Research Topics
Species | DOUGLAS HOOPERSummaryAffiliation: Thomas Jefferson University Country: USA Publications
Research Grants
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Detail Information
Publications
The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous systemD Craig Hooper
Center for Neurovirology, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
PLoS Negl Trop Dis 3:e535. 2009..However, the mechanisms that facilitate immune effector entry into CNS tissues are induced by infection with attenuated rabies virus...
Plant vaccines: an immunological perspectiveD C Hooper
Center for Neurovirology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107 6731, USA
Curr Top Microbiol Immunol 332:1-11. 2009..The purpose of this article is to examine the utility of plant-expression systems in vaccine development from an immunological perspective...
The role of immune responses in the pathogenesis of rabiesD Craig Hooper
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Neurovirol 11:88-92. 2005..The relationship between rabies virus and the immune system of the host is the focus of this review...- Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous systemTimothy W Phares
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 176:7666-75. 2006..This is likely the result of differences in the capacity of the tissues of the cerebellum and cerebral cortex to mediate the events required for BBB permeability changes and cell invasion during virus infection... - Failure to open the blood-brain barrier and deliver immune effectors to central nervous system tissues leads to the lethal outcome of silver-haired bat rabies virus infectionAnirban Roy
Center for Neurovirology, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust St, JAH 454, Philadelphia, PA 19107 6799, USA
J Virol 81:1110-8. 2007..Conceivably, at the stage of infection where immune access to the infected CNS tissues is limited, either the provision or the development of antiviral immunity will be ineffective... - Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophyPaola Luzi
Department of Neurology, Jefferson Medical College, 1020 Locust Street, Room 394, Philadelphia, PA 19107, USA
Brain Res 1300:146-58. 2009..There was a decrease in the number of apoptotic cells in the cerebellum of mice receiving anti-inflammatory drugs and BMT. These studies indicate a possible role for combined therapy in the treatment of GLD... - Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunityMarzena J Fabis
World Health Organization Center for Neurovirology, Department of Cancer Biology, Thomas Jefferson University, 1020 Locust Street, JAH 454, Philadelphia, PA 19107 6799, USA
Proc Natl Acad Sci U S A 105:15511-6. 2008..These findings indicate that BBB permeability changes can occur in the absence of neuropathology provided that cell invasion is restricted... - Immune evasion by rabies viruses through the maintenance of blood-brain barrier integrityAnirban Roy
Center for Neurovirology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
J Neurovirol 14:401-11. 2008.... - Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virusMilosz Faber
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 106:11300-5. 2009.... - Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic proteinSergei Spitsin
Thomas Jefferson University, 1020 Locust St, JAH room 470C, Philadelphia, PA 19107, United States
J Neuroimmunol 196:8-15. 2008..These results indicate that the early loss of BBB integrity in the cerebellum is likely to be a necessary step in the development of paralytic EAE... - A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary nor sufficientTimothy W Phares
Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 178:7334-43. 2007.... - Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrierAnirban Roy
Center for Neurovirology, Thomas Jefferson University, 1020 Locust St, JAH 454, Philadelphia, PA 19107 6799, USA
J Virol 81:7993-8. 2007..We conclude that the infiltration of immune effectors across the BBB is critical to surviving a rabies virus infection and that HPA axis activity may influence this process... - Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse modelsMarzena J Fabis
Center for Neurovirology, Department of Cancer Biology, Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
Proc Natl Acad Sci U S A 104:5656-61. 2007..Thus, the loss of BBB integrity seems to be a requisite event in the development of EAE and can occur in the absence of important inflammatory mediators... - ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrityGwen S Scott
Department of Microbiology and Immunology, Thomas Jefferson University, JAH 454, 1020 Locust Street, Philadelphia, PA 19107, USA
J Neuroimmunol 155:32-42. 2004.... - Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabiesMikhail Prosniak
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Infect Dis 188:53-6. 2003.... - The treatment of multiple sclerosis with inosineClyde E Markowitz
Neurology Department, University of Pennsylvania, Philadelphia, PA, USA
J Altern Complement Med 15:619-25. 2009.... - Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activationGwen S Scott
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Glia 41:105-16. 2003..Therefore, our results show that peroxynitrite exerts cytotoxic effects on oligodendrocytes in vitro independently of PARP activation... - Uric acid protects against secondary damage after spinal cord injuryGwen S Scott
Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 102:3483-8. 2005..They also raise the possibility that elevating UA levels may provide a therapeutic approach for the treatment of SCI as well as other neurological diseases with a peroxynitrite-mediated pathological component... - The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulationGwen S Scott
Department of Microbiology and Immunology, Thomas Jefferson University, JAH 454, 1020 Locust Street, Philadelphia, PA 19107, USA
J Pharmacol Exp Ther 310:1053-61. 2004..Therefore, the mode of action of PJ34 at the onset of EAE is likely mediated by a shift in the MBP-specific immune response from a proinflammatory Th1 toward an anti-inflammatory Th2 phenotype... - Differential expression of growth factors at the cellular level in virus-infected brainMikhail Prosniak
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 100:6765-70. 2003..Differences in the gene expression patterns suggest that the capacity of RV strains to infect nonneuronal cells and differentially modulate host gene expression may be important in virus replication and spread in the CNS...
Research Grants
- Inosine in the over-the-counter treatment of MSDOUGLAS HOOPER; Fiscal Year: 2004..abstract_text> ..
- Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?DOUGLAS HOOPER; Fiscal Year: 2007..In this proposal we will use a model system to determine whether raising uric acid levels may provide a safe, natural means of preventing secondary nerve cell death and improving the outcome of spinal cord injury. ..
- Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus ImmunizaitonDOUGLAS HOOPER; Fiscal Year: 2007..Immunohistochemical, cellular and molecular techniques will be used to characterize the activity of CD4 T cells, vascular endothelial cells, and BBB-associated astrocytes as well as the changes that occur at the BBB during infection. ..
- Passive Immunization for Neurotropic Virus InfectionDOUGLAS HOOPER; Fiscal Year: 2009..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..
- Passive Immunization for Neurotropic Virus InfectionDOUGLAS HOOPER; Fiscal Year: 2009..The ultimate aim of this project is to provide a protocol whereby exposure to neurotrophic viruses can be treated by passive immunization when contact with the agent is imminent or has recently occurred. ..