Research Topics
Species | A GugliucciSummaryAffiliation: Touro University Country: USA Publications
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Publications
Ischemia-modified albumin levels in cord blood: a case-control study in uncomplicated and complicated deliveriesAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University, California, Vallejo, 94592, USA
Clin Chim Acta 362:155-60. 2005..IMA level in cord blood could then serve as an indicator of fetal hypoxia and fetal tissue ischemia and serve as a biomarker of the severity of these conditions...- Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patientsAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA, USA
Clin Chim Acta 384:105-12. 2007..We also determined whether free serum acrolein levels are higher in renal failure, and assessed whether they decrease after hemodialysis (HD) and whether this change correlates with increases in PON-1 activity... 
Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteineAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310, Johnson Lane, Vallejo, CA 94592, USA
Life Sci 82:413-8. 2008..This could contribute to explain increased thrombogenicity in smokers and in other conditions, as well as pointing at dietary intervention or the use of thiol-conserving reducing compounds as putative coadjuvant therapeutic measures...- Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytesAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
Clin Chem Lab Med 46:1403-9. 2008..This has been shown for low-density lipoprotein, apolipoprotein AI and paraoxonase 1 (PON-1). Notably, plasminogen has 29 tyrosine residues and we previously demonstrated that it can be inactivated by nitration of these residues... - Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochloriteAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
Fitoterapia 80:138-42. 2009..Of interest, 5 caffeoylquinic acid at 5 micromol/L affords more than 60% protection of the activity reaching 100% at 25 micromol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity... - Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteinsA Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island Building H 83, 1310 Johnson Lane, Vallejo, CA 94592, USA
Fitoterapia 80:339-44. 2009..Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of maté tea... - Alternative antiglycation mechanisms: are spermine and fructosamine-3-kinase part of a carbonyl damage control pathway?A Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University California, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
Med Hypotheses 64:770-7. 2005..They could have altered steady state levels of polyamines and/or decreased FN-3-K expression or activity... - Polyamines as clinical laboratory toolsA Gugliucci
Laboratory of Biochemistry, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
Clin Chim Acta 344:23-35. 2004..Next, we will summarize the main analytical methods on which we count, and finally we will address their role in diagnosis of cancer as well their proposed role as antioxidant and antiglycation agents... - Human plasminogen is highly susceptible to peroxynitrite inactivationAlejandro Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island, Vallejo, CA 94592, USA
Clin Chem Lab Med 41:1064-8. 2003..If proven in ulterior in vivo studies, this factor would provide another mechanism by which nitrosative stress participates in diabetic complications... - Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adultsAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Touro University California, Vallejo, CA 94592, USA
Ann Nutr Metab 54:197-201. 2009..Obesity has an inflammatory component, but interestingly there are no studies on serum AGE levels in obesity or on the effects of LCD as a therapeutic measure on these markers of glycation... - The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?A Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University, College of Osteopathic Medicine, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, USA
Life Sci 72:2603-16. 2003..Protection is afforded against glycation by hexoses, trioses and dicarbonyls AGE precursors and is comparable to those of aminoguanidine and carnosine... - A practical method to study functional impairment of proteins by glycation and effects of inhibitors using current coagulation/fibrinolysis reagent kitsAlejandro Gugliucci
Biochemistry Laboratory, Touro University College of Osteopathic Medicine, Mare Island, Vallejo, CA, USA
Clin Biochem 36:155-8. 2003..They provide a practical system for monitoring the action of putative antiglycation agents... - The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin IIIA Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island Building H 83, 832 Walnut Ave, Vallejo, CA 94592, USA
Life Sci 72:279-92. 2002..If predictably milder glycated forms of AT III and plasminogen were to be secreted in vivo, the loss of activities shown here could act synergistically to generate hyperthrombicity... - Is diabetic hypercoagulability an acquired annexinopathy? Glycation of annexin II as a putative mechanism for impaired fibrinolysis in diabetic patientsA Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island, California, Vallejo 94592, USA
