J K Wolford

Summary

Affiliation: Translational Genomics Research Institute
Country: USA

Publications

  1. ncbi request reprint Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 80:338-43. 2003
  2. ncbi request reprint Genetic basis of type 2 diabetes mellitus: implications for therapy
    Johanna K Wolford
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    Treat Endocrinol 3:257-67. 2004
  3. ncbi request reprint Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians
    J K Wolford
    Translational Genomics Research Institute, Diabetes Research Unit, Phoenix, AZ 85004, USA
    Diabet Med 23:367-76. 2006
  4. ncbi request reprint Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians
    J K Wolford
    Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetologia 44:779-82. 2001
  5. ncbi request reprint Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:97-103. 2001
  6. ncbi request reprint Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians
    F Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 4212 North 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:360-3. 2001
  7. ncbi request reprint Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians
    M Prochazka
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Cell Probes 16:421-7. 2002
  8. ncbi request reprint Polymorphism screening of the insulin receptor-related receptor gene (INSRR) on 1q in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Cell Probes 15:223-7. 2001
  9. ncbi request reprint Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians
    F Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212, North 16th Street, 85016, Phoenix, AZ, USA
    Biochim Biophys Acta 1518:215-20. 2001
  10. ncbi request reprint Genome-wide scan for CAG/CTG repeat expansions in Pimas with early onset of type 2 diabetes mellitus
    J K Wolford
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, 85016
    Mol Genet Metab 66:62-7. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 80:338-43. 2003
    ..0+/-7.5]; P=0.02-0.004). Our findings suggest that genetic variants in the IL6R gene may play a role in susceptibility to obesity. Assessment of these SNPs in other populations will be useful to determine the magnitude of obesity risk...
  2. ncbi request reprint Genetic basis of type 2 diabetes mellitus: implications for therapy
    Johanna K Wolford
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    Treat Endocrinol 3:257-67. 2004
    ..In addition, identification of genetic variants that determine differences in antidiabetic drug responsiveness will be useful in assessing a first-line pharmacologic therapy for diabetic patients...
  3. ncbi request reprint Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians
    J K Wolford
    Translational Genomics Research Institute, Diabetes Research Unit, Phoenix, AZ 85004, USA
    Diabet Med 23:367-76. 2006
    ..As AKR1B1 is located on 7q35, where we have previously reported linkage to diabetic nephropathy in Pima Indians, this study examined the association of AKR1B1 variants with diabetic nephropathy in this population...
  4. ncbi request reprint Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians
    J K Wolford
    Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetologia 44:779-82. 2001
    ..Because obesity is a strongly predisposing factor for Type II diabetes, we hypothesized that the LMNA 3408C/T variant could be associated with diabetes and body mass index in Pima Indians...
  5. ncbi request reprint Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:97-103. 2001
    ..Our results indicate that variants in KCNJ9 are associated with diabetes in Pimas but do not account for the linkage of 1q with diabetes in this population...
  6. ncbi request reprint Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians
    F Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 4212 North 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:360-3. 2001
    ..We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population...
  7. ncbi request reprint Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians
    M Prochazka
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Cell Probes 16:421-7. 2002
    ..We conclude that variants in PRKAB2 are unlikely to contribute to the disease susceptibility in Pima Indians...
  8. ncbi request reprint Polymorphism screening of the insulin receptor-related receptor gene (INSRR) on 1q in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Cell Probes 15:223-7. 2001
    ..We conclude that INSRR has no detectable mutations contributing to diabetes in the Pima Indians. However, information on the novel markers may prove useful for association studies of this candidate gene in other populations...
  9. ncbi request reprint Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians
    F Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212, North 16th Street, 85016, Phoenix, AZ, USA
    Biochim Biophys Acta 1518:215-20. 2001
    ..The genomic structure of PBX1 provides a basis for similar systematic examinations of this candidate locus in other populations in relation to both type 2 diabetes and other metabolic disorders...
  10. ncbi request reprint Genome-wide scan for CAG/CTG repeat expansions in Pimas with early onset of type 2 diabetes mellitus
    J K Wolford
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, 85016
    Mol Genet Metab 66:62-7. 1999
    ..We conclude that this unstable CAG/CTG repeat may represent a novel locus, consisting of large, but apparently nonpathogenic, unstable sequences...
  11. ncbi request reprint Structure and expression of the human MTG8/ETO gene
    J K Wolford
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85016, USA
    Gene 212:103-9. 1998
    ..Identical alternatively spliced mRNA variants were found to be produced by the highly conserved homologous gene (Cbfa2t1) in the mouse, suggesting an evolutionary significance...
  12. ncbi request reprint Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Gene 241:143-8. 2000
    ..However, knowledge of the genomic structure of PEA15 provides the basis for similar systematic examinations of this candidate locus in relation to type 2 diabetes and other metabolic disorders in other populations...
