Erica Johnson

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Ubiquitin branches out
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nat Cell Biol 4:E295-8. 2002
  2. ncbi request reprint Protein modification by SUMO
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Biochem 73:355-82. 2004
  3. pmc Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
    Dafna Nathan
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:966-76. 2006
  4. pmc Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair
    Xiaole L Chen
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Genetics 177:17-30. 2007
  5. ncbi request reprint Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, and Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 67:765-72. 2007
  6. ncbi request reprint Multiple domains in Siz SUMO ligases contribute to substrate selectivity
    Alison Reindle
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Sci 119:4749-57. 2006
  7. pmc Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid
    Ling Xiong
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Biol Cell 20:1241-51. 2009
  8. ncbi request reprint Ubiquitin-dependent proteolytic control of SUMO conjugates
    Kristina Uzunova
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, Cologne, Germany
    J Biol Chem 282:34167-75. 2007
  9. pmc Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies
    James A Wohlschlegel
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Proteome Res 5:761-70. 2006
  10. ncbi request reprint Global analysis of protein sumoylation in Saccharomyces cerevisiae
    James A Wohlschlegel
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:45662-8. 2004

Research Grants

Collaborators

  • S L Berger
  • Steven I Reed
  • R Jürgen Dohmen
  • Hartmut Scheel
  • Xiaole L Chen
  • James A Wohlschlegel
  • Ling Xiong
  • Hannah R Silver
  • Puck Knipscheer
  • Ruea Yea Huang
  • Kristina Uzunova
  • Irina Belichenko
  • Nishant Gandhi
  • Gwendolyn R Bylebyl
  • Dafna Nathan
  • Alison Reindle
  • John R Yates
  • Noreen T Ahmed
  • Titia K Sixma
  • Matthias Mann
  • Willem J van Dijk
  • Alexander Fish
  • Annette Flotho
  • Helene Klug
  • Andrea Pichler
  • Jesper V Olsen
  • Caroline Adegite
  • Christoph Glanemann
  • Gerrit J K Praefcke
  • Michaela Niessen
  • David Kowalski
  • Marion Schnellhardt
  • Kay Hofmann
  • Hans Minderman
  • Stefan R Weisshaar
  • Maria Miteva
  • Kerstin Göttsche
  • Kelly A Whelan
  • David E Sterner
  • Pamela B Meluh
  • Mihajlo Krsmanovic
  • Jean A Dorsey
  • William S Lane
  • Kristin Ingvarsdottir
  • Milos Dokmanovic

Detail Information

Publications11

  1. ncbi request reprint Ubiquitin branches out
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nat Cell Biol 4:E295-8. 2002
    ....
  2. ncbi request reprint Protein modification by SUMO
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Biochem 73:355-82. 2004
    ..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
  3. pmc Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
    Dafna Nathan
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:966-76. 2006
    ..These results indicate that sumoylation is the first negative histone modification to be identified in S. cerevisiae and further suggest that sumoylation may serve as a general dynamic mark to oppose transcription...
  4. pmc Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair
    Xiaole L Chen
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Genetics 177:17-30. 2007
    ..Sumoylation is also required for growth of top1Delta cells. These results suggest that the SUMO pathway has a complex effect on genome stability that involves several mechanistically distinct processes...
  5. ncbi request reprint Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, and Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 67:765-72. 2007
    ..Cumulatively, these results reveal that SUMO modification of proteins mediates the doxorubicin cytotoxicity in yeast, at least partially, by modification of septins and of proteins that control the intracellular drug concentration...
  6. ncbi request reprint Multiple domains in Siz SUMO ligases contribute to substrate selectivity
    Alison Reindle
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Sci 119:4749-57. 2006
    ..Collectively, these results suggest that local concentration of the E3, rather than a single direct interaction with the substrate polypeptide, is the major factor in substrate selectivity by Siz proteins...
  7. pmc Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid
    Ling Xiong
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Biol Cell 20:1241-51. 2009
    ..This work also illustrates the importance of using cir(o) strains when studying mutants that affect the yeast SUMO pathway, to avoid confusing direct functions of the SUMO pathway with secondary effects of 2 microm amplification...
  8. ncbi request reprint Ubiquitin-dependent proteolytic control of SUMO conjugates
    Kristina Uzunova
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, Cologne, Germany
    J Biol Chem 282:34167-75. 2007
    ..Simultaneous inhibition of both mechanisms leads to severe phenotypic defects...
  9. pmc Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies
    James A Wohlschlegel
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Proteome Res 5:761-70. 2006
    ....
  10. ncbi request reprint Global analysis of protein sumoylation in Saccharomyces cerevisiae
    James A Wohlschlegel
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:45662-8. 2004
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes...
  11. doi request reprint Ubc9 sumoylation regulates SUMO target discrimination
    Puck Knipscheer
    The Netherlands Cancer Institute and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell 31:371-82. 2008
    ..The crystal structure of sumoylated Ubc9 demonstrates how the newly created binding interface can provide a gain in affinity otherwise provided by E3 ligases...

Research Grants5

  1. REGULATION OF SUMO CONJUGATION TO THE YEAST SEPTINS
    Erica Johnson; Fiscal Year: 2005
    ..Consequently, the fundamental understanding of SUMO conjugation provided by these studies should illuminate the role of SUMO not only in yeast septin function but also in inflammation and cancer. ..