Roger Pomerantz

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint The HIV-1 Vif protein: a paradigm for viral:cell interactions
    R J Pomerantz
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Mol Life Sci 60:2017-9. 2003
  2. ncbi request reprint Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 52:297-306. 2004
  3. ncbi request reprint Twenty years of therapy for HIV-1 infection
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Med 9:867-73. 2003
  4. ncbi request reprint Effects of HIV-1 Vpr on neuroinvasion and neuropathogenesis
    Roger J Pomerantz
    Biochemistry and Molecular Pharmacology, Division of Infectious Disease and Environmental Medicine, Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 23:227-38. 2004
  5. ncbi request reprint RNA interference:a potential novel therapeutic combating HIV-1 in the central nervous system
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 52:401-9. 2004
  6. ncbi request reprint First International Workshop on HIV-1 Persistence During Therapy
    Roger Pomerantz
    Center for Human Virology and Biodefense, Philadelphia, Pennsylvania, USA
    HIV Clin Trials 5:40-9. 2004
  7. ncbi request reprint Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways
    Wei Chen
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 334:59-73. 2005
  8. pmc Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells
    Rene Daniel
    Thomas Jefferson University, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, JAH Suite 321, 1020 Locust St, Philadelphia, PA 19107, USA
    J Virol 79:2058-65. 2005
  9. ncbi request reprint Spleen necrosis virus-based vector delivery of anti-HIV-1 genes potently protects human hematopoietic cells from HIV-1 infection
    Elena I Marusich
    Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Center for Human Virology and Biodefense, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 332:258-71. 2005
  10. pmc IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    Feng Xiang Wang
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:128-37. 2005

Research Grants

  1. MOLECULAR THERAPEUTICS FOR HIV1 INDUCED CNS DYSFUNCTION
    Roger Pomerantz; Fiscal Year: 2002
  2. Retroviral Vectors for Gene Therapy of HIV-1 Infection
    Roger Pomerantz; Fiscal Year: 2003
  3. HIV/AIDS Intravirion Reverse Transcription and Virucides
    Roger Pomerantz; Fiscal Year: 2004
  4. Alcohol's Effects on HIV-1 and the Blood: Brain Barrier
    Roger Pomerantz; Fiscal Year: 2004
  5. Gene Therapy of AIDS Dementia
    Roger Pomerantz; Fiscal Year: 2004
  6. Effects of HIV -1 Proteins on the Blood/ Brain Barrier
    Roger Pomerantz; Fiscal Year: 2004

