Research Topics
| Scott WaldmanSummaryAffiliation: Thomas Jefferson University Country: USA Publications
Research Grants
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Publications
Selection of optimal reference genes for normalization in quantitative RT-PCRInna Chervoneva
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
BMC Bioinformatics 11:253. 2010..Current methods of selecting reference genes make an assumption of independence in their innate variation. This assumption is not always justified, which may lead to selecting a suboptimal set of reference genes...
Clinical pharmacology: a paradigm for individualized medicineScott A Waldman
Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
Biomark Med 3:679-84. 2009....- Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancerScott A Waldman
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107, USA
JAMA 301:745-52. 2009..Guanylyl cyclase 2C (GUCY2C) is a marker expressed by colorectal tumors that could reveal occult metastases in lymph nodes and better estimate recurrence risk... - Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshellsScott A Waldman
Thomas Jefferson University, Jefferson Medical College, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA 19107, USA
Future Oncol 2:705-16. 2006.... - A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancerScott A Waldman
Department of Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
FEBS J 276:2157-64. 2009.... - MicroRNA signatures as diagnostic and therapeutic targetsScott A Waldman
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA
Clin Chem 54:943-4. 2008 - Relative quantification based on logistic models for individual polymerase chain reactionsInna Chervoneva
Division of Biostatistics, Department of Clinical Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Stat Med 26:5596-611. 2007..Real kinetic RT-PCR data are used to compare the proposed and standard methods. The methods are applied to the clinical data from the ongoing study of guanylyl cyclase C as a biomarker for colorectal cancer... - Statistical algorithm for assuring similar efficiency in standards and samples for absolute quantification by real-time reverse transcription polymerase chain reactionInna Chervoneva
Division of Biostatistics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Anal Biochem 348:198-208. 2006..These studies demonstrate that elimination of kinetic outliers from calibration standards and test samples improves the accuracy of absolute transcript quantification by RT-PCR... - GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patientsAlex Mejia
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Expert Rev Mol Diagn 9:777-85. 2009.... - Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancerGlen S Frick
Respiratory and Inflammation Centre of Excellence for Drug Discovery, Discovery Medicine, GlaxoSmithKline, PA, USA
Expert Rev Mol Diagn 5:701-13. 2005.... - Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9Wilhelm J Lubbe
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Res 69:3529-36. 2009..The notion that GCC-mediated regulation of cancer cell MMP-9 disrupts metastasis, in turn, underscores the unexplored utility of GCC hormone replacement therapy in the chemoprevention of colorectal cancer progression... - A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancerStephanie Schulz
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Cancer Res 12:4545-52. 2006..However, quantification of GCC expression in tissues by the quantitative reverse transcription-PCR (qRT-PCR) has not undergone analytic and clinicopathologic validation... - Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrityPeng Li
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 133:599-607. 2007..However, the role of GCC in neoplasia remains obscure... - Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancerWilhelm J Lubbe
Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Clin Cancer Res 12:1876-82. 2006..They underscore the previously unrecognized potential of specifically targeting tumor cell MMP-9 in interventional strategies to reduce mortality from metastatic colorectal cancer... - Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxinsGiovanni M Pitari
Division of Clinical Pharmacology, Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 65:11129-35. 2005..Thus, regimens that incorporate cytostatic bacterial enterotoxins and inhibitors of cGMP-mediated desensitization offer a previously unrecognized therapeutic paradigm for treatment and prevention of colorectal cancer... - Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxinsShiva Kazerounian
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Pharmacol Exp Ther 314:1013-22. 2005..They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP-directed therapy and prevention for colorectal tumors... - STa peptide analogs for probing guanylyl cyclase CXiaobing Tian
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Biopolymers 90:713-23. 2008..Peptides 3 and 6 behaved as agonists in stimulating cGMP production. The results reveal that the toxic domain of STa can be reduced to 12 amino acids... - Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomachJason Park
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Epidemiol Biomarkers Prev 11:739-44. 2002.... - Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cellsGiovanni M Pitari
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut Street, MOB Suite 810, Philadelphia, PA 19107, USA
Carcinogenesis 29:1601-7. 2008..Restoration of antitumorigenic CaR signaling by GCC ligand replacement therapy represents a previously unrecognized paradigm for the prevention and treatment of human colorectal cancer employing dietary Ca(2+) supplementation... - Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesisPeng Li
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA
Cancer Biol Ther 10:211-8. 2010.... - Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic targetJieru E Lin
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
Future Oncol 5:509-22. 2009..Compensatory upregulation of GCC in response to hormone loss provides a unique translational opportunity for prevention and treatment of colorectal tumors by hormone-replacement therapy... - Mucosally restricted antigens as novel immunological targets for antitumor therapyAdam E Snook
Thomas Jefferson University, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA, USA
Biomark Med 1:187-202. 2007.... - Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cellsGiovanni Mario Pitari
Division of Clinical Pharmacology, Departments of Pharmacology and Experimental Therapeutics and Medicine, Thomas Jefferson University, 1100 Walnut Street MOB 810, Philadelphia, PA 19107, USA
Mol Cancer Ther 5:1190-6. 2006..Moreover, combination therapies, including exisulind and agents that induce cGMP signaling, may require careful evaluation in patients with colon cancer... 
