Chirag A Patel

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3
    Chirag A Patel
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, 19107, USA
    BMC Cell Biol 6:3. 2005
  2. ncbi H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter
    Marcio A F de Godoy
    Departments of Medicine, Division of Gastroenterology and Hepatology, Pharmacology and Experimental Therapeutics, and Emergency Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennyslvania 19107, USA
    Gastroenterology 132:1401-9. 2007
  3. ncbi Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK
    Chirag A Patel
    Dept of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson Univ, 1025 Walnut St, Rm 901 College, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1747-56. 2007
  4. doi Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle
    Satish Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 294:G687-93. 2008
  5. ncbi Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter
    Satish Rattan
    Division of Gastroenterology and Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 131:108-16. 2006
  6. ncbi The RET finger protein interacts with the hinge region of SMC3
    Chirag A Patel
    Department of Pathology and Cell Biology, Thomas Jefferson University, 1020 Locust Street, JAH 371, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 330:333-40. 2005
  7. ncbi RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter
    Chirag A Patel
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 321:501-8. 2007
  8. ncbi Nitric oxide not carbon monoxide mediates nonadrenergic noncholinergic relaxation in the murine internal anal sphincter
    Satish Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, and Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 129:1954-66. 2005
  9. pmc Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation
    Kaijun Zhang
    Laboratory of Radiopharmaceuticals and Molecular Imaging, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 361 JAH, Philadelphia, PA 19107, USA
    Regul Pept 144:91-100. 2007
  10. ncbi Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle
    Chirag A Patel
    Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 1025 Walnut St, Rm 901, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 291:G830-7. 2006

Collaborators

Detail Information

Publications10

  1. pmc Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3
    Chirag A Patel
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, 19107, USA
    BMC Cell Biol 6:3. 2005
    ..The two proteins are constitutive components of the multimeric complex cohesin and form dimers by interacting at their central globular regions...
  2. ncbi H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter
    Marcio A F de Godoy
    Departments of Medicine, Division of Gastroenterology and Hepatology, Pharmacology and Experimental Therapeutics, and Emergency Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennyslvania 19107, USA
    Gastroenterology 132:1401-9. 2007
    ..The present studies evaluated the role of H-ras and its implications in the RhoA/Rho kinase (ROCK) pathway in regulating basal tone in the internal anal sphincter (IAS)...
  3. ncbi Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK
    Chirag A Patel
    Dept of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson Univ, 1025 Walnut St, Rm 901 College, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1747-56. 2007
    ..We conclude that RhoA/ROCK play a critical role in maintenance of spontaneous tone in the IAS SMC via inhibition of myosin light chain phosphatase...
  4. doi Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle
    Satish Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 294:G687-93. 2008
    ..We conclude that the IAS tone is critically dependent on ROCK activity, and H-1152 and Y-27632 are the most selective and potent ROCK inhibitors in the IAS...
  5. ncbi Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter
    Satish Rattan
    Division of Gastroenterology and Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 131:108-16. 2006
    ..An increase in Rho kinase (ROK) activity has been associated with agonist-induced sustained contraction of the smooth muscle, but its role in the pathophysiology of spontaneously tonic smooth muscle is not known...
  6. ncbi The RET finger protein interacts with the hinge region of SMC3
    Chirag A Patel
    Department of Pathology and Cell Biology, Thomas Jefferson University, 1020 Locust Street, JAH 371, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 330:333-40. 2005
    ..These studies identify a novel SMC3-interacting protein that may affect SMC3 availability to complex with its cohesin partners...
  7. ncbi RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter
    Chirag A Patel
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 321:501-8. 2007
    ..RhoA prenylation may play an important role in the translocation of RhoA to the smooth muscle cell membrane leading to its activation and for the maintenance of basal tone in the IAS...
  8. ncbi Nitric oxide not carbon monoxide mediates nonadrenergic noncholinergic relaxation in the murine internal anal sphincter
    Satish Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, and Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 129:1954-66. 2005
    ..We investigated the roles of 3 different neurohumoral agonists as possible i-NANC neurotransmitters: carbon monoxide (CO), nitric oxide (NO), and vasoactive intestinal peptide (VIP)...
  9. pmc Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation
    Kaijun Zhang
    Laboratory of Radiopharmaceuticals and Molecular Imaging, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 361 JAH, Philadelphia, PA 19107, USA
    Regul Pept 144:91-100. 2007
    ..Data demonstrate that these analogues are potent, have uncompromised biological activity and are worthy of further evaluation for accurate PET imaging of human breast cancers and in determining malignant and benign lesions...
  10. ncbi Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle
    Chirag A Patel
    Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 1025 Walnut St, Rm 901, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 291:G830-7. 2006
    ..We conclude that RhoA/ROK plays a critical role in the basal tone in the IAS by the inhibition of MLC phosphatase via the phosphorylation of MYPT1 and CPI-17...