X L Ma

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts
    X L Ma
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 292:912-20. 2000
  2. pmc Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury
    X L Ma
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:14617-22. 1999
  3. ncbi request reprint Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized rat
    X L Ma
    Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
    J Pharmacol Exp Ther 295:786-92. 2000
  4. ncbi request reprint Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats
    X L Ma
    Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 280:H876-84. 2001
  5. ncbi request reprint Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats
    X L Ma
    Department of Surgery, Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
    J Pharmacol Exp Ther 298:879-85. 2001
  6. ncbi request reprint Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion
    M R Siegfried
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
    J Pharmacol Exp Ther 260:668-75. 1992
  7. ncbi request reprint Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury
    X L Ma
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5004, USA
    Circ Res 80:894-901. 1997
  8. ncbi request reprint Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion
    A Karasawa
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Circ Shock 33:135-41. 1991
  9. ncbi request reprint Beneficial effects of transforming growth factor-beta and tissue plasminogen activator in splanchnic artery occlusion and reperfusion in cats
    A Karasawa
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    J Cardiovasc Pharmacol 18:95-105. 1991
  10. ncbi request reprint Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion
    C Carey
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Circ Shock 38:209-16. 1992

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts
    X L Ma
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 292:912-20. 2000
    ..This compound is directly toxic to the cardiac tissue at a relatively high concentration, but it can indirectly protect myocardial cells from neutrophil-induced injury at a much lower concentration...
  2. pmc Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury
    X L Ma
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:14617-22. 1999
    ..These results demonstrate that, although NO(.) is protective, NO(-) increases the tissue damage that occurs during ischemia/reperfusion and suggest that formation of nitroxyl may contribute to postischemic myocardial injury...
  3. ncbi request reprint Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized rat
    X L Ma
    Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
    J Pharmacol Exp Ther 295:786-92. 2000
    ..These results suggest that selective estrogen receptor modulators have therapeutic potential in diseases where endothelial dysfunction plays an important role...
  4. ncbi request reprint Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats
    X L Ma
    Division of Emergency Medicine, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 280:H876-84. 2001
    ....
  5. ncbi request reprint Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats
    X L Ma
    Department of Surgery, Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5004, USA
    J Pharmacol Exp Ther 298:879-85. 2001
    ..Antioxidant treatment with carvedilol exerted significant vascular protective effects, attenuated end-organ damage, and decreased mortality under these conditions...
  6. ncbi request reprint Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion
    M R Siegfried
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
    J Pharmacol Exp Ther 260:668-75. 1992
    ..Both NO donors decreased myocardial necrosis and decreased the reperfusion-induced endothelial dysfunction without significantly altering the pressure-rate index (i.e., an index of myocardial oxygen demand)...
  7. ncbi request reprint Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury
    X L Ma
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107 5004, USA
    Circ Res 80:894-901. 1997
    ..Carvedilol, a novel vasodilating beta-blocker with antioxidant activity, significantly preserved this self-defense system and protected tissue from oxidant injury...
  8. ncbi request reprint Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion
    A Karasawa
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Circ Shock 33:135-41. 1991
    ....
  9. ncbi request reprint Beneficial effects of transforming growth factor-beta and tissue plasminogen activator in splanchnic artery occlusion and reperfusion in cats
    A Karasawa
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    J Cardiovasc Pharmacol 18:95-105. 1991
    ..These findings suggest that TGF-beta alone or in combination with tPA may be potentially useful therapeutic regimens in splanchnic ischemia shock by preserving splanchnic parenchymal and endothelial cells...
  10. ncbi request reprint Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion
    C Carey
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Circ Shock 38:209-16. 1992
    ..Thus, treatment with the NO donor, C87-3754 reduced the accumulation of humoral mediators into the plasma while significantly attenuating endothelial dysfunction and improving short term survival...
  11. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
    X L Ma
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 99:1685-91. 1999
    ..Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/reperfusion, an extreme stress to the heart, is unknown...
  12. ncbi request reprint Protection of ischemia-reperfusion injury by sydnonimine NO donors via inhibition of neutrophil-endothelium interaction
    A M Lefer
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799
    J Cardiovasc Pharmacol 22:S27-33. 1993
    ..Thus, an NO donor infused at a rate calculated to replace the lost NO from the vascular endothelium of the ischemic region exerts significant protective effects on reperfusion of that ischemic vascular bed...
  13. ncbi request reprint Splanchnic vascular endothelial dysfunction in rat endotoxemia: role of superoxide radicals
    M R Siegfried
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Eur J Pharmacol 212:171-6. 1992
    ..Furthermore, because superoxide dismutase but not N-(2-mercaptopropionyl)-glycine preserves endothelial function, it is likely that superoxide radicals mediate the endothelial dysfunction observed in endotoxemic rats...
  14. ncbi request reprint Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion
    D Y Li
    Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, PA 19107, USA
    Apoptosis 11:923-30. 2006
    ..The aim of the present study was to determine whether ERK may play a role in the anti-apoptotic and cardioprotective effects of NO in myocardial ischemia/reperfusion (MI/R)...
  15. ncbi request reprint Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis
    B L Lopez
    Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Am J Hematol 64:15-9. 2000
    ..These results suggest that the initial NO level may serve as a marker for the severity of tissue ischemia. Sequential NO levels do not appear useful in predicting the course of SCC...