Paul E Marik

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi An Intranet-based system for inpatient billing in an academic medical center
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson Hospital, Philadelphia, PA, USA
    Am J Med 119:647-50. 2006
  2. ncbi Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
  3. ncbi Immunonutrition in critically ill patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intensive Care Med 34:1980-90. 2008
  4. ncbi Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
  5. ncbi Noninvasive positive-pressure ventilation in patients with malignancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 24:417-21. 2007
  6. ncbi Maximizing efficacy from parenteral nutrition in critical care: appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA, 19107, USA
    Curr Gastroenterol Rep 9:345-53. 2007
  7. ncbi Mechanisms and clinical consequences of critical illness associated adrenal insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 13:363-9. 2007
  8. ncbi Hypertensive crises: challenges and management
    Paul E Marik
    Department of Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA USA
    Chest 131:1949-62. 2007
  9. ncbi Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon?
    Paul E Marik
    Pulmonary and Critical Care, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, United States
    Resuscitation 74:191-3. 2007
  10. ncbi The definition of septic shock: implications for treatment
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Resusc 9:101-3. 2007

Detail Information

Publications98

  1. ncbi An Intranet-based system for inpatient billing in an academic medical center
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson Hospital, Philadelphia, PA, USA
    Am J Med 119:647-50. 2006
    ..We describe an Intranet-based system for inpatient billing that improves physician "productivity," reduces billing lag time, and increases the collection rate and total revenues...
  2. ncbi Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    ..Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed...
  3. ncbi Immunonutrition in critically ill patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Intensive Care Med 34:1980-90. 2008
    ..The role of immuno-modulating diets (IMDs) in critically ill patients is controversial...
  4. ncbi Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  5. ncbi Noninvasive positive-pressure ventilation in patients with malignancy
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 24:417-21. 2007
    ..In rare instances, NIPPV may have a role in treating patients with advanced cancer who have intractable dyspnea; however, NIPPV should not be used for the sole purpose of prolonging life in patients with terminal respiratory failure...
  6. ncbi Maximizing efficacy from parenteral nutrition in critical care: appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA, 19107, USA
    Curr Gastroenterol Rep 9:345-53. 2007
    ..A lipid emulsion containing fish oil, olive oil, or both should replace soybean-containing emulsions. Supplemental glutamine, 0.2 g/kg/d to 0.5 g/kg/d, has been shown to reduce the risk of infection and to improve glycemic control...
  7. ncbi Mechanisms and clinical consequences of critical illness associated adrenal insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 13:363-9. 2007
    ..The review summarizes our current understanding of the causes and consequences of adrenal insufficiency in critically ill patients...
  8. ncbi Hypertensive crises: challenges and management
    Paul E Marik
    Department of Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA USA
    Chest 131:1949-62. 2007
    ..This article reviews definitions, current concepts, common misconceptions, and pitfalls in the diagnosis and management of patients with acutely elevated BP as well as special clinical situations in which BP must be controlled...
  9. ncbi Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon?
    Paul E Marik
    Pulmonary and Critical Care, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, United States
    Resuscitation 74:191-3. 2007
    ..Indeed, recent randomized controlled studies have been unable to demonstrate any benefit from tight glucemic control. We suggest that the widespread adoption of tight glycemic control be abandoned at this time...
  10. ncbi The definition of septic shock: implications for treatment
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Resusc 9:101-3. 2007
    ....
  11. ncbi Should age limit admission to the intensive care unit?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 24:63-6. 2007
    ..This suggests that age alone should not be used in making intensive care unit triage decisions...
  12. ncbi Fungal infections in solid organ transplantation
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 7:297-305. 2006
    ..This article will review the risk factors, clinical presentation and treatment of invasive fungal infections in solid organ transplant patients, and evaluate the role of prophylactic therapy in this group of patients...
  13. ncbi The course of type 1 hepato-renal syndrome post liver transplantation
    Paul E Marik
    Department of Critical Care Medicine, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
    Nephrol Dial Transplant 21:478-82. 2006
    ..Liver transplantation is still considered the definitive treatment for HRS. However, the renal recovery rate and those factors that predict recovery post orthotopic liver transplantation have not been determined...
