Mathew Thakur

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 45:1381-9. 2004
  2. doi request reprint VPAC1 receptors for imaging breast cancer: a feasibility study
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 54:1019-25. 2013
  3. doi request reprint Targeting apoptosis for optical imaging of infection
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Imaging Biol 14:163-71. 2012
  4. ncbi request reprint Report of a summit on molecular imaging
    Mathew Thakur
    Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, 1020 Locust St, Suite 359 JAH, Philadelphia, PA 19107, USA
    AJR Am J Roentgenol 186:297-9. 2006
  5. pmc Genomic biomarkers for molecular imaging: predicting the future
    Mathew L Thakur
    Laboratories of Radiopharmaceutical Research and Molecular Imaging, Department of Radiology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Semin Nucl Med 39:236-46. 2009
  6. doi request reprint Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products
    Mathew L Thakur
    Department of Radiology, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA
    J Nucl Med 51:106-11. 2010
  7. ncbi request reprint Report of a summit on molecular imaging
    Mathew Thakur
    Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, Philadelphia, PA 19107, USA
    Radiology 236:753-5. 2005
  8. pmc Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation
    Kaijun Zhang
    Laboratory of Radiopharmaceuticals and Molecular Imaging, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 361 JAH, Philadelphia, PA 19107, USA
    Regul Pept 144:91-100. 2007
  9. doi request reprint PET imaging of EGFR expression in nude mice bearing MDA-MB-468, a human breast adenocarcinoma
    Kayvan Sadri
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennysylvania 19107, USA
    Nucl Med Commun 32:563-9. 2011
  10. ncbi request reprint PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer
    Kaijun Zhang
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 49:112-21. 2008

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 45:1381-9. 2004
    ..The purpose of this study was to assess the feasibility of PET imaging of oncogene VPAC1 receptors overexpressed in human breast cancer cells...
  2. doi request reprint VPAC1 receptors for imaging breast cancer: a feasibility study
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 54:1019-25. 2013
    ....
  3. doi request reprint Targeting apoptosis for optical imaging of infection
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Imaging Biol 14:163-71. 2012
    ..Targeting PS with intravenous administration of a PS-specific, near-infrared (NIR) fluorophore will permit localization of infectious foci by optical imaging...
  4. ncbi request reprint Report of a summit on molecular imaging
    Mathew Thakur
    Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, 1020 Locust St, Suite 359 JAH, Philadelphia, PA 19107, USA
    AJR Am J Roentgenol 186:297-9. 2006
  5. pmc Genomic biomarkers for molecular imaging: predicting the future
    Mathew L Thakur
    Laboratories of Radiopharmaceutical Research and Molecular Imaging, Department of Radiology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Semin Nucl Med 39:236-46. 2009
    ..The article also outlines a few examples predicting other possible applications of targeting such specific probes not yet used...
  6. doi request reprint Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products
    Mathew L Thakur
    Department of Radiology, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA
    J Nucl Med 51:106-11. 2010
    ..The objective of this investigation was to determine the ability of 1 of the peptide analogs, (64)Cu-TP3805, to detect BC in MMTVneu mice using (18)F-FDG as a gold standard...
  7. ncbi request reprint Report of a summit on molecular imaging
    Mathew Thakur
    Department of Radiology, Division of Nuclear Medicine, Thomas Jefferson University Medical College, Philadelphia, PA 19107, USA
    Radiology 236:753-5. 2005
  8. pmc Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation
    Kaijun Zhang
    Laboratory of Radiopharmaceuticals and Molecular Imaging, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 361 JAH, Philadelphia, PA 19107, USA
    Regul Pept 144:91-100. 2007
    ..Data demonstrate that these analogues are potent, have uncompromised biological activity and are worthy of further evaluation for accurate PET imaging of human breast cancers and in determining malignant and benign lesions...
  9. doi request reprint PET imaging of EGFR expression in nude mice bearing MDA-MB-468, a human breast adenocarcinoma
    Kayvan Sadri
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennysylvania 19107, USA
    Nucl Med Commun 32:563-9. 2011
    ..EGFR overexpression has been observed in a subset of breast cancers. The purpose of this study was to evaluate 64Cu-labeled cetuximab as an imaging agent using MDA-MB-468 breast cancer cells...
  10. ncbi request reprint PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer
    Kaijun Zhang
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 49:112-21. 2008
    ..All PC overexpresses VPAC1 receptors. This investigation evaluated a probe specific for a (64)Cu-labeled receptor for PET imaging of experimental human PC in athymic nude mice and spontaneously grown PC in transgenic mice...
  11. ncbi request reprint Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US
    Barry B Goldberg
    Department of Radiology, Thomas Jefferson University Hospital, 7th Floor Main Bldg, 132 S 10th St, Philadelphia, PA 19107, USA
    Radiology 230:727-34. 2004
    ....
  12. ncbi request reprint PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]chelator-peptide nucleic acid-IGF1 analog radiohybridization probes
    Xiaobing Tian
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Nucl Med 48:1699-707. 2007
    ..Therefore, we hypothesized that malignant breast masses could be imaged and quantitated externally by PET with a dual-specificity probe that targets both CCND1 mRNA and IGF1R...
  13. ncbi request reprint Role of lipid-soluble complexes in targeted tumor therapy
    Mathew L Thakur
    Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359JAH, Philadelphia, PA 19107, USA
    J Nucl Med 44:1293-300. 2003
    ..This study assessed the therapeutic significance of lipid-soluble compounds of (111)In, which passively diffuse through the cell membrane, bind to cytoplasmic components, and remain cell bound until decay...
  14. pmc Imaging oncogene expression
    Archana Mukherjee
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Eur J Radiol 70:265-73. 2009
    ..An overview of the investigations on oncogene expression imaging is given. Finally, the need for further improvement in antisense-based imaging agents and directions to improve oncogene mRNA targeting is stated...
  15. pmc Imaging thromboembolism with fibrin-avid 99mTc-peptide: evaluation in swine
    Mohan R Aruva
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 47:155-62. 2006
    ....
  16. ncbi request reprint Imaging oncogene expression
    Xiaobing Tian
    Department of Biochemistry Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ann N Y Acad Sci 1002:165-88. 2003
    ..This result enables testing of Tc-99m-peptide-PNA probes to image gene expression in tumors...
  17. ncbi request reprint Radionuclide-peptide nucleic acid in diagnosis and treatment of pancreatic cancer
    Eric Wickstrom
    Department of Biochemistry, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Methods Mol Med 106:135-91. 2005
  18. ncbi request reprint Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera
    Xiaobing Tian
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Bioconjug Chem 16:70-9. 2005
    ..Molecular imaging of oncogene mRNAs in solid tumors with radiolabel-PNA-peptide chimeras might provide additional genetic characterization of preinvasive and invasive breast cancers...
  19. ncbi request reprint Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism
    Gregory Bix
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Natl Cancer Inst 98:1634-46. 2006
    ..Here we investigated the role of endorepellin, an angiostatic protein fragment that is derived from the C-terminus of perlecan, a heparan sulfate proteoglycan, in controlling tumor angiogenesis in vivo...
  20. pmc Recent trends in soft-tissue infection imaging
    Nicholas Petruzzi
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Semin Nucl Med 39:115-23. 2009
    ..Overall, imaging such an agent via SPECT/CT or PET/CT will pave the way for greater clinical reliability in the localization of infection...
  21. ncbi request reprint VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
    Phyllis R Wachsberger
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 67:1526-37. 2007
    ....
  22. pmc An antimetastatic role for decorin in breast cancer
    Silvia Goldoni
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 173:844-55. 2008
    ..In contrast, AG879 failed to have any effect. Our data support a role for decorin as a powerful and effective therapeutic agent against breast cancer due to its inhibition of both primary tumor growth and metastatic spreading...
