Research Topics
| B N SettySummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Role of erythrocyte phosphatidylserine in sickle red cell-endothelial adhesionB N Yamaja Setty
Division of Research Hematology, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Blood 99:1564-71. 2002..Our study signals the entrance of an important new contributor to the field of sickle erythrocyte-endothelial adhesion. The implications of erythrocyte PS exposure in relation to the vascular pathology of SCD need to be assessed...- Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activationB N Setty
Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Blood 96:1119-24. 2000..We suggest that the use of such surrogate biologic markers in conjunction with F-cell numbers may provide valuable insights into the biology and consequences of in vivo sickling... - Thrombophilia in sickle cell disease: the red cell connectionB N Setty
Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Blood 98:3228-33. 2001..No such relationship with platelet PS was noted. The use of erythrocyte PS as a surrogate marker in trials testing new therapeutic modalities may provide insights into the vascular complications of SCD... - Hemostatic alterations in sickle cell disease: relationships to disease pathophysiologyM J Stuart
Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Pediatr Pathol Mol Med 20:27-46. 2001..The etiology(s) of thrombin generation in SCD will be described. Whether the activation of the cellular and plasmatic phases of hemostasis is causative or occurs as a result of vascular injury will be discussed... - Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesionB N Setty
Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Blood 97:2568-73. 2001..These findings extend knowledge regarding the protective effects of HbF in the pathophysiology of sickle cell disease... - Arachidonic acid metabolites are involved in mediating red blood cell adherence to endotheliumB N Setty
Division of Pediatric Hematology Oncology, St Christopher s Hospital For Children, Philadelphia, PA 19134 1095, USA
J Lab Clin Med 125:608-17. 1995..Our studies document a role for the lipoxygenase metabolites in modulating basal adhesion of RBCs to both macrovascular and microvascular endothelium; the major cyclooxygenase metabolites appear to play no role in this process... - Acute chest syndrome of sickle cell disease: new light on an old problemM J Stuart
Department of Pediatrics, Division of Research Hematology, Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Curr Opin Hematol 8:111-22. 2001..An additional section of this review will deal with experimental therapies. The use of inhaled nitric oxide will be explored in depth because advances in this area are current and uniquely relevant to acute chest syndrome... - Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiologyB N Yamaja Setty
Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Lab Clin Med 139:80-9. 2002..These properties of LTB(4) are relevant to disease pathophysiology, providing further evidence of the contribution of the neutrophil to the proinflammatory and proadhesive phenotype in SCD... - Vaso-occlusion in children with sickle cell disease: clinical characteristics and biologic correlatesCarlton Dampier
Marian Anderson Comprehensive Sickle Cell Center, St Christopher s Hospital For Children, Eric Avenue at Front Street, Philadelphia, PA 19134 1095, USA
J Pediatr Hematol Oncol 26:785-90. 2004..The higher frequency of these home-managed episodes suggests their potential utility as additional outcome measures in studies of vaso-occlusive pain... 
Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytesB N Yamaja Setty
Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Blood 111:905-14. 2008..Our results demonstrate the existence of a novel functional adhesion receptor for PS on the microendothelium that is up-regulated by such pathologically relevant agonists as hypoxia, cytokines, and heme...- Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiologyB N Yamaja Setty
Department of Pediatrics and the Marian Anderson Sickle Cell Center Core Laboratory, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Lancet 362:1450-5. 2003..Further more, hypoxaemia in the older child also occurs during the day; such mild untreated hypoxia could lead to an increased risk of vaso-occlusive episodes...