John G Pastorino

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 65:10545-54. 2005
  2. ncbi TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8
    John G Pastorino
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 285:G503-16. 2003
  3. ncbi Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain
    Nataly Shulga
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:30824-33. 2006
  4. ncbi Hexokinase II: the integration of energy metabolism and control of apoptosis
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Med Chem 10:1535-51. 2003
  5. ncbi Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity
    Nataly Shulga
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:9416-24. 2005
  6. ncbi Cellular signaling mechanisms in alcohol-induced liver damage
    Jan B Hoek
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Semin Liver Dis 24:257-72. 2004
  7. ncbi Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    John G Pastorino
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Jefferson Alumni Hall Rm 269, Philadelphia, PA 19107, USA
    J Biol Chem 277:7610-8. 2002
  8. ncbi Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition
    Marco Tafani
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10073-82. 2002
  9. ncbi Ethanol, oxidative stress, and cytokine-induced liver cell injury
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 269, 1020 Locust Street, Philadelphia, PA 19107, USA
    Alcohol 27:63-8. 2002
  10. ncbi Alcohol and mitochondria: a dysfunctional relationship
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 122:2049-63. 2002

Research Grants

  1. EFFECTS OF ETHANOL ON TNF CYTOTOXICITY
    JOHN PASTORINO; Fiscal Year: 2005
  2. Targeting Hexokinase II in Chemotherapy
    JOHN PASTORINO; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 65:10545-54. 2005
    ..Such findings indicate that interference with the binding of HXK II to mitochondria may be a practicable modality by which to potentiate the efficacy of conventional chemotherapeutic agents...
  2. ncbi TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8
    John G Pastorino
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 285:G503-16. 2003
    ....
  3. ncbi Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain
    Nataly Shulga
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:30824-33. 2006
    ..Moreover, ACBP required the presence of the peripheral benzodiazepine receptor (for which ACBP is a ligand) to be retained at the mitochondria, to activate mu-calpain, and to amplify Bid-induced mitochondrial damage...
  4. ncbi Hexokinase II: the integration of energy metabolism and control of apoptosis
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Med Chem 10:1535-51. 2003
    ..Mitochondrial binding of hexokinase II may constitute an attractive target for therapeutic intervention to suppress tumor growth...
  5. ncbi Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity
    Nataly Shulga
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:9416-24. 2005
    ....
  6. ncbi Cellular signaling mechanisms in alcohol-induced liver damage
    Jan B Hoek
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Semin Liver Dis 24:257-72. 2004
    ..We also discuss the complications and challenges of extrapolating these findings to the conditions in vivo and what we can learn from these studies regarding the nature of the liver defects associated with chronic alcohol consumption...
  7. ncbi Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    John G Pastorino
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Jefferson Alumni Hall Rm 269, Philadelphia, PA 19107, USA
    J Biol Chem 277:7610-8. 2002
    ..Similar results were found in intact cells, in which the detachment of mitochondrial bound HXK II or its overexpression potentiated and inhibited, respectively, Bax-induced mitochondrial dysfunction and cell death...
  8. ncbi Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition
    Marco Tafani
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10073-82. 2002
    ..It is concluded that the cleaving of PARP in Fas-mediated apoptosis allowed expression of an energy-dependent cell death program that included the translocation of full-length Bid to the mitochondria with induction of the MPT...
  9. ncbi Ethanol, oxidative stress, and cytokine-induced liver cell injury
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 269, 1020 Locust Street, Philadelphia, PA 19107, USA
    Alcohol 27:63-8. 2002
    ....
  10. ncbi Alcohol and mitochondria: a dysfunctional relationship
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 122:2049-63. 2002
    ....
  11. ncbi Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive
    John G Pastorino
    Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    J Biol Chem 283:25638-49. 2008
    ..Moreover, the caspase-4 and -12-dependent activation of SREBP-1 is insensitive to the normal negative feedback exerted by cholesterol and is mediated by the translocation of the scaffolding protein, TRAF-2, to the endoplasmic reticulum...

Research Grants4

  1. EFFECTS OF ETHANOL ON TNF CYTOTOXICITY
    JOHN PASTORINO; Fiscal Year: 2005
    ..abstract_text> ..
  2. Targeting Hexokinase II in Chemotherapy
    JOHN PASTORINO; Fiscal Year: 2007
    ....