Research Topics
Genomes and Genes | James BinleySummaryAffiliation: Torrey Pines Institute for Molecular Studies Country: USA Publications
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Detail Information
Publications
HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopesTommy Tong
Torrey Pines Institute for Molecular Studies, San Diego, California, USA
J Virol 86:3574-87. 2012..This suggests that trimer VLPs bear essentially pure native trimer that should allow its unfettered evaluation in a vaccine setting...- Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaquesKarin J Metzner
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
Retrovirology 3:97. 2006.... - Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralizationJames M Binley
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
J Virol 84:5637-55. 2010.... 
Specificities of broadly neutralizing anti-HIV-1 seraJames Binley
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California, USA
Curr Opin HIV AIDS 4:364-72. 2009....- Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120James M Binley
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego CA 92121, USA
Retrovirology 3:39. 2006.... - Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and CJames M Binley
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
J Virol 82:11651-68. 2008.... - Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1Penny L Moore
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
J Virol 80:2515-28. 2006..We hypothesize that these nonfunctional forms of Env on particle surfaces serve to divert the antibody response, helping the virus to evade neutralization... - Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralizationEmma T Crooks
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
Hum Antibodies 14:101-13. 2005..We conclude that these methods, together with other mapping approaches, may provide a better understanding of neutralization that could be useful in vaccine research... - Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralizationEmma T Crooks
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
Virology 377:364-78. 2008..We discuss the implications of these findings in weighing the relative contributions of size, multivalent binding and other possible effects of IgGs to explain their increased potency... - A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120Emma T Crooks
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
Virology 366:245-62. 2007..Therefore, to make progress toward a more effective VLP-based vaccine, we will need to find ways to refocus the attention of B cells on native trimers... - Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trimers intact and viral infectivity unaffectedEma T Crooks
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
J Virol 85:5825-39. 2011..Trimer VLPs" may be useful neutralizing antibody immunogens... 
Identification of a D-amino acid decapeptide HIV-1 entry inhibitorCesar Boggiano
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
Biochem Biophys Res Commun 347:909-15. 2006..These results suggest that dC13 is a useful HIV-1 coreceptor antagonist for CXCR4 and, due to its biostability and simplicity, may be of value for developing a new class of HIV-1 entry inhibitors...- Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodiesJames M Binley
IMM2, Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Virol 78:13232-52. 2004..As well as the significance for vaccine design, our data have implications for passive-immunization studies in countries where clade C viruses are common, given that only MAbs b12 and 4E10 were effective against viruses from this clade... - Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirionsJames M Binley
Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Virol 77:5678-84. 2003..Overall, this disulfide-shackled virus is a unique tool with potential utility in vaccine design, drug discovery, and elucidation of the HIV-1 entry process... - Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexesMaxime Moulard
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:6913-8. 2002.... - Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteinsJames M Binley
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Virol 76:2606-16. 2002..Coexpression of Env cleavage site mutants and furin is therefore a useful method for obtaining high-level expression of processed Env... - An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Josh D Nelson
Department of Immunology, 10550 North Torrey Pines Road IMM 2, The Scripps Research Institute, La Jolla, CA 92037, USA
J Virol 81:4033-43. 2007.... - Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virusKarin J Metzner
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
J Gen Virol 86:3375-84. 2005.... - Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoproteinNORBERT SCHULKE
Progenics Pharmaceuticals Inc, Tarrytown, New York 10591, USA
J Virol 76:7760-76. 2002..Overall, our findings have relevance for rational vaccine design...
Research Grants
- SELECTING ENV TRIMERS IN HIV-VLP VACCINE PRESENTATIONSJames Binley; Fiscal Year: 2007..In Specific Aim 3, we will test the immunogenicity of i) pseudovirions bearing only functional trimers and ii) receptor-engaged pseudovirions attached to autologous macaque lymphocytes. ..