Research Topics
Genomes and Genes
| Agnieszka K WitkiewiczSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Detail Information
Publications
RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancerAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Clin Cancer Res 18:5110-22. 2012..We sought to determine whether dysregulation of the retinoblastoma (RB) tumor suppressor pathway was associated with improved response to neoadjuvant chemotherapy in breast cancer...
Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancersAgnieszka K Witkiewicz
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 11:1108-17. 2012....
Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancerAgnieszka K Witkiewicz
Stem Cell Biology and Regenerative Medicine Center, Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Biol Ther 8:1071-9. 2009..Thus, determination of stromal Cav-1 levels may be a useful new biomarker for guiding the treatment of ER(+) DCIS patients...- An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancersAgnieszka K Witkiewicz
Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
Am J Pathol 174:2023-34. 2009..We conclude that Cav-1 functions as a tumor suppressor in the stromal microenvironment... - Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestinsAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Hum Pathol 41:26-32. 2010..These results suggest that progestin treatment affects subpopulations of lymphocytes in the endometrium and may induce immune suppression of complex atypical hyperplasia and well-differentiated endometrial carcinoma... - Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancersAgnieszka K Witkiewicz
Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, PA, USA
Cancer Biol Ther 10:135-43. 2010..Our current findings may have important implications for the close monitoring and treatment stratification of TN and basal-like breast cancer patients... - Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrenceAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
Cancer Biol Ther 10:391-6. 2010..Thus, stromal CD10 and SPARC expression levels are promising markers of DCIS recurrence and warrant evaluation in larger prospective studies... - Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissueFederica Sotgia
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 11:1445-54. 2012..Finally, MCT4(+) and TO MM20(-) "glycolytic" cancer cells were rarely observed, indicating that the conventional "Warburg effect" does not frequently occur in cancer-positive lymph node metastases... - Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissueDiana Whitaker-Menezes
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:4047-64. 2011..Thus, we believe that mitochondria are both the "powerhouse" and "Achilles' heel" of cancer cells... - Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesionsIsabelle Mercier
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Am J Pathol 174:1172-90. 2009..Thus, Cav-1(-/-) null mice are a new preclinical model for studying the molecular paradigm of estrogen hypersensitivity and the development of estrogen-dependent ductal carcinoma in situ lesions... - Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblastsDiana Whitaker-Menezes
Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:1772-83. 2011..Most importantly, our current findings provide a new rationale and novel strategy for anti-cancer therapies, by employing MCT inhibitors... - Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinomaAdam D Toll
Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
Hum Pathol 41:1205-9. 2010..Our study suggests that E-cadherin down-regulation may lead to enhancer of zeste homologue 2-mediated invasion and metastasis... - HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patientsNathan G Richards
Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Ann Surg 252:499-505; discussion 505-6. 2010..Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year... - Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survivalKaren N Wu
Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:4250-5. 2011..0001). In conclusion, high expression of stromal Cav-1 correlates with longer survival in malignant melanoma metastases, and high expression of Cav-1 in melanoma cells correlates with longer survival in primary malignant melanoma... - Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?Matias E Valsecchi
Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
BMC Cancer 12:104. 2012..RRM1 and ERCC1 overexpression has been extensively investigated as potential predictive markers of tumor sensitivity to conventional chemotherapy agents, most thoroughly in lung cancer. However, data in pancreatic cancer are scarce... - Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cellsUbaldo E Martinez-Outschoorn
Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:3256-76. 2010.... - Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitorsUbaldo E Martinez-Outschoorn
Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:2423-33. 2010..We discuss this possibility, in light of the launch of a new clinical trial that uses chloroquine to treat DCIS patients: PINC (Preventing Invasive Breast Neoplasia with Cholorquine) [See http://clinicaltrials.gov/show/NCT01023477]... - Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failureAmy R Peck
Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
J Clin Oncol 29:2448-58. 2011..To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5) as a marker of prognosis in node-negative breast cancer and as a predictor of response to antiestrogen therapy... - Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasisRemedios Castelló-Cros
