Edward C Stites

Summary

Affiliation: Translational Genomics Research Institute
Country: USA

Publications

  1. doi Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine
    Edward C Stites
    The Translational Genomics Research Institute, Clinical Translational Research Division, 13208 E Shea Blvd, Scottsdale, AZ 85258, USA
    Phys Biol 10:026004. 2013
  2. doi The response of cancers to BRAF inhibition underscores the importance of cancer systems biology
    Edward C Stites
    Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Sci Signal 5:pe46. 2012
  3. ncbi Mathematical investigation of how oncogenic ras mutants promote ras signaling
    Edward C Stites
    Medical Scientist Training Program, University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 880:69-85. 2012
  4. doi Mechanistic modeling to investigate signaling by oncogenic Ras mutants
    Edward C Stites
    Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, AZ, USA
    Wiley Interdiscip Rev Syst Biol Med 4:117-27. 2012
  5. ncbi A systems perspective of ras signaling in cancer
    Edward C Stites
    Medical Scientist Training Program and Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 29908, USA
    Clin Cancer Res 15:1510-3. 2009
  6. ncbi Network analysis of oncogenic Ras activation in cancer
    Edward C Stites
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Science 318:463-7. 2007
  7. doi Modeling membrane localization: case study of a Ras signaling model
    Edward C Stites
    Medical Scientist Training Program, University of Virginia, MR6 Rm 3708, 801386, Charlottesville, VA 22908, USA
    Adv Exp Med Biol 680:661-7. 2010
  8. pmc Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling
    Matthew S Creamer
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    BMC Syst Biol 6:107. 2012

Detail Information

Publications8

  1. doi Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine
    Edward C Stites
    The Translational Genomics Research Institute, Clinical Translational Research Division, 13208 E Shea Blvd, Scottsdale, AZ 85258, USA
    Phys Biol 10:026004. 2013
    ..As work in this area advances, one can envision a future where such models may meaningfully contribute to the clinical management of cancer patients...
  2. doi The response of cancers to BRAF inhibition underscores the importance of cancer systems biology
    Edward C Stites
    Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Sci Signal 5:pe46. 2012
    ..The results of these studies suggest that combined treatment of BRAF(V600E)-driven colon cancers with both vemurafenib and EGFR inhibitors is worth clinical evaluation...
  3. ncbi Mathematical investigation of how oncogenic ras mutants promote ras signaling
    Edward C Stites
    Medical Scientist Training Program, University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 880:69-85. 2012
    ..Computational analysis of the model resulted in several unanticipated predictions and suggested experiments that subsequently validated some of these predictions...
  4. doi Mechanistic modeling to investigate signaling by oncogenic Ras mutants
    Edward C Stites
    Clinical Translational Research Division, The Translational Genomics Research Institute, Phoenix, AZ, USA
    Wiley Interdiscip Rev Syst Biol Med 4:117-27. 2012
    ..These models also demonstrate differences in how models are developed and studied. Their evaluation suggests which approaches are most promising for future work...
  5. ncbi A systems perspective of ras signaling in cancer
    Edward C Stites
    Medical Scientist Training Program and Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 29908, USA
    Clin Cancer Res 15:1510-3. 2009
    ....
  6. ncbi Network analysis of oncogenic Ras activation in cancer
    Edward C Stites
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Science 318:463-7. 2007
    ..This system-level analysis of the oncogenic Ras network provides new insights and potential therapeutic strategies...
  7. doi Modeling membrane localization: case study of a Ras signaling model
    Edward C Stites
    Medical Scientist Training Program, University of Virginia, MR6 Rm 3708, 801386, Charlottesville, VA 22908, USA
    Adv Exp Med Biol 680:661-7. 2010
    ..For these predictions that are sensitive to the value of the membrane localization parameter, we find that the theoretically derived value of 250 results in model predictions that most closely match experimental observations...
  8. pmc Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling
    Matthew S Creamer
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    BMC Syst Biol 6:107. 2012
    ..To overcome this problem, the rule-based modeling approach has been developed for representing interactions within signaling networks efficiently and compactly through coarse-graining of the chemical kinetics of molecular interactions...