D J Whellan

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. doi request reprint Development of a method to risk stratify patients with heart failure for 30-day readmission using implantable device diagnostics
    David J Whellan
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Cardiol 111:79-84. 2013
  2. doi request reprint Utilization of hospice and predicted mortality risk among older patients hospitalized with heart failure: findings from GWTG-HF
    David J Whellan
    Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Card Fail 18:471-7. 2012
  3. doi request reprint Change in intrathoracic impedance measures during acute decompensated heart failure admission: results from the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study
    David J Whellan
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Card Fail 18:107-12. 2012
  4. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
  5. ncbi request reprint Metaanalysis and review of heart failure disease management randomized controlled clinical trials
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 149:722-9. 2005
  6. doi request reprint QT as a safety biomarker in drug development
    D J Whellan
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 86:101-4. 2009
  7. ncbi request reprint Diastolic heart failure and continuous hemodynamic monitoring
    David J Whellan
    Jefferson Heart Institute, Philadelphia, PA, USA
    Am Heart J 153:6-11. 2007
  8. pmc Costs of inpatient care among Medicare beneficiaries with heart failure, 2001 to 2004
    David J Whellan
    Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 3:33-40. 2010
  9. doi request reprint Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Hear
    David J Whellan
    Department of Medicine, Jefferson Medical College, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Am Coll Cardiol 55:1803-10. 2010
  10. doi request reprint Predictors of hospital length of stay in heart failure: findings from Get With the Guidelines
    David J Whellan
    Jefferson Medical College, Philadelphia, PA 19107, USA
    J Card Fail 17:649-56. 2011

Detail Information

Publications52

  1. doi request reprint Development of a method to risk stratify patients with heart failure for 30-day readmission using implantable device diagnostics
    David J Whellan
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Cardiol 111:79-84. 2013
    ..In conclusion, device-derived HF diagnostic criteria evaluated 7 days after discharge identified patients at significantly greater risk of a HF event within 30 days after discharge...
  2. doi request reprint Utilization of hospice and predicted mortality risk among older patients hospitalized with heart failure: findings from GWTG-HF
    David J Whellan
    Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Card Fail 18:471-7. 2012
    ..Little is known regarding utilization of hospice care in a contemporary cohort of patients hospitalized with HF and how this may vary by estimated mortality risk...
  3. doi request reprint Change in intrathoracic impedance measures during acute decompensated heart failure admission: results from the Diagnostic Data for Discharge in Heart Failure Patients (3D-HF) Pilot Study
    David J Whellan
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Card Fail 18:107-12. 2012
    ..A number of patients have implantable devices that might provide data to assist in determining readiness for discharge...
  4. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
    ..Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial...
  5. ncbi request reprint Metaanalysis and review of heart failure disease management randomized controlled clinical trials
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 149:722-9. 2005
    ..The aim of this study was to assess the effectiveness of DM programs in reducing hospitalization and mortality in patients with HF on the basis of the results of existing trials...
  6. doi request reprint QT as a safety biomarker in drug development
    D J Whellan
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 86:101-4. 2009
    ....
  7. ncbi request reprint Diastolic heart failure and continuous hemodynamic monitoring
    David J Whellan
    Jefferson Heart Institute, Philadelphia, PA, USA
    Am Heart J 153:6-11. 2007
  8. pmc Costs of inpatient care among Medicare beneficiaries with heart failure, 2001 to 2004
    David J Whellan
    Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 3:33-40. 2010
    ..Inpatient care is the primary driver of costs for patients with heart failure. It is unclear whether recent advances in heart failure care have reduced the costs to Medicare for the care of inpatients with heart failure...
  9. doi request reprint Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Hear
    David J Whellan
    Department of Medicine, Jefferson Medical College, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Am Coll Cardiol 55:1803-10. 2010
    ..We sought to determine the utility of combined heart failure (HF) device diagnostic information to predict clinical deterioration of HF in patients with systolic left ventricular dysfunction...
  10. doi request reprint Predictors of hospital length of stay in heart failure: findings from Get With the Guidelines
    David J Whellan
    Jefferson Medical College, Philadelphia, PA 19107, USA
    J Card Fail 17:649-56. 2011
    ..This study was undertaken to identify predictors of hospital length of stay (LOS) for heart failure (HF) patients using clinical variables available at the time of admission and hospital characteristics...
  11. doi request reprint Rationale, design, and baseline characteristics of a Program to Assess and Review Trending INformation and Evaluate CorRelation to Symptoms in Patients with Heart Failure (PARTNERS HF)
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 156:833-9, 839.e2. 2008
    ....
