Year: 2009
    ..The proposed studies will generate information on the maintenance of protective T cell responses and will facilitate the development of new vaccines and therapies against this class of pathogens. ..
  6. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2009
    ....
  7. Regulation of memory CD8+ T cell recruitment to the lung
    David L Woodland; Fiscal Year: 2010
    ..Together, these studies will identify the mechanisms that regulate cellular immune responses in the respiratory tract and will be important for the development of vaccines that promote effective immunity to respiratory pathogens. ..
  8. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  9. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2009
    ....
  10. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  11. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2000
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  12. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2000
    ....
  13. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2001
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  14. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  15. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  16. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2002
    ....
  17. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2003
    ....
  18. Research Training in Immunology and Infectious Diseases
    DAVID WOODLAND; Fiscal Year: 2007
    ..The training period will be 3 years in length. ..
  19. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  20. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 1999
    ....
  21. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2006
    ..abstract_text> ..
  22. T cell responses to chronic bacterial infection
    DAVID L contact WOODLAND; Fiscal Year: 2010
    ..The proposed studies will generate information on the maintenance of protective T cell responses and will facilitate the development of new vaccines and therapies against this class of pathogens. ..
  23. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2003
    ..Together, these studies will provide new insights into the mechanisms underlying T cell responses in vivo and will have significant implications for the development of vaccines that promote cellular immunity to pulmonary infections. ..
  24. Regulation of CD8+ T cell responses to influenza virus
    DAVID WOODLAND; Fiscal Year: 2007
    ..abstract_text> ..
  25. Regulation of memory CD8+ T cell recruitment to the lung
    DAVID WOODLAND; Fiscal Year: 2009
    ..Together, these studies will identify the mechanisms that regulate cellular immune responses in the respiratory tract and will be important for the development of vaccines that promote effective immunity to respiratory pathogens. ..
  26. Molecular Biology Core
    DAVID WOODLAND; Fiscal Year: 2007
    ..Funds are only requested for the development of reagents and assays that are currently unavailable. ..
  27. T CELL RECOGNITION OF BACTERIAL SUPERANTIGENS
    DAVID WOODLAND; Fiscal Year: 2002
    ..Cells expressing single peptide/MHC complexes will be used to test the idea that peptide discrimination enhances the T-cell response by limiting the density of superantigen presentation. ..
  28. Memory T cell subsets and pulmonary immunity
    DAVID WOODLAND; Fiscal Year: 2006
    ....