Weiguo Lu

Summary

Affiliation: TomoTherapy Inc
Country: USA

Publications

  1. ncbi Tomographic motion detection and correction directly in sinogram space
    Weiguo Lu
    Department of Medical Physics, University of Wisconsin Madison 53706, USA
    Phys Med Biol 47:1267-84. 2002
  2. ncbi Image guidance for precise conformal radiotherapy
    Thomas Rockwell Mackie
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 56:89-105. 2003
  3. ncbi Motion-encoded dose calculation through fluence/sinogram modification
    Weiguo Lu
    TomoTherapy Inc, Madison, Wisconsin 53717, USA
    Med Phys 32:118-27. 2005
  4. pmc Breathing-synchronized delivery: a potential four-dimensional tomotherapy treatment technique
    Tiezhi Zhang
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
    Int J Radiat Oncol Biol Phys 68:1572-8. 2007
  5. ncbi A simple fixed-point approach to invert a deformation field
    Mingli Chen
    TomoTherapy, Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 35:81-8. 2008
  6. doi Real-time motion-adaptive delivery (MAD) using binary MLC: II. Rotational beam (tomotherapy) delivery
    Weiguo Lu
    TomoTherapy Incorporated, 1240 Deming Way Madison, WI 53717, USA
    Phys Med Biol 53:6491-511. 2008
  7. doi Real-time motion-adaptive delivery (MAD) using binary MLC: I. Static beam (topotherapy) delivery
    Weiguo Lu
    TomoTherapy Incorporated, 1240 Deming Way Madison, WI 53717, USA
    Phys Med Biol 53:6491-511. 2008
  8. doi Real-time motion-adaptive-optimization (MAO) in TomoTherapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI, USA
    Phys Med Biol 54:4373-98. 2009
  9. ncbi Real-time respiration monitoring using the radiotherapy treatment beam and four-dimensional computed tomography (4DCT)--a conceptual study
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:4469-95. 2006
  10. ncbi Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:4357-74. 2006