  14. ncbi Dyslipidemia in the critically ill
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 1015 Chestnut Street, Suite M 100, Philadelphia, PA, 19107, USA
    Crit Care Clin 22:151-9, viii. 2006
    ..Hypocholesterolemia may predispose the critically ill patient to sepsis and adrenal failure. Early enteral nutrition and tight glycemic control accelerate the recovery of the cholesterol levels...
  15. ncbi Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:2667-74. 2008
    ..However, the hematocrit that should be maintained in any particular patient because the risks of further transfusion of RBC outweigh the benefits remains unclear...
  16. ncbi Acute lung injury following blood transfusion: expanding the definition
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:3080-4. 2008
    ..The objectives of this review are to summarize current knowledge of TRALI with an emphasis on issues pertinent to the intensivist and to define the newly recognized "Delayed TRALI syndrome."..
  17. ncbi Adrenal-exhaustion syndrome in patients with liver disease
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Intensive Care Med 32:275-80. 2006
    ..The goal of this study was to further characterize this syndrome...
  18. ncbi Bovine blood and neuromuscular paralysis as a bridge to recovery in a patient with severe autoimmune hemolytic anemia
    Monvasi Pachinburavan
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:172-3. 2008
    ....
  19. ncbi Noninvasive hemodynamic monitoring in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Crit Care Clin 23:383-400. 2007
    ..In addition this article reviews some of the surrogate markers that can be used to assess adequacy of cardiac output...
  20. ncbi The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Walnut Street, Philadelphia, Pennsylvania 19107, USA
    Crit Care 10:176. 2006
    ..In those patients in whom the diagnosis of adrenal insufficiency may be important, this diagnosis may best be made based on the free cortisol level or the total cortisol level stratified by serum albumin...
  21. ncbi Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cardiol 32:365-72. 2009
    ..The clinical benefit of dietary fish oil supplementation in preventing cardiovascular events in both high and low risk patients is unclear...
  22. ncbi Perioperative hypertension: a review of current and emerging therapeutic agents
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Clin Anesth 21:220-9. 2009
    ..While sodium nitroprusside and nitroglycerin are commonly used to treat these conditions, these agents are less than ideal. Intravenous beta blockers and calcium channel blockers have particular appeal in this setting...
  23. ncbi Hypertensive disorders of pregnancy
    Paul E Marik
    Pulmonary and Critical Care, Thomas Jefferson University, Philadelphia, PA, USA
    Postgrad Med 121:69-76. 2009
    ....
  24. ncbi The efficacy and dosage effect of corticosteroids for the prevention of atrial fibrillation after cardiac surgery: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Crit Care 24:458-63. 2009
    ..Corticosteroids down-regulate activation of the proinflammatory response (including C-reactive protein) after cardiopulmonary bypass and have been suggested to reduce the risk of postoperative AF...
  25. ncbi What is the best way to feed patients with pancreatitis?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 15:131-8. 2009
    ..Recent data, however, suggest that this approach may be associated with increased morbidity and mortality. This paper reviews evolving concepts in the nutritional management of patients with acute pancreatitis...
  26. ncbi Critical illness-related corticosteroid insufficiency
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 135:181-93. 2009
    ..The paper reviews cortisol physiology, CIRCI, and the role of corticosteroid therapy in critically ill patients...
  27. ncbi Requirement of perioperative stress doses of corticosteroids: a systematic review of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Ste 650, Philadelphia, PA 19107, USA
    Arch Surg 143:1222-6. 2008
    ..Patients receiving therapeutic dosages of corticosteroids frequently require surgery; these patients are almost universally treated with stress doses of corticosteroids during the perioperative period...
  28. ncbi Stress hyperglycemia and adrenal insufficiency in the critically ill
    Murugan Raghavan
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Semin Respir Crit Care Med 27:274-85. 2006
    ....
  29. ncbi Adrenal insufficiency in the critically ill: a new look at an old problem
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:1784-96. 2002
    ..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
  30. ncbi Fungal infections in bone marrow transplant recipients
    Tuhina Raman
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 7:307-15. 2006
    ..Treatment options include therapy with azoles, including the newer agent voriconazole, amphotericin and caspofungin...
  31. ncbi Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    BMJ 328:1407. 2004
    ..To compare the safety and clinical outcomes of enteral and parenteral nutrition in patients with acute pancreatitis...
