D K Dalton

Summary

Affiliation: Trudeau Institute
Country: USA

Publications

  1. pmc IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals
    Xujian Li
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:939-49. 2007
  2. pmc Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells
    D K Dalton
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:117-22. 2000
  3. ncbi Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice
    Dyana K Dalton
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    J Neuroimmunol 160:110-21. 2005
  4. pmc Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    C Q Chu
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:123-8. 2000
  5. ncbi IFN-gamma and NO in mycobacterial disease: new jobs for old hands
    Andrea M Cooper
    The Trudeau Institute, PO Box 59, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Microbiol 10:221-6. 2002
  6. ncbi Infection-induced apoptosis deletes bystander CD4+ T cells: a mechanism for suppression of autoimmunity during BCG infection
    Richard A O'Connor
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    J Autoimmun 24:93-100. 2005

Collaborators

Detail Information

Publications6

  1. pmc IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals
    Xujian Li
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:939-49. 2007
    ....
  2. pmc Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells
    D K Dalton
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:117-22. 2000
    ..Thus, IFN-gamma is essential to a regulatory mechanism that eliminates activated CD4 T cells and maintains CD4 T cell homeostasis during an immune response...
  3. ncbi Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice
    Dyana K Dalton
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    J Neuroimmunol 160:110-21. 2005
    ..INOS is not only required for apoptosis of CNS-CD4(+) T cells but also prevents overexpansion of autoreactive Th1 cells in the periphery and the CNS...
  4. pmc Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    C Q Chu
    Trudeau Institute, Saranac Lake, New York 12983, USA
    J Exp Med 192:123-8. 2000
    ..We thus present novel in vivo and in vitro evidence that IFN-gamma may limit the extent of EAE by suppressing expansion of activated CD4 T cells...
  5. ncbi IFN-gamma and NO in mycobacterial disease: new jobs for old hands
    Andrea M Cooper
    The Trudeau Institute, PO Box 59, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Microbiol 10:221-6. 2002
    ..avium infection, even leads to reduced bacterial growth...
  6. ncbi Infection-induced apoptosis deletes bystander CD4+ T cells: a mechanism for suppression of autoimmunity during BCG infection
    Richard A O'Connor
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    J Autoimmun 24:93-100. 2005
    ..The data suggest that mycobacterial infection attenuates the severity of EAE, at least in part, by promoting the apoptotic elimination of autoreactive CD4+ T cells...