Research Topics
| X L MaSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused heartsX L Ma
Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Pharmacol Exp Ther 292:912-20. 2000..This compound is directly toxic to the cardiac tissue at a relatively high concentration, but it can indirectly protect myocardial cells from neutrophil-induced injury at a much lower concentration...
Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injuryX L Ma
Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 96:14617-22. 1999..These results demonstrate that, although NO(.) is protective, NO(-) increases the tissue damage that occurs during ischemia/reperfusion and suggest that formation of nitroxyl may contribute to postischemic myocardial injury...- Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized ratX L Ma
Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
J Pharmacol Exp Ther 295:786-92. 2000..These results suggest that selective estrogen receptor modulators have therapeutic potential in diseases where endothelial dysfunction plays an important role... - Endothelial protective and antishock effects of a selective estrogen receptor modulator in ratsX L Ma
Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Am J Physiol Heart Circ Physiol 280:H876-84. 2001.... - Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive ratsX L Ma
Department of Surgery, Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
J Pharmacol Exp Ther 298:879-85. 2001..Antioxidant treatment with carvedilol exerted significant vascular protective effects, attenuated end-organ damage, and decreased mortality under these conditions... - Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusionM R Siegfried
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
J Pharmacol Exp Ther 260:668-75. 1992..Both NO donors decreased myocardial necrosis and decreased the reperfusion-induced endothelial dysfunction without significantly altering the pressure-rate index (i.e., an index of myocardial oxygen demand)... - Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injuryX L Ma
Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5004, USA
Circ Res 80:894-901. 1997..Carvedilol, a novel vasodilating beta-blocker with antioxidant activity, significantly preserved this self-defense system and protected tissue from oxidant injury... - Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusionA Karasawa
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Circ Shock 33:135-41. 1991.... - Beneficial effects of transforming growth factor-beta and tissue plasminogen activator in splanchnic artery occlusion and reperfusion in catsA Karasawa
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
J Cardiovasc Pharmacol 18:95-105. 1991..These findings suggest that TGF-beta alone or in combination with tPA may be potentially useful therapeutic regimens in splanchnic ischemia shock by preserving splanchnic parenchymal and endothelial cells... - Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusionC Carey
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
Circ Shock 38:209-16. 1992..Thus, treatment with the NO donor, C87-3754 reduced the accumulation of humoral mediators into the plasma while significantly attenuating endothelial dysfunction and improving short term survival... - Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusionX L Ma
Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Circulation 99:1685-91. 1999..Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/reperfusion, an extreme stress to the heart, is unknown... - Protection of ischemia-reperfusion injury by sydnonimine NO donors via inhibition of neutrophil-endothelium interactionA M Lefer
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799
J Cardiovasc Pharmacol 22:S27-33. 1993..Thus, an NO donor infused at a rate calculated to replace the lost NO from the vascular endothelium of the ischemic region exerts significant protective effects on reperfusion of that ischemic vascular bed... - Splanchnic vascular endothelial dysfunction in rat endotoxemia: role of superoxide radicalsM R Siegfried
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
Eur J Pharmacol 212:171-6. 1992..Furthermore, because superoxide dismutase but not N-(2-mercaptopropionyl)-glycine preserves endothelial function, it is likely that superoxide radicals mediate the endothelial dysfunction observed in endotoxemic rats... - Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusionD-Y Li
Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, PA 19107, USA
Apoptosis 11:923-30. 2006..Conclusion: These results demonstrate that nitric oxide exerts its anti-apoptotic and cardioprotective effects, at least in part, by activation of ERK in ischemic/reperfused heart... - Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisisB L Lopez
Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Am J Hematol 64:15-9. 2000..These results suggest that the initial NO level may serve as a marker for the severity of tissue ischemia. Sequential NO levels do not appear useful in predicting the course of SCC...