Collaborators

Detail Information

Publications63

  1. ncbi request reprint The HIV-1 Vif protein: a paradigm for viral:cell interactions
    R J Pomerantz
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Mol Life Sci 60:2017-9. 2003
  2. ncbi request reprint Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 52:297-306. 2004
    ..These will include induction of HIV-1 latent proviruses, suppression of residual viral replication and destruction of long-lived cellular sanctuaries, such astissue-bound macrophages...
  3. ncbi request reprint Twenty years of therapy for HIV-1 infection
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Med 9:867-73. 2003
    ..This article summarizes the accomplishments thus far and what lies ahead in our struggle to improve the treatment of, and possibly eliminate, HIV-1 infection...
  4. ncbi request reprint Effects of HIV-1 Vpr on neuroinvasion and neuropathogenesis
    Roger J Pomerantz
    Biochemistry and Molecular Pharmacology, Division of Infectious Disease and Environmental Medicine, Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 23:227-38. 2004
    ..One of these proteins, the accessory HIV-1 protein Vpr, is a critical moiety in these studies, and will be discussed in this article...
  5. ncbi request reprint RNA interference:a potential novel therapeutic combating HIV-1 in the central nervous system
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 52:401-9. 2004
    ..Thus, we now seek to combine our background in molecular therapeutics and RNAi with our long-standing interest in HIV-1 neuropathogenesis to target the CNS using siRNAs...
  6. ncbi request reprint First International Workshop on HIV-1 Persistence During Therapy
    Roger Pomerantz
    Center for Human Virology and Biodefense, Philadelphia, Pennsylvania, USA
    HIV Clin Trials 5:40-9. 2004
  7. ncbi request reprint Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways
    Wei Chen
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 334:59-73. 2005
    ..Thus, these data suggest rationally-designed, molecular targets for potential anti-HIV-1 neuroprotection...
  8. pmc Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cells
    Rene Daniel
    Thomas Jefferson University, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, JAH Suite 321, 1020 Locust St, Philadelphia, PA 19107, USA
    J Virol 79:2058-65. 2005
    ..Taken together, these data suggest that the effect(s) of caffeine on HIV-1 transduction is mediated at least partly by the inhibition of the ATR pathway but is not dependent on the caffeine-mediated inhibition of cell cycle checkpoints...
  9. ncbi request reprint Spleen necrosis virus-based vector delivery of anti-HIV-1 genes potently protects human hematopoietic cells from HIV-1 infection
    Elena I Marusich
    Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Center for Human Virology and Biodefense, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 332:258-71. 2005
    ....
  10. pmc IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    Feng Xiang Wang
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:128-37. 2005
    ....
  11. ncbi request reprint Pentoxifylline suppresses transduction by HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intervirology 50:377-86. 2007
    ....
  12. pmc Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains
    Rajnish S Dave
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust St, Suite 329, Philadelphia, PA 19107, USA
    J Virol 78:13687-96. 2004
    ....
  13. pmc Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque
    Philip M McKenna
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    J Virol 78:13455-9. 2004
    ..6P). There was no evidence of CD4(+) T-cell loss, and plasma viremia was controlled to undetectable levels by 6 weeks postchallenge and has remained suppressed out to 22 weeks postchallenge...
  14. ncbi request reprint Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents
    Joseph Kulkosky
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 20:497-505. 2004
    ....
  15. pmc Cross-packaging of human immunodeficiency virus type 1 vector RNA by spleen necrosis virus proteins: construction of a new generation of spleen necrosis virus-derived retroviral vectors
    Zahida Parveen
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, 1020 Locust St, Ste 329, Philadelphia, PA 19107, USA
    J Virol 78:6480-8. 2004
    ..These studies should provide further insight into the design and development of novel molecular approaches to block HIV-1 replication and to construct a new generation of SNV-based vectors...
  16. pmc Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases
    Edward A Acheampong
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Virol 79:4257-69. 2005
    ..The results of this study demonstrate that Nef likely contributes to the neuroinvasion and neuropathogenesis of HIV-1, through its effects on select cellular processes, including various apoptotic cascades...
  17. ncbi request reprint Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines
    Giuseppe Nunnari
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 335:177-84. 2005
    ..These data reveal the feasibility of therapeutic approaches targeting host cell proteins and further support the hypothesis that ATR and ATM proteins are involved in retroviral DNA integration...
  18. ncbi request reprint Down-modulation of the CXCR4 co-receptor by intracellular expression of a single chain variable fragment (SFv) inhibits HIV-1 entry into primary human brain microvascular endothelial cells and post-mitotic neurons
    Muhammad Mukhtar
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res Mol Brain Res 135:48-57. 2005
    ..The ability to selectively down-modulate the surface expression of CXCR4 in CNS cells may allow for the development of clinical molecular therapy strategies against HIV-1-related neurodegenerative disorders and neuroinvasion...
  19. ncbi request reprint Hide-and-seek: the challenge of viral persistence in HIV-1 infection
    Luc Geeraert
    Tibotec BVBA, BE 2800 Mechelen, Belgium
    Annu Rev Med 59:487-501. 2008
    ..A more detailed understanding of the basic mechanisms underlying the establishment and long-term maintenance of HIV-1 reservoirs will be critical in developing new eradication approaches...
  20. ncbi request reprint Effects of highly active antiretroviral therapy on HIV-1-associated oral complications
    Zahida Parveen
    Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Curr HIV Res 5:281-92. 2007
    ..Future directions envisioned by the National Institutes of Health as well as novel avenues to be explored are also presented...
  21. ncbi request reprint HIV-1 Vpr potently induces programmed cell death in the CNS in vivo
    Xiaodong Cheng
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    DNA Cell Biol 26:116-31. 2007
    ..We propose that this, in expensive animal model, may be of value to design-targeted neuroprotective therapeutics...
  22. ncbi request reprint siRNA targeting vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects
    Rajnish S Dave
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 348:489-97. 2006