  12. doi request reprint Review of advanced heart failure device diagnostics examined in clinical trials and the potential benefit from monitoring capabilities
    David J Whellan
    Coordinating Center for Clinical Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Prog Cardiovasc Dis 54:107-14. 2011
    ..These issues will be important to understand when evaluating future clinical trial results and developing new studies, particularly in other HF patient cohorts such as HF with preserved left ventricular function...
  13. ncbi request reprint Financial implications of a model heart failure disease management program for providers, hospital, healthcare systems, and payer perspectives
    David J Whellan
    Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Am J Cardiol 99:256-60. 2007
    ....
  14. pmc Benefit of exercise therapy for systolic heart failure in relation to disease severity and etiology-findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training study
    David J Whellan
    Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Am Heart J 162:1003-10. 2011
    ..This post hoc analysis of the HF-ACTION cohort explores the primary and secondary results of the HF-ACTION study by etiology and severity of illness...
  15. ncbi request reprint Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tra
    Daniel R Bensimhon
    Moses Cone Hospital, Greensboro, NC, USA
    Am Heart J 154:46-53. 2007
    ....
  16. ncbi request reprint Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study
    W A Gattis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 159:1939-45. 1999
    ..The multidisciplinary approach to managing heart failure has been shown to improve outcomes. The role of a clinical pharmacist in treating heart failure has not been evaluated...
  17. ncbi request reprint Economic effects of beta-blocker therapy in patients with heart failure
    Patricia A Cowper
    Outcomes Research and Assessment Group, Durham, North Carolina 27715, USA
    Am J Med 116:104-11. 2004
    ..We assessed the economic effects of beta-blocker therapy from various perspectives: societal, Medicare, hospital, physician, and patient...
  18. ncbi request reprint Effects of admission to a teaching hospital on the cost and quality of care for Medicare beneficiaries
    D H Taylor
    Center for Health Policy, Law, and Management, Terry Sanford Institute of Public Policy, Duke University, Durham, NC 27708, USA
    N Engl J Med 340:293-9. 1999
    ..e., public), or private for-profit hospitals...
  19. ncbi request reprint Costs for heart failure with normal vs reduced ejection fraction
    Lawrence Liao
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 166:112-8. 2006
    ..However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of elderly participants, we compared the costs and resource use of patients with HF and normal and reduced EF...
  20. ncbi request reprint Predicting significant coronary artery disease in patients with left ventricular dysfunction
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 152:340-7. 2006
    ..The objective of this study was to develop a model to assist clinicians in determining the likelihood of CAD before cardiac catheterization...
  21. ncbi request reprint Cost effectiveness of cardiac resynchronization therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial
    Arthur M Feldman
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Coll Cardiol 46:2311-21. 2005
    ....
  22. ncbi request reprint Heart failure disease management: implementation and outcomes
    David J Whellan
    Duke Clinical Research Institute, Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cardiol Rev 13:231-9. 2005
    ....
  23. pmc Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries
    Bradley G Hammill
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 121:63-70. 2010
    ..The relationship between the number of sessions attended and long-term outcomes is unknown...
  24. doi request reprint Advancing the research mission in an academic department: the creation of a center for translational medicine
    Arthur M Feldman
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 3:178-81. 2010
    ..The concept of a translational medicine center may be useful for many departments of academic medical centers...
  25. ncbi request reprint Outcomes in heart failure patients after major noncardiac surgery
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 44:1446-53. 2004
    ..The purpose of this study was to evaluate mortality and readmission rates of heart failure (HF) patients after major noncardiac surgery...
  26. doi request reprint Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
    ..Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent...
  27. ncbi request reprint Medicaid, managed care, and the care of patients hospitalized for acute myocardial infarction
    F A Sloan
    Center for Health Policy, Law and Management, and Department of Economics, Duke University, Durham, NC 27708, USA
    Am Heart J 139:567-76. 2000
    ....
  28. pmc Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tr
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 158:S53-63. 2009
    ..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results...
  29. ncbi request reprint Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?
    Jamieson Macdonald Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:758-67. 2003
    ..The assessment of viable myocardium by nuclear imaging studies has shown promise in predicting improvements in ejection fraction and symptoms. However, the relationship of viability to long-term mortality has not been fully established...
  30. ncbi request reprint Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging
    Jamieson M Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Nucl Cardiol 11:118-25. 2004
    ..All of these differences must be incorporated into proper outcomes examinations. We sought to identify the nuclear perfusion imaging referral pattern for patients with left ventricular (LV) dysfunction and significant CAD...
  31. pmc Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 301:1439-50. 2009
    ..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes...
