Michael R Sperling


Affiliation: Thomas Jefferson University
Country: USA


  1. Asadi Pooya A, Sperling M. Age at onset in patients with medically refractory temporal lobe epilepsy and mesial temporal sclerosis: impact on clinical manifestations and postsurgical outcome. Seizure. 2015;30:42-5 pubmed publisher
  2. Asadi Pooya A, Rostami C, Rabiei A, Sperling M. Factors associated with tonic-clonic seizures in patients with drug-resistant mesial temporal epilepsy. J Neurol Sci. 2015;359:452-4 pubmed publisher
    ..16-0.77; p=0.008). Epigastric auras may indicate that a specific anatomic location is involved in epileptogenesis from which generalization is harder because of that location's poor connections with other brain regions. ..
  3. Asadi Pooya A, Nei M, Sharan A, Sperling M. Type of preoperative aura may predict postsurgical outcome in patients with temporal lobe epilepsy and mesial temporal sclerosis. Epilepsy Behav. 2015;50:98-100 pubmed publisher
  4. Sperling M, French J, Jacobson M, Pazdera L, Gough M, Cheng H, et al. Conversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies. Neurology. 2016;86:1095-102 pubmed publisher
    ..This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. ..
  5. Asadi Pooya A, Nei M, Sharan A, Sperling M. Auras in patients with temporal lobe epilepsy and mesial temporal sclerosis. J Neurol Sci. 2016;364:24-6 pubmed publisher
    ..However, the presence of presumed non-mesial temporal auras in a patient with MTS may herald a more widespread epileptogenic zone. ..
  6. Sperling M, Barshow S, Nei M, Asadi Pooya A. A reappraisal of mortality after epilepsy surgery. Neurology. 2016;86:1938-44 pubmed publisher
    ..These observations provide further rationale for earlier consideration of epilepsy surgery. ..
  7. Asadi Pooya A, Asadollahi M, Shimamoto S, Lorenzo M, Sperling M. Spike voltage topography in temporal lobe epilepsy. J Neurol Sci. 2016;366:209-212 pubmed publisher
    ..The present results do not allow an immediate clinical application of our findings; however, detecting a polar spike in a patient with TLE may increase the possibility of mesial temporal sclerosis as the underlying etiology. ..
  8. Moseley B, Sperling M, Asadi Pooya A, Diaz A, Elmouft S, Schiemann J, et al. Efficacy, safety, and tolerability of adjunctive brivaracetam for secondarily generalized tonic-clonic seizures: Pooled results from three Phase III studies. Epilepsy Res. 2016;127:179-185 pubmed publisher
    ..4%) of patients were rendered completely free of SGTCS during the 12-week treatment period when taking BRV ≥50mg/day. BRV was well tolerated, with a TEAE profile consistent with that of the overall study population. ..
  9. Asadi Pooya A, Rabiei A, Gracely E, Sperling M. Remote preoperative tonic-clonic seizures do not influence outcome after surgery for temporal lobe epilepsy. J Neurol Sci. 2016;369:330-332 pubmed publisher
    ..A recent history of tonic-clonic seizures in a patient with MTLE may reflect more widespread epileptogenicity extending beyond the borders of mesial temporal structures. ..

More Information


  1. Asadi Pooya A, Asadollahi M, Bujarski K, Rabiei A, Aminian N, Wyeth D, et al. Ictal verbal help-seeking: Occurrence and the underlying etiology. Epilepsy Behav. 2016;64:15-17 pubmed publisher
    ..Ictal verbal help-seeking is a rare finding among patients evaluated in epilepsy monitoring units. Ictal verbal help-seeking may suggest that seizures arise in or propagate to the right temporal lobe. ..
  2. Asadi Pooya A, Wyeth D, Nei M, Sharan A, Sperling M. Postsurgical outcome in patients with auditory auras and drug-resistant epilepsy. Epilepsy Behav. 2017;66:49-52 pubmed publisher
    ..The presence of an auditory aura in a patient with drug-resistant TLE carries a worse prognosis for a postoperative seizure free outcome and this is not related to the side of surgery. ..
  3. Asadi Pooya A, Nei M, Centurion E, Lorenzo M, Sperling M. Postsurgical outcome in patients with olfactory auras and drug-resistant epilepsy. Epilepsy Behav. 2017;68:8-10 pubmed publisher
    ..A multicenter approach, which can enroll more patients, is needed to devise better therapies for patients with drug-resistant epilepsy and this symptom. ..
  4. Asadi Pooya A, Wyeth D, Sperling M. Ictal crying. Epilepsy Behav. 2016;59:1-3 pubmed publisher
    ..Epileptic ictal crying is often a rare type of partial seizure in patients with focal epilepsy. Dacrystic seizures do not provide clinical value in predicting localization of the epileptogenic zone. ..
  5. Asadi Pooya A, Asadollahi M, Sperling M. Ictal pain: occurrence, clinical features, and underlying etiologies. Epilepsy Behav. 2016;61:59-62 pubmed publisher
    ..Psychogenic nonepileptic seizures are the most common cause, but ictal pain is not specific for this diagnosis. Location of the ictal pain in a limb may help differentiate an epileptic cause from others. ..
  6. Kang J, Sperling M. Epileptologist's view: Laser interstitial thermal ablation for treatment of temporal lobe epilepsy. Epilepsy Res. 2018;142:149-152 pubmed publisher
    ..More research must be done to establish optimal targeting of structures for ablation and selection of candidates for surgery, and more patients must be studied to better establish efficacy and adverse effect rates. ..
  7. Carreño M, Bien C, Asadi Pooya A, Sperling M, Marusic P, Elisak M, et al. Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies. Epilepsy Res. 2017;129:101-105 pubmed publisher
    ..Outcome seems to be worse than that expected in other etiologies, even in the presence of unilateral HS. Intracranial EEG may be required in some patients. ..