    ..These studies demonstrate the utility of E3L-specific siRNAs as potent antiviral agents for small pox and related pox viruses...
  23. ncbi request reprint Anti-HIV-1 microbicides -- 'chemical condoms' designed to limit the scourge of the HIV-1 pandemic
    Stephen J Scholand
    Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Curr Pharm Des 11:3747-56. 2005
    ..Important features include safety, efficacy and user acceptability. This review summarizes some of the important products in the development pipeline...
  24. ncbi request reprint IL-7 as a potential therapy for HIV-1-infected individuals
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Expert Opin Biol Ther 5:1421-6. 2005
    ..In this present review, different immunological and virological properties of IL-7 are discussed, along with the possibility of its use as part of a combined antiretroviral-immune rationally based HIV-1 eradication approach...
  25. ncbi request reprint T-Cells and excitotoxicity: HIV-1 and other neurodegenerative disorders
    Muhammad Mukhtar
    The Jefferson Institute for Research in Human Virology and Biodefense Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Neuromolecular Med 7:265-73. 2005
    ....
  26. ncbi request reprint Seminal reservoirs during an HIV type 1 eradication trial
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:768-75. 2005
    ..This study suggests viral compartmentalization of the semen microenvironment after an intensification and stimulatory HIV-1 eradication protocol, with evidence of viral evolution...
  27. ncbi request reprint Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 11:319-28. 2005
    ....
  28. ncbi request reprint HIV type 1 cervicovaginal reservoirs in the era of HAART
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Jefferson Alumni Hall, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:714-8. 2005
    ..Nonetheless, the presence of even low cell-free HIV-1 RNA in cervicovaginal secretions continues to suggest the importance of practicing protected sex, even in the era of HAART...
  29. ncbi request reprint Antiretroviral therapy in the developing world
    Lalita Chulamokha
    Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Neurovirol 11:76-80. 2005
  30. ncbi request reprint Current status of gene therapy strategies to treat HIV/AIDS
    David S Strayer
    Department of Pathology, Jefferson Medical College, 1020 Locust Street, Room 251, Philadelphia, PA 19107, USA
    Mol Ther 11:823-42. 2005
    ..This review focuses on the newest developments in these areas and provides a strong basis for renewed optimism that gene therapy will have an important role to play in treating people infected with HIV-1...
  31. ncbi request reprint The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes
    Jianhua Fang
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 336:299-307. 2005
    ..Thus, these data suggest a molecular mechanism(s) for restricted replication in astrocytes as a potential low-level site of residual HIV-1 in vivo...
  32. ncbi request reprint ATM: HIV-1's Achilles heel?
    Rene Daniel
    Nat Cell Biol 7:452-3. 2005
  33. ncbi request reprint HIV-1 Vif versus APOBEC3G: newly appreciated warriors in the ancient battle between virus and host
    Elias G Argyris
    Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Disease and Environmental Medicine, Dept of Medicine, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Trends Microbiol 12:145-8. 2004
  34. pmc HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
    Yan Xu
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:7070-5. 2004
    ..These analyses suggest molecular mechanisms for the induction of apoptosis relating to the exposure of viral and host cell factors and rationally designed approaches toward neuroprotection...
  35. pmc In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months
    Michele Di Mascio
    Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    J Virol 77:2271-5. 2003
    ..This range of half-lives is consistent with the estimated half-life of the latent HIV-1 reservoir in the peripheral blood. Those patients without decay of viral load in plasma may have significant cryptic HIV-1 residual replication...
  36. ncbi request reprint Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells
    Edward Acheampong
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferdon University, Philadelphia, Pennsylvania 19107, USA
    Virology 304:222-34. 2002
    ..Thus, these studies demonstrate ethanol's potential for inducing apoptosis of human MVECs with relevant HIV-1-specific proteins and suggest a potential synergistic effect in augmenting HIV-1 neuroinvasion and neuropathogenesis in vivo...
  37. ncbi request reprint Approaching eradication of highly active antiretroviral therapy-persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy
    Joseph Kulkosky
    Dorrance H Hamilton Laboratories, Center for Human Virology and Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Infect Dis 35:1520-6. 2002
    ..These studies and new approaches to activating latent virus in resting CD4+ T cells are reviewed and critically analyzed in the present report. Development of novel IAT may lead to long-term remission or viral eradication in the future...
  38. ncbi request reprint Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy
    Joseph Kulkosky
    Dorrance Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 186:1403-11. 2002
    ..Additional experimental approaches must be developed if HIV-1 eradication is to become possible in patients receiving virally suppressive HAART...
  39. ncbi request reprint HIV-1 reservoirs
    Roger J Pomerantz
    Dorrance H Hamilton Laboratory, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Lab Med 22:651-80, vi. 2002
    ..The advent of combination therapeutics for HIV-1 (i.e., highly active antiretroviral therapy [HAART]) has led to dramatic reductions in viral replication in vivo and morbidity and mortality, at least in the developed world...
  40. ncbi request reprint Eliminating HIV-1 reservoirs
    Roger J Pomerantz
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Opin Investig Drugs 3:1133-7. 2002
    ..In understanding the molecular pathogenesis of HIV-1 disease, one can potentially target these cellular reservoirs of HIV-1 persistence...
  41. ncbi request reprint RNA interference meets HIV-1: will silence be golden?
    Roger J Pomerantz
    Nat Med 8:659-60. 2002
  42. ncbi request reprint Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN
    Muhammad Mukhtar
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Virology 297:78-88. 2002
    ..These data will assist in further understanding lentiviral entry into the CNS...
  43. ncbi request reprint Gene therapy using a simian virus 40-derived vector inhibits the development of in vivo human immunodeficiency virus type 1 infection of severe combined immunodeficiency mice implanted with human fetal thymic and liver tissue
    Harris Goldstein
    Departments of Pediatrics and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 185:1425-30. 2002
    ..In addition, these data indicate that SV40-derived vectors may provide a system capable of efficient in vivo gene delivery...