Sex modulates intestinal transformation by the tumor-suppressor GCCPeng Li
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Transl Sci 1:146-50. 2008..However, the molecular intersection between intestinal paracrine and systemic sex hormones opposing intestinal neoplasia has not been explored...- Applications of nanoparticles to diagnostics and therapeutics in colorectal cancerPaolo Fortina
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA 19107, USA
Trends Biotechnol 25:145-52. 2007..Although the scenarios outlined in this article are hypothetical, they might stimulate ideas about how other cancers could be attacked using nanotechnology... - Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotidesInez Ruiz-Stewart
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Eur J Biochem 269:2186-93. 2002..This allosteric inhibition is mediated by direct interaction of adenine nucleotides with sGC, likely at the catalytic domain in a region outside the substrate-binding site... - Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasmsVincenzo Ciocca
Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Histopathology 55:182-8. 2009.... - GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?P Li
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Drug News Perspect 22:313-8. 2009..The correlative therapeutic hypothesis suggests that colorectal cancer is a disease of hormone insufficiency that can be prevented or treated by oral hormone replacement therapy employing GCC ligands... - Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunityAdam E Snook
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South Tenth St, Philadelphia, PA 19107, USA
J Natl Cancer Inst 100:950-61. 2008..Here we defined the immunogenicity and antitumor efficacy of guanylyl cyclase C (GCC), a protein that is normally restricted to intestinal mucosa and universally expressed by metastatic colorectal cancer... - The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomasMatthew E Witek
Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Clin Cancer Res 11:8549-56. 2005..Here, Cdx2 expression and function was quantified in tumors and matched normal mucosa from patients with colorectal cancer... - Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tractRuth Birbe
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Hum Pathol 36:170-9. 2005.... - Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axisLi Gong
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Transl Sci 2:286-93. 2009..Induction of this axis provides the context for lineage-addicted tumorigenesis, in which autonomous activation of AKT corrupts adaptive intestinal NF-kappaB signaling, amplifying tumorigenic programs... - Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calciumShiva Kazerounian
Division of Clinical Pharmacology, Department of Medicine and Biochemistry, Thomas Jefferson University, Philadelphia, PA 19107, USA
Biochemistry 41:3396-404. 2002..These data suggest that sGC is a constitutive Ca(2+) binding protein whose allosteric function is conditionally dependent upon ligand activation... - Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cellsPhilip R Debruyne
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 130:1191-206. 2006..The present studies examine the expression of GC-C in normal tissues and tumors from esophagus and stomach and mechanisms regulating its expression by acid and bile acids... - Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory diseaseAdam E Snook
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Res 69:3537-44. 2009..These observations support the utility of GCC-targeted immunotherapy in patients at risk for systemic metastases, including those with inflammatory bowel disease, hereditary colorectal cancer syndromes, and sporadic colorectal cancer... - Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrityLi Gong
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Curr Opin Hematol 11:7-14. 2004.... - Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestinePeng Li
Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut St MOB 810, Philadelphia, PA 19107, USA
Am J Pathol 171:1847-58. 2007..In the context of uniform loss of GC-C signaling during tumorigenesis, dysregulation of those homeostatic processes may contribute to mechanisms underlying colon cancer... - Pathological staging and therapy of oesophageal and gastric cancerPhilip R Debruyne