  32. ncbi request reprint The changing face of postoperative atrial fibrillation prevention: a review of current medical therapy
    Sarah E Mayson
    Division of Cardiology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cardiol Rev 15:231-41. 2007
    ..However, there is a need for further large-scale investigations that incorporate standard methodologies and diagnostic criteria, which have been lacking in past trials...
  33. doi request reprint Racial disparity in the relationship between hospital volume and mortality among patients undergoing coronary artery bypass grafting
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Ann Surg 248:886-92. 2008
    ..To examine whether the volume-mortality relationship in coronary artery bypass grafting (CABG) differs by race and operative risk...
  34. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  35. ncbi request reprint Cardiac rehabilitation and survival in patients with left ventricular systolic dysfunction
    D J Whellan
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 142:160-6. 2001
    ..It remains unproven whether exercise training improves survival...
  36. ncbi request reprint Heart transplant center practice patterns affect access to donors and survival of patients classified as status 1 by the United Network of Organ Sharing
    D J Whellan
    Department of Medicine and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 140:443-50. 2000
    ..To determine the effect of adult cardiac transplant center practice patterns within a single organ procurement organization on access to donors and survival for patients listed as United Network of Organ Sharing (UNOS) status 1...
  37. pmc Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:S64-71. 2009
    ..We examined associations between patient-reported measures of health-related quality of life and clinical indicators of disease severity in a large, heterogeneous sample of patients with heart failure...
  38. ncbi request reprint Meta-analysis of survival and relief of angina pectoris after transmyocardial revascularization
    Lawrence Liao
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 95:1243-5. 2005
    ..At 1 year, transmyocardial laser revascularization produced a significant improvement in angina class (p <0.0001) but no improvement in survival (p = 0.75)...
  39. pmc N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 158:S37-44. 2009
    ..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...
  40. ncbi request reprint Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study
    Lawrence Liao
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 153:245-52. 2007
    ..In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term costs and resource use of elderly patients with HF...
  41. pmc Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    JAMA 301:1451-9. 2009
    ..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent...
  42. doi request reprint Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative
    Jonathan P Piccini
    Duke Clinical Research Institute and Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 158:317-26. 2009
    ..Priority pursuit of these consensus-based directions should facilitate both safer drugs and accelerated access to new drugs, as concomitant public health benefits...
  43. ncbi request reprint Economic burden of heart failure in the elderly
    Lawrence Liao
    The Duke Clinical Research Institute, Durham, NC, USA
    Pharmacoeconomics 26:447-62. 2008
    ..Further studies are needed to examine the impact of pharmacological and non-pharmacological interventions on costs and resource use in elderly individuals with HF...
  44. ncbi request reprint Pharmacologic therapy of chronic heart failure
    Eman Hamad
    Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Cardiovasc Drugs 7:235-48. 2007
    ....
  45. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure
    Karen E Joynt
    Department of Medicine Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 93:783-5. 2004
    ..Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and aspirin or statin use...
  46. ncbi request reprint Why is depression bad for the failing heart? A review of the mechanistic relationship between depression and heart failure
    Karen E Joynt
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Card Fail 10:258-71. 2004
    ..Depression is 4 to 5 times as common in heart failure (HF) patients as in the general population, might confer a higher risk of developing HF, and negatively affects prognosis in established HF...
  47. doi request reprint Hospice use among patients with heart failure
    Kevin T Bain
    Department of Quality Outcomes, excelleRx, Inc, 1601 Cherry Street, Philadelphia, PA 19102, USA
    Am Heart J 158:118-25. 2009
    ..Hospices provide end-of-life care for heart failure (HF) patients, but hospice is underused for these patients, and its use has not been well described...
  48. ncbi request reprint Training trials in heart failure: time to exercise restraint?
    David J Whellan
    Am Heart J 147:190-2. 2004
  49. ncbi request reprint The state of exercise training: a need for action
    David J Whellan
    Am Heart J 144:1-4. 2002
  50. pmc Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)
    Daniel R Bensimhon
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:712-7. 2008
    ..Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test...
  51. doi request reprint Delivering heart failure disease management in 3 tertiary care centers: key clinical components and venues of care
    Monica R Shah
    Washington Hospital Center, Washington, DC 20010, USA
    Am Heart J 155:764.e1-5. 2008
    ..We aimed to describe the intensity of outpatient HF care (clinic visits and telephone calls) and medical and nonpharmacological interventions in the outpatient setting...
  52. ncbi request reprint Natural history, adherence, or iatrogenic insult: repeat hospitalizations as a predictor of survival
    David J Whellan
    Am Heart J 154:203-5. 2007