Giuseppe Nunnari

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 11:319-28. 2005
  2. ncbi request reprint Seminal reservoirs during an HIV type 1 eradication trial
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:768-75. 2005
  3. ncbi request reprint IL-7 as a potential therapy for HIV-1-infected individuals
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Expert Opin Biol Ther 5:1421-6. 2005
  4. ncbi request reprint HIV type 1 cervicovaginal reservoirs in the era of HAART
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Jefferson Alumni Hall, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:714-8. 2005
  5. pmc IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    Feng Xiang Wang
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:128-37. 2005
  6. ncbi request reprint Peripheral blood Dendritic cells are not a major reservoir for HIV type 1 in infected individuals on virally suppressive HAART
    Miguel Otero
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 19:1097-103. 2003
  7. ncbi request reprint Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy
    Joseph Kulkosky
    Dorrance Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 186:1403-11. 2002
  8. pmc Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells
    Keyang Chen
    Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1040 Locust Street, Philadelphia, PA 19107, USA
    J Virol 80:7645-57. 2006
  9. pmc Inhibition of endogenous reverse transcription of human and nonhuman primate lentiviruses: potential for development of lentivirucides
    Elias G Argyris
    Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 334, Philadelphia, PA 19107, USA
    Virology 353:482-90. 2006
  10. ncbi request reprint Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections
    Giuseppe Nunnari
    Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS 16:39-45. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurovirol 11:319-28. 2005
    ....
  2. ncbi request reprint Seminal reservoirs during an HIV type 1 eradication trial
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:768-75. 2005
    ..This study suggests viral compartmentalization of the semen microenvironment after an intensification and stimulatory HIV-1 eradication protocol, with evidence of viral evolution...
  3. ncbi request reprint IL-7 as a potential therapy for HIV-1-infected individuals
    Giuseppe Nunnari
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Expert Opin Biol Ther 5:1421-6. 2005
    ..In this present review, different immunological and virological properties of IL-7 are discussed, along with the possibility of its use as part of a combined antiretroviral-immune rationally based HIV-1 eradication approach...
  4. ncbi request reprint HIV type 1 cervicovaginal reservoirs in the era of HAART
    Giuseppe Nunnari
    Institute for Human Virology and Biodefense, Thomas Jefferson University, Jefferson Alumni Hall, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 21:714-8. 2005
    ..Nonetheless, the presence of even low cell-free HIV-1 RNA in cervicovaginal secretions continues to suggest the importance of practicing protected sex, even in the era of HAART...
  5. pmc IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    Feng Xiang Wang
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:128-37. 2005
    ....
  6. ncbi request reprint Peripheral blood Dendritic cells are not a major reservoir for HIV type 1 in infected individuals on virally suppressive HAART
    Miguel Otero
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 19:1097-103. 2003
    ..These populations of peripheral blood DCs are likely not a major HIV-1 reservoir in patients on HAART with clinically undetectable plasma viral RNA...
  7. ncbi request reprint Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy
    Joseph Kulkosky
    Dorrance Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 186:1403-11. 2002
    ..Additional experimental approaches must be developed if HIV-1 eradication is to become possible in patients receiving virally suppressive HAART...
  8. pmc Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells
    Keyang Chen
    Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1040 Locust Street, Philadelphia, PA 19107, USA
    J Virol 80:7645-57. 2006
    ....
  9. pmc Inhibition of endogenous reverse transcription of human and nonhuman primate lentiviruses: potential for development of lentivirucides
    Elias G Argyris
    Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 334, Philadelphia, PA 19107, USA
    Virology 353:482-90. 2006
    ..Our findings demonstrate the potential clinical utility of approaches based on inhibiting NERT in sexual transmission of HIV-1, through the development of effective anti-HIV-1 microbicides, such as NRTIs and NNRTIs...
  10. ncbi request reprint Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections
    Giuseppe Nunnari
    Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS 16:39-45. 2002
    ..Despite HAART, on-going in vivo infection of HIV-1-seropositive patients' PBMC was demonstrated by the detection of episomal HIV-1 moieties, known as HIV-1 two-long terminal repeat (2-LTR) DNA circles...
  11. pmc HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
    Yan Xu
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:7070-5. 2004
    ..These analyses suggest molecular mechanisms for the induction of apoptosis relating to the exposure of viral and host cell factors and rationally designed approaches toward neuroprotection...
  12. ncbi request reprint Pentoxifylline suppresses transduction by HIV-1-based vectors
    Johanna A Smith
    Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intervirology 50:377-86. 2007
    ....
  13. ncbi request reprint Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines
    Giuseppe Nunnari
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 335:177-84. 2005
    ..These data reveal the feasibility of therapeutic approaches targeting host cell proteins and further support the hypothesis that ATR and ATM proteins are involved in retroviral DNA integration...
  14. ncbi request reprint HIV and GB virus C--can two viruses be better than one?
    Roger J Pomerantz
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University, Philadelphia, USA
    N Engl J Med 350:963-5. 2004
  15. ncbi request reprint siRNA targeting vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects
    Rajnish S Dave
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 348:489-97. 2006
    ..These studies demonstrate the utility of E3L-specific siRNAs as potent antiviral agents for small pox and related pox viruses...
  16. pmc Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts
    Elias G Argyris
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 77:12140-51. 2003
    ....
  17. ncbi request reprint Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report
    Benedetto M Celesia
    AIDS 21:1495-6. 2007
  18. ncbi request reprint Slower progression of HIV-1 infection in persons with GB virus C co-infection correlates with an intact T-helper 1 cytokine profile
    Giuseppe Nunnari
    University of Catania, Italy
    Ann Intern Med 139:26-30. 2003
    ..Progression to AIDS is slower in persons infected with both HIV-1 and GB virus C (GBV-C), also known as hepatitis G virus...
  19. ncbi request reprint [Association between raised IL-8 serum levels and resistance to combined peg-interferon plus ribavirin therapy in HCV+ active chronic hepatitis]
    Bruno Cacopardo
    Sezione di Malattie Infettive, Dipartimento di Medicina Interna e Medicina Specialistica, Universita di Catania, Italy
    Infez Med 16:80-5. 2008
    ..Serum IL-8 can be considered and proposed as a non-invasive and predictive marker of response to combined PEG IFN alpha2b + Ribavirin in CAH HCV +...
  20. ncbi request reprint Do Vgamma2Vdelta2 T cells influence HIV disease progression?
    Giuseppe Nunnari
    Clin Infect Dis 46:1473-5. 2008