  44. ncbi request reprint Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons
    Charvi A Patel
    The Dorrance H Hamilton Laboratories, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 8:86-99. 2002
    ..Thus, Vpr delivered intracellularly, as well as extracellularly, is involved in the induction of significant neuronal apoptosis and may be one of the molecular mechanisms in HIV-1-induced encephalopathy...
  45. ncbi request reprint Combination genetic therapy to inhibit HIV-1
    David S Strayer
    Department of Pathology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Ther 5:33-41. 2002
    ..Thus, combination gene therapies may inhibit HIV-1 better than single agents, and rSV40s may facilitate delivery of multigene therapeutics...
  46. ncbi request reprint Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections
    Giuseppe Nunnari
    Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS 16:39-45. 2002
    ..Despite HAART, on-going in vivo infection of HIV-1-seropositive patients' PBMC was demonstrated by the detection of episomal HIV-1 moieties, known as HIV-1 two-long terminal repeat (2-LTR) DNA circles...
  47. pmc Rhabdovirus-based vectors with human immunodeficiency virus type 1 (HIV-1) envelopes display HIV-1-like tropism and target human dendritic cells
    Heather D Foley
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 76:19-31. 2002
    ..The ability of RV-based vectors to infect professional antigen-presenting cells efficiently further emphasizes the potential use of recombinant RVs as vaccines...
  48. ncbi request reprint Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ
    Naiming Zhou
    The Dorrance H Hamilton Laboratories, Thomas Jefferson University, Jefferson Medical College, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 307:22-36. 2003
    ..The CNS represents a unique reservoir site for HIV-1. As such, molecular therapeutics and small molecular inhibitors of HIV-1 entry via this unique CNS receptor are now able to be rationally designed...
  49. ncbi request reprint Reservoirs, sanctuaries, and residual disease: the hiding spots of HIV-1
    Roger J Pomerantz
    Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    HIV Clin Trials 4:137-43. 2003
    ..An understanding of these sanctuaries and reservoirs for HIV-1 in the setting of virally suppressive HAART will be critical in developing new approaches to induce HIV-1 remissions or the possibility of viral eradication in the future...
  50. ncbi request reprint Daily low-dose subcutaneous interleukin-2 added to single- or dual-nucleoside therapy in HIV infection does not protect against CD4+ T-cell decline or improve other indices of immune function: results of a randomized controlled clinical trial (ACTG 248)
    Mary A Vogler
    New York University Medical Center, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 36:576-87. 2004
    ..Approaches to preserve or enhance immune function in HIV-1 infection are needed...
  51. ncbi request reprint Spliced spleen necrosis virus vector RNA is not encapsidated: implications for retroviral replication and vector design
    Adrienne Goodrich
    Center for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Ther 9:557-65. 2004
    ..The results of this study present key information on spliced RNA and its encapsidation, as well as data for the construction of a new generation of SNV-derived retroviral vectors...
  52. ncbi request reprint Recombinant rhabdoviruses as potential vaccines for HIV-1 and other diseases
    Philip M McKenna
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Curr HIV Res 1:229-37. 2003
    ..This review gives an overview of the use of RV and VSV as promising new candidates in the fight against HIV-1 and other human diseases...
  53. ncbi request reprint HIV-1 infection and genomics: sorting out the complexity
    Roger J Pomerantz
    J Infect Dis 189:567-71. 2004
  54. ncbi request reprint Treatment of Mycobacterium avium complex immune reconstitution disease in HIV-1-infected individuals
    Joseph A Desimone
    Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Patient Care STDS 17:617-22. 2003
    ..Finally, we propose recommendations and a clinical algorithm regarding the optimal means of treatment of MAC immune reconstitution disease during HIV-1 infection...
  55. ncbi request reprint Peripheral blood Dendritic cells are not a major reservoir for HIV type 1 in infected individuals on virally suppressive HAART
    Miguel Otero
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 19:1097-103. 2003
    ..These populations of peripheral blood DCs are likely not a major HIV-1 reservoir in patients on HAART with clinically undetectable plasma viral RNA...
  56. ncbi request reprint Inhibition of HIV-1 in the central nervous system by IFN-alpha2 delivered by an SV40 vector
    Pierre Cordelier
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Interferon Cytokine Res 23:477-88. 2003
    ..These findings may have implications for therapy of HIV-1 infection in the CNS...
  57. ncbi request reprint Genotypic alteration of HAART-persistent HIV-1 reservoirs in vivo
    Joseph Kulkosky
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 314:617-29. 2003
    ....
  58. ncbi request reprint Cell-type-specific gene delivery into neuronal cells in vitro and in vivo
    Zahida Parveen
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Center for Human Virology and Biodefense, and Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 314:74-83. 2003
    ..Cell-type-specific gene delivery into neurons may present quite specific gene therapy approaches for many degenerative diseases of the brain...
  59. ncbi request reprint Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1
    Naiming Zhou
    The Dorrance H Hamilton Laboratories, Thomas Jefferson University, Jefferson Medical College, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Virology 312:196-203. 2003
    ..ALX40-4C, as an antagonist to APJ, directly binds to and prevents use of APJ as a HIV-1 co-receptor. Thus, ALX-4C has potential utility for further elucidation of HIV-1 neuropathogenesis and therapy of HIV-1-induced encephalopathy...
  60. ncbi request reprint HIV: cross-talk and viral reservoirs
    Roger J Pomerantz
    Nature 424:136-7. 2003
  61. ncbi request reprint Slower progression of HIV-1 infection in persons with GB virus C co-infection correlates with an intact T-helper 1 cytokine profile
    Giuseppe Nunnari
    University of Catania, Italy
    Ann Intern Med 139:26-30. 2003
    ..Progression to AIDS is slower in persons infected with both HIV-1 and GB virus C (GBV-C), also known as hepatitis G virus...
  62. pmc The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
    Hui Zhang
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 424:94-8. 2003
    ..Importantly, the accumulation of CEM15-mediated non-lethal hypermutation in the replicating viral genome could potently contribute to the genetic variation of primate lentiviral populations...
  63. ncbi request reprint Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication
    Roger J Pomerantz
    Dorrance H Hamilton Laboratories and Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Infect Dis 34:91-7. 2002
    ....

