B N Setty

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Role of erythrocyte phosphatidylserine in sickle red cell-endothelial adhesion
    B N Yamaja Setty
    Division of Research Hematology, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 99:1564-71. 2002
  2. ncbi request reprint Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 96:1119-24. 2000
  3. ncbi request reprint Thrombophilia in sickle cell disease: the red cell connection
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 98:3228-33. 2001
  4. ncbi request reprint Hemostatic alterations in sickle cell disease: relationships to disease pathophysiology
    M J Stuart
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Pediatr Pathol Mol Med 20:27-46. 2001
  5. ncbi request reprint Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesion
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 97:2568-73. 2001
  6. ncbi request reprint Arachidonic acid metabolites are involved in mediating red blood cell adherence to endothelium
    B N Setty
    Division of Pediatric Hematology Oncology, St Christopher s Hospital For Children, Philadelphia, PA 19134 1095, USA
    J Lab Clin Med 125:608-17. 1995
  7. ncbi request reprint Acute chest syndrome of sickle cell disease: new light on an old problem
    M J Stuart
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Curr Opin Hematol 8:111-22. 2001
  8. ncbi request reprint Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology
    B N Yamaja Setty
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Lab Clin Med 139:80-9. 2002
  9. ncbi request reprint Vaso-occlusion in children with sickle cell disease: clinical characteristics and biologic correlates
    Carlton Dampier
    Marian Anderson Comprehensive Sickle Cell Center, St Christopher s Hospital For Children, Eric Avenue at Front Street, Philadelphia, PA 19134 1095, USA
    J Pediatr Hematol Oncol 26:785-90. 2004
  10. pmc Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes
    B N Yamaja Setty
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 111:905-14. 2008

Detail Information

Publications11

  1. ncbi request reprint Role of erythrocyte phosphatidylserine in sickle red cell-endothelial adhesion
    B N Yamaja Setty
    Division of Research Hematology, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 99:1564-71. 2002
    ..Our study signals the entrance of an important new contributor to the field of sickle erythrocyte-endothelial adhesion. The implications of erythrocyte PS exposure in relation to the vascular pathology of SCD need to be assessed...
  2. ncbi request reprint Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 96:1119-24. 2000
    ..We suggest that the use of such surrogate biologic markers in conjunction with F-cell numbers may provide valuable insights into the biology and consequences of in vivo sickling...
  3. ncbi request reprint Thrombophilia in sickle cell disease: the red cell connection
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 98:3228-33. 2001
    ..No such relationship with platelet PS was noted. The use of erythrocyte PS as a surrogate marker in trials testing new therapeutic modalities may provide insights into the vascular complications of SCD...
  4. ncbi request reprint Hemostatic alterations in sickle cell disease: relationships to disease pathophysiology
    M J Stuart
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Pediatr Pathol Mol Med 20:27-46. 2001
    ..The etiology(s) of thrombin generation in SCD will be described. Whether the activation of the cellular and plasmatic phases of hemostasis is causative or occurs as a result of vascular injury will be discussed...
  5. ncbi request reprint Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesion
    B N Setty
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 97:2568-73. 2001
    ..These findings extend knowledge regarding the protective effects of HbF in the pathophysiology of sickle cell disease...
  6. ncbi request reprint Arachidonic acid metabolites are involved in mediating red blood cell adherence to endothelium
    B N Setty
    Division of Pediatric Hematology Oncology, St Christopher s Hospital For Children, Philadelphia, PA 19134 1095, USA
    J Lab Clin Med 125:608-17. 1995
    ..Our studies document a role for the lipoxygenase metabolites in modulating basal adhesion of RBCs to both macrovascular and microvascular endothelium; the major cyclooxygenase metabolites appear to play no role in this process...
  7. ncbi request reprint Acute chest syndrome of sickle cell disease: new light on an old problem
    M J Stuart
    Department of Pediatrics, Division of Research Hematology, Jefferson Medical College and the Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Curr Opin Hematol 8:111-22. 2001
    ..An additional section of this review will deal with experimental therapies. The use of inhaled nitric oxide will be explored in depth because advances in this area are current and uniquely relevant to acute chest syndrome...
  8. ncbi request reprint Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology
    B N Yamaja Setty
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Division of Research Hematology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Lab Clin Med 139:80-9. 2002
    ..These properties of LTB(4) are relevant to disease pathophysiology, providing further evidence of the contribution of the neutrophil to the proinflammatory and proadhesive phenotype in SCD...
  9. ncbi request reprint Vaso-occlusion in children with sickle cell disease: clinical characteristics and biologic correlates
    Carlton Dampier
    Marian Anderson Comprehensive Sickle Cell Center, St Christopher s Hospital For Children, Eric Avenue at Front Street, Philadelphia, PA 19134 1095, USA
    J Pediatr Hematol Oncol 26:785-90. 2004
    ..The higher frequency of these home-managed episodes suggests their potential utility as additional outcome measures in studies of vaso-occlusive pain...
  10. pmc Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes
    B N Yamaja Setty
    Marian Anderson Comprehensive Sickle Cell Anemia Care and Research Center, Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 111:905-14. 2008
    ..Our results demonstrate the existence of a novel functional adhesion receptor for PS on the microendothelium that is up-regulated by such pathologically relevant agonists as hypoxia, cytokines, and heme...
  11. ncbi request reprint Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology
    B N Yamaja Setty
    Department of Pediatrics and the Marian Anderson Sickle Cell Center Core Laboratory, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Lancet 362:1450-5. 2003
    ..We attempted to examine the biological relations, and describe the haematological risk factors for oxyhaemoglobin desaturation...