  32. ncbi Techniques for assessment of intravascular volume in critically ill patients
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Intensive Care Med 24:329-37. 2009
    ..This paper reviews the evolution and accuracy of methods for assessing fluid responsiveness in critically ill patients...
  33. ncbi Current diagnosis and management of hypertensive emergency
    Andrew R Haas
    Division of Critical Care, Pulmonary, Allergy and Immunologic Disease, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Semin Dial 19:502-12. 2006
    ..In contrast, with hypertensive urgency, blood pressure control can be achieved with the use of oral medications within 24-48 hours. This paper reviews the management of hypertensive emergencies...
  34. ncbi Norepinephrine or dopamine for septic shock: systematic review of randomized clinical trials
    Tajender S Vasu
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 27:172-8. 2012
    ..According to current guidelines either dopamine or norepinephrine may be considered as the first-line agent for the management of refractory hypotension of septic shock...
  35. ncbi The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction
    Daniel Salerno
    Division of Pulmonary and Critical Care Medicine, Christiana Health Care System, Newark, Delaware 19805, USA
    J Intensive Care Med 24:372-5. 2009
    ..This study suggests that clinicians should have a low threshold for ordering a CT scan in MICU patients with acute neurological dysfunction...
  36. ncbi Early goal-directed therapy: on terminal life support?
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Am J Emerg Med 28:243-5. 2010
    ..Although the concept of early resuscitation is a scientifically sound concept, we believe that the major elements of the sepsis bundle are fatally flawed...
  37. ncbi Association between time of admission to the ICU and mortality: a systematic review and metaanalysis
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Chest 138:68-75. 2010
    ..A change in the ICU staffing structure frequently occurs at nighttime and on weekends (off-hours). We postulated that patients who are admitted to an ICU during off hours may be at an increased risk of death...
  38. ncbi The hospital-survival and prognostic factors of patients with solid tumors admitted to an ICU
    Vinia Mendoza
    Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 25:240-3. 2008
    ..The relatively high survival rate of this cohort of patients should prompt a reevaluation of the ICU admission criteria for patients with solid tumors who become critically ill...
  39. ncbi Hypertensive emergencies: an update
    Paul E Marik
    Department of Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Curr Opin Crit Care 17:569-80. 2011
    ..However, only patients with true hypertensive emergencies require the immediate and controlled reduction of blood pressure with an intravenous antihypertensive agent...
  40. ncbi The hepatoadrenal syndrome: a common yet unrecognized clinical condition
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 33:1254-9. 2005
    ..Treatment of patients with adrenal failure may improve outcome. High baseline serum cortisol levels may be a maker of disease severity and portend a poor prognosis...
  41. ncbi Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    JPEN J Parenter Enteral Nutr 34:378-86. 2010
    ..The goal of this meta-analysis was to determine the impact of IMDs on the clinical outcomes of high-risk patients undergoing elective surgery...
  42. ncbi Is the band count useful in the diagnosis of infection? An accuracy study in critically ill patients
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 25:353-7. 2010
    ..However, the literature regarding the diagnostic accuracy of an elevated band count for the diagnosis of infection is limited...
  43. ncbi An 18-year-old woman with fever, diffuse pulmonary opacities, and rapid onset of respiratory failure: idiopathic acute eosinophilic pneumonia
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University Hospital, 1015 Chestnut St, Suite M-100, Philadelphia, PA 19107, USA
    Chest 130:1938-41. 2006
  44. ncbi Therapy of intracranial hypertension in patients with fulminant hepatic failure
    Murugan Raghavan
    Liver Transplant ICU, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Neurocrit Care 4:179-89. 2006
    ..In this article, we review the pathophysiology of IH in patients with FHF and outline various therapeutic strategies currently available in managing these patients in the critical care setting...
  45. ncbi Multidisciplinary family meetings in the ICU facilitate end-of-life decision making
    Enrique Machare Delgado
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA
    Am J Hosp Palliat Care 26:295-302. 2009
    ..The aim of this study was to assess the feasibility of establishing a multi-disciplinary family meeting (MDFM) program and the impact of such a program on the end-of-life decision making in the setting of an ICU...
