Eugene P Kennedy

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint The case for routine use of adjuvant therapy in pancreatic cancer
    Eugene P Kennedy
    Department of Surgery, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Surg Oncol 95:597-603. 2007
  2. doi request reprint Implementation of a critical pathway for distal pancreatectomy at an academic institution
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 605 College Building, Philadelphia, PA 19107, USA
    J Gastrointest Surg 13:938-44. 2009
  3. doi request reprint The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Gastrointest Surg 15:1411-6. 2011
  4. doi request reprint Defining treatment and outcomes of hepaticojejunostomy failure following pancreaticoduodenectomy
    Richard A Burkhart
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Gastrointest Surg 17:451-60. 2013
  5. doi request reprint A dual-institution randomized controlled trial of remnant closure after distal pancreatectomy: does the addition of a falciform patch and fibrin glue improve outcomes?
    Timothy I Carter
    Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    J Gastrointest Surg 17:102-9. 2013
  6. doi request reprint A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients
    Theresa P Yeo
    Jefferson School of Nursing, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Am Coll Surg 214:463-75; discussion 475-7. 2012
  7. doi request reprint Perioperative surgical care bundle reduces pancreaticoduodenectomy wound infections
    Harish Lavu
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Surg Res 174:215-21. 2012
  8. doi request reprint HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    Nathan G Richards
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Ann Surg 252:499-505; discussion 505-6. 2010
  9. ncbi request reprint Is gastrectomy safe in the elderly? A single institution review
    Eric S Hager
    Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am Surg 77:488-92. 2011
  10. doi request reprint Preoperative mechanical bowel preparation does not offer a benefit for patients who undergo pancreaticoduodenectomy
    Harish Lavu
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Surgery 148:278-84. 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The case for routine use of adjuvant therapy in pancreatic cancer
    Eugene P Kennedy
    Department of Surgery, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Surg Oncol 95:597-603. 2007
    ..Additional benefit to patients awaits the development of new agents, molecular targeted drugs, and novel approaches such as immunotherapy...
  2. doi request reprint Implementation of a critical pathway for distal pancreatectomy at an academic institution
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 605 College Building, Philadelphia, PA 19107, USA
    J Gastrointest Surg 13:938-44. 2009
    ..This study was designed to identify quantifiable parameters to track performance improvements brought about by the implementation of a critical pathway for complex alimentary tract surgery...
  3. doi request reprint The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Gastrointest Surg 15:1411-6. 2011
    ..Decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear...
  4. doi request reprint Defining treatment and outcomes of hepaticojejunostomy failure following pancreaticoduodenectomy
    Richard A Burkhart
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Gastrointest Surg 17:451-60. 2013
    ..Hepatogastroenterology 50:254-257, 12)...
  5. doi request reprint A dual-institution randomized controlled trial of remnant closure after distal pancreatectomy: does the addition of a falciform patch and fibrin glue improve outcomes?
    Timothy I Carter
    Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    J Gastrointest Surg 17:102-9. 2013
    ..A retrospective analysis by Iannitti et al. (J Am Coll Surg 203(6):857-864, 2006) detected a decreased leak rate in patients receiving a traditional closure buttressed with an autologous falciform ligament patch and fibrin glue...
  6. doi request reprint A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients
    Theresa P Yeo
    Jefferson School of Nursing, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Am Coll Surg 214:463-75; discussion 475-7. 2012
    ..Fatigue is the most commonly reported symptom in all cancer patients. Exercise has been found to effectively decrease fatigue levels and improve physical functioning in cancer patients...
  7. doi request reprint Perioperative surgical care bundle reduces pancreaticoduodenectomy wound infections
    Harish Lavu
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Surg Res 174:215-21. 2012
    ....
  8. doi request reprint HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    Nathan G Richards
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Ann Surg 252:499-505; discussion 505-6. 2010
    ..Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year...
  9. ncbi request reprint Is gastrectomy safe in the elderly? A single institution review
    Eric S Hager
    Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am Surg 77:488-92. 2011
    ..This information is imperative to convey to the elderly patients in the preoperative period before gastric resection...
