C Schmutte

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi The interaction of DNA mismatch repair proteins with human exonuclease I
    C Schmutte
    Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 276:33011-8. 2001
  2. ncbi Human exonuclease I interacts with the mismatch repair protein hMSH2
    C Schmutte
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 58:4537-42. 1998
  3. ncbi Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 58:5023-6. 1998
  4. ncbi BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
    A Slupianek
    Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Mol Cell 8:795-806. 2001
  5. ncbi Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:4564-9. 1999
  6. ncbi Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:3010-5. 1997
  7. ncbi Genomic instability: first step to carcinogenesis
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Anticancer Res 19:4665-96. 1999
  8. ncbi The role of mismatch repair in small-cell lung cancer cells
    L T Hansen
    Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Eur J Cancer 39:1456-67. 2003
  9. ncbi Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene
    K Hammani
    Division of Hematology Oncology, Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California 90054 0700, USA
    J Biol Chem 271:25498-505. 1996

Collaborators

Detail Information

Publications9

  1. ncbi The interaction of DNA mismatch repair proteins with human exonuclease I
    C Schmutte
    Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 276:33011-8. 2001
    ..In addition, hExoI forms an immunoprecipitable complex with hMLH1/hPMS2 in vivo. The study of interaction regions suggests a biochemical mechanism of the involvement of hExoI as a downstream effector in MMR and/or DNA recombination...
  2. ncbi Human exonuclease I interacts with the mismatch repair protein hMSH2
    C Schmutte
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 58:4537-42. 1998
    ..hExoI was found to interact strongly with the human MMR protein hMSH2, suggesting its involvement in the MMR process and/or DNA recombination...
  3. ncbi Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 58:5023-6. 1998
    ..These results clarify the position of the chromosome 2 hereditary nonpolyposis colorectal cancer locus, which was originally reported to be associated with an adjacent region (chromosome 2p14-16)...
  4. ncbi BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
    A Slupianek
    Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Mol Cell 8:795-806. 2001
    ..Induction of the mammalian RecA homologs establishes a unique mechanism for DNA damage resistance in mammalian cells transformed by an oncogenic tyrosine kinase...
  5. ncbi Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:4564-9. 1999
    ..No indication of hypermethylation was found. These results suggest that hRad51 is not a tumor suppressor because it is either an essential gene, redundant gene and/or independent of the BRCA1/BRCA2 tumor suppressor pathway(s)...
  6. ncbi Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:3010-5. 1997
    ..At present, we have found no evidence that TDG is central to the development of gastric cancer, limiting the importance of TDG in T:G mismatch repair and subsequent carcinogenesis...
  7. ncbi Genomic instability: first step to carcinogenesis
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Anticancer Res 19:4665-96. 1999
    ..Therefore, genomic instability including genetic and/or epigenetic alterations may be the first step in carcinogenesis. Knowledge of these biochemical mechanisms are likely to lead to more effective cancer diagnosis and therapy...
  8. ncbi The role of mismatch repair in small-cell lung cancer cells
    L T Hansen
    Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Eur J Cancer 39:1456-67. 2003
    ..We conclude that MMR deficiency is largely not associated with the pathogenesis of SCLC...
  9. ncbi Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene
    K Hammani
    Division of Hematology Oncology, Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California 90054 0700, USA
    J Biol Chem 271:25498-505. 1996
    ..These differences are likely to explain the specific roles that these inhibitors play in the regulation of matrix metalloproteinases...