  46. ncbi Management of patients with metastatic malignancy in the intensive care unit
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Hosp Palliat Care 23:479-82. 2006
    ..Intensivists, who are charged with making the best use of limited resources, should ultimately be the individuals who determine the appropriateness of admitting such patients to the intensive care unit...
  47. ncbi Management of sepsis during the early "golden hours"
    Murugan Raghavan
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Emerg Med 31:185-99. 2006
    ..In this article we review the multi-modality approach to early diagnosis and intervention in the therapy of patients with severe sepsis and septic shock...
  48. ncbi Adrenal insufficiency during septic shock
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:141-5. 2003
    ..However, we believe that a random cortisol concentration of <25 microg/dL in a highly stressed patient is a useful diagnostic threshold for the diagnosis of adrenal insufficiency...
  49. ncbi Anemia, allogenic blood transfusion, and immunomodulation in the critically ill
    Murugan Raghavan
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Chest 127:295-307. 2005
    ..In this article, we review the immune-modulatory role of allogenic RBC transfusions in critically ill patients...
  50. ncbi The management of acute severe asthma
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Emerg Med 23:257-68. 2002
    ..Mechanical ventilation is usually well tolerated and may be lifesaving in patients with refractory asthma. Precautions are required to prevent dynamic hyperinflation during assisted ventilation...
  51. ncbi Pulmonary complications of novel antineoplastic agents for solid tumors
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Chest 133:528-38. 2008
    ..The approach to diagnosis, risk factors, and possible mechanisms of antineoplastic agent-induced pulmonary toxicity are discussed in this article...
  52. ncbi A 53-year-old man with fever, clubbing, hemoptysis, and rapid onset of respiratory failure
    Sajive Aleyas
    Thomas Jefferson University Hospital, Department of Pulmonary and Critical Care Medicine, Philadelphia, PA, USA
    Chest 131:1974-7. 2007
  53. ncbi Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Chest 136:1631-43. 2009
    ..75; 95% CI, 0.63 to 0.89; p < 0.001; I(2), 43%) and for those treated before day 14 (RR, 0.71; 95% CI, 0.59 to 0.85; p < 0.001; I(2), 40%)...
  54. ncbi Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patients
    Paul E Marik
    Department of Critical Care Medicine, Mercy Hospital of Pittsburgh, PA, USA
    Crit Care Med 31:818-22. 2003
    ..The P(SL)CO2-diff and/or P(SL)CO2 may prove to be a useful marker for goal-directed therapy and for assessing the response to clinical interventions aimed at improving tissue oxygenation...
  55. ncbi Stress-hyperglycemia, insulin and immunomodulation in sepsis
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 640A Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:748-56. 2004
    ..This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder...
  56. ncbi Brain natriuretic peptide measurement in pulmonary medicine
    Daniel Salerno
    Tulane University Health Sciences Center, Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, 1430 Tulane Avenue, Office 204, New Orleans, LA 70112, USA
    Respir Med 105:1770-5. 2011
    ..The present paper reviews the role of natriuretic peptides for diagnosis, risk stratification and prognosis of several pulmonary disorders...
  57. ncbi Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Clin 27:589-607. 2011
    ..The authors recommend prolonged methylprednisolone at 1 mg/kg/d initially in early ARDS, increasing to 2 mg/kg/d after 7 to 9 days of no improvement...
  58. ncbi Inferior vena cava variation compared to pulse contour analysis as predictors of fluid responsiveness: a prospective cohort study
    Enrique Machare-Delgado
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Intensive Care Med 26:116-24. 2011
    ..Accurately predicting fluid responsiveness (FRes) allows for optimization of cardiac performance while avoiding fluid overload and prolonged mechanical ventilation...
  59. ncbi Recurrent episodes of dermatomyositis-associated pneumonitis masquerading as hypersensitivity pneumonitis
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Mt Sinai J Med 73:895-7. 2006
    ..Further work-up showed clinical and serologic evidence of dermatomyositis-associated pneumonitis. The patient was treated with oral prednisone and azathioprine. The subject of dermatomyositis-associated pneumonitis is discussed...
  60. ncbi Severe autoimmune hemolytic anemia treated by paralysis, induced hypothermia, and splenic embolization
    Ronna Campbell
    Department of Critical Care, University of Pittsburgh, 640A Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Chest 127:678-81. 2005
    ..We present a case of an adult with life-threatening AIHA secondary to ulcerative colitis emergently managed with neuromuscular paralysis, induced hypothermia, and splenic embolization...