  10. doi request reprint Preoperative mechanical bowel preparation does not offer a benefit for patients who undergo pancreaticoduodenectomy
    Harish Lavu
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Surgery 148:278-84. 2010
    ..The aim of this study was to determine whether MBP offers an advantage to patients who undergo PD...
  11. doi request reprint Serum blood urea nitrogen and serum albumin on the first postoperative day predict pancreatic fistula and major complications after pancreaticoduodenectomy
    Daniel M Relles
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Gastrointest Surg 17:326-31. 2013
    ..We set out to determine the impact of blood urea nitrogen (BUN) and albumin on POD 1 for patients undergoing PD...
  12. doi request reprint Surgical Apgar score predicts perioperative morbidity in patients undergoing pancreaticoduodenectomy at a high-volume center
    M Mura Assifi
    Department of Surgery and Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 16:275-81. 2012
    ..Numerous studies have evaluated factors to predict patients at risk. The aim of this study was to determine whether the surgical Apgar score (SAS) predicts perioperative morbidity and mortality...
  13. doi request reprint Impact of obesity on perioperative morbidity and mortality after pancreaticoduodenectomy
    Timothy K Williams
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Disease Center, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:210-7. 2009
    ..Obesity has been implicated as a risk factor for perioperative and postoperative complications. The aim of this study was to determine the impact of obesity on morbidity and mortality in patients undergoing pancreaticoduodenectomy (PD)...
  14. doi request reprint Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma
    Harish Lavu
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Gastrointest Surg 13:1937-46; discussion 1946-7. 2009
    ....
  15. doi request reprint Optimal technical management of stump closure following distal pancreatectomy: a retrospective review of 215 cases
    Lisa J Harris
    Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, MOB Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 14:998-1005. 2010
    ..Pancreatic fistula (PF) is a major source of morbidity following distal pancreatectomy (DP). Our aim was to identify risk factors related to PF following DP and to determine the impact of technique of transection and stump closure...
  16. pmc The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature
    David W Rittenhouse
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    J Gastrointest Surg 15:1643-9. 2011
    ..Dorsal agenesis of the pancreas (DAP) is a rare congenital anomaly, with only 44 cases having been reported in the English literature since 1966...
  17. doi request reprint Reoperative completion pancreatectomy for suspected malignant disease of the pancreas
    Harish Lavu
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary, and Related Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Surg Res 170:89-95. 2011
    ..In this study, we document our institution's experience with CP for recurrent malignant disease of the pancreas, describing indications for surgery, procedures performed, and patient outcomes...
  18. ncbi request reprint Initiation of a critical pathway for pancreaticoduodenectomy at an academic institution--the first step in multidisciplinary team building
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Am Coll Surg 204:917-23; discussion 923-4. 2007
    ..This study was designed to track performance improvements brought about by the implementation of a critical pathway for complex alimentary tract surgery...
  19. pmc The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    Christina L Costantino
    Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 69:4567-72. 2009
    ..We propose that HuR levels in PDA modulate the therapeutic efficacy of gemcitabine, thus serving as a marker of the clinical utility of this common chemotherapeutic agent and a potential target for intervention in pancreatic cancer...
  20. doi request reprint Preoperative imaging for resectable periampullary cancer: clinicopathologic implications of reported radiographic findings
    Zhi Ven Fong
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Gastrointest Surg 17:1098-106. 2013
    ..High-resolution, multiphase, computed tomography (CT) is a standard preoperative test prior to pancreatectomy, yet the clinical significance of routinely reported findings remains unknown...
  21. ncbi request reprint Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome
    Agnieszka K Witkiewicz
    Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 7:3021-5. 2008
    ..Thus, Cav-1 and FASN may functionally cooperate in the process of pancreatic tumorigenesis, and as such, may be good candidate prognostic markers and targets for therapeutic intervention...