Collaborators

Detail Information

Publications28

  1. ncbi Tomographic motion detection and correction directly in sinogram space
    Weiguo Lu
    Department of Medical Physics, University of Wisconsin Madison 53706, USA
    Phys Med Biol 47:1267-84. 2002
    ..The method could be applied to projection data used in CT and ECT, as well as in tomotherapy delivery modification and dose reconstruction...
  2. ncbi Image guidance for precise conformal radiotherapy
    Thomas Rockwell Mackie
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 56:89-105. 2003
    ..To review the state of the art in image-guided precision conformal radiotherapy and to describe how helical tomotherapy compares with the image-guided practices being developed for conventional radiotherapy...
  3. ncbi Motion-encoded dose calculation through fluence/sinogram modification
    Weiguo Lu
    TomoTherapy Inc, Madison, Wisconsin 53717, USA
    Med Phys 32:118-27. 2005
    ....
  4. pmc Breathing-synchronized delivery: a potential four-dimensional tomotherapy treatment technique
    Tiezhi Zhang
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
    Int J Radiat Oncol Biol Phys 68:1572-8. 2007
    ..To introduce a four-dimensional (4D) tomotherapy treatment technique with improved motion control and patient tolerance...
  5. ncbi A simple fixed-point approach to invert a deformation field
    Mingli Chen
    TomoTherapy, Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 35:81-8. 2008
    ..Simulations and real data tests demonstrated the efficacy and the accuracy of the proposed algorithm...
  6. doi Real-time motion-adaptive delivery (MAD) using binary MLC: II. Rotational beam (tomotherapy) delivery
    Weiguo Lu
    TomoTherapy Incorporated, 1240 Deming Way Madison, WI 53717, USA
    Phys Med Biol 53:6491-511. 2008
    ..No hot and cold spots were noticeable. For irregular respiration with some missing breathing cycles, this method demonstrates the capability for motion margin reduction...
  7. doi Real-time motion-adaptive delivery (MAD) using binary MLC: I. Static beam (topotherapy) delivery
    Weiguo Lu
    TomoTherapy Incorporated, 1240 Deming Way Madison, WI 53717, USA
    Phys Med Biol 53:6491-511. 2008
    ..The delivered dose conforms well to the target, and significant margin reduction can be achieved provided that accurate, real-time tumor localization is available...
  8. doi Real-time motion-adaptive-optimization (MAO) in TomoTherapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI, USA
    Phys Med Biol 54:4373-98. 2009
    ..Extension of the method to real-time adaptive radiation therapy (ART) that compensates for all kinds of delivery errors was proposed. Further validation and clinical implementation is underway...
  9. ncbi Real-time respiration monitoring using the radiotherapy treatment beam and four-dimensional computed tomography (4DCT)--a conceptual study
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:4469-95. 2006
    ..This technique can also be applied in other delivery systems such as orthogonal x-ray systems, although in those cases it would entail the delivery of additional non-treatment radiation...
  10. ncbi Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:4357-74. 2006
    ..The applications of deformable registration in ART, including 'deformable dose accumulation', 'automatic re-contouring' and 'tumour growth/regression evaluation' throughout the course of radiotherapy are also studied...
  11. doi A non-voxel-based broad-beam (NVBB) framework for IMRT treatment planning
    Weiguo Lu
    TomoTherapy Inc, Madison, WI 53717, USA
    Phys Med Biol 55:7175-210. 2010
    ..Compared with using the current VBS framework on a computer cluster, the planning time is significantly reduced using the NVBB framework on a single workstation with a GPU card...
  12. ncbi Automatic re-contouring in 4D radiotherapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:1077-99. 2006
    ..This algorithm could also be used to re-contour daily images for treatment evaluation and adaptive radiotherapy...
  13. ncbi Accurate convolution/superposition for multi-resolution dose calculation using cumulative tabulated kernels
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 50:655-80. 2005
    ..5 mm voxels and the voxels up to 8 mm (4 mm) are around 1% of the maximum dose. Among all three methods, the CCK algorithm is demonstrated to be the most accurate one for multi-resolution dose calculations...
  14. ncbi Fast free-form deformable registration via calculus of variations
    Weiguo Lu
    TomoTherapy Inc, Madison, WI 53717, USA
    Phys Med Biol 49:3067-87. 2004
    ..The registration method could also be equally applied in diagnostic radiology...
  15. doi Fluence-convolution broad-beam (FCBB) dose calculation
    Weiguo Lu
    TomoTherapy Inc, Madison, WI 53717, USA
    Phys Med Biol 55:7211-29. 2010
    ..Combined with the 'adaptive full dose correction', the algorithm is well suitable for calculating the iteration dose during IMRT optimization...
  16. doi Adaptive fractionation therapy: I. Basic concept and strategy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 53:5495-511. 2008
    ....
  17. ncbi Treatment plan optimization incorporating respiratory motion
    Tiezhi Zhang
    Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Med Phys 31:1576-86. 2004
    ..Results show that treatment optimization incorporating motion achieved similar high dose conformality on a mobile target compared with static delivery. The residual motion effects due to imperfect breathing tracking were also analyzed...
  18. ncbi Ultrafast convolution/superposition using tabulated and exponential kernels on GPU
    Quan Chen
    TomoTherapy Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 38:1150-61. 2011
    ..Collapsed-cone convolution/superposition (CCCS) dose calculation is the workhorse for IMRT dose calculation. The authors present a novel algorithm for computing CCCS dose on the modern graphic processing unit (GPU)...
  19. doi Adaptive fractionation therapy: II. Biological effective dose
    Mingli Chen
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 53:5513-25. 2008
    ..Extensive simulations demonstrate the effectiveness of our method compared with the conventional fractionation method...
  20. doi Efficient gamma index calculation using fast Euclidean distance transform
    Mingli Chen
    Tomo Therapy Inc, Madison, WI 53717, USA
    Phys Med Biol 54:2037-47. 2009
    ..The gradient can be used to identify the main causes of the discrepancy from the reference distribution at any dose point in the test distribution or incorporated in treatment planning and machine parameter optimization...
  21. doi Theoretical analysis of the thread effect in helical TomoTherapy
    Mingli Chen
    Accuray Inc, Madison, WI, USA
    Med Phys 38:5945-60. 2011
    ..In this work, the factors that cause the thread effect were unveiled, including jaw profile divergence, the inverse square law, attenuation, and the cone effect, and their impact on the thread effect were studied...
  22. ncbi Dynamic tomotherapy delivery
    Yu Chen
    TomoTherapy Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 38:3013-24. 2011
    ..Several dynamic techniques are introduced to speed up TomoTherapy delivery and improve longitudinal conformity. These techniques include dynamic jaws, dynamic couch, and their combinations...
  23. ncbi A slit method to determine the focal spot size and shape of TomoTherapy system
    Quan Chen
    TomoTherapy, Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 38:2841-9. 2011
    ..The slit model allows the use of a shorter and more easily available slit-collimator, while accurate source profile measurements can still be obtained...
  24. doi Quantitative characterization of tomotherapy MVCT dosimetry
    Mingli Chen
    21st Century Oncology, Madison, WI 53719, USA
    Med Dosim 38:280-6. 2013
    ..The results can provide an overall picture of dose distribution and a reference data set that enables estimation of CT dose index for the tomotherapy MVCT. ..
  25. ncbi Generalized equivalent field size for nonuniform fluence maps in IMRT dose calculation
    Mingli Chen
    TomoTherapy Inc, 1240 Deming Way, Madison, Wisconsin 53717, USA
    Med Phys 38:449-54. 2011
    ..However, its application is limited to fluence maps with uniform intensity. In this work, we propose a generalized EFS (GEFS) for nonuniform fluence maps and present a formula for GEFS-based dose calculation...
  26. ncbi Fast treatment plan modification with an over-relaxed Cimmino algorithm
    Chuan Wu
    Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Med Phys 31:191-200. 2004
    ..It takes us using the ORC algorithm to finish a treatment plan modification at least three times faster than the re-optimization procedure compared...
  27. ncbi Evaluation of two tomotherapy-based techniques for the delivery of whole-breast intensity-modulated radiation therapy
    Victor J Gonzalez
    Florida State University College of Medicine, Tallahassee, FL, USA
    Int J Radiat Oncol Biol Phys 65:284-90. 2006
    ..To evaluate two different techniques for whole-breast treatments delivered using the Hi-ART II tomotherapy device...
  28. doi Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformable image registration
    Choonik Lee
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 71:1563-71. 2008
    ..To analyze changes in parotid gland dose resulting from anatomic changes throughout a course of radiotherapy in a cohort of head-and-neck cancer patients...