  61. ncbi Regional carbon dioxide monitoring to assess the adequacy of tissue perfusion
    Paul E Marik
    Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Crit Care 11:245-51. 2005
    ..Regional carbon dioxide monitoring appears to be ideally suited to monitoring the adequacy of resuscitation. This review provides an update on this evolving technology...
  62. ncbi Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Crit Care Med 38:2222-8. 2010
    ..Stress ulcer prophylaxis may, however, increase the risk of hospital-acquired pneumonia and Clostridia difficile infection...
  63. ncbi Management of the critically ill geriatric patient
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 34:S176-82. 2006
    ..To review the effect of an aging society on the utilization of critical care services and the physiology of aging as it applies to critical illness and prognosis and management issues in the intensive care unit (ICU)...
  64. ncbi Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Chest 137:544-51. 2010
    ..The goal of this systematic review was to determine the benefits and risks of tight glycemic control in ICU patients and to explain the differences in outcomes among reported trials...
  65. ncbi Management of head trauma
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:699-711. 2002
    ..However, it is likely that many patients with TBI are not treated according to current treatment principles. This article presents an overview of the current management of patients with TBI...
  66. ncbi Gastric versus post-pyloric feeding: a systematic review
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:R46-51. 2003
    ..Our objective was to evaluate the impact of gastric versus post-pyloric feeding on the incidence of pneumonia, caloric intake, intensive care unit (ICU) length of stay (LOS), and mortality in critically ill and injured ICU patients...
  67. ncbi Sublingual capnometry: a non-invasive measure of microcirculatory dysfunction and tissue hypoxia
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Physiol Meas 27:R37-47. 2006
    ..This paper reviews the technology and application of sublingual PCO(2) monitoring...
  68. ncbi Natriuretic peptides in acute pulmonary embolism: a systematic review
    Rodrigo Cavallazzi
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Intensive Care Med 34:2147-56. 2008
    ..Patients with pulmonary embolism (PE) have a high risk of death, and it is important to recognize factors associated with higher mortality. Recently, several biomarkers have been studied for risk stratification in patients with PE...
  69. ncbi Multiple venous thromboses in a young man with sarcoidosis: is there a relation between sarcoidosis and venous thrombosis?
    Bobbak Vahid
    Department of Pulmonary and Critical Care Medicine, e Thomas Jefferson University, Philadelphia, PA, USA
    South Med J 99:998-9. 2006
    ..Lymph node tissue culture and special stains were negative for mycobacterial or fungal infection. This is an unusual case of multiple deep venous thromboses and sarcoidosis. The subject of sarcoidosis and venous thrombosis is discussed...
  70. ncbi Adrenal insufficiency in critically ill patients with human immunodeficiency virus
    Paul E Marik
    Mercy Hospital of Pittsburgh, PA, USA
    Crit Care Med 30:1267-73. 2002
    ..Because of the high incidence of inadequate adrenal function, all critically ill HIV-infected patients should undergo an evaluation for adrenal insufficiency with the stress cortisol concentration and LD-ACTH stimulation tests...
  71. ncbi The hazards of blood transfusion
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Br J Hosp Med (Lond) 70:12-5. 2009
    ..This article reviews the major complications associated with blood transfusion...
  72. ncbi The optimal endpoint of resuscitation in trauma patients
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 7:19-20. 2003
  73. ncbi Methicillin-resistant Staphylococcus aureus pneumonia after thoracic surgery: successful treatment with linezolid after failed vancomycin therapy
    Daniel Salerno
    Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 83:1888-91. 2007
    ..All 3 patients were cured with linezolid...
  74. ncbi Aspiration pneumonia and dysphagia in the elderly
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 124:328-36. 2003
    ..This may include swallow therapy, dietary modification, aggressive oral care, and consideration for treatment with an angiotensin-converting enzyme inhibitor...
  75. ncbi Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the bad
    Holt Murray
    Chest 127:707-9. 2005
  76. ncbi Steroids in cardiac arrest: not ready for prime time?
