Giovanni M Pitari

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
    Giovanni Mario Pitari
    Division of Clinical Pharmacology, Departments of Pharmacology and Experimental Therapeutics and Medicine, Thomas Jefferson University, 1100 Walnut Street MOB 810, Philadelphia, PA 19107, USA
    Mol Cancer Ther 5:1190-6. 2006
  2. ncbi request reprint The paracrine hormone hypothesis of colorectal cancer
    G M Pitari
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 82:441-7. 2007
  3. pmc Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells
    Giovanni M Pitari
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut Street, MOB Suite 810, Philadelphia, PA 19107, USA
    Carcinogenesis 29:1601-7. 2008
  4. pmc Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9
    Wilhelm J Lubbe
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 69:3529-36. 2009
  5. ncbi request reprint Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins
    Giovanni M Pitari
    Division of Clinical Pharmacology, Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 65:11129-35. 2005
  6. ncbi request reprint Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins
    Shiva Kazerounian
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 314:1013-22. 2005
  7. pmc Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine
    Peng Li
    Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut St MOB 810, Philadelphia, PA 19107, USA
    Am J Pathol 171:1847-58. 2007
  8. ncbi request reprint Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
    Peng Li
    Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 133:599-607. 2007
  9. pmc Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer
    David S Zuzga
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Cancer 130:2539-48. 2012
  10. doi request reprint Sex modulates intestinal transformation by the tumor-suppressor GCC
    Peng Li
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:146-50. 2008

Collaborators

  • Stephanie Schulz
  • Peng Li
  • Ruth J Muschel
  • Inna Chervoneva
  • Gyorgy Hajnoczky
  • S A Waldman
  • Muniswamy Madesh
  • Tong Li
  • Glen S Frick
  • Shiva Kazerounian
  • Wilhelm J Lubbe
  • David S Zuzga
  • Inez Ruiz-Stewart
  • Li Gong
  • Joshua Pelta-Heller
  • Jieru Egeria Lin
  • Jieru E Lin
  • Weili Fu
  • Philip R Debruyne
  • Satish R Tiyyagura
  • Joanne Burke
  • Alessandro Bombonati
  • Ahmara Vivian Gibbons
  • Glen Marszlowicz
  • Terry Marie Hyslop
  • Adam Eugene Snook
  • Abhijit Dasgupta
  • Zengyi Zhou
  • Rafael Fridman
  • Tianru Jin
  • David Zuzga
  • Juan P Palazzo
  • Zengyi Y Zhou
  • Claire Domon-Cell
  • Matthew Witek
  • Ruth Birbe
  • Jean Noel Freund
  • Fawad J Shah
  • Howard E Greenberg
  • John A Wagner
  • Melanie Gleave
  • Sandi VanBuren
  • Walter K Kraft