Research Grants26

  1. MOLECULAR THERAPEUTICS FOR HIV1 INDUCED CNS DYSFUNCTION
    Roger Pomerantz; Fiscal Year: 2002
    ..As such, these specific aims hope to yield critical data in the design of therapeutics to alter HIV-1 infection in CNS-based cells, and potentially for ADC in HIV-1-infected-individuals. ..
  2. Retroviral Vectors for Gene Therapy of HIV-1 Infection
    Roger Pomerantz; Fiscal Year: 2003
    ..abstract_text> ..
  3. HIV/AIDS Intravirion Reverse Transcription and Virucides
    Roger Pomerantz; Fiscal Year: 2004
    ..These studies are also designed to move analysis of intravirion reverse transcription from the bench towards clinical utility in altering sexual transmission of human lentiviruses. ..
  4. Alcohol's Effects on HIV-1 and the Blood: Brain Barrier
    Roger Pomerantz; Fiscal Year: 2004
    ..With these inter-related specific aims, it is proposed that a series of new technologies will be combined towards determining the precise effects of Etoh on inducing alterations in the BBB with HW-l I infection of these cells. ..
  5. Gene Therapy of AIDS Dementia
    Roger Pomerantz; Fiscal Year: 2004
    ..abstract_text> ..
  6. Effects of HIV -1 Proteins on the Blood/ Brain Barrier
    Roger Pomerantz; Fiscal Year: 2004
    ....