Maurizio Pacifici

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Cellular and molecular mechanisms of synovial joint and articular cartilage formation
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, 501 Curtis Bldg 1015, Walnut Street, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 1068:74-86. 2006
  2. ncbi request reprint Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Birth Defects Res C Embryo Today 75:237-48. 2005
  3. ncbi request reprint Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    J Bone Miner Metab 23:191-9. 2005
  4. pmc Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 305:40-51. 2007
  5. pmc Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine
    Christina Mundy
    Department of Orthopaedic Surgery, College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Biol 351:70-81. 2011
  6. ncbi request reprint Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
    Yoshihiro Tamamura
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:19185-95. 2005
  7. ncbi request reprint Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function
    Blanche Young
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19017, USA
    Dev Biol 299:272-82. 2006
  8. pmc Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University, College of Medicine, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 1116:100-12. 2007
  9. ncbi request reprint Temporomandibular joint formation and condyle growth require Indian hedgehog signaling
    Yoshihiro Shibukawa
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 236:426-34. 2007
  10. ncbi request reprint Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis
    Tsuyoshi Shimo
    Department of Orthopaedic Surgery, Thomas Jefferson University Medical School, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 229:607-17. 2004

Research Grants

  1. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2010
  2. Signaling Molecules and Long Bone Formation
    Maurizio Pacifici; Fiscal Year: 2005
  3. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2007
  4. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2009
  5. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2009
  6. TRANSCRIPTION FACTOR ERG AND SKELETOGENESIS
    Maurizio Pacifici; Fiscal Year: 2004
  7. REGULATION OF CHONDROCYTE PROLIFERATION
    Maurizio Pacifici; Fiscal Year: 2002

