Jay Schneider

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Predictors of cognitive outcomes in early Parkinson disease patients: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Parkinsonism Relat Disord 16:507-12. 2010
  2. doi request reprint Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mov Disord 28:663-7. 2013
  3. pmc Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Toxicol Lett 217:75-81. 2013
  4. doi request reprint Effects of memantine and galantamine on cognitive performance in aged rhesus macaques
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA19107, USA
    Neurobiol Aging 34:1126-32. 2013
  5. pmc A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients
    Jay S Schneider
    Dept of Pathology, Anatomy and Cell Biology and Parkinson s Disease Research Unit, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neurol Sci 324:140-8. 2013
  6. pmc Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Toxicol Sci 129:108-25. 2012
  7. pmc Differential effect of postnatal lead exposure on gene expression in the hippocampus and frontal cortex
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    J Mol Neurosci 47:76-88. 2012
  8. pmc Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Behav Brain Res 211:236-9. 2010
  9. pmc Effects of chronic manganese exposure on working memory in non-human primates
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 1258:86-95. 2009
  10. ncbi request reprint Postnatal lead poisoning impairs behavioral recovery following brain damage
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Neurotoxicology 28:1153-7. 2007

Research Grants

Detail Information

Publications31

  1. pmc Predictors of cognitive outcomes in early Parkinson disease patients: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Parkinsonism Relat Disord 16:507-12. 2010
    ....
  2. doi request reprint Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mov Disord 28:663-7. 2013
    ..Therefore, remediation of PD cognitive deficits is a major unmet need. However, drug development efforts have been hampered by lack of an animal model in which motor and cognitive deficits can be examined simultaneously...
  3. pmc Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Toxicol Lett 217:75-81. 2013
    ..These data suggest potential epigenetic effects of developmental Pb exposure on DNA methylation mediated at least in part through dysregulation of methyltransferases...
  4. doi request reprint Effects of memantine and galantamine on cognitive performance in aged rhesus macaques
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA19107, USA
    Neurobiol Aging 34:1126-32. 2013
    ..These data suggest that the nonhuman primate might have more predictive validity for drug development in this area than comparable rodent assays...
  5. pmc A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients
    Jay S Schneider
    Dept of Pathology, Anatomy and Cell Biology and Parkinson s Disease Research Unit, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neurol Sci 324:140-8. 2013
    ..The data from this small study suggest that GM1 may have symptomatic and potentially disease modifying effects on PD...
  6. pmc Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Toxicol Sci 129:108-25. 2012
    ....
  7. pmc Differential effect of postnatal lead exposure on gene expression in the hippocampus and frontal cortex
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    J Mol Neurosci 47:76-88. 2012
    ....
  8. pmc Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Behav Brain Res 211:236-9. 2010
    ..10 mg/kg). These data suggest that clonidine or drugs of this class, perhaps with greater receptor subtype selectivity and low sedation liability, might be effective therapeutics for cognitive dysfunction associated with PD...
  9. pmc Effects of chronic manganese exposure on working memory in non-human primates
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 1258:86-95. 2009
    ....
  10. ncbi request reprint Postnatal lead poisoning impairs behavioral recovery following brain damage
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Neurotoxicology 28:1153-7. 2007
    ..Considering the increased risk for hypertension and cardiovascular disease in lead-exposed humans, diminished capacity for repair or adaptation following lead exposure needs to now be examined in greater detail...
  11. pmc Sex-based differences in gene expression in hippocampus following postnatal lead exposure
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Toxicol Appl Pharmacol 256:179-90. 2011
    ..These results show that a brief exposure to lead produced significant changes in expression of a variety of genes in the hippocampus and that the response of the brain to a given lead exposure may vary depending on sex...
  12. ncbi request reprint Behavioral persistence deficit in Parkinson's disease patients
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Eur J Neurol 14:300-4. 2007
    ....
  13. doi request reprint GM1 ganglioside in Parkinson's disease: Results of a five year open study
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neurol Sci 292:45-51. 2010
    ..Additional study is required to more completely assess the degree to which GM1 treatment may be a symptomatic and/or disease-modifying agent for treatment of PD...
  14. pmc Effects of chronic manganese exposure on cognitive and motor functioning in non-human primates
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 1118:222-31. 2006
    ..These results suggest that chronic exposure to levels of manganese achieved in this study may have detrimental effects on behavior, cognition and motor functioning...
  15. ncbi request reprint The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 306:401-6. 2003
    ....
  16. ncbi request reprint Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration of symptoms
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 990:38-44. 2003
    ....
  17. ncbi request reprint The synthetic ceramide analog L-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 1099:199-205. 2006
    ..These data suggest that the administration of L-PDMP as a means to enhance endogenous brain GM1 levels may hold limited promise as a potential neuroprotective or neurorestorative therapeutic strategy for Parkinson's disease...
  18. ncbi request reprint Inhibition of progenitor cell proliferation in the dentate gyrus of rats following post-weaning lead exposure
    J S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Neurotoxicology 26:141-5. 2005
    ..These results suggest that postnatal lead exposure can have significant deleterious effects on progenitor cell proliferation and thus the structure and function of the hippocampus...
  19. ncbi request reprint Beta2* and beta4* nicotinic acetylcholine receptor expression changes with progressive parkinsonism in non-human primates
    Jennifer M Kulak
    Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, 1020 Locust St, 521 JAH Philadelphia, PA 19107, USA
    Neurobiol Dis 27:312-9. 2007
    ....
  20. ncbi request reprint [125I]Iodomethyllycaconitine binds to alpha7 nicotinic acetylcholine receptors in monkey brain
    Jennifer M Kulak
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, 521 JAH, Philadelphia, PA 19107, USA
    Eur J Neurosci 23:2604-10. 2006
    ..This radioligand may be a useful tool for selectively imaging alpha7-containing nAChRs in vivo...
  21. ncbi request reprint Differences in alpha7 nicotinic acetylcholine receptor binding in motor symptomatic and asymptomatic MPTP-treated monkeys
    Jennifer M Kulak
    Department of Pathology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 999:193-202. 2004
    ....
  22. ncbi request reprint Striatal preprotachykinin gene expression reflects parkinsonian signs
    Timothy V Wade
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Rm 521 Jefferson Alumni Hall, Philadelphia, PA 19107, USA
    Neuroreport 15:2481-4. 2004
    ..Thus, PPT gene expression in the striatum appears to reflect presence or absence of sensorimotor deficits in MPTP-treated cats...
  23. ncbi request reprint GABA(A) and mu-opioid receptor binding in the globus pallidus and endopeduncular nucleus of animals symptomatic for and recovered from experimental Parkinsonism
    Joseph A Schroeder
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, 521 JAH, Philadelphia, PA 19107, USA
    Brain Res 947:284-9. 2002
    ..Upon recovery from experimental parkinsonism, however, pallidal GABA(A) receptor binding returns to normal levels while mu-opioid receptor binding reflecting enkephalin release remains elevated...
  24. ncbi request reprint Neuroprotection in Parkinson models varies with toxin administration protocol
    David W Anderson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia PA 19107, USA
    Eur J Neurosci 24:3174-82. 2006
    ..This strategy may better identify compounds with broad neuroprotective/neurorestorative profiles that may be more likely to be clinically effective...
  25. ncbi request reprint Experimental parkinsonism is associated with increased pallidal GAD gene expression and is reversed by site-directed antisense gene therapy
    Jay S Schneider
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mov Disord 18:32-40. 2003
    ....
  26. pmc Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
    Jingli Cai
    Farber Institute for Neurosciences, Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Stem Cells Dev 19:1017-23. 2010
    ....
  27. ncbi request reprint Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 202:381-90. 2006
    ....
  28. doi request reprint Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:1948-59. 2008
    ..These changes may explain the subtle cognitive deficits previously demonstrated in these same animals...
  29. ncbi request reprint Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 94:351-8. 2006
    ..This is supported by a significantly decreased, in the parietal cortex, NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction...
  30. ncbi request reprint Lead neurotoxicity in children: basic mechanisms and clinical correlates
    Theodore I Lidsky
    Center for Trace Element Studies and Environmental Neurotoxicology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain 126:5-19. 2003
    ..The public health implications of these findings are discussed...
  31. pmc Manganese: recent advances in understanding its transport and neurotoxicity
    Michael Aschner
    Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232 2495, USA
    Toxicol Appl Pharmacol 221:131-47. 2007
    ..Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans...

