Kevin Jon Williams

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellul
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Virol J 5:11. 2008
  2. doi request reprint Rapid regression of atherosclerosis: insights from the clinical and experimental literature
    Kevin Jon Williams
    Department of Medicine Division of Endocrinology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nat Clin Pract Cardiovasc Med 5:91-102. 2008
  3. ncbi request reprint Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Diabetes 54:1116-22. 2005
  4. pmc Molecular processes that handle -- and mishandle -- dietary lipids
    Kevin Jon Williams
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5005, USA
    J Clin Invest 118:3247-59. 2008
  5. pmc Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
    Cecilia M Devlin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 28:1723-30. 2008
  6. pmc Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke
    Chun jun Li
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Pathol 182:1552-62. 2013
  7. pmc Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
    Mingzhen Li
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 30:1818-24. 2010
  8. ncbi request reprint Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification
    Ming Lin Liu
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, 3322 North Broad Street, Medical Office Building, Room 212, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 32:2113-21. 2012
  9. doi request reprint The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
    Xiangdong Wu
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Lipidol 23:334-44. 2012
  10. pmc Decorin deficiency enhances progressive nephropathy in diabetic mice
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Pathol 171:1441-50. 2007

Research Grants

  1. Transmigration of HIV-1-infected cells in NeuroAIDS
    Kevin Jon Williams; Fiscal Year: 2006

Collaborators

Detail Information

Publications23

  1. pmc Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellul
    Johanna A Smith
    Division of Infectious Diseases Center for Human Virology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Virol J 5:11. 2008
    ..A model is proposed emphasizing similarities and differences between PIR and DSB repair. Differences between the pathways may eventually allow strategies to block PIR while still allowing DSB repair...
  2. doi request reprint Rapid regression of atherosclerosis: insights from the clinical and experimental literature
    Kevin Jon Williams
    Department of Medicine Division of Endocrinology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nat Clin Pract Cardiovasc Med 5:91-102. 2008
    ..Hence, there is a clear need for testing of new agents expected to facilitate atherosclerosis regression. Additional mechanistic insights will allow further progress...
  3. ncbi request reprint Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Diabetes 54:1116-22. 2005
    ..Suppression of hepatic NDST may contribute to diabetic dyslipidemia, and stimulation of NDST activity by AngII inhibitors may provide cardiovascular protection...
  4. pmc Molecular processes that handle -- and mishandle -- dietary lipids
    Kevin Jon Williams
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5005, USA
    J Clin Invest 118:3247-59. 2008
    ..These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion...
  5. pmc Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
    Cecilia M Devlin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 28:1723-30. 2008
    ..We now sought to test a direct causative role for acid SMase in lipoprotein retention and atherogenesis in vivo...
  6. pmc Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke
    Chun jun Li
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Pathol 182:1552-62. 2013
    ..Proteolytically active MVs induced by tobacco smoke may be novel mediators of clinical important matrix destruction in smokers...
  7. pmc Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
    Mingzhen Li
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 30:1818-24. 2010
    ....
  8. ncbi request reprint Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification
    Ming Lin Liu
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, 3322 North Broad Street, Medical Office Building, Room 212, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 32:2113-21. 2012
    ..We determined whether UC-induced MVs (UCMVs) might transmit endogenous danger signals and, if so, what molecular processes might be responsible for their production, recognition, and detoxification...
  9. doi request reprint The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
    Xiangdong Wu
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Lipidol 23:334-44. 2012
    ..Here, we review recent work on hepatic SEIRR indicating that deranged insulin signaling may have a remarkably simple molecular basis...
  10. pmc Decorin deficiency enhances progressive nephropathy in diabetic mice
    Kevin Jon Williams
