STEPHEN SMILEY

Summary

Affiliation: Trudeau Institute
Country: USA

Publications

  1. pmc Fibrin-mediated protection against infection-stimulated immunopathology
    Lawrence L Johnson
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 197:801-6. 2003
  2. ncbi request reprint Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    S T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 167:2887-94. 2001
  3. pmc Immune defense against pneumonic plague
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 225:256-71. 2008
  4. pmc Current challenges in the development of vaccines for pneumonic plague
    Stephen T Smiley
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Expert Rev Vaccines 7:209-21. 2008
  5. ncbi request reprint Cell-mediated defense against Yersinia pestis infection
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY, USA
    Adv Exp Med Biol 603:376-86. 2007
  6. pmc Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis
    Deyan Luo
    Trudeau Institute, Saranac Lake, New York, USA
    Infect Immun 80:91-9. 2012
  7. pmc Cell-mediated protection against pulmonary Yersinia pestis infection
    Michelle A Parent
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Infect Immun 73:7304-10. 2005
  8. pmc Antibodies and cytokines independently protect against pneumonic plague
    Lawrence W Kummer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Vaccine 26:6901-7. 2008
  9. pmc Vaccination with live Yersinia pestis primes CD4 and CD8 T cells that synergistically protect against lethal pulmonary Y. pestis infection
    Alexander V Philipovskiy
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Infect Immun 75:878-85. 2007
  10. pmc D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague
    Frank M Szaba
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Infect Immun 77:4295-304. 2009

Research Grants

  1. Roles for coagulation in immunity
    Stephen T Smiley; Fiscal Year: 2010
  2. Cell-mediated protection against pneumonic plague
    Stephen T Smiley; Fiscal Year: 2010
  3. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2009
  4. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2009
  5. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2006
  6. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2005
  7. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
  8. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2004
  9. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2007
  10. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2005

Collaborators

Detail Information

Publications16

  1. pmc Fibrin-mediated protection against infection-stimulated immunopathology
    Lawrence L Johnson
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 197:801-6. 2003
    ....
  2. ncbi request reprint Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    S T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 167:2887-94. 2001
    ..Our data suggest that extravascular fibrin(ogen) induces macrophage chemokine expression, thereby promoting immune surveillance at sites of inflammation...
  3. pmc Immune defense against pneumonic plague
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 225:256-71. 2008
    ..Here, I review the immunology of pneumonic plague, focusing on evidence that humoral and cellular defense mechanisms collaborate to defend against pulmonary Y. pestis infection...
  4. pmc Current challenges in the development of vaccines for pneumonic plague
    Stephen T Smiley
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Expert Rev Vaccines 7:209-21. 2008
    ..pestis may be exploited as a bioweapon. Here, I review the history and status of plague vaccine research and advocate that pneumonic plague vaccines should strive to prime both humoral and cellular immunity...
  5. ncbi request reprint Cell-mediated defense against Yersinia pestis infection
    Stephen T Smiley
    Trudeau Institute, Saranac Lake, NY, USA
    Adv Exp Med Biol 603:376-86. 2007
    ..We conclude that next-generation plague vaccines should strive to prime both cellular and humoral immunity...
  6. pmc Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis
    Deyan Luo
    Trudeau Institute, Saranac Lake, New York, USA
    Infect Immun 80:91-9. 2012
    ....
  7. pmc Cell-mediated protection against pulmonary Yersinia pestis infection
    Michelle A Parent
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Infect Immun 73:7304-10. 2005
    ..These findings establish that vaccine-primed cellular immunity can protect against pulmonary Y. pestis infection and suggest that vaccines promoting both humoral and cellular immunity will most effectively combat pneumonic plague...
  8. pmc Antibodies and cytokines independently protect against pneumonic plague
    Lawrence W Kummer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Vaccine 26:6901-7. 2008
    ..pestis...
  9. pmc Vaccination with live Yersinia pestis primes CD4 and CD8 T cells that synergistically protect against lethal pulmonary Y. pestis infection
    Alexander V Philipovskiy
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Infect Immun 75:878-85. 2007
    ..pestis strains lacking the capacity to express F1, LcrV, and all pCD1/pPCP-encoded proteins, suggesting that protective T cells likely recognize antigens distinct from those previously defined as targets for humoral immunity...
  10. pmc D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague
    Frank M Szaba
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Infect Immun 77:4295-304. 2009
    ..This study describes a new model for studying T-cell-mediated protection against pneumonic plague and demonstrates the capacity for live, highly attenuated, Y. pestis vaccine strains to prime protective memory T-cell responses safely...
  11. pmc Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection
    Michelle A Parent
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Infect Immun 74:3381-6. 2006
    ..pestis challenge. These observations strongly suggest that plague vaccines should strive to maximally prime both cellular and humoral immunity...
  12. pmc Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration
    Richard T Robinson
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:5560-7. 2008
    ..pestis-26 degrees. The data demonstrate the molecular pathway by which Y. pestis evades induction of early DC activation as measured by migration and IL-12(p40)(2) production...
  13. pmc Yersinia pestis V protein epitopes recognized by CD4 T cells
    Michelle A Parent
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Infect Immun 73:2197-204. 2005
    ....
  14. pmc Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo
    Frank M Szaba
    Trudeau Institute, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Blood 99:1053-9. 2002
    ....
  15. pmc Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection
    Kevin N Couper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 182:3985-94. 2009
    ....
  16. pmc Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells
    Georgia Perona-Wright
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Host Microbe 6:503-12. 2009
    ..In contrast to disseminating pathogens, locally restricted infections did not elicit NK cell IL-10. Thus systemic infections uniquely engage NK cells in an IL-10-mediated immunoregulatory circuit that functions to alleviate inflammation...

Research Grants15

  1. Roles for coagulation in immunity
    Stephen T Smiley; Fiscal Year: 2010
    ....
  2. Cell-mediated protection against pneumonic plague
    Stephen T Smiley; Fiscal Year: 2010
    ..This proposal aims to fundamentally improve that vaccine by incorporating the protective capacities of both B and T cells. ..
  3. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2009
    ....
  4. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2009
    ..This proposal aims to fundamentally improve that vaccine by incorporating the protective capacities of both B and T cells. ..
  5. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2006
    ..abstract_text> ..
  6. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2005
    ..abstract_text> ..
  7. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
    ..abstract_text> ..
  8. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2004
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  9. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2007
    ..abstract_text> ..
  10. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2005
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  11. Priming CD4+ T cells to protect against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
    ..Our long-term goals are to use that information to develop effective pneuinonic plague vaccines. ..
  12. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2003
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  13. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2002
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..