MADEPALLI KRISHNAPPA LAKSHMANA

Summary

Affiliation: Torrey Pines Institute for Molecular Studies
Country: USA

Publications

  1. pmc Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice
    Crystal D Hayes
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 7:e45841. 2012
  2. pmc RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes
    J P Palavicini
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987 2352, USA
    Cell Death Dis 4:e667. 2013
  3. pmc RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice
    Juan Pablo Palavicini
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 8:e66908. 2013
  4. pmc RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain
    Hongjie Wang
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 9:e85484. 2014
  5. pmc Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine
    Crystal D Hayes
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, SW Village Parkway 11350, Port Saint Lucie, FL 34987, USA
    BMC Med 11:81. 2013
  6. pmc Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain
    Madepalli K Lakshmana
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, USA
    FASEB J 26:2072-83. 2012

Research Grants

Collaborators

  • Crystal D Hayes
  • Hongjie Wang
  • Juan Pablo Palavicini
  • J P Palavicini
  • Ruizhi Wang
  • Shaohua Xu
  • D E Kang
  • S Xu
  • H Wang
  • E Bianchi
  • Brandon Noel Lloyd
  • J S Rao
  • Ken Dawson-Scully
  • Elisabetta Bianchi
  • David E Kang

Detail Information

Publications6

  1. pmc Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice
    Crystal D Hayes
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 7:e45841. 2012
    ..However, whether long-term administration of 2-CDA can lead to any adverse effects in patients or animal models is not yet clearly known...
  2. pmc RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes
    J P Palavicini
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987 2352, USA
    Cell Death Dis 4:e667. 2013
    ..More importantly, both APΔE9 and APΔE9/RanBP9 mice showed impaired learning and memory skills compared to WT controls. These data suggest that RanBP9 might play a crucial role in the loss of spines and synapses in AD...
  3. pmc RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice
    Juan Pablo Palavicini
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 8:e66908. 2013
    ..Both ERK1 and L1CAM interact with RanBP9. Thus, RanBP9 appears to control brain growth and development through signaling mechanisms involving ERK1 and L1CAM receptor...
  4. pmc RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain
    Hongjie Wang
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, United States of America
    PLoS ONE 9:e85484. 2014
    ..01) and drebrin levels by 33% (p<0.01). Taken together these data suggest that RanBP9 overexpression accelerates loss of synaptic proteins in the mouse brain. ..
  5. pmc Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine
    Crystal D Hayes
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, SW Village Parkway 11350, Port Saint Lucie, FL 34987, USA
    BMC Med 11:81. 2013
    ..Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship between cancer and AD. Therefore, we reasoned that oncology drugs may be effective against AD...
  6. pmc Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain
    Madepalli K Lakshmana
    Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, USA
    FASEB J 26:2072-83. 2012
    ..If so, RanBP9 provides a great opportunity to develop novel therapy for AD...

Research Grants1

  1. Role of RanBP9 on dendritic and spine injury in an Alzheimer's mouse model
    MADEPALLI KRISHNAPPA LAKSHMANA; Fiscal Year: 2010
    ..If RanBP9 is confirmed as a bona fide target in vivo in this study, the triple transgenic mice may prove to be useful as an accelerated model for synaptic and behavioral deficits. ..