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Pathol 171:1441-50. 2007
    ..We conclude that decorin is a natural protective factor against diabetic nephropathy and that the Dcn(-/-) diabetic mouse is a useful new model of progressive diabetic nephropathy...
  11. pmc Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins
    Keyang Chen
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Hepatology 52:1957-67. 2010
    ..Likewise, both hormones enhanced remnant lipoprotein catabolism in vitro. Conclusion: SULF2 is an unexpected suppressor of atherogenic lipoprotein clearance by hepatocytes and an attractive target for inhibition...
  12. ncbi request reprint Autophagy of an oxidized, aggregated protein beyond the ER: a pathway for remarkably late-stage quality control
    Edward A Fisher
    Department of Medicine, Leon H Charney Division of Cardiology, New York University School of Medicine, New York, New York 10016, USA
    Autophagy 4:721-3. 2008
    ..ApoB secretory control via autophagosomes is likely a key component of normal and pathological regulation of plasma lipoprotein levels, as well as a means for remarkably late-stage quality control of a secreted protein...
  13. pmc Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor
    Keyang Chen
    Division of Endocrinology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 288:13988-99. 2013
    ....
  14. pmc NOX4 pathway as a source of selective insulin resistance and responsiveness
    Xiangdong Wu
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 32:1236-45. 2012
    ....
  15. doi request reprint Recent insights into factors affecting remnant lipoprotein uptake
    Kevin Jon Williams
    Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Lipidol 21:218-28. 2010
    ..Here, we review recent work that clarified long-standing controversies over the molecular mediators of remnant clearance by the liver, as well as their dysregulation - but possible correction - during alterations in caloric balance...
  16. ncbi request reprint Cellular and molecular mechanisms for rapid regression of atherosclerosis: from bench top to potentially achievable clinical goal
    Kevin Jon Williams
    Department of Medicine Division of Endocrinology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Curr Opin Lipidol 18:443-50. 2007
    ..Decades of literature have unambiguously demonstrated regression and remodeling of atherosclerotic lesions, including advanced plaques. Recent insights into underlying mechanisms are reviewed...
  17. doi request reprint Microvesicles: potential markers and mediators of endothelial dysfunction
    Ming Lin Liu
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Endocrinol Diabetes Obes 19:121-7. 2012
    ..Here, we focus on new clinical and basic work that implicates microvesicles as markers and mediators of endothelial dysfunction and hence novel contributors to cardiovascular and other diseases...
  18. ncbi request reprint Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications
    Ira Tabas
    Department of Medicine, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA
    Circulation 116:1832-44. 2007
    ....
  19. ncbi request reprint Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles
    Ming Lin Liu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arterioscler Thromb Vasc Biol 27:430-5. 2007
    ..Because cellular cholesterol accumulation is an important feature of atherosclerotic vascular disease, we now examined effects of cholesterol enrichment on MV release from human monocytes and macrophages...
  20. ncbi request reprint Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory?
    Kevin Jon Williams
    Division of Endocrinology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 8:139-46. 2005
    ..We summarize recent data on the roles played by oxidative metabolism in different tissues and pathways, and address whether it is currently advisable to use antioxidant supplements to reduce cardiovascular risk...
  21. pmc Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    Meihui Pan
    The Zena and Michael A Wiener Cardiovascular Institute and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 113:1277-87. 2004
    ....
  22. ncbi request reprint Lipoprotein retention--and clues for atheroma regression
    Kevin Jon Williams
    Arterioscler Thromb Vasc Biol 25:1536-40. 2005
    ..Dissection of the molecular participants provides fresh insight into how this major killer might be reversed. Efflux of harmful lipids derived from retained lipoproteins may be crucial in promoting beneficial remodeling of lesions...
  23. ncbi request reprint Editorial: The mystery--and importance--of diabetic atherosclerotic vascular disease
    Kevin Jon Williams
    J Clin Endocrinol Metab 87:33-4. 2002

Research Grants2

  1. Transmigration of HIV-1-infected cells in NeuroAIDS
    Kevin Jon Williams; Fiscal Year: 2006
    ..In addition, our work may provide a new use for statins to prevent or treat AIDS-related dementia and to deplete or eradicate the CNS as an HIV-1 sanctuary. ..