Division of Clinical Pharmacology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Expert Opin Pharmacother 4:1083-96. 2003..Standard curative treatment for gastro-oesophageal junction and gastric cancer includes surgery and adjuvant chemoradiotherapy. Chemotherapy is an option for the treatment of advanced and recurrent gastric cancer... - Derivation and fluidity of acutely induced dysfunctional CD8+ T cellsGabriela Plesa
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 180:5300-8. 2008..Together, these results suggest that persistence of dysfunctional cells generated in this manner depends upon continual exposure to high Ag levels and that such cells may ultimately predominate if functional cells become exhausted... - H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincterMarcio A F de Godoy
Departments of Medicine, Division of Gastroenterology and Hepatology, Pharmacology and Experimental Therapeutics, and Emergency Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennyslvania 19107, USA
Gastroenterology 132:1401-9. 2007..The present studies evaluated the role of H-ras and its implications in the RhoA/Rho kinase (ROCK) pathway in regulating basal tone in the internal anal sphincter (IAS)... - Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincterSandeep Rathi
Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Room no 901 College, Philadelphia, PA 19107, USA
J Pharmacol Exp Ther 305:615-24. 2003..These studies may have important implications in anorectal and other gastrointestinal motility disorders... - Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMPSatish R Tiyyagura
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Vitam Horm 69:69-94. 2004..This chapter describes the molecular mechanisms regulating intracellular Ca2+ and cGMP, and their integration in specific cellular responses... - A comparative molecular field analysis (COMFA) of the structural determinants of heat-stable enterotoxins mediating activation of guanylyl cyclase CHenry R Wolfe
Targeted Diagnostics and Therapeutics, Inc, 1045 Andrew Drive, West Chester, Pennsylvania 19380, USA
J Med Chem 45:1731-4. 2002.... - In vivo imaging of human colon cancer xenografts in immunodeficient mice using a guanylyl cyclase C--specific ligandHenry R Wolfe
Research and Development Department, Targeted Diagnostics and Therapeutics, Inc, West Chester, Pennsylvania 19380, USA
J Nucl Med 43:392-9. 2002..This study examined the utility of a radiolabeled conjugate of STa (5--18) to selectively target and image extraintestinal human colon cancer xenografts in vivo in nude mice... - Markers of cell cycle-mediated drug resistance and prognosis of patients receiving preoperative combined modality therapy for rectal cancerScott A Waldman
Ann Surg Oncol 11:949-50. 2004 - Translating MicroRNA discovery into clinical biomarkers in cancerScott A Waldman
JAMA 297:1923-5. 2007
Research Grants
- Short-term Training Program in Translational Cancer ReseScott Waldman; Fiscal Year: 2007..abstract_text> ..
- CLINICAL PHARMACOLOGY TRAINING PROGRAMScott Waldman; Fiscal Year: 2007..Alternatively, fellows may opt for careers in the pharmaceutical industry or in regulatory clinical pharmacology. ..
- TRAINING PROGRAM IN HUMAN INVESTIGATIONScott Waldman; Fiscal Year: 2007..Upon completion of the program, trainees are qualified to perform independent clinical research with certification through a Master's of Science in Human Investigation. ..
- GUANYLYL CYCLASE C IN BLOOD AND COLORECTAL CANCERScott Waldman; Fiscal Year: 2007..These studies will form the foundation for future trials utilizing GC-C to identify patients at risk for recurrence who might benefit from therapeutic intervention. ..
- GUANYLYL CYCLASE C IN BLOOD AND COLORECTAL CANCERScott Waldman; Fiscal Year: 2007..These studies will form the foundation for future trials utilizing GC-C to identify patients at risk for recurrence who might benefit from therapeutic intervention. ..
- GUANYLYL CYCLASE C AS A BI0MARKER FOR COLORECTAL CANCERScott Waldman; Fiscal Year: 2006....
- GUANYLYL CYCLASE C AS A BIOMARKER FOR COLORECTAL CANCERScott Waldman; Fiscal Year: 1999....
- TRAINING PROGRAM IN HUMAN INVESTIGATIONScott Waldman; Fiscal Year: 2004..Upon completion of the program, trainees will be qualified to perform independent clinical research with certification through a Master's of Science in Human Investigation. ..