A Gugliucci

Summary

Affiliation: Touro University
Country: USA

Publications

  1. ncbi Ischemia-modified albumin levels in cord blood: a case-control study in uncomplicated and complicated deliveries
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University, California, Vallejo, 94592, USA
    Clin Chim Acta 362:155-60. 2005
  2. ncbi Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA, USA
    Clin Chim Acta 384:105-12. 2007
  3. doi Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310, Johnson Lane, Vallejo, CA 94592, USA
    Life Sci 82:413-8. 2008
  4. doi Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
    Clin Chem Lab Med 46:1403-9. 2008
  5. ncbi Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
    Fitoterapia 80:138-42. 2009
  6. doi Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins
    A Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310 Johnson Lane, Vallejo, CA 94592, USA
    Fitoterapia 80:339-44. 2009
  7. ncbi Alternative antiglycation mechanisms: are spermine and fructosamine-3-kinase part of a carbonyl damage control pathway?
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University California, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
    Med Hypotheses 64:770-7. 2005
  8. ncbi Polyamines as clinical laboratory tools
    A Gugliucci
    Laboratory of Biochemistry, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
    Clin Chim Acta 344:23-35. 2004
  9. ncbi Human plasminogen is highly susceptible to peroxynitrite inactivation
    Alejandro Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island, Vallejo, CA 94592, USA
    Clin Chem Lab Med 41:1064-8. 2003
  10. doi Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
    Ann Nutr Metab 54:197-201. 2009

