Agnieszka K Witkiewicz

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. doi request reprint RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cancer Res 18:5110-22. 2012
  2. pmc Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    Agnieszka K Witkiewicz
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1108-17. 2012
  3. pmc An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    Agnieszka K Witkiewicz
    Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:2023-34. 2009
  4. ncbi request reprint Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer
    Agnieszka K Witkiewicz
    Stem Cell Biology and Regenerative Medicine Center, Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Biol Ther 8:1071-9. 2009
  5. doi request reprint Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 41:26-32. 2010
  6. pmc Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers
    Agnieszka K Witkiewicz
    Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 10:135-43. 2010
  7. pmc Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 10:391-6. 2010
  8. pmc Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue
    Federica Sotgia
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1445-54. 2012
  9. pmc Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue
    Diana Whitaker-Menezes
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:4047-64. 2011
  10. pmc Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions
    Isabelle Mercier
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:1172-90. 2009

Collaborators

Detail Information

Publications60

  1. doi request reprint RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cancer Res 18:5110-22. 2012
    ..We sought to determine whether dysregulation of the retinoblastoma (RB) tumor suppressor pathway was associated with improved response to neoadjuvant chemotherapy in breast cancer...
  2. pmc Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    Agnieszka K Witkiewicz
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1108-17. 2012
    ....
  3. pmc An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    Agnieszka K Witkiewicz
    Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:2023-34. 2009
    ..We conclude that Cav-1 functions as a tumor suppressor in the stromal microenvironment...
  4. ncbi request reprint Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer
    Agnieszka K Witkiewicz
    Stem Cell Biology and Regenerative Medicine Center, Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Biol Ther 8:1071-9. 2009
    ..Thus, determination of stromal Cav-1 levels may be a useful new biomarker for guiding the treatment of ER(+) DCIS patients...
  5. doi request reprint Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 41:26-32. 2010
    ..These results suggest that progestin treatment affects subpopulations of lymphocytes in the endometrium and may induce immune suppression of complex atypical hyperplasia and well-differentiated endometrial carcinoma...
  6. pmc Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers
    Agnieszka K Witkiewicz
    Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 10:135-43. 2010
    ..Our current findings may have important implications for the close monitoring and treatment stratification of TN and basal-like breast cancer patients...
  7. pmc Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 10:391-6. 2010
    ..Thus, stromal CD10 and SPARC expression levels are promising markers of DCIS recurrence and warrant evaluation in larger prospective studies...
  8. pmc Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue
    Federica Sotgia
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1445-54. 2012
    ..Finally, MCT4(+) and TO MM20(-) "glycolytic" cancer cells were rarely observed, indicating that the conventional "Warburg effect" does not frequently occur in cancer-positive lymph node metastases...
  9. pmc Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue
    Diana Whitaker-Menezes
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:4047-64. 2011
    ..Thus, we believe that mitochondria are both the "powerhouse" and "Achilles' heel" of cancer cells...
  10. pmc Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions
    Isabelle Mercier
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:1172-90. 2009
    ..Thus, Cav-1(-/-) null mice are a new preclinical model for studying the molecular paradigm of estrogen hypersensitivity and the development of estrogen-dependent ductal carcinoma in situ lesions...
  11. pmc Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
    Barbara Chiavarina
    Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer Biol Ther 12:1101-13. 2011
    ..As such, this subgroup of patients may benefit therapeutically from potent inhibitors targeting glycolysis, autophagy and/or mitochondrial activity (such as metformin)...
  12. pmc Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    Diana Whitaker-Menezes
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1772-83. 2011
    ..Most importantly, our current findings provide a new rationale and novel strategy for anti-cancer therapies, by employing MCT inhibitors...
  13. doi request reprint HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    Nathan G Richards
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Ann Surg 252:499-505; discussion 505-6. 2010
    ..Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year...
  14. doi request reprint Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma
    Adam D Toll
    Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    Hum Pathol 41:1205-9. 2010
    ..Our study suggests that E-cadherin down-regulation may lead to enhancer of zeste homologue 2-mediated invasion and metastasis...
  15. doi request reprint Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival
    Karen N Wu
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:4250-5. 2011
    ..0001). In conclusion, high expression of stromal Cav-1 correlates with longer survival in malignant melanoma metastases, and high expression of Cav-1 in melanoma cells correlates with longer survival in primary malignant melanoma...
  16. pmc Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
    Matias E Valsecchi
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    BMC Cancer 12:104. 2012
    ..RRM1 and ERCC1 overexpression has been extensively investigated as potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most thoroughly in lung cancer. However, data in pancreatic cancer are scarce...
  17. pmc Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3256-76. 2010
    ..As such, the effects of stromal oxidative stress can be laterally propagated, amplified and are effectively "contagious"--spread from cell-to-cell like a virus--creating an "oncogenic/mutagenic" field promoting widespread DNA damage...