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:2021-34. 2011..Thus, the secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism... - Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironmentUbaldo E Martinez-Outschoorn
Department of Medical Oncology and The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:3515-33. 2010..These complementary targeted therapies could be administered either individually or in combination, to prevent the onset of autophagy in the tumor stromal compartment, which results in a "lethal" tumor microenvironment... - Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancersAgnieszka K Witkiewicz
Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:1794-809. 2011.... - PTP1B suppresses prolactin activation of Stat5 in breast cancer cellsKevin J Johnson
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Pathol 177:2971-83. 2010..Collectively, our data implicate PTP1B as an important negative regulator of Stat5 phosphorylation in invasive breast cancer... - The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblastsGloria Bonuccelli
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:1960-71. 2010..We also identify the stromal expression of PKM2 and LDH-B as new candidate biomarkers for the "Reverse Warburg Effect" or "Stromal-Epithelial Metabolic Coupling" in human breast cancers... - Towards a new "stromal-based" classification system for human breast cancer prognosis and therapyAgnieszka K Witkiewicz
Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cell Cycle 8:1654-8. 2009.... - Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepitheliaErik S Knudsen
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Breast Cancer Res Treat 133:1009-24. 2012..Together, these studies indicate that lesion-specific differences in gene expression associated with invasive phenotype are particularly relevant in the progression of DCIS to invasive breast cancer... - Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumorsJeffry L Dean
Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 11:2756-61. 2012..These studies provide important insights into the spectrum of breast tumors that could be treated with CDK4/6 inhibitors, and defines functional determinants of response analogous to those identified through neoadjuvant studies... - Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblastsFederica Sotgia
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10 Street, Philadelphia, PA 19107, USA
Am J Pathol 174:746-61. 2009..Thus, these results have important implications for understanding the role of cancer-associated fibroblasts and RB inactivation in promoting tumor angiogenesis... - The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stromaStephanos Pavlides
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 8:3984-4001. 2009..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value... - Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutationIsabelle Mercier
Kimmel Cancer Center, Department of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cell Cycle 8:1396-401. 2009..As such, the punctate Cav-1 immunostaining pattern can now be used as a screening tool to select patients for Cav-1 mutational analysis... - Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcomeAgnieszka K Witkiewicz
Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cell Cycle 7:3021-5. 2008..Thus, Cav-1 and FASN may functionally cooperate in the process of pancreatic tumorigenesis, and as such, may be good candidate prognostic markers and targets for therapeutic intervention... - Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancerChellappagounder Thangavel
Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
Endocr Relat Cancer 18:333-45. 2011..These findings underscore the clinical utility of downstream cytostatic therapies in treating tumors that have experienced failure of endocrine therapy... - Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinomaKathryn C Behling
Department of Pathology, Thomas Jefferson University and Kimmel Cancer Center, Philadelphia, PA 19107, USA
Breast Cancer Res Treat 129:717-24. 2011..23, P = 0.067). In conclusion, SIAH may represent a useful prognostic biomarker that predicts DCIS progression to invasive breast cancer... - The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinaseChristina L Costantino
Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Res 69:4567-72. 2009..We propose that HuR levels in PDA modulate the therapeutic efficacy of gemcitabine, thus serving as a marker of the clinical utility of this common chemotherapeutic agent and a potential target for intervention in pancreatic cancer... - Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formationFederica Sotgia
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
Am J Pathol 174:613-29. 2009..Our current studies have broad implications for using the lactogenic microenvironment as a paradigm to discover new therapies for the prevention and/or treatment of human breast cancers... - Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironmentAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Am J Pathol 179:1171-8. 2011..Together, the data herein describe dual aspects of RB-pathway biology that are associated with disease recurrence through the epithelial or stromal compartment of DCIS... - Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinomaMatias E Valsecchi
Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
Cancer 118:3484-93. 2012.... - pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAsTimothy K Williams
Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e15455. 2010..Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy... - Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growthBarbara Chiavarina
Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cancer Biol Ther 12:1101-13. 2011..As such, this subgroup of patients may benefit therapeutically from potent inhibitors targeting glycolysis, autophagy and/or mitochondrial activity (such as metformin)... - Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patientVanessa A Talbott
Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Surg Res 176:154-8. 2012..Studying molecular markers of synchronous and metachronous lesions may aid to clarify the biology of this often deadly disease... - Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literatureAdam D Toll
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
Int J Surg Pathol 19:795-9. 2011..In addition, the authors review the published cases reporting acinar cell carcinoma with intraductal and/or papillary growth patterns... - Caveolin-2-deficient mice show increased sensitivity to endotoxemiaCecilia J de Almeida
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:2151-61. 2011.... - RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional controlRyan J Bourgo
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Mol Cell 43:663-72. 2011..Together, these studies establish an essential role of the LXCXE binding motif for RB-mediated transcriptional control, response to genotoxic insult, and tumor suppression... - Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active targetAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Am Coll Surg 208:781-7; discussion 787-9. 2009..We hypothesize that expression of the IDO2 enzyme in primary pancreatic ductal adenocarcinomas (PDA) can help cancer cells evade immune detection... - Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinomaJonathan R Brody
Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
Mod Pathol 22:651-9. 2009..In summary, although pancreatic adenosquamous carcinoma and ductal adenocarcinoma have overlapping pathologic and molecular characteristics, there are distinct differences that may be helpful in diagnostic and therapeutic strategies... - Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathwayShayna L Showalter
Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Gastroenterol Hepatol 25:738-44. 2010..We hypothesized that the well-tolerated and naturally occurring VK1 and VK2 may be used to inhibit pancreatic cancer cell survival... - Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanismThai H Tran
Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA
Cancer Res 70:1711-21. 2010..52; P < 0.001) but not with Stat5b. Loss of prolactin-Stat5a signaling and concomitant upregulation of BCL6 may represent a regulatory switch facilitating undifferentiated histology and poor prognosis of breast cancer... - The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developmentsAgnieszka K Witkiewicz
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:2497-503. 2011..As reviewed here, the alternative expression of p16(ink4a) represents an ideal marker for considering RB-pathway function, tumor heterogeneity, and novel means for directing therapy... - Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survivalJonathan R Brody
Department of Surgery, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
Cell Cycle 8:1930-4. 2009..These data support the notion that metastatic MM cells select for expression of IDO to evade immunologic detection. Therefore, inhibition of IDO in MM patients may be a useful treatment strategy... - Expression of K homology domain containing protein (KOC) in pancreatic cytology with corresponding histologyAdam D Toll
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
Acta Cytol 53:123-9. 2009.... - Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysisAgnieszka K Witkiewicz
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 14:1418-23. 2005..Quantitative image analysis is a novel way to accurately and reproducibly evaluate immunohistochemistry in breast tissue samples using high-density tissue microarrays... - The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progressionAnkur Sharma
Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Clin Invest 120:4478-92. 2010..Together, these data reveal what we believe to be a new paradigm for RB function in controlling prostate tumor progression and lethal tumor phenotypes... - Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cellsAgnieszka K Witkiewicz
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Hum Pathol 36:154-61. 2005..Similar patterns are seen in cervical neoplasia, suggesting a link between benign and neoplastic cervical epithelial differentiation... - Detection of Merkel cell carcinoma polyomavirus in mucosal Merkel cell carcinomaKaren N Wu
Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Surg Pathol 18:342-6. 2010..This is the first report to demonstrate the presence of MCPyV and CM2B4 in a mucosal MCC and its metastasis... - Somatostatin receptor scintigraphy in patients with metastatic uveal melanomaMatias E Valsecchi
Departments of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Melanoma Res 23:33-9. 2013..Therapeutic approaches targeting SSTR might be beneficial in patients with metastatic uveal melanoma... - Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skinKaren N Wu
Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 8:3593-7. 2009..In aGVHD of the skin, T-regs increased with the degree of inflammation and GVHD grade. Mast cells were present at the same density whether aGVHD was of lower or higher grade... - Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breastJorge Albores-Saavedra
Department of Pathology, Louisiana State University, Health Sciences Center School of Medicine, Shreveport, USA
Am J Clin Pathol 123:866-73. 2005..However, adenoid cystic carcinoma displays an infiltrative growth pattern, cytologic atypia, and mitotic figures and lacks the continuous, thickened basement membrane...