Collaborators

Detail Information

Publications28

  1. ncbi Ischemia-modified albumin levels in cord blood: a case-control study in uncomplicated and complicated deliveries
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University, California, Vallejo, 94592, USA
    Clin Chim Acta 362:155-60. 2005
    ..IMA level in cord blood could then serve as an indicator of fetal hypoxia and fetal tissue ischemia and serve as a biomarker of the severity of these conditions...
  2. ncbi Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA, USA
    Clin Chim Acta 384:105-12. 2007
    ..We also determined whether free serum acrolein levels are higher in renal failure, and assessed whether they decrease after hemodialysis (HD) and whether this change correlates with increases in PON-1 activity...
  3. doi Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310, Johnson Lane, Vallejo, CA 94592, USA
    Life Sci 82:413-8. 2008
    ..This could contribute to explain increased thrombogenicity in smokers and in other conditions, as well as pointing at dietary intervention or the use of thiol-conserving reducing compounds as putative coadjuvant therapeutic measures...
  4. doi Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
    Clin Chem Lab Med 46:1403-9. 2008
    ..This has been shown for low-density lipoprotein, apolipoprotein AI and paraoxonase 1 (PON-1). Notably, plasminogen has 29 tyrosine residues and we previously demonstrated that it can be inactivated by nitration of these residues...
  5. ncbi Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
    Fitoterapia 80:138-42. 2009
    ..Of interest, 5 caffeoylquinic acid at 5 micromol/L affords more than 60% protection of the activity reaching 100% at 25 micromol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity...
  6. doi Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins
    A Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310 Johnson Lane, Vallejo, CA 94592, USA
    Fitoterapia 80:339-44. 2009
    ..Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of maté tea...
  7. ncbi Alternative antiglycation mechanisms: are spermine and fructosamine-3-kinase part of a carbonyl damage control pathway?
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University California, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
    Med Hypotheses 64:770-7. 2005
    ..They could have altered steady state levels of polyamines and/or decreased FN-3-K expression or activity...
  8. ncbi Polyamines as clinical laboratory tools
    A Gugliucci
    Laboratory of Biochemistry, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
    Clin Chim Acta 344:23-35. 2004
    ..Next, we will summarize the main analytical methods on which we count, and finally we will address their role in diagnosis of cancer as well their proposed role as antioxidant and antiglycation agents...
  9. ncbi Human plasminogen is highly susceptible to peroxynitrite inactivation
    Alejandro Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island, Vallejo, CA 94592, USA
    Clin Chem Lab Med 41:1064-8. 2003
    ..If proven in ulterior in vivo studies, this factor would provide another mechanism by which nitrosative stress participates in diabetic complications...
  10. doi Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
    Ann Nutr Metab 54:197-201. 2009
    ..Obesity has an inflammatory component, but interestingly there are no studies on serum AGE levels in obesity or on the effects of LCD as a therapeutic measure on these markers of glycation...
  11. ncbi The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University, College of Osteopathic Medicine, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
    Life Sci 72:2603-16. 2003
    ..Protection is afforded against glycation by hexoses, trioses and dicarbonyls AGE precursors and is comparable to those of aminoguanidine and carnosine...
  12. ncbi A practical method to study functional impairment of proteins by glycation and effects of inhibitors using current coagulation/fibrinolysis reagent kits
    Alejandro Gugliucci
    Biochemistry Laboratory, Touro University College of Osteopathic Medicine, Mare Island, Vallejo, CA, USA
    Clin Biochem 36:155-8. 2003
    ..They provide a practical system for monitoring the action of putative antiglycation agents...
  13. ncbi The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island Building H 83, 832 Walnut Ave, Vallejo, CA 94592, USA
    Life Sci 72:279-92. 2002
    ..If predictably milder glycated forms of AT III and plasminogen were to be secreted in vivo, the loss of activities shown here could act synergistically to generate hyperthrombicity...
  14. ncbi Is diabetic hypercoagulability an acquired annexinopathy? Glycation of annexin II as a putative mechanism for impaired fibrinolysis in diabetic patients
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island, California, Vallejo 94592, USA
    Med Hypotheses 59:247-51. 2002
    ..If our hypothesis is correct, one of the components of the increased thrombogenicity seen in diabetic patients might then be an acquired annexinopathy...
  15. ncbi Three different pathways for human LDL oxidation are inhibited in vitro by water extracts of the medicinal herb Achyrocline satureoides
    A Gugliucci
    Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island Building H 83, 832 Walnut Ave, Vallejo, CA, USA
    Life Sci 71:693-705. 2002
    ..In all three systems employed an effect is already substantiated at a concentration of the AS extract of 4 microg/ml, which corresponds to a 1/100 dilution of the preparations usually drunk...
  16. ncbi Glycation as the glucose link to diabetic complications
    A Gugliucci
    Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Vallejo, Calif 94592, USA
    J Am Osteopath Assoc 100:621-34. 2000
    ..Results of animal studies and phase III clinical trials reveal that the inhibition of this process attenuates the development of a range of these complications...
  17. ncbi Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance
    Alejandro Gugliucci
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Vallejo, CA, USA, and Department of Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama City, Japan
    Clin Chim Acta 377:213-20. 2007
    ..We hypothesized that retention of uremic toxins and or "middle molecules" including advanced glycation (AGE) free adducts and peptides could play a mechanistic role in decreasing PON-1 activity...
  18. ncbi Circulating advanced glycation peptides in streptozotocin-induced diabetic rats: evidence for preferential modification of IgG light chains
    A Gugliucci
    Division of Basic Sciences, Touro University College of Osteopathic Medicine, San Francisco, California 94115, USA
    Life Sci 62:2141-50. 1998
    ....
  19. ncbi Nitration of human plasminogen by RAW 264.7 macrophages reduces streptokinase-induced plasmin activity
    Chinhnam Hathuc
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
    Clin Chem Lab Med 44:213-9. 2006
    ..Nitrosative stress may be implicated in impaired fibrinolysis. New therapeutic approaches for nitrosative stress in atherosclerosis and diabetes should limit the formation of superoxides and peroxynitrite...
  20. ncbi Protective action of Ilex paraguariensis extract against free radical inactivation of paraoxonase-1 in high-density lipoprotein
    Teresita Menini
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
    Planta Med 73:1141-7. 2007
    ..05). In conclusion, we demonstrate that IP extract may, to some extent, prevent the loss of the antiatherogenic function of HDL afforded by PON-1 when the particle is under oxidant stress...
  21. ncbi Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea
    Nicole Lunceford
    Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA, USA
    Fitoterapia 76:419-27. 2005
    ..The inhibition of AGE formation was comparable to that obtained by using millimolar concentrations of the standard antiglycation agent aminoguanidine...
  22. ncbi Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity
    Mindy Bixby
    Glycation, Oxidation and Disease Laboratory, Division of Basic Sciences, Touro University California, 1310 Johnson Lane, Mare Island Vallejo, CA 94592, USA
    Life Sci 77:345-58. 2005
    ..Further studies aiming at isolation of the active principles and assessment of their bioavailability are warranted...
  23. doi "Blinding" of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?
    A Gugliucci
    Glycation, Oxidation and Disease Laboratory, Touro University California, Mare Island Building H 83, 1310, Johnson Lane, Vallejo, CA 94592, USA
    Med Hypotheses 73:921-4. 2009
    ..Future targets for type 2 diabetes treatments will likely be those that can effect beneficial changes in the activity of AMPK, and our theory predicts that anti-glycation agents may become part of that armamentarium...
  24. ncbi Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidation
    Nelson Bracesco
    Laboratory de Radiobiología, Department of Biofísica, Facultad Medicina, University of the República, Montevideo, Uruguay
    J Altern Complement Med 9:379-87. 2003
    ..Ip is thus a rich source of polyphenols and has antioxidant properties comparable to those of green tea which merit further in vivo intervention and cross-sectional studies...
  25. ncbi Circulating levels of nitrated apolipoprotein A-I are increased in type 2 diabetic patients
    Ricardo Hermo
    Department of Clinical Laboratory, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Clin Chem Lab Med 43:601-6. 2005
    ..If proven in subsequent functional and in vivo studies, increased nitrated apoA-I would represent another mechanism by which nitrosative stress participates in diabetic macro-angiopathy...
  26. ncbi Lower serum paraoxonase-1 activity in type 2 diabetic patients correlates with nitrated apolipoprotein A-I levels
    Alejandro Gugliucci
    Clin Chim Acta 368:201-2. 2006
  27. ncbi High free serum acrolein levels in bacterial infection and other disease states associated with oxidative stress: a potential biomarker?
    Alejandro Gugliucci
    Clin Chem Lab Med 45:1559-60. 2007
  28. doi Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome: a preliminary study
    Kazuhiko Kotani
    Clin Chim Acta 395:184-5. 2008