  13. ncbi request reprint Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)
    J Vaughn
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ 85016, USA
    Biochem Biophys Res Commun 274:302-9. 2000
    ..The characterization of the KCNJ9 gene should facilitate further studies on the function of the KCNJ9 protein and allow evaluation of the potential role of the locus in Type II diabetes...
  14. ncbi request reprint High-throughput SNP detection by using DNA pooling and denaturing high performance liquid chromatography (DHPLC)
    J K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institues of Health, Phoenix, AZ 85016, USA
    Hum Genet 107:483-7. 2000
    ..We conclude that DNA pooling of samples for DHPLC analysis is an effective way to increase throughput efficiency of SNP detection...
  15. ncbi request reprint Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Phoenix, Arizona 85016, USA
    Mol Genet Metab 72:231-8. 2001
    ..c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population...
  16. ncbi request reprint Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males
    J K Wolford
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    Biochem Biophys Res Commun 246:624-6. 1998
    ..01), waist circumference (p = 0.008), and thigh circumference (p = 0.02). Comparative analysis of all 13 MTG8 exons in 30 Pimas did not reveal any genetic variants which could explain the association with obesity in males...
  17. ncbi request reprint Analysis of quantitative lipid traits in the genetics of NIDDM (GENNID) study
    Alka Malhotra
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Diabetes 54:3007-14. 2005
    ..1-3q13.31, 11p15.4-11p11.3, and 19p13.2-19q13.42 that may influence traits underlying lipid abnormalities associated with type 2 diabetes...
  18. pmc Sequence variation in PPARG may underlie differential response to troglitazone
    Johanna K Wolford
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
    Diabetes 54:3319-25. 2005
    ..05). Three variants were also associated with changes in Si as a continuous variable. Our results suggest that PPARG variation may underlie response to TZD therapy in women at risk for type 2 diabetes...
  19. ncbi request reprint Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans
    Alka Malhotra
    Diabetes and Obesity Research Unit, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Hum Mol Genet 14:3955-62. 2005
    ..0429) for TG. Statistically significant evidence for linkage and low heterogeneity on chromosome 1q therefore suggest that this region may harbor a gene underlying the inheritance of LDL in African Americans...
  20. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  21. ncbi request reprint Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes
    Alka Malhotra
    Diabetes and Obesity Research Unit, Genetic Basis of Human Disease, Translational Genomics Research Institute, 445 N 5th Street, Phoenix, AZ 85004, USA
    Diabetes 56:890-6. 2007
    ....
  22. ncbi request reprint Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study
    Robert L Hanson
    Translational Genomics Research Institute, 445 North Fifth St, Phoenix, AZ 85004, USA
    Diabetes 56:975-83. 2007
    ..01. The strongest evidence for association was found for rs2648875 (P = 0.0000018; 2.97 [1.90-4.65]), which maps to intron 8 of PVT1. Together, these results suggest that PVT1 may contribute to ESRD susceptibility in diabetes...
  23. ncbi request reprint Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians
    Barbora Vozarova de Courten
    Translational Genomics Research Institute, Diabetes Research Unit, NIDDK, NIH, 400 North 5th St, Phoenix, Arizona, USA
    Diabetes 54:284-9. 2005
    ..Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population...
  24. ncbi request reprint Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians
    Yasmine L Konheim
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 113:377-81. 2003
    ....
  25. ncbi request reprint Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, AZ 85016, USA
    Mol Genet Metab 79:61-6. 2003
    ..77+/-0.25 vs. 0.67+/-0.23 mg/kgEMBS/min; p=0.02). These results provide evidence supporting a role for the eicosanoid biosynthesis pathway in type 2 diabetes mellitus pathophysiology...
  26. ncbi request reprint A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 78:136-44. 2003
    ..However, these findings suggest that variation within the CRP locus may play a role in diabetes susceptibility in Pima Indians...
  27. ncbi request reprint The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 112:409-13. 2003
    ..001). These findings are consistent with a role for genetic determinants of inflammation in the development of T2DM in both Native Americans and Caucasians...
  28. ncbi request reprint Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians
    Vidya S Farook
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:3342-6. 2002
    ..1 to 2.9. We conclude that these variants in KCNJ10 are unlikely to be the cause of linkage of type 2 diabetes with 1q in Pima Indians...
  29. ncbi request reprint Estimation of single nucleotide polymorphism allele frequency in DNA pools by using Pyrosequencing
    Jonathan D Gruber
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 110:395-401. 2002
    ....
  30. ncbi request reprint Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians
    Farook Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Gene 290:217-25. 2002
    ..We did not find evidence for association of any LMX1A SNPs with T2DM and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians...
  31. ncbi request reprint Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes
    Meredith P Millis
    Translational Genomics Research Institute, 445 North Fifth St, Phoenix, AZ 85004, USA
    Diabetes 56:3027-32. 2007
    ..The objective of this study was to evaluate the extent to which these variants mediate susceptibility in other populations...
  32. ncbi request reprint Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians
    Farook Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Hum Genet 113:353-8. 2003
    ..We conclude that alterations of MGST3 are unlikely to contribute to T2DM or differences in insulin sensitivity in the Pima Indians...