James P McGettigan

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc ICAM-1-based rabies virus vaccine shows increased infection and activation of primary murine B cells in vitro and enhanced antibody titers in-vivo
    James E Norton
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e87098. 2014
  2. pmc Investigating the role for IL-21 in rabies virus vaccine-induced immunity
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    PLoS Negl Trop Dis 7:e2129. 2013
  3. pmc Safety and serological response to a matrix gene-deleted rabies virus-based vaccine vector in dogs
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, United States Jefferson Vaccine Center, Thomas Jefferson University, Philadelphia, PA, United States Electronic address
    Vaccine 32:1716-9. 2014
  4. pmc Experimental rabies vaccines for humans
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Vaccine Center, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, JAH 466, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 9:1177-86. 2010
  5. ncbi request reprint Enhanced humoral HIV-1-specific immune responses generated from recombinant rhabdoviral-based vaccine vectors co-expressing HIV-1 proteins and IL-2
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, BLSB 330, Philadelphia, PA 19107 6799, USA
    Virology 344:363-77. 2006
  6. pmc Interferon-beta expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity
    Elizabeth J Faul
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA
    Virology 382:226-38. 2008
  7. pmc Rabies virus glycoprotein as a carrier for anthrax protective antigen
    Mary Ellen Smith
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 353:344-56. 2006
  8. ncbi request reprint Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach
    Gene S Tan
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 331:82-93. 2005
  9. pmc Second-generation rabies virus-based vaccine vectors expressing human immunodeficiency virus type 1 gag have greatly reduced pathogenicity but are highly immunogenic
    James P McGettigan
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 77:237-44. 2003
  10. pmc Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Vaccine 26:6405-14. 2008

Research Grants

  1. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
  2. Replication-deficient rabies vectors against rabies infection
    James McGettigan; Fiscal Year: 2009
  3. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc ICAM-1-based rabies virus vaccine shows increased infection and activation of primary murine B cells in vitro and enhanced antibody titers in-vivo
    James E Norton
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e87098. 2014
    ....
  2. pmc Investigating the role for IL-21 in rabies virus vaccine-induced immunity
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    PLoS Negl Trop Dis 7:e2129. 2013
    ..Collectively, our preliminary data show that IL-21 is critical for the development of optimal vaccine-induced primary but not secondary antibody responses against RABV infections...
  3. pmc Safety and serological response to a matrix gene-deleted rabies virus-based vaccine vector in dogs
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, United States Jefferson Vaccine Center, Thomas Jefferson University, Philadelphia, PA, United States Electronic address
    Vaccine 32:1716-9. 2014
    ....
  4. pmc Experimental rabies vaccines for humans
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Vaccine Center, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, JAH 466, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 9:1177-86. 2010
    ....
  5. ncbi request reprint Enhanced humoral HIV-1-specific immune responses generated from recombinant rhabdoviral-based vaccine vectors co-expressing HIV-1 proteins and IL-2
    James P McGettigan
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, BLSB 330, Philadelphia, PA 19107 6799, USA
    Virology 344:363-77. 2006
    ..This suggests the potential use of IL-2 in RV-based HIV-1 vaccine strategies, which may require the induction of both arms of the immune response...
  6. pmc Interferon-beta expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity
    Elizabeth J Faul
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA
    Virology 382:226-38. 2008
    ..The increased CD8+ T cell activation in the presence of IFN-beta, even with greatly reduced viral replication, indicates the beneficial effect of IFN-beta for the host...
  7. pmc Rabies virus glycoprotein as a carrier for anthrax protective antigen
    Mary Ellen Smith
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 353:344-56. 2006
    ..These data demonstrate that a viral envelope protein can carry a bacterial protein and that a viral carrier can display whole polypeptides compared to the limited epitope presentation of previous viral systems...
  8. ncbi request reprint Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach
    Gene S Tan
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 331:82-93. 2005
    ..Our results show that it is feasible to elicit robust cellular and humoral anti-HIV responses using two different live attenuated Rhabdovirus vectors to sequentially prime and boost...
  9. pmc Second-generation rabies virus-based vaccine vectors expressing human immunodeficiency virus type 1 gag have greatly reduced pathogenicity but are highly immunogenic
    James P McGettigan
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 77:237-44. 2003
    ..These findings demonstrate that very safe and highly effective RV-based vaccines can be constructed and further emphasize their potential utility as efficacious antiviral vaccines...
  10. pmc Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Vaccine 26:6405-14. 2008
    ....
  11. ncbi request reprint A single immunization with a recombinant canine adenovirus expressing the rabies virus G protein confers protective immunity against rabies in mice
    Jianwei Li
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 356:147-54. 2006
    ....
  12. pmc Characterization of a single-cycle rabies virus-based vaccine vector
    Emily A Gomme
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Virol 84:2820-31. 2010
    ..These findings demonstrate that single-cycle RV is an effective alternative to replication-competent RV vectors for future development of vaccines for HIV-1 and other infectious diseases...
  13. pmc Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates
    Jonathan Cenna
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 200:1251-60. 2009
    ..The data presented in this article suggest that the M gene-deleted RV vaccine is safe and effective and holds the potential of replacing current pre- and postexposure RV vaccines...
  14. pmc Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIV(mac251) challenge
    Elizabeth J Faul
    Jefferson Vaccine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Vaccine 28:299-308. 2009
    ..These findings indicate promise for RV-based vectors and have important implications for the development of an efficacious HIV vaccine...
  15. ncbi request reprint Highly attenuated rabies virus-based vaccine vectors expressing simian-human immunodeficiency virus89.6P Env and simian immunodeficiency virusmac239 Gag are safe in rhesus macaques and protect from an AIDS-like disease
    Philip M McKenna
    Department of Microbiology, Thomas Jefferson University, Philadelphia, PA, USA
    J Infect Dis 195:980-8. 2007
    ..Upon challenge with SHIV(89.6P) test macaques controlled the infection, whereas control macaques had high levels of viremia and a profound loss of CD4(+) T cells, with 1 control macaque dying of an AIDS-like disease...
  16. pmc Functional human immunodeficiency virus type 1 (HIV-1) Gag-Pol or HIV-1 Gag-Pol and env expressed from a single rhabdovirus-based vaccine vector genome
    James P McGettigan
    Department of Biochemistry and Molecular Pharmacology Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 77:10889-99. 2003
    ..This research opens up the possibility for the further improvement of rhabdovirus-based HIV-1 vaccines and their use to express large foreign proteins, perhaps from multiple human pathogens...
  17. pmc B cell infection and activation by rabies virus-based vaccines
    Andrew G Lytle
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Virol 87:9097-110. 2013
    ....
  18. pmc Rabies virus nucleoprotein as a carrier for foreign antigens
    Martin L Koser
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 5541, USA
    Proc Natl Acad Sci U S A 101:9405-10. 2004
    ..These data indicate the usefulness of RV-based vectors as killed vaccines against other infectious diseases...
  19. ncbi request reprint Recombinant rhabdoviruses as potential vaccines for HIV-1 and other diseases
    Philip M McKenna
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Curr HIV Res 1:229-37. 2003
    ..This review gives an overview of the use of RV and VSV as promising new candidates in the fight against HIV-1 and other human diseases...
  20. pmc Reinvestigating the role of IgM in rabies virus postexposure vaccination
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Virol 87:9217-22. 2013
    ..Considering the importance for the rapid induction of VNAs to protect against RABV infections in postexposure prophylaxis settings, these findings may help guide the development of a single-dose human rabies vaccine. ..
  21. pmc Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response
    Milosz Faber
    Department of Microbiology and Immunology, Center for Human Virology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 76:3374-81. 2002
    ....
  22. ncbi request reprint HIV-1 vaccines: the search continues
    James P McGettigan
    Department of Biochemistry and Molecular Pharmacology, Dorrance H Hamilton Laboratories, Center for Human Virology, Philadelphia, PA 19107 6799, USA
    Clin Lab Med 22:799-820, viii. 2002
    ....
  23. pmc Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFkappaB signaling pathway
    Jianwei Li
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA
    Vaccine 26:419-26. 2008
    ..Thus, the extent of upregulation of NFkappaB pathway-related genes in DCs infected with the live RV vaccine strain might explain the strong protective activity of SPBNGAS-GAS...
  24. ncbi request reprint siRNA targeting vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects
    Rajnish S Dave
    The Dorrance H Hamilton Laboratories, Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 348:489-97. 2006
    ..These studies demonstrate the utility of E3L-specific siRNAs as potent antiviral agents for small pox and related pox viruses...
  25. pmc Protective vaccine-induced CD4(+) T cell-independent B cell responses against rabies infection
    Corin L Dorfmeier
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Virol 86:11533-40. 2012
    ..We show that vaccines that can exploit early pathways of B cell activation and development may hold the key for the development of a single-dose RV vaccine wherein the rapid induction of VNA is critical...
  26. pmc Covalently linked human immunodeficiency virus type 1 gp120/gp41 is stably anchored in rhabdovirus particles and exposes critical neutralizing epitopes
    Philip M McKenna
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 77:12782-94. 2003
    ....
  27. doi request reprint The cell biology of rabies virus: using stealth to reach the brain
    Matthias J Schnell
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Rev Microbiol 8:51-61. 2010
    ....
  28. ncbi request reprint Live and killed rhabdovirus-based vectors as potential hepatitis C vaccines
    Catherine A Siler
    The Dorrance H Hamilton Laboratories, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Virology 292:24-34. 2002
    ..In addition, RV vaccine vehicles were able to induce cellular responses against HCV E2. These results further suggest that recombinant RVs are potentially useful vaccine vectors against important human viral diseases...
  29. pmc Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A
    Takashi Irie
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 78:2657-65. 2004
    ....

Research Grants3

  1. Second Generation Rabies Vaccines
    James McGettigan; Fiscal Year: 2007
    ..The development of treatment that relies on only one to two doses of vaccine instead of six inoculations will greatly enhance the effectiveness of rabies virus prevention. ..
  2. Replication-deficient rabies vectors against rabies infection
    James McGettigan; Fiscal Year: 2009
    ....
  3. Replication-deficient rabies vectors against rabies infection
    James P McGettigan; Fiscal Year: 2010
    ....