Detail Information

Publications20

  1. ncbi request reprint Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
    Giovanni Mario Pitari
    Division of Clinical Pharmacology, Departments of Pharmacology and Experimental Therapeutics and Medicine, Thomas Jefferson University, 1100 Walnut Street MOB 810, Philadelphia, PA 19107, USA
    Mol Cancer Ther 5:1190-6. 2006
    ..Moreover, combination therapies, including exisulind and agents that induce cGMP signaling, may require careful evaluation in patients with colon cancer...
  2. ncbi request reprint The paracrine hormone hypothesis of colorectal cancer
    G M Pitari
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 82:441-7. 2007
    ....
  3. pmc Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells
    Giovanni M Pitari
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut Street, MOB Suite 810, Philadelphia, PA 19107, USA
    Carcinogenesis 29:1601-7. 2008
    ..Restoration of antitumorigenic CaR signaling by GCC ligand replacement therapy represents a previously unrecognized paradigm for the prevention and treatment of human colorectal cancer employing dietary Ca(2+) supplementation...
  4. pmc Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9
    Wilhelm J Lubbe
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 69:3529-36. 2009
    ..The notion that GCC-mediated regulation of cancer cell MMP-9 disrupts metastasis, in turn, underscores the unexplored utility of GCC hormone replacement therapy in the chemoprevention of colorectal cancer progression...
  5. ncbi request reprint Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins
    Giovanni M Pitari
    Division of Clinical Pharmacology, Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 65:11129-35. 2005
    ..Thus, regimens that incorporate cytostatic bacterial enterotoxins and inhibitors of cGMP-mediated desensitization offer a previously unrecognized therapeutic paradigm for treatment and prevention of colorectal cancer...
  6. ncbi request reprint Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins
    Shiva Kazerounian
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 314:1013-22. 2005
    ..They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP-directed therapy and prevention for colorectal tumors...
  7. pmc Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine
    Peng Li
    Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut St MOB 810, Philadelphia, PA 19107, USA
    Am J Pathol 171:1847-58. 2007
    ..In the context of uniform loss of GC-C signaling during tumorigenesis, dysregulation of those homeostatic processes may contribute to mechanisms underlying colon cancer...
  8. ncbi request reprint Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
    Peng Li
    Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 133:599-607. 2007
    ..However, the role of GCC in neoplasia remains obscure...
  9. pmc Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer
    David S Zuzga
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Cancer 130:2539-48. 2012
    ..Reconstitution of physiological cGMP circuitry through VASP, in turn, represents an attractive targeted approach for patients with colorectal cancer...
  10. doi request reprint Sex modulates intestinal transformation by the tumor-suppressor GCC
    Peng Li
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:146-50. 2008
    ..However, the molecular intersection between intestinal paracrine and systemic sex hormones opposing intestinal neoplasia has not been explored...
  11. pmc Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target
    Jieru E Lin
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
    Future Oncol 5:509-22. 2009
    ..Compensatory upregulation of GCC in response to hormone loss provides a unique translational opportunity for prevention and treatment of colorectal tumors by hormone-replacement therapy...
  12. ncbi request reprint Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer
    Wilhelm J Lubbe
    Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cancer Res 12:1876-82. 2006
    ..Conversely, whereas cancer cells within those tumors may induce stromal cells to produce MMP-9 and may be targets for MMP-9 activity, they are not the source of MMP-9 underlying metastasis...
  13. ncbi request reprint Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides
    Inez Ruiz-Stewart
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Eur J Biochem 269:2186-93. 2002
    ..This allosteric inhibition is mediated by direct interaction of adenine nucleotides with sGC, likely at the catalytic domain in a region outside the substrate-binding site...
  14. ncbi request reprint Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells
    Philip R Debruyne
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 130:1191-206. 2006
    ..The present studies examine the expression of GC-C in normal tissues and tumors from esophagus and stomach and mechanisms regulating its expression by acid and bile acids...
  15. ncbi request reprint Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP
    Satish R Tiyyagura
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Vitam Horm 69:69-94. 2004
    ..This chapter describes the molecular mechanisms regulating intracellular Ca2+ and cGMP, and their integration in specific cellular responses...
  16. ncbi request reprint Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity
    Li Gong
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Opin Hematol 11:7-14. 2004
    ....
  17. pmc Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis
    Giovanni M Pitari
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Drug Des Devel Ther 7:351-60. 2013
    ..This review will present important concepts underlying the pharmacology and therapeutic utility of GCC agonists for patients with ulcerative colitis, one of the most prevalent inflammatory bowel disease disorders...
  18. ncbi request reprint Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium
    Shiva Kazerounian
    Division of Clinical Pharmacology, Department of Medicine and Biochemistry, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochemistry 41:3396-404. 2002
    ..These data suggest that sGC is a constitutive Ca(2+) binding protein whose allosteric function is conditionally dependent upon ligand activation...
  19. pmc The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling
    Jieru Egeria Lin
    Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Gastroenterology 138:241-54. 2010
    ..It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. We investigated the effects of GUCY2C loss on intestinal cell proliferation, metabolism, signaling, and tumorigenesis in mice...
  20. ncbi request reprint Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation
    Joanne Burke
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Clin Pharmacol 43:983-9. 2003
    ..These data demonstrate that 1.6 mM AA reproducibly induces platelet aggregation in PRP from healthy volunteers without overcoming the antiplatelet effect of daily low-dose aspirin therapy...