James Binley

Summary

Affiliation: Torrey Pines Institute for Molecular Studies
Country: USA

Publications

  1. pmc M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
    Philippe Selhorst
    Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Antwerp, B 2000, Belgium
    Retrovirology 10:12. 2013
  2. pmc HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes
    Tommy Tong
    Torrey Pines Institute for Molecular Studies, San Diego, California, USA
    J Virol 86:3574-87. 2012
  3. pmc Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Retrovirology 3:97. 2006
  4. pmc Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego CA 92121, USA
    Retrovirology 3:39. 2006
  5. doi request reprint Specificities of broadly neutralizing anti-HIV-1 sera
    James Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California, USA
    Curr Opin HIV AIDS 4:364-72. 2009
  6. pmc Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Virol 84:5637-55. 2010
  7. pmc Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
    J Virol 82:11651-68. 2008
  8. pmc Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1
    Penny L Moore
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Virol 80:2515-28. 2006
  9. pmc Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Virology 377:364-78. 2008
  10. pmc Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Hum Antibodies 14:101-13. 2005

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
    Philippe Selhorst
    Department of Biomedical Sciences, Unit of Virology, Institute of Tropical Medicine, Antwerp, B 2000, Belgium
    Retrovirology 10:12. 2013
    ..HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen...
  2. pmc HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes
    Tommy Tong
    Torrey Pines Institute for Molecular Studies, San Diego, California, USA
    J Virol 86:3574-87. 2012
    ..This suggests that trimer VLPs bear essentially pure native trimer that should allow its unfettered evaluation in a vaccine setting...
  3. pmc Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    Retrovirology 3:97. 2006
    ....
  4. pmc Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego CA 92121, USA
    Retrovirology 3:39. 2006
    ....
  5. doi request reprint Specificities of broadly neutralizing anti-HIV-1 sera
    James Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California, USA
    Curr Opin HIV AIDS 4:364-72. 2009
    ....
  6. pmc Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Virol 84:5637-55. 2010
    ....
  7. pmc Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C
    James M Binley
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
    J Virol 82:11651-68. 2008
    ....
  8. pmc Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1
    Penny L Moore
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Virol 80:2515-28. 2006
    ..We hypothesize that these nonfunctional forms of Env on particle surfaces serve to divert the antibody response, helping the virus to evade neutralization...
  9. pmc Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Virology 377:364-78. 2008
    ..We discuss the implications of these findings in weighing the relative contributions of size, multivalent binding and other possible effects of IgGs to explain their increased potency...
  10. pmc Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Hum Antibodies 14:101-13. 2005
    ..We conclude that these methods, together with other mapping approaches, may provide a better understanding of neutralization that could be useful in vaccine research...
  11. pmc A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120
    Emma T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Virology 366:245-62. 2007
    ..Therefore, to make progress toward a more effective VLP-based vaccine, we will need to find ways to refocus the attention of B cells on native trimers...
  12. ncbi request reprint Identification of a D-amino acid decapeptide HIV-1 entry inhibitor
    Cesar Boggiano
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 347:909-15. 2006
    ..These results suggest that dC13 is a useful HIV-1 coreceptor antagonist for CXCR4 and, due to its biostability and simplicity, may be of value for developing a new class of HIV-1 entry inhibitors...
  13. pmc Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trimers intact and viral infectivity unaffected
    Ema T Crooks
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    J Virol 85:5825-39. 2011
    ..Trimer VLPs" may be useful neutralizing antibody immunogens...
  14. pmc Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes
    Maxime Moulard
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:6913-8. 2002
    ....
  15. pmc Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions
    James M Binley
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:5678-84. 2003
    ..Overall, this disulfide-shackled virus is a unique tool with potential utility in vaccine design, drug discovery, and elucidation of the HIV-1 entry process...
  16. pmc Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins
    James M Binley
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Virol 76:2606-16. 2002
    ..Coexpression of Env cleavage site mutants and furin is therefore a useful method for obtaining high-level expression of processed Env...
  17. pmc Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies
    James M Binley
    IMM2, Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 78:13232-52. 2004
    ..As well as the significance for vaccine design, our data have implications for passive-immunization studies in countries where clade C viruses are common, given that only MAbs b12 and 4E10 were effective against viruses from this clade...
  18. pmc Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein
    NORBERT SCHULKE
    Progenics Pharmaceuticals Inc, Tarrytown, New York 10591, USA
    J Virol 76:7760-76. 2002
    ..Overall, our findings have relevance for rational vaccine design...
  19. ncbi request reprint Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus
    Karin J Metzner
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
    J Gen Virol 86:3375-84. 2005
    ....
  20. pmc An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10
    Josh D Nelson
    Department of Immunology, 10550 North Torrey Pines Road IMM 2, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 81:4033-43. 2007
    ....

Research Grants5

  1. SELECTING ENV TRIMERS IN HIV-VLP VACCINE PRESENTATIONS
    James Binley; Fiscal Year: 2007
    ..In Specific Aim 3, we will test the immunogenicity of i) pseudovirions bearing only functional trimers and ii) receptor-engaged pseudovirions attached to autologous macaque lymphocytes. ..