  18. pmc Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure
    Amy R Peck
    Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
    J Clin Oncol 29:2448-58. 2011
    ..To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5) as a marker of prognosis in node-negative breast cancer and as a predictor of response to antiestrogen therapy...
  19. ncbi request reprint Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2423-33. 2010
    ..We discuss this possibility, in light of the launch of a new clinical trial that uses chloroquine to treat DCIS patients: PINC (Preventing Invasive Breast Neoplasia with Cholorquine) [See http://clinicaltrials.gov/show/NCT01023477]...
  20. pmc Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis
    Remedios Castelló-Cros
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2021-34. 2011
    ..Thus, the secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism...
  21. pmc Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology and The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3515-33. 2010
    ..These complementary targeted therapies could be administered either individually or in combination, to prevent the onset of autophagy in the tumor stromal compartment, which results in a "lethal" tumor microenvironment...
  22. pmc Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers
    Agnieszka K Witkiewicz
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1794-809. 2011
    ....
  23. pmc PTP1B suppresses prolactin activation of Stat5 in breast cancer cells
    Kevin J Johnson
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 177:2971-83. 2010
    ..Collectively, our data implicate PTP1B as an important negative regulator of Stat5 phosphorylation in invasive breast cancer...
  24. ncbi request reprint Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy
    Agnieszka K Witkiewicz
    Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Cycle 8:1654-8. 2009
    ....
  25. ncbi request reprint The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
    ..We also identify the stromal expression of PKM2 and LDH-B as new candidate biomarkers for the "Reverse Warburg Effect" or "Stromal-Epithelial Metabolic Coupling" in human breast cancers...
  26. doi request reprint Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia
    Erik S Knudsen
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Breast Cancer Res Treat 133:1009-24. 2012
    ..Together, these studies indicate that lesion-specific differences in gene expression associated with invasive phenotype are particularly relevant in the progression of DCIS to invasive breast cancer...
  27. pmc Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors
    Jeffry L Dean
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:2756-61. 2012
    ..These studies provide important insights into the spectrum of breast tumors that could be treated with CDK4/6 inhibitors, and defines functional determinants of response analogous to those identified through neoadjuvant studies...
  28. ncbi request reprint The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
    ..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value...
  29. pmc Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
    Federica Sotgia
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
    Am J Pathol 174:746-61. 2009
    ..Thus, these results have important implications for understanding the role of cancer-associated fibroblasts and RB inactivation in promoting tumor angiogenesis...
  30. ncbi request reprint Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation
    Isabelle Mercier
    Kimmel Cancer Center, Department of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Cycle 8:1396-401. 2009
    ..As such, the punctate Cav-1 immunostaining pattern can now be used as a screening tool to select patients for Cav-1 mutational analysis...
  31. ncbi request reprint Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome
    Agnieszka K Witkiewicz
    Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 7:3021-5. 2008
    ..Thus, Cav-1 and FASN may functionally cooperate in the process of pancreatic tumorigenesis, and as such, may be good candidate prognostic markers and targets for therapeutic intervention...
  32. pmc EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer
    Erik S Knudsen
    Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA
    Cell Cycle 12:2042-50. 2013
    ..Therefore, ALDH1 within the DCIS lesion can add to the prognostic significance of EZH2, particularly in the context of risk of development of invasive disease. ..
  33. pmc Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer
    Chellappagounder Thangavel
    Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    Endocr Relat Cancer 18:333-45. 2011
    ..These findings underscore the clinical utility of downstream cytostatic therapies in treating tumors that have experienced failure of endocrine therapy...
  34. pmc Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma
    Kathryn C Behling
    Department of Pathology, Thomas Jefferson University and Kimmel Cancer Center, Philadelphia, PA 19107, USA
    Breast Cancer Res Treat 129:717-24. 2011
    ..23, P = 0.067). In conclusion, SIAH may represent a useful prognostic biomarker that predicts DCIS progression to invasive breast cancer...
  35. pmc Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation
    Federica Sotgia
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
    Am J Pathol 174:613-29. 2009
    ..Our current studies have broad implications for using the lactogenic microenvironment as a paradigm to discover new therapies for the prevention and/or treatment of human breast cancers...
  36. pmc The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    Christina L Costantino
    Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 69:4567-72. 2009
    ..We propose that HuR levels in PDA modulate the therapeutic efficacy of gemcitabine, thus serving as a marker of the clinical utility of this common chemotherapeutic agent and a potential target for intervention in pancreatic cancer...
  37. pmc Regulation of miR106b cluster through the RB pathway: mechanism and functional targets
    Chellappagounder Thangavel
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Cell Cycle 12:98-111. 2013
    ..These data provide a mechanistic basis for cross-talk between the RB pathway and p21 and PTEN through the regulation of the MCM7/miR106b locus...
  38. pmc Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 179:1171-8. 2011
    ..Together, the data herein describe dual aspects of RB-pathway biology that are associated with disease recurrence through the epithelial or stromal compartment of DCIS...