  22. pmc Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature
    Laura H Rosenberger
    Department of Surgery, University of Virginia Health System, Medical Research Building 4, P O Box 801359, Charlottesville, VA 22908, USA
    J Gastrointest Surg 16:762-70. 2012
    ..Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic neoplasm characterized by excessive mucin secretion by ductal epithelial cells resulting in a cystic dilation of the pancreatic duct...
  23. doi request reprint Extended follow-up and outcomes of patients undergoing pancreaticoduodenectomy for nonmalignant disease
    Nicholas Thomas Orfanidis
    Department of Gastroenterology and Hepatology, Thomas Jefferson University, 132 South 10th Street, Main Building, Suite 480, Philadelphia, PA 19107, USA
    J Gastrointest Surg 16:80-7; discussion 87-8. 2012
    ..Due to improved surgical outcomes and increased detection of pancreatic lesions, the resection of nonmalignant and indeterminate lesions of the pancreas has increased...
  24. doi request reprint Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:738-47; discussion 747-9. 2009
    ..We tested the hypothesis that a duct to mucosa pancreaticojejunostomy would reduce the PF rate...
  25. doi request reprint Reconstruction following the pylorus preserving Whipple resection: PJ, HJ, and DJ
    Eugene P Kennedy
    Department of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    J Gastrointest Surg 14:408-15. 2010
    ..Pancreaticoduodenectomy is one of the most challenging procedures performed by general surgeons...
  26. doi request reprint Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future
    Shayna L Showalter
    Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Jefferson Pancreatic Tumor Registry, Department of Surgery, Suite 611A Curtis Building, Philadelphia, PA 19107, USA
    Expert Opin Drug Deliv 7:273-84. 2010
    ..The current targeted treatment options for PDA are reviewed. A new multidisciplinary approach for stratifying PDA patients for promising targeted adjuvant therapy and familial risk counseling is proposed...
  27. doi request reprint Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 39:1548-51. 2008
    ..This case highlights the importance of carefully evaluating patients with autoimmune pancreatitis to rule out an underlying neoplasm and the importance of following those who were treated nonsurgically until the disease fully resolves...
  28. ncbi request reprint Pancreaticoduodenectomy with extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma
    Eugene P Kennedy
    Department of Surgery, Thomas Jefferson University, Jefferson Medical College, 1025 Walnut Street, Suite 605 College Building, Philadelphia, PA 19107, USA
    Surg Oncol Clin N Am 16:157-76. 2007
    ..These studies, including a large randomized trial of 280 patients from Johns Hopkins University, indicate that there is no demonstrable survival benefit to extended lymphadenectomy for periampullary cancer...
  29. doi request reprint Commentary: Two stage pancreaticojejunostomy in pancreaticoduodenectomy: a retrospective analysis of short-term results
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Jefferson Center for Pancreatic, Biliary and Related Cancers, Philadelphia, PA, USA
    Am J Surg 196:11-2. 2008
  30. doi request reprint Giant splenic artery pseudoaneurysm
    Ross Frederick Goldberg
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1025 Walnut Street, College Bldg, Suite 605, Philadelphia, PA 19107, USA
    J Gastrointest Surg 15:1063-6. 2011
    ..We document the successful operative management of one of the largest splenic artery pseudoaneurysms (18 cm) ever reported as well as review the world literature on the subject...
  31. ncbi request reprint Renal cell carcinoma metastatic to the duodenum: treatment by classic pancreaticoduodenectomy and review of the literature
    Robert Adamo
    Department of Surgery, Jefferson Medical College, 1015 Walnut Street Suite 620, Philadelphia, PA, 19107, USA
    J Gastrointest Surg 12:1465-8. 2008
    ..Pathology confirmed metastatic RCC without lymph node involvement. Our case report and review of the English language literature underscore the rarity of this entity and support aggressive surgical treatment in such patients...
  32. pmc Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
    Shayna L Showalter
    Department of Surgery, Thomas Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University Philadelphia, Pennsylvania 19107, USA
    Cancer Biol Ther 7:986-94. 2008
    ..Future research could perhaps be directed towards alternate targets and metabolites of 5-fluorouracil, in an effort to find a clinically relevant biomarker panel for response and to optimize fluoropyrimidine-based therapy...