Research Grants28

  1. Clinical Center: Parkinson's Disease Neuroprotection Trial
    Jay Schneider; Fiscal Year: 2007
    ..abstract_text> ..
  2. Nicotine and Cognition in Parkinsonism
    Jay Schneider; Fiscal Year: 2007
    ..Information obtained from these studies will hopefully lead to more efficient design of nicotinic therapeutics for patients with a variety of cognitive disorders. ..
  3. GM1 Ganglioside Effects on Parkinson's Disease
    Jay Schneider; Fiscal Year: 2007
    ..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. ..
  4. Attention and Executive Functioning in Aging and Parkisonism
    Jay Schneider; Fiscal Year: 2009
    ....
  5. Attention and Executive Functioning in Aging and Parkisonism
    Jay S Schneider; Fiscal Year: 2010
    ....
  6. Environment and Gene Effects on Brain and Behavior
    Jay Schneider; Fiscal Year: 2009
    ....
  7. GM1 GANGLIOSIDE EFFECTS ON PARKINSONS DISEASE
    Jay Schneider; Fiscal Year: 2003
    ....
  8. Nicotine and Cognition in Parkinsonism
    Jay Schneider; Fiscal Year: 2005
    ..abstract_text> ..
  9. Environment and Gene Effects on Brain and Behavior
    Jay S Schneider; Fiscal Year: 2010
    ....