    Joseph Varon
    Am J Emerg Med 25:376-7. 2007
  77. ncbi Unraveling the mystery of adrenal failure in the critically ill
    Paul E Marik
    Crit Care Med 32:596-7. 2004
  78. ncbi Bedside ultrasonography in the ICU: part 1
    Yanick Beaulieu
    Division of Cardiology and Critical Care Medicine, Hôpital Sacré Coeur de Montréal, Universite de Montreal, 5400 boul Gouin O, Montreal, Quebec, Canada, H4J 1C5
    Chest 128:881-95. 2005
    ..This two-part article reviews the application of bedside ultrasonography in the ICU...
  79. ncbi Bedside ultrasonography in the ICU: part 2
    Yanick Beaulieu
    Division of Cardiology and Critical Care Medicine, Hôpital Sacré Coeur de Montréal, Universite de Montreal, 5400 boul Gouin O, Montreal, Quebec, Canada, H4J 1C5
    Chest 128:1766-81. 2005
    ..This technology, as a powerful adjunct to the physical examination, will become an indispensable tool in the management of critically ill patients...
  80. ncbi Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006
  81. ncbi The central nervous system hypothalamic-pituitary-adrenal axis in sepsis
    Paul E Marik
    Crit Care Med 30:490-1. 2002
  82. ncbi Perioperative hypertension management
    Joseph Varon
    The University of Texas Health Science Center at Houston, TX, USA
    Vasc Health Risk Manag 4:615-27. 2008
    ..When treatment is necessary, therapy should be individualized for the patient. This paper reviews the pharmacologic agents and strategies commonly used in the management of perioperative hypertension...
  83. ncbi Steroids and drotrecogin alfa (activated) for severe sepsis
    Paul E Marik
    Chest 124:2033-4. 2003
  84. ncbi ICU care at the end of life
    Kelly A Wood
    Chest 126:1403-6. 2004
  85. ncbi Corticosteroids for septic shock
    Paul E Marik
    N Engl J Med 358:2069-70; author reply 2070-1. 2008
  86. ncbi Clinical review: the management of hypertensive crises
    Joseph Varon
    Pulmonary and Critical Care Section, Baylor College of Medicine, The University of Texas Health Science Center, Houston, USA
    Crit Care 7:374-84. 2003
    ..This article reviews current concepts, and common misconceptions and pitfalls in the diagnosis and management of patients with acutely elevated blood pressure...
  87. ncbi Death by parenteral nutrition
    Paul E Marik
    Intensive Care Med 29:867-9. 2003
  88. ncbi Open versus closed units: chaos versus a well-oiled machine
    Paul E Marik
    Crit Care Med 31:2567-8; author reply 2568. 2003
  89. ncbi Arginine: too much of a good thing may be bad!
    Paul E Marik
    Crit Care Med 34:2844-7. 2006
  90. ncbi Death by total parenteral nutrition: part deaux
    Paul E Marik
    Crit Care Med 34:3062; author reply 3062-3. 2006
  91. ncbi Death by TPN... the final chapter?
    Paul E Marik
    Crit Care Med 36:1964-5. 2008
  92. ncbi Goal-directed therapy for severe sepsis
    Paul E Marik
    N Engl J Med 346:1025-6; author reply 1025-6. 2002
  93. ncbi Therapeutic sedation: has its time come?
    Paul E Marik
    Crit Care Med 30:949-52. 2002
  94. ncbi Definition of sepsis: not quite time to dump SIRS?
    Paul E Marik
    Crit Care Med 30:706-8. 2002
  95. ncbi Nuclear factor-kappaB inhibition in sepsis: steroids versus specific nuclear factor-kappaB inhibitors?
    Paul E Marik
    Crit Care Med 30:2393-4. 2002
  96. ncbi Comment on "Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient?" by Heidegger et al
    Paul E Marik
    Intensive Care Med 33:1855; author reply 1857. 2007
  97. ncbi Cardiopulmonary resuscitation in patients with cancer
    Joseph Varon
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Am J Hosp Palliat Care 24:224-9. 2007
    ..This article reviews those factors that affect the outcome of cardiopulmonary resuscitation in patients with cancer and provides recommendations on obtaining do-not-resuscitate orders in these patients...
  98. ncbi IV 2beta or not 2beta, that is the question!
    Joseph Varon
    Chest 122:1116-8. 2002