  39. doi request reprint Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma
    Matias E Valsecchi
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cancer 118:3484-93. 2012
    ....
  40. pmc pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs
    Timothy K Williams
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e15455. 2010
    ..Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy...
  41. pmc Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3
    Ethan V Abel
    Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 123:2155-68. 2013
    ....
  42. doi request reprint Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient
    Vanessa A Talbott
    Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Surg Res 176:154-8. 2012
    ..Studying molecular markers of synchronous and metachronous lesions may aid to clarify the biology of this often deadly disease...
  43. doi request reprint Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature
    Adam D Toll
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    Int J Surg Pathol 19:795-9. 2011
    ..In addition, the authors review the published cases reporting acinar cell carcinoma with intraductal and/or papillary growth patterns...
  44. pmc Caveolin-2-deficient mice show increased sensitivity to endotoxemia
    Cecilia J de Almeida
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2151-61. 2011
    ....
  45. doi request reprint RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control
    Ryan J Bourgo
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 43:663-72. 2011
    ..Together, these studies establish an essential role of the LXCXE binding motif for RB-mediated transcriptional control, response to genotoxic insult, and tumor suppression...
  46. ncbi request reprint Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway
    Shayna L Showalter
    Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Gastroenterol Hepatol 25:738-44. 2010
    ..We hypothesized that the well-tolerated and naturally occurring VK1 and VK2 may be used to inhibit pancreatic cancer cell survival...
  47. doi request reprint Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma
    Jonathan R Brody
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Mod Pathol 22:651-9. 2009
    ..In summary, although pancreatic adenosquamous carcinoma and ductal adenocarcinoma have overlapping pathologic and molecular characteristics, there are distinct differences that may be helpful in diagnostic and therapeutic strategies...
  48. pmc Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:781-7; discussion 787-9. 2009
    ..We hypothesize that expression of the IDO2 enzyme in primary pancreatic ductal adenocarcinomas (PDA) can help cancer cells evade immune detection...
  49. pmc Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism
    Thai H Tran
    Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Res 70:1711-21. 2010
    ..52; P < 0.001) but not with Stat5b. Loss of prolactin-Stat5a signaling and concomitant upregulation of BCL6 may represent a regulatory switch facilitating undifferentiated histology and poor prognosis of breast cancer...
  50. doi request reprint Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma
    Matias E Valsecchi
    Departments of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Melanoma Res 23:33-9. 2013
    ..Therapeutic approaches targeting SSTR might be beneficial in patients with metastatic uveal melanoma...
  51. ncbi request reprint Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival
    Jonathan R Brody
    Department of Surgery, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
    Cell Cycle 8:1930-4. 2009
    ..These data support the notion that metastatic MM cells select for expression of IDO to evade immunologic detection. Therefore, inhibition of IDO in MM patients may be a useful treatment strategy...
  52. ncbi request reprint Expression of K homology domain containing protein (KOC) in pancreatic cytology with corresponding histology
    Adam D Toll
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    Acta Cytol 53:123-9. 2009
    ....
  53. pmc The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments
    Agnieszka K Witkiewicz
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2497-503. 2011
    ..As reviewed here, the alternative expression of p16(ink4a) represents an ideal marker for considering RB-pathway function, tumor heterogeneity, and novel means for directing therapy...
  54. ncbi request reprint Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis
    Agnieszka K Witkiewicz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 14:1418-23. 2005
    ..Quantitative image analysis is a novel way to accurately and reproducibly evaluate immunohistochemistry in breast tissue samples using high-density tissue microarrays...
  55. pmc The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
    Ankur Sharma
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:4478-92. 2010
    ..Together, these data reveal what we believe to be a new paradigm for RB function in controlling prostate tumor progression and lethal tumor phenotypes...
  56. ncbi request reprint Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells
    Agnieszka K Witkiewicz
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 36:154-61. 2005
    ..Using antibodies to basal cell markers, we analyzed biopsies with MGH to profile the distribution and evolution of reserve cells and their relationship to these epithelial components...
  57. doi request reprint Detection of Merkel cell carcinoma polyomavirus in mucosal Merkel cell carcinoma
    Karen N Wu
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Surg Pathol 18:342-6. 2010
    ..This is the first report to demonstrate the presence of MCPyV and CM2B4 in a mucosal MCC and its metastasis...
  58. ncbi request reprint Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin
    Karen N Wu
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3593-7. 2009
    ..In aGVHD of the skin, T-regs increased with the degree of inflammation and GVHD grade. Mast cells were present at the same density whether aGVHD was of lower or higher grade...
  59. ncbi request reprint Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast
    Jorge Albores-Saavedra
    Department of Pathology, Louisiana State University, Health Sciences Center School of Medicine, Shreveport, USA
    Am J Clin Pathol 123:866-73. 2005
    ..However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane...
  60. pmc RB tumor suppressive function in response to xenobiotic hepatocarcinogens
    Christopher Reed
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania
    Am J Pathol 184:1853-9. 2014
    ..These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress. ..