Jorge A Roman-Blas

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Osteoarthritis associated with estrogen deficiency
    Jorge A Roman-Blas
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid 28040, Spain
    Arthritis Res Ther 11:241. 2009
  2. ncbi request reprint NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    J A Roman-Blas
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA19107 5541, USA
    Osteoarthritis Cartilage 14:839-48. 2006
  3. doi request reprint Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis
    Jorge A Roman-Blas
    Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA
    Int Rev Immunol 27:351-74. 2008
  4. doi request reprint Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 39:71-80. 2009
  5. pmc Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
    Miriam Bellido
    Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Avda, Reyes Catolicos, 2, 28040 Madrid, Spain
    Arthritis Res Ther 12:R152. 2010
  6. doi request reprint Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes
    Jorge A Roman-Blas
    Joint and Bone Research Unit, Rheumatology Service, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Eur J Pharmacol 623:125-31. 2009
  7. doi request reprint Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Ann Rheum Dis 70:1523-5. 2011
  8. pmc RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis
    María J Martínez-Calatrava
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez D237 az, Universidad Autonoma, Av, Reyes Catolicos 2, 28040, Madrid, Spain
    Arthritis Res Ther 14:R149. 2012
  9. doi request reprint Subchondral bone as a key target for osteoarthritis treatment
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, IIS Princesa, Universidad Autonoma, Madrid, Spain
    Biochem Pharmacol 83:315-23. 2012
  10. doi request reprint An OA phenotype may obtain major benefit from bone-acting agents
    Jorge A Roman-Blas
    Bone and Joint Research Unit, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 43:421-8. 2014

Detail Information

Publications15

  1. pmc Osteoarthritis associated with estrogen deficiency
    Jorge A Roman-Blas
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid 28040, Spain
    Arthritis Res Ther 11:241. 2009
    ..Thus, a better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ...
  2. ncbi request reprint NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    J A Roman-Blas
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA19107 5541, USA
    Osteoarthritis Cartilage 14:839-48. 2006
    ....
  3. doi request reprint Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis
    Jorge A Roman-Blas
    Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA
    Int Rev Immunol 27:351-74. 2008
    ..In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis...
  4. doi request reprint Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 39:71-80. 2009
    ....
  5. pmc Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
    Miriam Bellido
    Service of Rheumatology, Fundacion Jimenez Diaz, Universidad Autonoma, Avda, Reyes Catolicos, 2, 28040 Madrid, Spain
    Arthritis Res Ther 12:R152. 2010
    ..Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model...
  6. doi request reprint Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes
    Jorge A Roman-Blas
    Joint and Bone Research Unit, Rheumatology Service, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Eur J Pharmacol 623:125-31. 2009
    ..Therefore, NAC might have a symptomatic effect on the synovium rather than a structural effect on the cartilage in osteoarthritis...
  7. doi request reprint Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis
    Gabriel Herrero-Beaumont
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Ann Rheum Dis 70:1523-5. 2011
    ..Four clinical settings could arise from this relationship, and furthermore two phenotypes may be identified whether early osteoarthritis coexists with high or low BMD...
  8. pmc RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis
    María J Martínez-Calatrava
    Bone and Joint Research Unit, Service of Rheumatology, IIS Fundación Jiménez D237 az, Universidad Autonoma, Av, Reyes Catolicos 2, 28040, Madrid, Spain
    Arthritis Res Ther 14:R149. 2012
    ..This study aimed to determine whether RANKL produced by chondrocytes induces osteoclastogenesis and juxta-articular bone loss associated with chronic arthritis...
  9. doi request reprint Subchondral bone as a key target for osteoarthritis treatment
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, IIS Princesa, Universidad Autonoma, Madrid, Spain
    Biochem Pharmacol 83:315-23. 2012
    ....
  10. doi request reprint An OA phenotype may obtain major benefit from bone-acting agents
    Jorge A Roman-Blas
    Bone and Joint Research Unit, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Semin Arthritis Rheum 43:421-8. 2014
    ..Despite this, the treatment of knee OA patients with antiresorptive drugs has given discordant results, suggesting the existence of a particular patient subset with good response to halting high subchondral remodeling...
  11. doi request reprint PTH [1-34] enhances bone response around titanium implants in a rabbit model of osteoporosis
    M Isabel Almagro
    Department of Dentistry, IIS Fundación Jiménez Díaz, Universidad Autonoma, Madrid, Spain
    Clin Oral Implants Res 24:1027-34. 2013
    ..Therefore, we studied the effects of intermittent PTH [1-34] on bone response around titanium implants in experimental osteoporosis induced by ovariectomy and glucocorticoid administration...
  12. doi request reprint Efficacy and safety of a selective estrogen receptor β agonist, ERB-041, in patients with rheumatoid arthritis: a 12-week, randomized, placebo-controlled, phase II study
    Jorge A Roman-Blas
    Universidad Autonoma, Madrid, Spain
    Arthritis Care Res (Hoboken) 62:1588-93. 2010
    ..This study aimed to compare the efficacy and safety of one of these agonists, ERB-041, in subjects with rheumatoid arthritis (RA)...
  13. ncbi request reprint Progression of chondrogenesis in C3H10T1/2 cells is associated with prolonged and tight regulation of ERK1/2
    M Reza Seghatoleslami
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 88:1129-44. 2003
    ..Our findings show that the activity of ERK1/2 in chondrogenic cultures of C3H10T1/2 cells is tightly controlled and can cross interact with other signaling activities mediated by BMP-2 to positively regulate chondrogensis...
  14. doi request reprint Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model
    Yejia Zhang
    Departments of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 33:831-8. 2008
    ..Rabbit knee articular chondrocytes overexpressing human growth factors were injected into cultured intervertebral disc explants. Survival of the injected cells and accumulation of extracellular matrix were assessed...
  15. pmc Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes
    J A Roman-Blas
    Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Osteoarthritis Cartilage 15:1367-77. 2007
    ....