Michael J Demeure

Summary

Affiliation: Translational Genomics Research Institute
Country: USA

Publications

  1. ncbi request reprint Whole-genome Sequencing of an Aggressive BRAF Wild-type Papillary Thyroid Cancer Identified EML4-ALK Translocation as a Therapeutic Target
    Michael J Demeure
    Translational Genomics Research Institute, 445 N Fifth St, Phoenix, AZ, 85004, USA
    World J Surg 38:1296-305. 2014
  2. doi request reprint PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target
    Michael J Demeure
    Translational Genomics Research Institute, Phoenix, AZ Electronic address
    Surgery 154:1405-16; discussion 1416. 2013
  3. doi request reprint Multi-institutional tumor banking: lessons learned from a pancreatic cancer biospecimen repository
    Michael J Demeure
    Scottsdale Healthcare Cancer Surgery, Scottsdale, AZ, USA
    Pancreas 39:949-54. 2010
  4. doi request reprint Preclinical investigation of nanoparticle albumin-bound paclitaxel as a potential treatment for adrenocortical cancer
    Michael J Demeure
    Virginia G Piper Cancer Center, Scottsdale, AZ, USA
    Ann Surg 255:140-6. 2012
  5. pmc Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer
    Yoganand Balagurunathan
    Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    Mol Cancer Ther 7:3071-80. 2008
  6. pmc A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges
    Glen J Weiss
    Virginia G Piper Cancer Center Clinical Trials at Scottsdale Healthcare VGPCC, Scottsdale, Arizona, United States of America The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
    PLoS ONE 8:e76438. 2013
  7. doi request reprint Targeted therapies for adrenocortical carcinoma: IGF and beyond
    Michael J Demeure
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ, USA
    Horm Cancer 2:385-92. 2011
  8. doi request reprint Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells
    Bret Stephens
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, USA
    Mol Cancer Ther 7:202-10. 2008
  9. doi request reprint Genomic and expression profiling of adrenocortical carcinoma: application to diagnosis, prognosis and treatment
    Kimberly J Bussey
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Future Oncol 5:641-55. 2009
  10. pmc Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs
    Alexis Christoforides
    Translational Genomics Research Institute, Neurogenomics Division, Phoenix, AZ 85004, USA
    BMC Genomics 14:302. 2013

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Whole-genome Sequencing of an Aggressive BRAF Wild-type Papillary Thyroid Cancer Identified EML4-ALK Translocation as a Therapeutic Target
    Michael J Demeure
    Translational Genomics Research Institute, 445 N Fifth St, Phoenix, AZ, 85004, USA
    World J Surg 38:1296-305. 2014
    ..A 62-year-old man who underwent multiple operations for papillary thyroid cancer and whose metastases progressed despite standard treatments provided tumor tissue...
  2. doi request reprint PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target
    Michael J Demeure
    Translational Genomics Research Institute, Phoenix, AZ Electronic address
    Surgery 154:1405-16; discussion 1416. 2013
    ..Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data for prognostic biomarkers and therapeutic targets...
  3. doi request reprint Multi-institutional tumor banking: lessons learned from a pancreatic cancer biospecimen repository
    Michael J Demeure
    Scottsdale Healthcare Cancer Surgery, Scottsdale, AZ, USA
    Pancreas 39:949-54. 2010
    ..This article summarizes the key hurdles encountered and solutions we found in the process of developing a successful multi-institution biospecimen repository...
  4. doi request reprint Preclinical investigation of nanoparticle albumin-bound paclitaxel as a potential treatment for adrenocortical cancer
    Michael J Demeure
    Virginia G Piper Cancer Center, Scottsdale, AZ, USA
    Ann Surg 255:140-6. 2012
    ....
  5. pmc Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer
    Yoganand Balagurunathan
    Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    Mol Cancer Ther 7:3071-80. 2008
    ..These validated gene combinations thus encompass a list of cell-surface targets that can be used to develop multimeric ligands for the imaging and treatment of pancreatic cancer...
  6. pmc A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges
    Glen J Weiss
    Virginia G Piper Cancer Center Clinical Trials at Scottsdale Healthcare VGPCC, Scottsdale, Arizona, United States of America The Translational Genomics Research Institute, Phoenix, Arizona, United States of America
    PLoS ONE 8:e76438. 2013
    ....
  7. doi request reprint Targeted therapies for adrenocortical carcinoma: IGF and beyond
    Michael J Demeure
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ, USA
    Horm Cancer 2:385-92. 2011
    ..On the horizon are other agents targeting other tyrosine kinases, including EGF and FGF, and novel strategies such as individualized tumor analysis to select treatment...
  8. doi request reprint Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells
    Bret Stephens
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, USA
    Mol Cancer Ther 7:202-10. 2008
    ..These data support the hypothesis that PRL phosphatases regulate key pathways involved in tumorigenesis and metastasis and that knockdown of both PRL-1 and PRL-2 is required to disrupt PRL phosphatase function in pancreatic cancer cells...
  9. doi request reprint Genomic and expression profiling of adrenocortical carcinoma: application to diagnosis, prognosis and treatment
    Kimberly J Bussey
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Future Oncol 5:641-55. 2009
    ....
  10. pmc Identification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs
    Alexis Christoforides
    Translational Genomics Research Institute, Neurogenomics Division, Phoenix, AZ 85004, USA
    BMC Genomics 14:302. 2013
    ....
  11. doi request reprint Toward a pathway-centered approach for the treatment of adrenocortical carcinoma
    Kimberly J Bussey
    Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
    Curr Opin Oncol 23:34-44. 2011
    ..The rarity of the disease has stymied therapeutic development. Recent work toward understanding the molecular pathogenesis of the disease has identified several potential new diagnostic and therapeutic targets...
  12. doi request reprint Adrenocortical cancer
    Melissa Wandoloski
    Translational Genomics Research Institute, Clinical Translational Research Division, Phoenix, AZ 85004, USA
    Surg Clin North Am 89:1255-67. 2009
    ..2% of all cancer deaths This article reviews the incidence, presentation, and pathology of ACC. Particular attention is paid to the molecular oncogenesis of this disease, and the surgical and therapeutic options available for its cure...
  13. doi request reprint Adrenocortical carcinoma survival rates correlated to genomic copy number variants
    Elizabeth A Stephan
    Genetic Basis of Human Disease Division, Translational Genomics Research Institute, 445 North 5th Street, Phoenix, AZ 85004, USA
    Mol Cancer Ther 7:425-31. 2008
    ..These regions may hold prognostic indicators and offer therapeutic targets that can be used to develop novel treatments for aggressive tumors...
  14. pmc Advancing a clinically relevant perspective of the clonal nature of cancer
    Christian Ruiz
    Clinical Translational Research Division, Translational Genomics Research Institute, Scottsdale, AZ 85259, USA
    Proc Natl Acad Sci U S A 108:12054-9. 2011
    ..We propose that our high-definition analyses of the genomes of distinct clonal populations of cancer cells in patients in vivo can help guide diagnoses and tailor approaches to personalized treatment...