D C Hooper

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent
    D C Hooper
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 167:3470-7. 2001
  2. ncbi Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
    D C Hooper
    Department of Microbiology and Immunology, Kimmel Cancer Institute, and the Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 14:691-8. 2000
  3. ncbi Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1
    V Yusibov
    Biotechnology Foundation Laboratories, Thomas Jefferson University, 1020 Locust Street, Room 346 JAH, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 94:5784-8. 1997
  4. ncbi Genetic engineering of live rabies vaccines
    K Morimoto
    Department of Microbiology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Vaccine 19:3543-51. 2001
  5. ncbi Expression of the rabies virus glycoprotein in transgenic tomatoes
    P B McGarvey
    Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, PA 19107, USA
    Biotechnology (N Y) 13:1484-7. 1995
  6. ncbi High level expression of a human rabies virus-neutralizing monoclonal antibody by a rhabdovirus-based vector
    K Morimoto
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Immunol Methods 252:199-206. 2001
  7. ncbi Overexpression of cytochrome C by a recombinant rabies virus attenuates pathogenicity and enhances antiviral immunity
    R Pulmanausahakul
    Department of Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 75:10800-7. 2001
  8. ncbi Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure
    S Spitsin
    Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Hum Hypertens 24:359-62. 2010
  9. ncbi Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
    D C Hooper
    Center for Neurovirology, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Proc Natl Acad Sci U S A 95:675-80. 1998
  10. ncbi Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
    G S Scott
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Neuroimmunol 117:78-86. 2001

Collaborators

Detail Information

Publications18

  1. ncbi The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent
    D C Hooper
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 167:3470-7. 2001
    ..These results indicate that the CNS inflammatory response to neurotropic virus infection is likely to be dependent upon the activity of ONOO(-) or its products on the blood-brain barrier...
  2. ncbi Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
    D C Hooper
    Department of Microbiology and Immunology, Kimmel Cancer Institute, and the Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 14:691-8. 2000
    ....
  3. ncbi Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1
    V Yusibov
    Biotechnology Foundation Laboratories, Thomas Jefferson University, 1020 Locust Street, Room 346 JAH, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 94:5784-8. 1997
    ..The plant-produced protein (virus particles) was purified and used for immunization of mice. Both antigens elicited specific virus-neutralizing antibodies in immunized mice...
  4. ncbi Genetic engineering of live rabies vaccines
    K Morimoto
    Department of Microbiology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Vaccine 19:3543-51. 2001
    ..The ability to confer protective immunity depended largely upon conservation of the G protein antigenic structure between the vaccine and challenge virus, as well as on the route of immunization...
  5. ncbi Expression of the rabies virus glycoprotein in transgenic tomatoes
    P B McGarvey
    Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, PA 19107, USA
    Biotechnology (N Y) 13:1484-7. 1995
    ....
  6. ncbi High level expression of a human rabies virus-neutralizing monoclonal antibody by a rhabdovirus-based vector
    K Morimoto
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Immunol Methods 252:199-206. 2001
    ..This recombinant virus can infect a variety of mammalian cell lines and is non-cytolytic, allowing the use of cell culture technology routinely employed to produce rabies vaccines...
  7. ncbi Overexpression of cytochrome C by a recombinant rabies virus attenuates pathogenicity and enhances antiviral immunity
    R Pulmanausahakul
    Department of Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Virol 75:10800-7. 2001
    ..The strong increase in immunogenicity, coupled with the marked reduction in pathogenicity, identifies the SPBN-Cyto c(+) construct as a candidate for a live rabies virus vaccine...
  8. ncbi Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure
    S Spitsin
    Biotechnology Foundation Laboratories, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Hum Hypertens 24:359-62. 2010
    ..Our findings indicate that raising the serum UA levels to upper normal physiological levels for a period of up to 1-year does not influence blood pressure significantly...
  9. ncbi Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
    D C Hooper
    Center for Neurovirology, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Proc Natl Acad Sci U S A 95:675-80. 1998
    ....
  10. ncbi Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
    G S Scott
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Neuroimmunol 117:78-86. 2001
    ..To conclude, the results of the present investigation suggest that PARS activity may contribute to the pathogenesis of EAE...
  11. ncbi Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine
    V Yusibov
    Biotechnology Foundation Laboratories at Thomas Jefferson University, 1020 Locust Street, Room 346 JAH, Philadelphia, PA 19107, USA
    Vaccine 20:3155-64. 2002
    ..These findings provide clear indication of the potential of the plant virus-based expression systems as supplementary oral booster for rabies vaccinations...
  12. ncbi Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice
    G S Scott
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, JAH 454, Philadelphia, PA 19107, USA
    Neurosci Lett 311:125-8. 2001
    ..Therefore, the development of more potent and selective scavengers of peroxynitrite is necessary for use in EAE...
  13. ncbi Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins
    S Spitsin
    Department of Immunology and Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mult Scler 7:165-6. 2001
    ..These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin...
  14. ncbi Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease
    S Spitsin
    Biotechnology Foundation Laboratories at Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mult Scler 7:313-9. 2001
    ....
  15. ncbi Effect of rabies virus infection on gene expression in mouse brain
    M Prosniak
    Center for Neurovirology, Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107-6799, USA
    Proc Natl Acad Sci U S A 98:2758-63. 2001
    ..The gene activation patterns and the known functions of their products suggest that a number of host genes may be involved in the replication and spread of RV in the brain...
  16. ncbi Immunopathology and immunoprotection in CNS virus infections: mechanisms of virus clearance from the CNS
    D C Hooper
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA
    Curr Top Microbiol Immunol 265:163-82. 2002
  17. ncbi The role of uric acid in protection against peroxynitrite-mediated pathology
    G S Scott
    Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Med Hypotheses 56:95-100. 2001
    ..We hypothesize that higher uric acid levels in hominoids evolved to protect against this process...
  18. ncbi IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages
    A E O'Connell
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Parasite Immunol 31:741-9. 2009
    ..Thus, lethality during M. corti infection of IL-4(-/-) mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages...