Research Topics
| S K JosephSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexinS K Joseph
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
Biochem J 342:153-61. 1999..We propose that calnexin is a key chaperone involved in the folding, assembly and oligomerization of newly synthesized IP(3) receptors in the ER...
The inositol triphosphate receptor familyS K Joseph
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
Cell Signal 8:1-7. 1996..Most cell types appear to contain multiple receptor isoforms. The review summarizes recent progress on IP3 receptor biology with a particular emphasis on distinctive structural and regulatory features of the individual isoforms...- The interaction of calmodulin with alternatively spliced isoforms of the type-I inositol trisphosphate receptorC Lin
Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 275:2305-11. 2000..We conclude that the deletion of the SII splice site in the type-I IP(3)R results in the differential regulation of the alternatively spliced isoforms by Ca(2+), CaM, and protein kinase A... - Factors determining the composition of inositol trisphosphate receptor hetero-oligomers expressed in COS cellsS K Joseph
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 275:16084-90. 2000..However, hetero-oligomers were synthesized with a longer lag period, suggesting that there may be kinetic constraints that favor homo-oligomers over hetero-oligomers... - Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channelsD Boehning
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
J Biol Chem 276:13509-12. 2001..We propose that the pore of IP(3)R channels has two distinct sites that control monovalent cation permeation (Val(2548)) and Ca(2+) selectivity (Asp(2550))... - Functional properties of recombinant type I and type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cellsD Boehning
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 275:21492-9. 2000..This assay therefore provides a useful tool for studying the regulatory properties of individual IP(3)R isoforms as well as for screening pore mutations prior to more detailed electrophysiological analyses... - Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptorsD Boehning
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA
EMBO J 19:5450-9. 2000.... - Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathwayS Bokkala
Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 272:12454-61. 1997..We conclude that Ang II-stimulated IP3R degradation involves enhanced ubiquitination of the protein and degradation by the proteasome pathway... - Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation systemS K Joseph
Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 272:1579-88. 1997..A second oligomerization domain involved in stabilization of heteroligomers is present within the first four transmembrane domains... - Single-channel recordings of recombinant inositol trisphosphate receptors in mammalian nuclear envelopeD Boehning
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19103, USA
Biophys J 81:117-24. 2001..This approach provides a powerful new methodology to study the permeation and gating properties of recombinant mammalian InsP(3)Rs in a native mammalian membrane environment at the single-channel level... - Transforming growth factor-beta1 inhibits type I inositol 1,4,5-trisphosphate receptor expression and enhances its phosphorylation in mesangial cellsK Sharma
Department of Medicine, Nephrology Division, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 272:14617-23. 1997..It is proposed that TGF-beta-mediated effects on the IP3R may be an important characteristic of its ability to modulate the response of cells to factors that employ IP3R-mediated calcium release... - Effect of mutation of a calmodulin binding site on Ca2+ regulation of inositol trisphosphate receptorsX Zhang
Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Biochem J 360:395-400. 2001.... - Renal type I inositol 1,4,5-trisphosphate receptor is reduced in streptozotocin-induced diabetic rats and miceK Sharma
Nephrology Division, Pathology, and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
Am J Physiol 276:F54-61. 1999..These findings demonstrate that there is reduced type I IP3R in glomerular and vascular smooth muscle cells in the diabetic kidney, which may contribute to the altered renal vasoregulation and renal hypertrophy of diabetes... - Characterization of membrane-associated proteasomes in WB rat liver epithelial cellsM T Khan
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
Arch Biochem Biophys 385:99-107. 2001..Thus, the principal difference between cytosolic and membrane activity was that the latter fractions contained a novel membrane-associated LC-insensitive protease(s) catalyzing three of the major peptidase activities of the proteasome... - The effect of mersalyl on inositol trisphosphate receptor binding and ion channel functionS K Joseph
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107
J Biol Chem 270:3588-93. 1995..This contrasts with the high affinity receptor/active Ca2+ channel induced by thimerosal, suggesting that even closely related thiol agents may interact at different thiol groups... - Single-channel properties in endoplasmic reticulum membrane of recombinant type 3 inositol trisphosphate receptorD O Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Gen Physiol 115:241-56. 2000.... - Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cellsS K Joseph
Department of Pathology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 270:23310-6. 1995..We conclude that the WB cell contains both type-I and type-III IP3R isoforms and that a proportion of these receptors exist as heterotetramers... - Effect of angiotensin II and ethanol on the expression of connexin 43 in WB rat liver epithelial cellsS Bokkala
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Biochem J 357:769-77. 2001..We conclude that Cx43 biosynthesis is regulated by Ca(2+)-mobilizing agonists and ethanol in WB cells. The changes in Cx43 expression might have a role in modifying the conduction of metabolites and second messengers between cells...