Med Hypotheses 59:247-51. 2002..If our hypothesis is correct, one of the components of the increased thrombogenicity seen in diabetic patients might then be an acquired annexinopathy... - Three different pathways for human LDL oxidation are inhibited in vitro by water extracts of the medicinal herb Achyrocline satureoidesA Gugliucci
Biochemistry Laboratory, Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Mare Island Building H 83, 832 Walnut Ave, Vallejo, CA, USA
Life Sci 71:693-705. 2002..In all three systems employed an effect is already substantiated at a concentration of the AS extract of 4 microg/ml, which corresponds to a 1/100 dilution of the preparations usually drunk... - Glycation as the glucose link to diabetic complicationsA Gugliucci
Division of Basic Medical Sciences, Touro University College of Osteopathic Medicine, Vallejo, Calif 94592, USA
J Am Osteopath Assoc 100:621-34. 2000..Results of animal studies and phase III clinical trials reveal that the inhibition of this process attenuates the development of a range of these complications... - Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearanceAlejandro Gugliucci
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Vallejo, CA, USA, and Department of Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama City, Japan
Clin Chim Acta 377:213-20. 2007..We hypothesized that retention of uremic toxins and or "middle molecules" including advanced glycation (AGE) free adducts and peptides could play a mechanistic role in decreasing PON-1 activity... - Circulating advanced glycation peptides in streptozotocin-induced diabetic rats: evidence for preferential modification of IgG light chainsA Gugliucci
Division of Basic Sciences, Touro University College of Osteopathic Medicine, San Francisco, California 94115, USA
Life Sci 62:2141-50. 1998.... - Nitration of human plasminogen by RAW 264.7 macrophages reduces streptokinase-induced plasmin activityChinhnam Hathuc
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University-California, Mare Island, Vallejo, CA 94592, USA
Clin Chem Lab Med 44:213-9. 2006..Nitrosative stress may be implicated in impaired fibrinolysis. New therapeutic approaches for nitrosative stress in atherosclerosis and diabetes should limit the formation of superoxides and peroxynitrite... - Protective action of Ilex paraguariensis extract against free radical inactivation of paraoxonase-1 in high-density lipoproteinTeresita Menini
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University California, Mare Island, Vallejo, CA 94592, USA
Planta Med 73:1141-7. 2007..05). In conclusion, we demonstrate that IP extract may, to some extent, prevent the loss of the antiatherogenic function of HDL afforded by PON-1 when the particle is under oxidant stress... - Ilex paraguariensis extracts inhibit AGE formation more efficiently than green teaNicole Lunceford
Glycation, Oxidation and Disease Laboratory, Division of Basic Medical Sciences, Touro University-California, Mare Island, Vallejo, CA, USA
Fitoterapia 76:419-27. 2005..The inhibition of AGE formation was comparable to that obtained by using millimolar concentrations of the standard antiglycation agent aminoguanidine... - Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicityMindy Bixby
Glycation, Oxidation and Disease Laboratory, Division of Basic Sciences, Touro University-California, 1310 Johnson Lane, Mare Island Vallejo, CA 94592, USA
Life Sci 77:345-58. 2005..Further studies aiming at isolation of the active principles and assessment of their bioavailability are warranted... - "Blinding" of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?A Gugliucci
Glycation, Oxidation and Disease Laboratory, Touro University California, Mare Island Building H 83, 1310, Johnson Lane, Vallejo, CA 94592, USA
Med Hypotheses 73:921-4. 2009..Future targets for type 2 diabetes treatments will likely be those that can effect beneficial changes in the activity of AMPK, and our theory predicts that anti-glycation agents may become part of that armamentarium... - Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidationNelson Bracesco
, , Facultad Medicina, , Montevideo, Uruguay
J Altern Complement Med 9:379-87. 2003..Ip is thus a rich source of polyphenols and has antioxidant properties comparable to those of green tea which merit further in vivo intervention and cross-sectional studies... - Circulating levels of nitrated apolipoprotein A-I are increased in type 2 diabetic patientsRicardo Hermo
Department of Clinical Laboratory, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
Clin Chem Lab Med 43:601-6. 2005..If proven in subsequent functional and in vivo studies, increased nitrated apoA-I would represent another mechanism by which nitrosative stress participates in diabetic macro-angiopathy... - Lower serum paraoxonase-1 activity in type 2 diabetic patients correlates with nitrated apolipoprotein A-I levelsAlejandro Gugliucci
Clin Chim Acta 368:201-2. 2006 - High free serum acrolein levels in bacterial infection and other disease states associated with oxidative stress: a potential biomarker?Alejandro Gugliucci
Clin Chem Lab Med 45:1559-60. 2007 - Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome: a preliminary studyKazuhiko Kotani
Clin Chim Acta 395:184-5. 2008