Hongxia Zhou

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    Cao Huang
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002011. 2011
  2. pmc Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime
    Cao Huang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 6:396-406. 2010
  3. pmc TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
    Tian Tian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:234-43. 2011
  4. pmc Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
    Hongxia Zhou
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:753-61. 2011
  5. pmc Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
    Hongxia Zhou
    Department of Neurology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:1180-7. 2011
  6. pmc Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
    Hongxia Zhou
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 6:e1000887. 2010
  7. pmc A construct with fluorescent indicators for conditional expression of miRNA
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    BMC Biotechnol 8:77. 2008
  8. pmc Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
    Jianbin Tong
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 32:1917-26. 2013
  9. pmc Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
    Cao Huang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Mol Genet 21:4602-14. 2012
  10. pmc Reactive astrocytes secrete lcn2 to promote neuron death
    Fangfang Bi
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 110:4069-74. 2013

Collaborators

Detail Information

Publications16

  1. pmc FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    Cao Huang
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002011. 2011
    ..Our FUS transgenic rats reproduced some phenotypes of ALS and FTLD and will provide a useful model for mechanistic studies of FUS-related diseases...
  2. pmc Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime
    Cao Huang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 6:396-406. 2010
    ..To faithfully model the pathology of TDP-43- or FUS gene mutations in rodents, we must replicate the expression patterns of the TDP-43 and the FUS gene in animals...
  3. pmc TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice
    Tian Tian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:234-43. 2011
    ..Our finding provides in vivo evidence suggesting that disease proteins such as TDP-43 and α-synuclein may play a synergistic role in disease induction in neurodegenerative diseases...
  4. pmc Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake
    Hongxia Zhou
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:753-61. 2011
    ....
  5. pmc Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice
    Hongxia Zhou
    Department of Neurology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 7:1180-7. 2011
    ....
  6. pmc Transgenic rat model of neurodegeneration caused by mutation in the TDP gene
    Hongxia Zhou
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 6:e1000887. 2010
    ..TDP transgenic rats will be useful for deciphering the mechanisms underlying TDP-43-related neurodegenerative diseases...
  7. pmc A construct with fluorescent indicators for conditional expression of miRNA
    Linghua Qiu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    BMC Biotechnol 8:77. 2008
    ..Furthermore, because microRNA (miRNA) targeting specific genes can be expressed simultaneously with protein coding genes, incorporation of fluorescent marker proteins can simplify the screening and analysis of transgenic RNAi animals...
  8. pmc Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
    Jianbin Tong
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 32:1917-26. 2013
    ..This motor neuron death likely involves deficiency in neuroprotective genes and induction of neurotoxic genes in astrocytes. ..
  9. pmc Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
    Cao Huang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Mol Genet 21:4602-14. 2012
    ..As rosiglitazone is clinically used to treat diabetes, our results would encourage immediate application of PPAR-γ agonists in treating patients with cortical dementia...
  10. pmc Reactive astrocytes secrete lcn2 to promote neuron death
    Fangfang Bi
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 110:4069-74. 2013
    ..Partial depletion of lcn2 by immunoprecipitation reduced conditioned medium-mediated neurotoxicity. Our data indicate that reactive astrocytes secrete lcn2, which is a potent neurotoxic mediator...
  11. pmc XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats
    Jianbin Tong
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    J Neurochem 123:406-16. 2012
    ..Although it remains to determine how mutation of TDP-43 leads to the failure of the UPR, our data demonstrate that failure of the UPR is implicated in TDP-43 pathogenesis...
  12. pmc Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
    Cao Huang
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 122:107-18. 2012
    ..Our finding suggests that mutant TDP-43 in motor neurons is sufficient to promote the onset and progression of ALS and that motor neuron degeneration is partially reversible, at least in mutant TDP-43 transgenic rats...
  13. pmc Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice
    Hongxia Zhou
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 3:242-50. 2007
    ..The results demonstrate that silencing of the PINK1 gene does not induce a reliable mouse model for Parkinson's disease, but that technically the inducible U6 promoter is useful for conditional RNAi in vivo...
  14. pmc Developing tTA transgenic rats for inducible and reversible gene expression
    Hongxia Zhou
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biol Sci 5:171-81. 2009
    ..The tTA transgenic rat allows for inducible and reversible gene expression in the rat; this important tool will be valuable in the development of genetic rat models of human diseases...
  15. pmc Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity
    Fangfang Bi
    Department of Neurology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Int J Biol Sci 9:149-55. 2013
    ..A loss of neuroprotective functions contributes to the pathogenesis of VPS35 mutation in Parkinson's disease...
  16. pmc A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem
    Hongxia Zhou
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 508 JAH, 1020 Locust Avenue, Philadelphia, PA 19107, USA
    Biochim Biophys Acta 1779:773-9. 2008
    ..This newly developed U6 miRNA system would make multi-gene silencing efficient and reversible...