  23. pmc Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity
    Adam E Snook
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South Tenth St, Philadelphia, PA 19107, USA
    J Natl Cancer Inst 100:950-61. 2008
    ..Here we defined the immunogenicity and antitumor efficacy of guanylyl cyclase C (GCC), a protein that is normally restricted to intestinal mucosa and universally expressed by metastatic colorectal cancer...
  24. ncbi request reprint External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras
    Xiaobing Tian
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 45:2070-82. 2004
    ....
  25. doi request reprint Apoptotic abscess imaging with 99mTc-HYNIC-rh-Annexin-V
    David L Penn
    Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nucl Med Biol 37:29-34. 2010
    ..02+/-0.16 and 0.72+/-0.17 %ID/g at 4 (P<or=.05) and 24 h (P<or=.01). (99m)Tc-HYNIC-AnxV represents a minimally invasive and promising agent to image and potentially distinguish between infectious and inflammatory abscesses...
  26. ncbi request reprint External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras
    Xiaobing Tian
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 S 10th Street, Suite 219, Philadelphia, PA 19107 5541, USA
    Ann N Y Acad Sci 1059:106-44. 2005
    ..External molecular imaging of oncogene mRNAs in solid tumors with radiolabel-PNA-peptide chimeras might in the future provide additional genetic characterization of pre-invasive and invasive breast cancers...
  27. ncbi request reprint Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation
    Daniela G Seidler
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:26408-18. 2006
    ..Furthermore, decorin induced apoptosis via activation of caspase-3. This could represent an additional mechanism whereby decorin might influence cell growth and survival...
  28. pmc Design of (Gd-DO3A)n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents
    Nariman V Amirkhanov
    Laboratory of Nucleic Acids Chemistry, Institute of Chemical Biology and Fundamental Medicine, Philadelphia, PA 19107, USA
    Biopolymers 89:1061-76. 2008
    ..84 +/- 20.48 mM(-1) s(-1)) (P < 0.05). Higher generations of PDAP dendrimers with 32 or more Gd-DO3A residues attached to PNA-D(Cys-Ser-Lys-Cys) genetic imaging agents might provide greater contrast for more sensitive detection...
  29. ncbi request reprint Joint SNM/RSNA Molecular Imaging Summit Statement
    Mathew L Thakur
    J Nucl Med 46:11N-13N, 42N. 2005
  30. ncbi request reprint Radiolabeled peptides in oncology: role in diagnosis and treatment
    Ronald E Weiner
    Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington, Connecticut 06030 2804, USA
    BioDrugs 19:145-63. 2005
    ..Other peptides currently under investigation, some of which have shown promising results, include Rhenium-188 (188Re)-P2045 and 90Y-alpha(v)beta3 antagonist...
  31. ncbi request reprint Radiolabeled peptides in the diagnosis and therapy of oncological diseases
    Ronald E Weiner
    Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington 06030 2804, USA
    Appl Radiat Isot 57:749-63. 2002
    ..Octreotide and its analogues labeled with 111In, 90Y, 64Cu or 177Lu are under study for the treatment of patients with promising results...

Research Grants7

  1. IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDE
    Mathew Thakur; Fiscal Year: 2002
    ..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..
  2. PET Imaging of Breast Cancer Using Oncogene Expression
    Mathew Thakur; Fiscal Year: 2005
    ..abstract_text> ..
  3. PET Imaging of Breast Cancer Using Oncogene Expression
    Mathew Thakur; Fiscal Year: 2006
    ..abstract_text> ..
  4. Improved Molecular Imaging with SPECT
    Mathew Thakur; Fiscal Year: 2006
    ..It also takes advantage of adapting existing clinical SPECT machines, rather than developing a dedicated small animal imaging system, which makes it much less expensive and more widely available. ..
  5. PET Imaging of Breast Cancer Using Oncogene Expression
    Mathew Thakur; Fiscal Year: 2007
    ..abstract_text> ..