S K Joseph

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexin
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    Biochem J 342:153-61. 1999
  2. ncbi request reprint The inositol triphosphate receptor family
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    Cell Signal 8:1-7. 1996
  3. ncbi request reprint The interaction of calmodulin with alternatively spliced isoforms of the type-I inositol trisphosphate receptor
    C Lin
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:2305-11. 2000
  4. ncbi request reprint Factors determining the composition of inositol trisphosphate receptor hetero-oligomers expressed in COS cells
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:16084-90. 2000
  5. ncbi request reprint Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channels
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
    J Biol Chem 276:13509-12. 2001
  6. ncbi request reprint Functional properties of recombinant type I and type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cells
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:21492-9. 2000
  7. pmc Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    EMBO J 19:5450-9. 2000
  8. ncbi request reprint Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathway
    S Bokkala
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:12454-61. 1997
  9. ncbi request reprint Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system
    S K Joseph
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:1579-88. 1997
  10. pmc Single-channel recordings of recombinant inositol trisphosphate receptors in mammalian nuclear envelope
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
    Biophys J 81:117-24. 2001

Collaborators

Detail Information

Publications18

  1. pmc Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexin
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    Biochem J 342:153-61. 1999
    ..We propose that calnexin is a key chaperone involved in the folding, assembly and oligomerization of newly synthesized IP(3) receptors in the ER...
  2. ncbi request reprint The inositol triphosphate receptor family
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    Cell Signal 8:1-7. 1996
    ..Most cell types appear to contain multiple receptor isoforms. The review summarizes recent progress on IP3 receptor biology with a particular emphasis on distinctive structural and regulatory features of the individual isoforms...
  3. ncbi request reprint The interaction of calmodulin with alternatively spliced isoforms of the type-I inositol trisphosphate receptor
    C Lin
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:2305-11. 2000
    ..We conclude that the deletion of the SII splice site in the type-I IP(3)R results in the differential regulation of the alternatively spliced isoforms by Ca(2+), CaM, and protein kinase A...
  4. ncbi request reprint Factors determining the composition of inositol trisphosphate receptor hetero-oligomers expressed in COS cells
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:16084-90. 2000
    ..However, hetero-oligomers were synthesized with a longer lag period, suggesting that there may be kinetic constraints that favor homo-oligomers over hetero-oligomers...
  5. ncbi request reprint Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channels
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
    J Biol Chem 276:13509-12. 2001
    ..We propose that the pore of IP(3)R channels has two distinct sites that control monovalent cation permeation (Val(2548)) and Ca(2+) selectivity (Asp(2550))...
  6. ncbi request reprint Functional properties of recombinant type I and type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cells
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:21492-9. 2000
    ..This assay therefore provides a useful tool for studying the regulatory properties of individual IP(3)R isoforms as well as for screening pore mutations prior to more detailed electrophysiological analyses...
  7. pmc Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
    EMBO J 19:5450-9. 2000
    ....
  8. ncbi request reprint Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathway
    S Bokkala
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:12454-61. 1997
    ..We conclude that Ang II-stimulated IP3R degradation involves enhanced ubiquitination of the protein and degradation by the proteasome pathway...
  9. ncbi request reprint Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system
    S K Joseph
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:1579-88. 1997
    ..A second oligomerization domain involved in stabilization of heteroligomers is present within the first four transmembrane domains...
  10. pmc Single-channel recordings of recombinant inositol trisphosphate receptors in mammalian nuclear envelope
    D Boehning
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
    Biophys J 81:117-24. 2001
    ..This approach provides a powerful new methodology to study the permeation and gating properties of recombinant mammalian InsP(3)Rs in a native mammalian membrane environment at the single-channel level...
  11. ncbi request reprint Transforming growth factor-beta1 inhibits type I inositol 1,4,5-trisphosphate receptor expression and enhances its phosphorylation in mesangial cells
    K Sharma
    Department of Medicine, Nephrology Division, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:14617-23. 1997
    ..It is proposed that TGF-beta-mediated effects on the IP3R may be an important characteristic of its ability to modulate the response of cells to factors that employ IP3R-mediated calcium release...
  12. pmc Effect of mutation of a calmodulin binding site on Ca2+ regulation of inositol trisphosphate receptors
    X Zhang
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem J 360:395-400. 2001
    ....
  13. ncbi request reprint Renal type I inositol 1,4,5-trisphosphate receptor is reduced in streptozotocin-induced diabetic rats and mice
    K Sharma
    Nephrology Division, Pathology, and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol 276:F54-61. 1999
    ..These findings demonstrate that there is reduced type I IP3R in glomerular and vascular smooth muscle cells in the diabetic kidney, which may contribute to the altered renal vasoregulation and renal hypertrophy of diabetes...
  14. ncbi request reprint Characterization of membrane-associated proteasomes in WB rat liver epithelial cells
    M T Khan
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Arch Biochem Biophys 385:99-107. 2001
    ..Thus, the principal difference between cytosolic and membrane activity was that the latter fractions contained a novel membrane-associated LC-insensitive protease(s) catalyzing three of the major peptidase activities of the proteasome...
  15. ncbi request reprint The effect of mersalyl on inositol trisphosphate receptor binding and ion channel function
    S K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107
    J Biol Chem 270:3588-93. 1995
    ..This contrasts with the high affinity receptor/active Ca2+ channel induced by thimerosal, suggesting that even closely related thiol agents may interact at different thiol groups...
  16. pmc Single-channel properties in endoplasmic reticulum membrane of recombinant type 3 inositol trisphosphate receptor
    D O Mak
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Gen Physiol 115:241-56. 2000
    ....
  17. ncbi request reprint Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells
    S K Joseph
    Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 270:23310-6. 1995
    ..We conclude that the WB cell contains both type-I and type-III IP3R isoforms and that a proportion of these receptors exist as heterotetramers...
  18. pmc Effect of angiotensin II and ethanol on the expression of connexin 43 in WB rat liver epithelial cells
    S Bokkala
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Biochem J 357:769-77. 2001
    ..We conclude that Cx43 biosynthesis is regulated by Ca(2+)-mobilizing agonists and ethanol in WB cells. The changes in Cx43 expression might have a role in modifying the conduction of metabolites and second messengers between cells...