Collaborators

Detail Information

Publications36

  1. pmc Cellular and molecular mechanisms of synovial joint and articular cartilage formation
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, 501 Curtis Bldg 1015, Walnut Street, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 1068:74-86. 2006
    ....
  2. ncbi request reprint Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Birth Defects Res C Embryo Today 75:237-48. 2005
    ....
  3. ncbi request reprint Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis
    Maurizio Pacifici
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    J Bone Miner Metab 23:191-9. 2005
    ....
  4. pmc Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 305:40-51. 2007
    ..The results suggest that ERG is part of molecular mechanisms leading chondrocytes into a permanent developmental path and become joint forming cells, and may do so by acting downstream of GDF-5...
  5. pmc Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine
    Christina Mundy
    Department of Orthopaedic Surgery, College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Biol 351:70-81. 2011
    ..The data indicate also that defects in joint formation reverberate on, and delay, overall long bone growth...
  6. ncbi request reprint Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
    Yoshihiro Tamamura
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:19185-95. 2005
    ....
  7. ncbi request reprint Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function
    Blanche Young
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19017, USA
    Dev Biol 299:272-82. 2006
    ..The cranial base appears to be a skeletal structure in which growth and ossification patterns along its antero-posterior axis are orchestrated by both Ihh and Shh...
  8. pmc Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University, College of Medicine, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 1116:100-12. 2007
    ..The joint-forming functions of the cells appear to normally involve a previously unsuspected asymmetric distribution along the ventral-to-dorsal plane of the developing joint...
  9. ncbi request reprint Temporomandibular joint formation and condyle growth require Indian hedgehog signaling
    Yoshihiro Shibukawa
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 236:426-34. 2007
    ..Absence of articular disc and joint cavities in single and double mutants points to irreplaceable Ihh roles in formation of those critical TMJ components...
  10. ncbi request reprint Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis
    Tsuyoshi Shimo
    Department of Orthopaedic Surgery, Thomas Jefferson University Medical School, Philadelphia, Pennsylvania 19107, USA
    Dev Dyn 229:607-17. 2004
    ..The data are the first to indicate that Ihh action in chondrocyte proliferation involves syndecan-3 and to identify a specific member of the syndecan family as mediator of hedgehog function...
  11. doi request reprint Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse
    Julie A Williams
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 328:315-27. 2009
    ..Since aggrecan is critical for growth plate function, its deficiency in RAR-mutant mice is likely to have contributed directly to their growth retardation...
  12. pmc Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses
    Julianne Huegel
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Biol 377:100-12. 2013
    ..Alterations in these mechanisms may contribute to exostosis formation in HME, particularly at the expense of regions rich in progenitor cells including the groove of Ranvier...
  13. pmc A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 316:62-73. 2008
    ..The cells appear to be patterned along specific limb symmetry axes and rely on local signaling tools to make distinct contributions to joint formation...
  14. pmc Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover
    Rika Yasuhara
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:317-27. 2010
    ..Taken together, our data indicate that the Wnt and retinoid signaling pathways do interact in chondrocytes, and their cross-talks and cross-regulation play important roles in the regulation of cartilage matrix homeostasis...
  15. pmc Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover
    Julie A Williams
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:36674-81. 2010
    ....
  16. pmc Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells
    Rika Yasuhara
    Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Lab Invest 91:1739-52. 2011
    ..Together, the data reveal that Wnt/β-catenin signaling is a key regulator of SFZ cell phenotype and proliferation, and may be as important for articular cartilage long-term function...
  17. ncbi request reprint Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases
    Tsuyoshi Shimo
    Department of Orthopedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 20:867-77. 2005
    ..Recently, CTGF (CCN2) was found to regulate chondrocyte function, particularly in the hypertrophic zone. The goal of the study was to determine whether CTGF is a retinoid signaling effector molecule, how it is regulated, and how it acts...
  18. ncbi request reprint The balancing act of transcription factors C-1-1 and Runx2 in articular cartilage development
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 328:777-82. 2005
    ..The factors are powerful chondrocyte regulators and their functional interrelationships may be important for steering the cells toward alternative developmental paths...
  19. ncbi request reprint Expression and roles of connective tissue growth factor in Meckel's cartilage development
    Tsuyoshi Shimo
    Department of Orthopaedic Surgery, Thomas Jefferson University Medical School, Philadelphia, Pennsylvania
    Dev Dyn 231:136-47. 2004
    ..CTGF may aid chondrogenesis by acting down-stream of transforming growth factor-beta and stimulating cell-cell interactions and expression of condensation-associated genes...
  20. pmc Intervertebral disc development is regulated by Wnt/β-catenin signaling
    Naoki Kondo
    Department of Orthopaedic Surgery, Thomas Jefferson University, College of Medicine, Philadelphia, PA, USA
    Spine (Phila Pa 1976) 36:E513-8. 2011
    ..Histologic analysis of intervertebral disc (IVD) in three types of transgenic mice...
  21. pmc Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice
    Takahito Yuasa
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 175:1993-2003. 2009
    ....
  22. pmc Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements
    Eiki Koyama
    Department of Orthopaedic Surgery, College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 137:3795-800. 2010
    ..The re-emergence of such anatomical structures suggests that their genetic blueprint is still present in the mouse genome but is normally modified to the needs of the mammalian joint-formation program by distinct Hox11 function...
  23. ncbi request reprint Chick limbs with mouse teeth: an effective in vivo culture system for tooth germ development and analysis
    Eiki Koyama
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Dev Dyn 226:149-54. 2003
    ..The inhibitory effects of Shh neutralizing antibody treatment are discussed in relation to roles of this signaling pathway proposed by this and other groups previously...
  24. pmc Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Development 134:2159-69. 2007
    ....
  25. pmc Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice
    Leslie Cantley
    Translational Research Program in Pediatric Orthopaedics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 182:917-27. 2013
    ..The findings in our study indicate that loss of β-catenin expression in chondrocytes induces periosteal chondroma-like masses and may be linked to, and cause, the persistence of cartilage caps in osteochondromas...
  26. ncbi request reprint Sonic hedgehog functions as a mitogen during bell stage of odontogenesis
    Changshan Wu
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA
    Connect Tissue Res 44:92-6. 2003
    ....
  27. pmc Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists
    Kengo Shimono
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania, USA
    Nat Med 17:454-60. 2011
    ..The data indicate that RAR-γ agonists are potent inhibitors of heterotopic ossification in mouse models and, thus, may also be effective against injury-induced and congenital heterotopic ossification in humans...
  28. doi request reprint Inhibition of ectopic bone formation by a selective retinoic acid receptor alpha-agonist: a new therapy for heterotopic ossification?
    Kengo Shimono
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Orthop Res 28:271-7. 2010
    ....
  29. ncbi request reprint Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential
    Ali Fakhry
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, 4010 Locust Street, Philadelphia, PA 19104, USA
    Bone 36:254-66. 2005
    ....
  30. doi request reprint Hox11 paralogous genes are required for formation of wrist and ankle joints and articular surface organization
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, USA
    Ann N Y Acad Sci 1192:307-16. 2010
    ....
  31. ncbi request reprint Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs
    Tsuyoshi Shimo
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6003, USA
    Dev Dyn 224:267-78. 2002
    ....
  32. doi request reprint Fibronectin splicing variants in human intervertebral disc and association with disc degeneration
    D Greg Anderson
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Spine (Phila Pa 1976) 35:1581-8. 2010
    ..In this study, normal intervertebral disc (IVD) tissues and degenerative human IVD tissues were compared for presence of fibronectin (FN) mRNA splice variants and for FN fragments (FN-f)...
  33. pmc The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family
    George Feldman
    Thomas Jefferson University and the Rothman Institute of Orthopaedics, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:337-44. 2010
    ..Discovering the genetic basis of the disease would be an important step in understanding the etiology of this disabling condition...
  34. ncbi request reprint Syndecan-3 is a selective regulator of chondrocyte proliferation
    Thorsten Kirsch
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 277:42171-7. 2002
    ..In conclusion, the results suggest that syndecan-3 is a direct and selective regulator of the mitotic behavior of chondrocytes and its role may involve formation of dimeric/oligomeric structures on their cell surface...
  35. ncbi request reprint The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis
    Motomi Enomoto-Iwamoto
    Department of Molecular, Cell and Tumor Biology, Osaka University Faculty of Dentistry, Suita, Osaka 565 0871, Japan
    Dev Biol 251:142-56. 2002
    ..Phases of skeletogenesis, such as terminal chondrocyte maturation and joint formation, appear to be particularly dependent on Wnt signaling and thus very sensitive to Frzb-1 antagonistic action...
  36. ncbi request reprint Antiangiogenic treatment delays chondrocyte maturation and bone formation during limb skeletogenesis
    Melinda Yin
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104 6003, USA
    J Bone Miner Res 17:56-65. 2002
    ....

Research Grants24

  1. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2010
    ..It should also generate mouse models of degenerative joint disease that could be used to test future gene- and cell-based therapies for joints conditions common to osteoarthritic patients and aging individuals. ..
  2. Signaling Molecules and Long Bone Formation
    Maurizio Pacifici; Fiscal Year: 2005
    ..The results will provide much needed information on the regulation of long bone formation, and will have relevance to questions of skeletal growth, fracture repair and congenital conditions of cartilage and bone. ..
  3. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2007
    ..It should also generate mouse models of degenerative joint disease that could be used to test future gene- and cell-based therapies for joints conditions common to osteoarthritic patients and aging individuals. ..
  4. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2009
    ..It should also generate mouse models of degenerative joint disease that could be used to test future gene- and cell-based therapies for joints conditions common to osteoarthritic patients and aging individuals. ..
  5. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2009
    ..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
  6. TRANSCRIPTION FACTOR ERG AND SKELETOGENESIS
    Maurizio Pacifici; Fiscal Year: 2004
    ..abstract_text> ..
  7. REGULATION OF CHONDROCYTE PROLIFERATION
    Maurizio Pacifici; Fiscal Year: 2002
    ....